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About Sickkids
About SickKids

Annie A. Huang, MD, PhD, FRCP(C)

The Hospital for Sick Children
Staff Oncologist, Paediatric Brain Tumour Program
Haematology/Oncology

Research Institute
Senior Scientist
Cell Biology

Principal Investigator
The Arthur and Sonia Labatt Brain Tumour Research Centre

University of Toronto
Professor
Department of Paediatrics


Phone: 416-813-7360 or 416-813-7654 ext. 207360
Fax: 416-813-8024
Email: annie.huang@sickkids.ca

For more information, visit:

Huang Lab

Brief Biography

Dr. Annie Huang is Senior Neuro-Oncologist with the Paediatric Brain Tumour Program at The Hospital for Sick Children, Toronto, where she also holds appointments as Senior Scientist in Cell Biology, and Principal Investigator at the Arthur and Sonia Labatt Brain Tumour Research Centre. She is an Associate Professor in the Departments of Paediatrics, Lab Medicine and Pathobiology, University of Toronto, Toronto, Canada.

After completing her MD and a PhD in medical and molecular genetics in 1995, Dr. Huang pursued clinical training in paediatrics and paediatric hematology-oncology followed by a post-doctoral research fellowship. Dr. Huang’s research program integrates her clinical interest in malignant brain tumours of infancy with laboratory investigations focused on the biology of rare paediatric brain tumours and mechanisms of brain tumour metastasis. Her past and recent laboratory work has specifically aimed to elucidate the pathogenesis of CNS-PNETs and Rhabdoid brain tumours (ATRTs) - two highly lethal brain tumours for which molecular mechanisms of disease remains poorly defined.

As a post-doctoral fellow, she initiated an international collaborative network for rare embryonal brain tumours which has grown into one of the largest global, collaborative network and bio-repository for these rare diseases. Work conducted by this global research network has led to discovery of new disease entities and molecular sub-types of known diseases. In addition to advancing recognition and diagnosis of rare brain tumours, work from this consortium has enabled the discovery of novel disease mechanisms as well as better understanding of CNS-PNETs and ATRTs biology that is informing design of more specific treatment approaches to these rare diseases.  

Clinical Care Activities:

  • Novel therapies for infant brain tumour
  • Supra-tentorial primitive neuroectodermal tumours

Research Interests

  • Molecular pathogenesis of malignant paediatric brain tumours
  • Role of Myc proteins in medulloblastoma PNET pathogenesis
  • Atypical Teratoid Rhabdoid brain tumours (ATRTs)

Research Activities

Dr. Annie Huang is a Neuro-Oncologist and Senior Scientist with a research program focused on understanding the pathogenesis of malignant pediatric embryonal brain tumours (EBTs) which collectively represent the most common brain neoplasms in children. Her research elaborates on major challenges in treatment of EBTs. One of the main themes of her research program is on clinical and biological studies of infant brain tumours, which she believes have the potential to broadly inform and lead to changes in conventional treatment paradigms for malignant PBTs.

Dr. Huang’s research combines a laboratory interest in molecular pathogenesis of EBTs, with a clinical translational interest in infant brain tumours, and has resulted in the development of two major programs in her laboratory over the last 12 years:(1) To define the role of the Myc oncogene in EBT progression “Myc oncogene driven pathogenic pathways in EBTs”. (2) To define the biology of poorly studied rare EBTs of childhood “Biology of rare “orphan” embryonal brain tumours”. Research activities in these programs are aimed at developing novel therapeutic insights into EBTs.

External Funding

  • National Cancer Institute of Canada
  • The Brain Tumor Society
  • Canadian Institute of Health Research (CIHR)
  • Cancer Society Research Institute (CCSRI)
  • SickKids Garron Family Cancer Centre Small Grants
  • University of Toronto and University of Sao Paolo Joint Call
  • Genome Canada

Achievements

International:

  1. Pediatric Brain Tumour Foundation, Traynor Lectureship and Award, University of California, San Francisco, California. USA. October 2015
  2. International Primitive Neuroectodermal Brain Tumour Working and Advisory Group, Invited Founding Member. 2014
  3. International Society of Pediatric Oncology – Europe (SIOP-BTe), Brain Tumour Working Group, Invited Member. 2012
  4. LIMA International Award for Excellence in Pediatric Brain Tumor Research, Children's Brain Tumor Foundation, USA. First International Awardee. 2005

National/Provincial:

  1. Canadian Cancer Society Research Institute Award for Excellence: Bernard and Francine Dorval Prize. Nominee: 2013, 2014.
  2. Charles Hollenberg Senior Fellow/Clinician Scientist Research Award sponsored by Eli Lilly/Cancer Care Ontario/Canadian Institute of Health Research – One of two Inaugural Awardees. Phase 1- 2002-2004; Phase 2 - 2005-2008 (renewal).  
  3. Canadian Institute of Health Research Post-Doctoral Research Award. 2001-2002, 2002-2003 (declined).  
  4. Ontario Cancer and Treatment Foundation.  Ivan H. Smith Studentship for Undergraduate Medical Trainees, 1993; 1994.
  5. National Cancer Institute of Canada, Steve Fonyo Doctoral Research Studentship. 1987-1989; 1989 -1991(renewal).
  6. Ontario Graduate Scholarship, Ministry of Education, Ontario. 1986

Local/Hospital/University:

  1. Mid-Career Physician Researcher Award, (recognizes research excellence for faculty members beyond first 10 years of appointment), Department of Paediatrics, SickKids Hospital, Toronto, ON. 2015
  2. Award for Excellence in Undergraduate Life Sciences teaching, Department of Lab Medicine and Pathobiology, University of Toronto, Nominee: 2013.
  3. Charles E. Snelling Award for Research, Department of Medicine, University of Toronto. 1994
  4. Harry Lyman Hooker Senior Graduate Fellowship, McMaster University, Hamilton Canada (declined). 1987
  5. Roman Pakula Memorial Merit Award for Excellence in Graduate studies, University of Toronto, Toronto, 1986.
  6. Open Graduate Research Fellowship, University of Toronto, 1986.  

Publications

View full list of publications on Pub Med »»