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About Sickkids
About SickKids

Jean-Philippe Julien, PhD

Research Institute
Scientist
Molecular Medicine

University of Toronto
Assistant Professor
Departments of Biochemistry, Immunology

Chair Positions
Canada Research Chair
Structural Immunology


Phone: 416-813-7654 ext. 309424
Fax: 416-813-5993
Email: jean-philippe.julien@sickkids.ca
Alternate Contact: Elisa Lam
Alternate Phone: 416-813-5748
Alternate Email: elisa.lam@sickkids.ca

For more information, visit:

The Julien lab 

Brief Biography

  • B.Sc., Biochemistry McGill University, 2005
  • PhD, Biochemistry University of Toronto, 2010
  • Postdoctoral Fellow, Integrative Structural and Computational Biology The Scripps Research Institute, USA, 2010 to 2014

Research Interests

  • Protein Structure and Function
  • Structure-Based Vaccine Design
  • Structure-Assisted Development of Therapeutics

Research Activities

Surface glycoproteins on immune cells often play critical roles that directly influence responses to invading pathogens. A better understanding of their atomic structure and the three-dimensional molecular complexes they form allows us to gain insight into their specific functions. This molecular understanding provides roadmaps for us to design improved vaccines, and treatments in cancer and autoimmune diseases.

B cell receptors in vaccines and disease

Dr. Julien is interested in the structure/function study of the B cell receptor, antibodies and critical co-receptors on the B cell surface. 

The B cell possesses several unique surface molecules that are involved in regulating B cell development and function, communicating with the extracellular environment, interpreting the BCR signal and secreting antibodies. Several of these molecules are critical to humoral immunity and have mostly remained structurally uncharacterized.

Dr. Julien’s laboratory focuses on the characterization of these B cell receptors by using a combination of biochemical, biophysical, immunological and structural techniques. Studies of their interactions with cognate molecules, therapeutics and pathogens (malaria parasite and HIV) are active areas of research in the laboratory.

Publications

Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, Sidhu SS, Magram J, Sinclair AM, Fransson J, Julien JP. Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A. 2019 Mar 20; doi: 10.1073/pnas.1817246116.

Kundu P, Semesi A, Jore MM, Morin MJ, Price VL, Liang A, Li J, Miura K, Sauerwein RW, King CR, Julien JP. Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45. Nat Commun. 2018 Oct 26; 9: 4458. doi: 10.1038/s41467-018-06742-9.

Imkeller K, Scally SW, Bosch A, Martí GP, Costa G, Triller G, Murugan R, Renna V, Jumaa H, Kremsner PG, Sim BKL, Hoffman SL, Mordmüller B, Levashina E, Julien JP, Wardemann H. Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science. 2018 Jun 22; 360(6395): 1358-1362. doi: 10.1126/science.aar5304. First Release 2018 Jun 7.

Scally SW, McLeod B, Bosch A, Miura K, Liang Q, Carroll S, Reponen S, Nguyen N, Giladi E, Rämisch S, Yusibov V, Bradley A, Lemiale F, Schief WR, Emerling D, Kellam P, King CR, Julien JP. Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25. Nat Commun. 2017 Nov 16; 8:1568. doi: 10.1038/s41467-017-01924-3.

Ereño-Orbea J, Sicard T, Cui H, Mazhab-Jafari MT, Benlekbir S, Guarné A, Rubinstein JL, Julien JP. Molecular basis of human CD22 function and therapeutic targeting. Nat Commun. 2017 Oct 2; 8:764. doi: 10.1038/s41467-017-00836-6. 

For a full list of publications, please visit PubMed