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About Sickkids
About SickKids

Tilman Humpl, MD, PhD

The Hospital for Sick Children
Staff Physician
Critical Care Medicine

Staff Physician

University of Toronto
Associate Professor
Department of Pediatrics

Phone: 416-813-6477
Email: tilman.humpl@sickkids.ca
Alternate Contact: Melanie Hamilton
Alternate Phone: 416-813-7654 x 228385
Alternate Fax: 416-813-7299
Alternate Email: melanie.hamilton@sickkids.ca

Brief Biography

Dr. Humpl is a Paediatric Cardiologist and Paediatric Intensivist who has been on staff at the Hospital for Sick Children since February 2003. He was the acting Director of Cardiac Critical Care Medicine until December 2005 and is primarily involved in Paediatric Cardiac Critical Care.

One focus of his clinical work is the management of children on a ventricular assist device. As the Director of the Pulmonary Hypertension Service at the Hospital for Sick Children, he runs an outpatient clinic with referrals from several provinces.

Humpl was appointed the role of Program Director in 2005 - 2011 and resumed this position in April 2016. He is actively involved in resident and fellow teaching (Critical Care Medicine, Anaesthesia, Neonatology and Cardiology). Humpl also chairs the Combined Cardiac Mortality and Morbidity rounds.


S.L. Katz, I. Adatia, E. Louca, K. Leung, T. Humpl, J.T. Reyes JT, A.L. Coates: Nebulized therapies for childhood pulmonary hypertension: An in vitro model. Pediatr Pulmonol (2006) 41:666-73

T. Humpl, J.T. Reyes, H.Holtby, D. Stephens, I. Adatia: Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a single-drug, open-label, pilot study. Circulation (2005) 111:3274-3280

T. Humpl, S.H.E. Zaidi, J.Y. Coe J. Russell Y. Kaneda, L. Benson, M. Rabinovitch: Gene delivery of prostaglandin synthase maintains patency of the newborn lamb arterial duct. Pediatr Res (2005) 58:976-980

T. Humpl, B. Söderberg, B.W. McCrindle, D.G. Nykanen, R.M. Freedom, W.G. Williams, L.N. Benson: Percutanous balloon valvotomy in pulmonary atresia with intact ventricular septum: the impact on patient care. Circulation (2003) 108: 826-832

T. Humpl, B.W. McCrindle, J.F. Smallhorn: The relative roles of transthoracic compared with transoesophageal echocardiography in children with suspected infective endocarditis. J Am Coll Card (2003) 41:2068-2071

T. Humpl, R. Campbell, D. Stephens, G. van Arsdell, L.N. Benson, H.M. Holtby, A.S. Slutsky, I. Adatia: Levels of exhaled nitric oxide before and after surgical and transcatheter closure of atrial septal defects in children. Ann Thorac Surg (2002) 124:806-810

Apritz, C,  Reyes JT, Holtby H, Redington A, Humpl T.  Pharmacokinetic and Hemodynamic Responses to Oral Sildenafil during Invasive Testing in Children with Pulmonary Hypertension.  J Am Coll Card (2010) 55:1456-1462

Walsh M, Asoh K, Van Arsdell G, Humpl T.  Critical Care Outcomes in Pulmonary Atresia and Intact Ventricular Septum Undergoing Single Ventricle Palliation.  Cardiol Young  (2010)  20:290-6

Smith G, Reyes J, Russell J, Humpl T.  Safety of Maximal Exercise Testing in Children with Pulmonary Hypertension.  Chest  (2009)  135:1209-1214

Furness S, Hyslop-St George C, Pound B, Earle M, Maurich A, Rice D, Humpl T.  Development of an Interprofessional Pediatric Ventricular Assist Device Support Team.  ASAIO J.  (2008)  54:483-485V

Wermelt JZ, Honjo O, Kilic A, Van Arsdell G, Gruenwald C, Humpl T.  Use of a Pulsatile Ventricular Assist Device (Berlin Heart EXCOR) and an Interventional Lung Assist Device (Novalung) in an Animal Model.  ASAIO J.  (2008)  54:  498-503  

Jerath N, Frndova H, McCrindle B, Gurofsky R, Humpl T.  Clinical impact of vasopressin infusion on hemodynamics, liver and renal function in pediatric patients.  Intensive Care Medicine  (2008)  34:1274-80