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About Sickkids
About SickKids

Jamie Hutchison, MD, FRCPC

The Hospital for Sick Children
Research Director
Critical Care Medicine

Research Institute
Senior Scientist
Neurosciences & Mental Health

University of Toronto
Professor
Departments of Critical Care and Paediatrics

Chair Positions

Canadian Critical Care Trials Group
Co-Chair of the Paediatric Interest Group

Canadian Critical Care Translational Biology Group
Chair

Canadian Traumatic Brain Injury Research and Clinical Network
Chair


Phone: 416-813-4918
Fax: 416-813-7299
Email: jamie.hutchison@sickkids.ca

Brief Biography

Dr. Hutchison is a Professor of Paediatrics at the University of Toronto and a recognized international expert in Paediatric Neurocritical Care. He graduated from Medicine at Queen’s University, Kingston, Ontario, Canada in 1983. Following a Paediatrics Residency he completed his Royal College Paediatric Critical Care training at the University of Western Ontario in 1992 and completed research training in ‘The biophysics of microvascular dysfunction following ischemic brain injury’ with Drs. Frewen, Sibbald and Ellis at the Burton Vascular Laboratory in London, Ontario in 1993. Dr. Hutchison then worked as a Paediatric Intensivist at the Children’s Hospital of Eastern Ontario (CHEO), Ottawa and was Director of the Critical Care Unit at CHEO from 2000-2002.

Dr. Hutchison started work in the Department of Critical Care Medicine (CCM) at SickKids in the fall of 2002 and has a clinical, education and research focus of ‘Paediatric Neurocritical Care’. In addition to being the Research Director of the CCM Program, he runs a laboratory and clinical research program in brain injury and is a Senior Scientist in the Neuroscience and Mental Health Research Program at the SickKids Research Institute. He has published over 60 peer reviewed manuscripts, delivered over 120 invited lectures and is chair of the Canadian Critical Care Translational Biology Group and Canadian Traumatic Brain Injury Research and Clinical Network. His research has been funded by the Canadian Institutes of Health Research, the Canadian Foundation for Innovation, Brain Canada, the National Institutes of Health, the Heart and Stroke Foundation of Ontario, the Ontario Neurotrauma Foundation, the Victoria Neurotrauma Initiative, Physicians Services Incorporated and the Hospital for Sick Children Foundation.

Research Interests

Laboratory research

  1. Role of leukocyte adhesion to endothelial cells in the cerebral microcirculation following global cerebral ischemia.
  2. Role of inhibitor of apoptosis proteins following brain injury.
  3. Mechanisms of hypothermia therapy following brain injury.

Clinical research

Epidemiology, prognosis and therapeutic trials in brain injury.

External Funding

  • Brain Canada and Funding Partners
  • Canadian Institutes of Health Research
  • National Institutes of Health
  • Heart and Stroke Foundation of Ontario
  • Ontario Neurotrauma Foundation
  • SickKids Foundation
  • Physician Services Incorporated

Publications

Time on the scene and interventions are associated with improved survival in pediatric out-of-hospital cardiac arrest. Tijssen JA, Prince DK, Morrison LJ, Atkins DL, Austin MA, Berg R, Brown SP, Christenson J, Egan D, Fedor PJ, Fink EL, Meckler GD, Osmond MH, Sims KA, Hutchison JS; Resuscitation Outcomes Consortium.

Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Clark AE, Browning B, Pemberton VL, Page K, Shankaran S, Hutchison JS, Newth CJ, Bennett KS, Berger JT, Topjian A, Pineda JA, Koch JD, Schleien CL, Dalton HJ, Ofori-Amanfo G, Goodman DM, Fink EL, McQuillen P, Zimmerman JJ, Thomas NJ, van der Jagt EW, Porter MB, Meyer MT, Harrison R, Pham N, Schwarz AJ, Nowak JE, Alten J, Wheeler DS, Bhalala US, Lidsky K, Lloyd E, Mathur M, Shah S, Wu T, Theodorou AA, Sanders RC Jr, Dean JM, THAPCA Trial Investigators. Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children. N Engl J Med. 2015 Apr 25.

Payne ET, Zhao XY, Frndova H, McBain K, Sharma R, Hutchison JS. Hahn C Seizure burden is independently associated with short term outcome in critically ill children. Brain. 2014 May;137(5):1429-1438.

Nenadovic V, Perez Velazquez JL, Hutchison JS. Phase synchronization in electroencephalographic recordings prognosticates outcome in paediatric coma. PLoS One. 2014 Jan 1;9(4):e94942.

Hutchison JS, Guerguerian AM. Cooling of children with severe traumatic brain injury. Lancet Neurol. 2013 Jun;12(6):527-529.

Fraser DD, Close TE, Rose KL, Ward R, Mehl M, Farrell C, Lacroix J, Creery D, Kesselman M, Stanimirovic D, Hutchison JS for the Canadian Critical Care Translational Biology Group. Severe traumatic Brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum. Ped Crit Care Med. 2011;12:319-324.

Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: a post hoc analysis of the Hypothermia Pediatric Head Injury Trial.
Hutchison JS, Frndova H, Lo TY, Guerguerian AM; Hypothermia Pediatric Head Injury Trial Investigators; Canadian Critical Care Trials Group.

Doherty DR, Parshuram CS, Hoskote A, Lacroix J, Tucci M, Joffe A, Choong K, Gaboury I, Farrell R, Bohn DJ, Hutchison JS on behalf of the Canadian Critical Care Trials Group. Hypothermia therapy after pediatric cardiac arrest. Circulation 2009;119:1492-1500.

Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Ferguson D, Gottesman R, Joffe A, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW for the Hypothermia Pediatric Head Injury Trial investigators and the Canadian Critical Care Trials Group. Hypothermia therapy following traumatic brain injury in children. N Engl J Med 2008;358:28-37.

Hutchison JS, Doherty DR, Orlowski J, Kissoon N. Hypothermia therapy for cardiac arrest in pediatric patients. Pediatr Clin N Am 2008;55:529-544.

Hare GMT, Mazer CD, Hutchison JS, McLaren AT, Liu E, Rassouli A, Ai J, Shaye R, Lockwood JA, Hawkins CE, Sikich N, To K, Baker AJ. Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma. J Appl Physiology 2007; 103:1021-1029.

Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet J-P, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ, on behalf of the TRIPICU investigators, for the Canadian Critical Care Trials Group and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Transfusion requirements in pediatric intensive care units study — a multicenter randomized controlled noninferiority clinical trial. New Engl J Med 2007; 356:1609-1619.

Mikrogianakis A, Shaye RE, Griffin P, Gendron NH, Gaboury I, MacKenzie AE, Hutchison JS. The effect of hypoxia on inhibitor of apoptosis protein (IAP) expression following traumatic brain injury in the mouse. J Neurotrauma 2007;24:338-353.

Haqqani A, Hutchison J, Ward R, Stanimirovic D. Protein biomarkers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LCMS/MS. J Neurotrauma 2007;24:54-74.

Hutchison J, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, Meyer P, Morris K, Kirpalani H, Singh R, Dirks P, Bohn D, Moher D, for the HyP-HIT investigators and the Canadian Critical Care Trials Group. Hypothermia pediatric head injury trial (HyP-HIT): the value of a pre-trial clinical evaluation phase. Dev Neurosci 2006;28 (4-5):291-301.

McIntyre LA, Fergusson DA, Hébert PC, Moher D, Hutchison JS. Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review. JAMA 2003; 289:2992-9.