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About Sickkids
About SickKids

Michal Inbar-Feigenberg, MD, FCCMG

The Hospital for Sick Children
Staff Physician
Clinical and Metabolic Genetics

Research Institute
Project Investigator
Research Institute

University of Toronto
Associate Professor
Department of Paediatrics


Phone: 416-813-5340
Fax: 416-813-4940
Email: michal.inbar-feigenberg@sickkids.ca

Brief Biography

Dr. Inbar-Feigenberg has completed her medical training in Israel. She completed a General Pediatric Residency Program in 2009 followed by a fellowship in Clinical Genetics at the Hadassah Hospital, Hebrew University, Israel. Upon moving to Canada, she pursued an interest in epigenetics through a clinical and research fellowship at the Division of Clinical and Metabolic Genetics, Hospital for Sick Children (2013). Thereafter, she had completed CCMG Clinical Biochemical Genetics fellowship training. Inbar-Feigenberg joined the Division of Clinical and Metabolic Genetics as a Staff Metabolic Geneticist in September 2016.

Research Interests

Treatment of Lysosomal Storage Diseases

Publications

Kazi ZB Desai AK, Berrier KL, Troxler B, Wang RY, Abdul-Rahman OA, Tanpaiboon P, Mendelsohn NJ,  Herskowitz E, Kronn D,  Inbar-Feigenberg M,  Ward-Melver C, Polan M,  Gupta P,  S. Rosenberg A, Kishnani PS. Sustained immune tolerance induction in enzyme replacement therapy-treated CRIM-negative patients with infantile Pompe disease. JCI Insight. 2017 Aug 17;2(16). pii: 94328. doi: 10.1172/jci.insight.94328. [Epub ahead of print]

Lionel AC, Costain G, Monfared N, Walker S, Reuter MS, Hosseini SM, Thiruvahindrapuram B, Merico D, Jobling R,  Nalpathamkalam T, Pellecchia, G,  Sung W, Wang Z,  Bikangaga P, Boelman C, Carter MT, Cordeiro D, Dell S, Dhir P, Dowling JJ, Heon E, Hewson S, Hiraki L, Inbar-Feigenberg M, Klatt R, Kronick J, Laxer R, Licht C,  McDonald H, Mercimek-Mahmutoglu S, Mendoza-Londono R, Piscione T, Schneider R, Schulze A, Silverman E, Siriwardena K, Snead C, Sondheimer N, Sutherland J, Vincent A, Wasserman J, Weksberg R, Shuman C, Carew  C, Szego MJ, Hayeems RZ,  Basran R, Stavropoulos DJ,  Ray PN, arah Bowdin S,  Meyn S, Cohn RD, Scherer SW, Marshall CR. Improved diagnostic yield compared to targeted gene sequencing panels suggests a role for whole –genome sequencing as a first tire genetic test. Genet Med. 2017 Aug 3. doi: 10.1038/gim.2017.119. [Epub ahead of print]

Butcher TC, Cytrynbaum C, Turinsk Y AL, Siu MT, Inbar-Feigenberg M, Mendoza-Londono R, Chitayat D, Walker S , Machado J, Caluseriu O, Grafodatskaya D, Reardon W, Gilbert-Dussardier B, Verloes A, Bilan F,  Milunsky J, Basran R, Papsin B, Stockley T, Scherer S, Choufani S,Brudno M, Weksberg R.  CHARGE and Kabuki syndromes: Unique DNA methylation signatures identify common molecular mechanisms in these clinically overlapping conditions. Am J Hum Genet 2017: 4: 100(5). Impact Factor: 10.794
Al Teneiji A, Bruun T, Cordeiro D, Patel J, Inbar-Feigenberg M, Weiss S, Struys E, Mahmutoglu S. Pyridoxine dependent epilepsy: phenotype, biochemical features, genotype and treatment outcome. Metab Brain Dis 2016: 2017 Apr; 32(2):443-451.


Marshall C, Stavropoulos D, Merico D, Jobling R, Bowdin S, Monfared N, Thiruvahindrapuram B, Nalpathamkalam T, Pellecchia G, Yuen R, Szego M, Hayeems R, Zlotnik Shaul R, Brudno M, Girdea M, Frey B, Alipanahi B, Ahmed S, Babul-Hirji R, Badilla Porras R, Carter M, Chad S, Chaudhry S, Chitayat S, Jougheh S, Cytrynbaum C, Dupuis L, Ejaz R, Fishman L, Guerin A, Hashemi B, Helal M, Hewson S, Inbar-Feigenberg M, Kannu P, Karp N, Kim R, Kronick J, Liston E, MacDonald H, Mercimek-Mahmutoglu S, Mendoza-Londono R, Nasr E, Nimmo G, Parkinson N, Quercia N, Raiman J, Roifman M, Schulze A,Shugar A, Shuman C, Sinajon P, Siriwardena K, Weksberg R, Yoon G, Carew C, Erickson R, Leach R, Klein R, Ray P, Meyn S, Scherer S, Cohn R. Whole Genome Sequencing Expands Diagnostic Utility and Improves Clinical Management in Pediatric Medicine. npj Genomic Medicine 2016. doi: 10:1038/ ngjgenmed. 2015. 12.

Inbar-Feigenberg M, Meirowitz N, Nanda D, Toi A, Okun N, Chitayat D. Beals syndrome (congenital contractural arachnodactyly) - Prenatal Ultrasound Findings and Molecular analysis. Ultrasound Obstet Gynecol 2014: 44(4): 486-490.

Inbar-Feigenberg M, Choufani S, Butcher DT, Roifman M, Weksberg R. Basic Concepts of Epigenetics. Fertil Steril 2013: 99(3): 607-615. Impact Factor: 4.426.

Inbar-Feigenberg M, Choufani S, Cytrynbaum C, Chen YA, Steele L, Shuman C, Ray PN, Weksberg R. Multiple imprinting disorders due to mosaicism for genome-wide paternal uniparental disomy: diagnostic and management issues. Am J Med Genet Part A 2013: 161 A(1): 13-20. Impact Factor: 2.082.

Ben-Neriah Z, Michaelson-Cohen R, Inbar-Feigenberg M, Nadjaril M, Zeligson S, Shaag A, Zenvirtr S, Elpeleg O, Levy-Lahad E. A deleterious founder mutation in the BMPER gene causes diaphanospondylodysostosis (DSD). Am J Med Genet Part A 2011; 155:2801-2806. Impact Factor: 2.082.

Inbar-Feigenberg M, Simanovsky N, Weiss W, Eisenstein E.M.  Crico pharyngeal spasm associated with cow milk protein allergy in infancy. Allergy 2007: 62: 87-88. Impact Factor: 6.335.