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About Sickkids
About SickKids

Osami Honjo, MD, PhD

The Hospital for Sick Children
Interim Head
Cardiovascular Surgery

Co-medical director
Tissue Laboratory

Research Institute
Senior Associate Scientist
Translational Medicine

University of Toronto
Assistant Professor
Department of Surgery

Phone: 416-813-6420
Fax: 416-813-7984
Email: osami.honjo@sickkids.ca

Brief Biography

Dr. Osami Honjo became a staff cardiovascular surgeon at SickKids in July 2010, and is the Interim Head of the Division of Cardiovascular Surgery.

He finished his fellowship in cardiovascular surgery at SickKids and St. Michael’s Hospital, University of Toronto. His clinical practice focuses on open heart surgery in neonates and infants, surgical palliation for single ventricle patients, mechanical cardiopulmonary support in pediatric population, and surgery for patients with adult congenital heart diseases.

Dr. Honjo’s academic interest in basic science has been mechanical circulatory support for neonates and infants with single ventricle physiology. Working with Dr. Glen Van Arsdell, he developed a mechanical pump system that is able to support the patients with cavopulmonary connection. This support system may be a way of neonatal surgical palliation for critically ill patients or a way of bridge to transplantation. Dr. Van Arsdell and Dr. Honjo are currently conducting the first human study using this pump system in patients with hypoplastic left heart syndrome. His new study protocols include establishment of new circulatory support system in patients with single ventricle physiology that potentially eliminates two out of three staged surgical palliations. The other interest is to develop brain protection strategies for neonates and infants who require deep hypothermic circulatory arrest, for which Dr. Honjo obtained 2010 University of Toronto Roscoe Reid Graham Scholarship in Surgical Science

Dr. Honjo’s academic interests in clinical research have been preoperative and intraoperative decision making on critically ill patients. His research primarily focuses on seeking for clinical predictors/factors that influences outcome, which improve the quality of surgeons’ decision making.

Dr. Honjo obtained medical degree at Shimane Medical University and PhD at Okayama University, Japan. He is a diplomat of Japan Surgical Society (general surgery board), and Japanese board of cardiovascular surgery.


Clinical Research

  1. Honjo O, Atlin C, Mertens L, Al-Radi OO, Redington AN, Caldarone CA, Van Arsdell GS. Atrioventricular Valve Repair in Patients with Functional Single Ventricle Physiology: Impact of Ventricular Function and Morphology, Valve Morphology and Mechanism of Insufficiency on Survival and Reintervention. The Journal of Thoracic and Cardiovascular Surgery 2011 in press
  2. Honjo O, Atlin CR, Hamilton BCS, Viola N, Coles JG, Van Arsdell GS, Caldarone CA. Primary Sutureless Repair for Infants with Mixed Total Anomalous Pulmonary Venous Drainage. The Annals of Thoracic Surgery 2010;90:862-868.
  3. Honjo O, Tran KC, Hua Z, Sapra P, Alghamdi AA, Caldarone CA, Van Arsdell GS.  Impact of Evolving Surgical Strategy on Clinical Outcomes and Central Pulmonary Artery Growth in Patients with Bilateral Superior Vena Cava Undergoing Bidirectional Cavopulmonary Shunt. The Journal of Thoracic and Cardiovascular Surgery 2010 ;140:522-8.
  4.  Honjo O, Benson LN, Mewhort HE, Predescu D, Holtby H, Van Aradell GS, Caldarone CA. Pulmonary Artery Growth, Clinical Outcomes, and Program Evolution in Hybrid and Norwood Palliations. The Annals of Thoracic Surgery 2009; 87:1885-92; discussion 1892-3.
  5.  Honjo O, Al-Radi OO, MacDonald C, Tran KC, Sapra P, Davey L, Caldarone CA, Van Arsdell GS. Functional Intraoperative Pulmonary Blood Flow Study is a Sensitive Predictor of Right Ventricular Pressure and Successful VSD Closure for Following Complete Unifocalization in Patients with Pulmonary Atresia with Ventricular Septal Defect and Major Aortopulmonary Collaterals. Circulation 2009 120(11 Suppl):S46-52.
  6. Kotani Y, Honjo O, Goto K, Fujita Y, Ito A, Nakakura M, Kawada M, Sano S, Kotani K, Hiroshi Date, M.D. Modified ‘low-flow’ ultrafiltration ameliorates hemodynamics and early graft function and reduces blood loss in living-donor lobar lung transplantation. Journal of Heart and Lung Transplantation 2009;28:340-6.
  7.  Honjo O, Kotani Y, Osaki S, Fujita Y, Suezawa T, Tateishi T, Ishino K, Kawada M, Akagi T, Sano S. Discrepancy between intraoperative transesophageal echocardiography and postoperative transthoracic echocardiography in assessing congenital valve surgery. Annals of Thoracic Surgery 2006; 82: 2240-6.
  8.  Honjo O, Ishino K, Kawada M, Akagi T, Sano S. Midterm outcome of mitral valve repair for congenital mitral regurgitation in infants and children. Interactive Cardiovascular and Thoracic Surgery 2006; 5: 589-93.

Basic Science

  1.  Tomii T, Honjo O, Matsumoto T, Tachibana H, Ishino K, Ogasawara Y, Sano S. Impact of Chronic Cyanosis and Re-oxygenation on the Microheterogeneity of the Myocardial Blood Flow: A Digital Radiographic Study in Neonatal Rats. General Thoracic and Cardiovascular Surgery 2011 in press (Corresponding author)
  2.  Ugaki S, Honjo O, Nakakura M, Douguchi T, Yokoyama N, Ohuchi K, Takatani S, Sano S. The Miniaturized Circuit with TinyPump Assisted Venous Drainage Makes Transfusion-Free Cardiopulmonary Bypass Feasible and Prevents Cardiopulmonary Damages in Neonatal Piglets. The Annals of Thoracic Surgery 2010;90:1615-21.
  3.  Merklinger SL, Honjo O, Al-Radi OO, Poe J, Wang J, Oka N, Van Arsdell GS. Mechanical lung assist in neonatal pigs as a model for primary in-series palliation of hypoplastic left heart syndrome. ASAIO Journal 2009; 55(6):620-5.
  4. Lee KJ, Hinek A, Chaturvedi RR, Almeida CL, Honjo O, Koren G, Benson LN. Rapamycin-eluting stents in the arterial duct: experimental observations in the pig model. Circulation 2009;119:2078-85.
  5. Ugaki S, Honjo O, Kotani Y, Nakakura M, Sano S. Ultrafiltration of priming blood before cardiopulmonary bypass attenuates inflammatory response and maintains cardiopulmonary function in neonatal piglets. ASAIO Journal 2009;55:291-5.
  6.  Osaki S, Ishino K, Kotani Y, Honjo O, Suezawa T, Kohmoto T, Sano S. Circulatory load during hypoxia impairs post-transplant myocardial recovery in donation after cardiac death. Journal of Heart and Lung Transplantation 2009; 28:266-72.
  7.  Honjo O, Merklinger SL, Poe JB, Guerguerian AM, Alghanmdi AA, Takatani S, Van Arsdell GS. Mechanical Cavopulmonary Assist Maintains Pulmonary and Cerebral Blood Flow in a Piglet Model of a Bidirectional Cavopulmonary Shunt with High Pulmonary Vascular Resistance. Journal of Thoracic and Cardiovascular Surgery 2009; 137: 355-61.
  8.  Wermelt JZ, Honjo O, Kilic A, Van Arsdell G, Gruenwald C, Humpl T. Use of a Pulsatile Ventricular Assist Device (Berlin Heart EXCOR®) and an Interventional Lung Assist Device (Novalung®) in an Animal Model. ASAIO J 2008; 54: 498-503.
  9. Oka N, Wang L, Mi W, Zhu W, Honjo O, Caldarone CA. Cyclosporine A prevents apotosis-related mitochondrial dysfunction after neonatal cardioplegic arrest. The Journal of Thoracic and Cardiovascular Surgery 2008; 135: 123-30.
  10. Honjo O, Merklinger SL, Poe J, Guerguerian AM, Alghamdi AA, Takatani S, Van Arsdell GS. A novel mechanical lung assist system sustains primary bidirectional cavopulmonary shunt circulation in pigs. ASAIO Journal 2007; 53: 720-4.