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About Sickkids
About SickKids

Hartmut Grasemann, MD

The Hospital for Sick Children
Staff Respirologist
Respiratory Medicine

Research Institute
Senior Associate Scientist
Translational Medicine

University of Toronto
Professor
Department of Paediatrics


Phone: 416-813-2196
Email: hartmut.grasemann@sickkids.ca

Brief Biography

Hartmut Grasemann graduated from University of Essen medical school in Germany in 1992. Following his initial training in paediatrics and a post doctoral training in biochemistry he came to the Brigham and Women’s Hospital in Boston, Harvard Medical School for a research fellowship in respiratory medicine. He returned to Germany in 2000 to complete his paediatric training at the Children’s Hospital in Essen, where he was appointed Assistant Professor in 2002 before joining the Division of Respiratory Medicine at SickKids.

Clinical Care Activities

Lung Transplantation
Staff Respirologist

Research Interests

- genetics of chronic airway diseases
- non-invasive measurements of airway inflammation
- nitric oxide metabolism
- lung disease in sickle cell patients

Future Research Interests

Recent work from our group has demonstrated alterations in nitric oxide metabolism with potential detrimental effects on multiple aspects of obstructive airway diseases. These involve increased activity of arginase, an enzyme competing with nitric oxide synthases for the common substrate L-arginine. Furthermore, we found evidence that L-arginine deficiency contributes to both decreased NO formation and airway obstruction in patients with cystic fibrosis. Future research will focus on identifying the underlying mechanisms resulting in increased arginase activity and L-arginine deficiency in airway obstruction.

Achievements

2003 European Respiratory Society Annual Award for paediatric respiratory research in Europe.
2007 Adolf Windorfer German CF Foundation Biannual Award
2009 Zellers Senior Scientist Award, Canadian Cystic Fibrosis Foundations

Publications

For full list of publications, see NCBI bibliography.