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About Sickkids
About SickKids

Paul Kantor, MBBCh, DCH, FRCPC

The Hospital for Sick Children
Transplant Cardiologist
Cardiac Transplant Program

Staff Cardiologist
Cardiology

Head: Cardiomyopathy and Heart Function Program
Cardiology

University of Toronto
Associate Professor
Department of Paediatrics


Phone: 416-813-7239
Fax: 416-813-7547
Email: paul.kantor@sickkids.ca

For more information, visit:

Cardiology
Cardiac Transplant Program

Clinical Care Interests

2003
Principal Investigator: “Development and prospective evaluation of a multivariate assessment tool for the severity of the ductus arteriosus shunt in premature newborns.”

2003
Principal Investigator: “ Tissue Doppler assessment of myocardial Force-frequency relationship in patients with acute phase septic shock.”

1999
Collaborative investigator: “ Effect of angiotensin converting enzyme inhibitors on cardiac function in asymptomatic anthracycline mediated cardiotoxicity.”
A multicentre trial of the Pediatric Oncology Group of investigators

1997
Principal Investigator: “ Pulmonary artery stenting in extreme pulmonary arterial hypoplasia in infancy.”

1996
Principal Investigator: “The effect of dexamethasone on cardiac structure and function in the premature infant.”

1995
Principal Investigator: “Fetal tachyarrhythmia: incidence and outcome.” A retrospective study.

External Funding

Left Ventricular Dysfunction in Adult survivors with Tetralogy of Fallot. Funded by the Labatt Family Heart Centre innovation fund, 2008

Improving pediatric cardiac care in Ontario: leveraging information to enchance patient outcomes, provide accountability and system monitoring. Ontario Ministry of Health and Long Term Care, 2006 - 2007

Ventricular Function and Vascular Stiffness in Children with Dilated Cardiomyopathy. Funded by Pediatric Consultants at The Hospital for Sick Children, 2007

Impact of Medical therapy on the survival of patients with Dilated Cardiomyopathy. Funded by Pediatric Consultants at The Hospital for Sick Children, 2005. 
Ventricular Function and Vascular Stiffness in Dilated Cardiomyopathy.

Haemodynamic and biochemical outcomes in a neonatal experimental model of left ventricular volume overload and hypertrophy. Funded by Children's Health Foundation of Northern Alberta, the Alberta Heritage Foundation for Medical Research and the Heart and Stroke Foundation of Canada (1996-1998) - Principal Investigator

Molecular characterization and role of malonyl CoA decarboxylase in the mammalian heart. (Funded by the Alberta Heritage foundation for Medical Research & the Canadian Diabetes Association) Co-investigator

Cloning, expression and physiologic role of cardiac fatty acyl CoA synthetase. Co-investigator

Haemodynamic and biochemical outcomes in a neonatal experimental model of left ventricular volume overload and hypertrophy.(Funded by Children’s Health foundation of Northern Alberta, & Alberta Heritage foundation for Medical Research & Heart and Stroke Foundation of Canada.) Principal investigator

1996-98: Heart and Stroke foundation of Canada Research Fellowship
Heritage Cardiovascular Research Group, University of Alberta, Edmonton.

The effect of post infarction exercise training on ventricular fibrillation threshold in the ischemic rat heart.(Funded by the South African Medical Research Council) Co-investigator

The effect of sulfonylurea drugs on the electrophysiology and arrhythmias of the ischemic rat heart. (Funded by the South African Medical Research Council) Principal Investigator

Factors governing the development of Ischemic and reperfusion arrhythmias in diabetes and diabetic Cardiomyopathy in the rat.  Principal Investigator

MRC Ischemic Heart Disease Research Unit: University of Cape Town Medical School. Postdoctoral Research Fellow, 1986-88

Achievements

Postgraduate:

1998
Canadian Cardiovascular Society, Richard Rowe Prize
for outstanding research in Pediatric Cardiology.

1997
Alberta Heritage Foundation for Medical Research fellowship.

1997
Heart and Stroke Foundation of Canada Research fellowship

1996
University of British Columbia: Joseph J Diamond Memorial Prize Award (for academic achievement).

1986
University of Cape Town: Guy Elliot Research Fellowship

1985
University of Cape Town: Guy Elliot Research Fellowship

Undergraduate

1979
University of the Witwatersrand Convocation Merit Scholarship (for academic achievement)

Publications

Friedberg, MK, Roche SL, Mohammed AF, Balasingam M, Atenafu EG and Kantor PF: Left ventricular diastolic mechanical dyssynchrony and associated clinical outcomes in children with dilated cardiomyopathy. Circulation: Cardiovascular Imaging. 2008;1:50-57

Lemaire M, Kantor PF, Manson D, Grasemann H: Index of suspicion- PDA. Pediatrics in Review 2008:

Dutta S, Mihailovic A, Benson L, Kantor PF, Fitzgerald PG, Walton JM, Langer JC, Cameron BH: Thoracoscopic ligation versus coil occlusion for patent ductus arteriosus: A matched cohort study of outcomes and cost. Surg Endosc 2008;22(7):1643-1648

Walsh MA, Benson LN, Dipchand AI, Redington AN, Caldarone CA, Van Arsdell GS, Kantor PF: Surgical repair of the mitral valve in children with dilated cardiomyopathy and mitral regurgitation. Ann Thorac Surg 2008;85(6):2085-2088.

Roche SL, Kaufmann J, Dipchand AI, Kantor PF: Hypertension after pediatric heart transplantation is primarily associated with immunosuppressive regimen. Journal of Heart and Lung Transplantation 2008;27(5):501-507. SRA.

Friedberg MF, Roche SL, Balasingam M, Stephenson E, Slorach C, Fackoury C, Kantor PF: Evaluation of mechanical dyssynchrony in children with idiopathic dilated cardiomyopathy and associated clinical outcomes. Am J Cardiol 2008;101(8):1191-1195.

Pollock-BarZiv SM, den Hollander N, Ngan BY, Kantor P, McCrindle B, and Dipchand AI: Pediatric heart transplantation in human leukocyte antigen sensitized patients: evolving management and assessment of intermediate-term outcomes in a high-risk population. Circulation 2007: 116(1Supp): pp I172-I178. C

Kantor PF, and Slorach C: Clinical considerations for heart rhythm allied professionals: understanding heart failure in congenital heart disease (CHD) patients. Feb 2007. Heart Rhythm Journal 2007: 4(2): pp 248-250.

Canter CE, Kantor PF:  Heart transplant for pediatric cardiomyopathy. Progress in Pediatric Cardiology 2007: 23(2007): pp 67-72

Kantor PF, Lucien A, Kozak R, Lopaschuk GD: The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl conenzyme A thiolase. Circulation Research 2000: 86(5): pp 580-588. PA

Dyck JR, Berthiaume LG, Thomas PD, Kantor PF, Barr AJ, Barr R, Singh D, Hopkins TA, Voilley N, Prentki M, Lopaschuk GD: Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism. Biochemical Journal 2000: 350 Pt 2: pp 599-608.

Kantor P. Heart murmurs in children Canadian Journal of CME,October, 2000.

Kantor PF, (commentary). Nuchal fold translucency thickness as a screening test for fetal congenital heart disease: Evidence Based Cardiovascular Medicine, 2000.

Kantor PF, Robertson MA, Coe JY, Lopaschuk GD: Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism. Journal of the American College of Cardiology 1999: 33(6): pp 1724-1734. PA

Lopaschuk GD, Kantor PF, Dyck JRB. Optimizing cardiac metabolism: a new reference approach in the management of ischemic heart disease? Medicographia 1999;21:109-115.

Kantor PF, Robertson M, Coe JY, Lopaschuk GD. Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation fatty acid metabolism. J Am Coll Cardiol.1999;33:1724-1734.

Kantor PF, Dyck JRB, Lopaschuk GD. Abnormalities of fatty acid metabolism in the ischemic and reperfused myocardium. Am J Med Sciences.1999.

Makinde A-O, Kantor PF, Lopaschuk GD. Maturation of fatty acid and carbohydrate metabolism in the newborn heart. Mol Cell Biochem 1998;188:49-56.

Kantor PF, Coetzee WA, Carmeliet EE, Dennis SC, Opie LH: Reduction of ischemic K+ loss arrhythmias in rat hearts: effect of glibenclamide, a sulfonylurea. Circulation Research 1990;66:478-485.

D. Posel, T. Noakes, P. Kantor, M. Lambert and L. Opie: Exercise training after experimental myocardial infarction increases the ventricular fibrillation threshold before and after the onset of reinfarction in the isolated rat heart. Circulation 1989;80:138-145.