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About Sickkids
About SickKids

Ran Kafri, PhD, M.Sc.

Research Institute
Scientist
Cell Biology

University of Toronto
Assistant Professor
Molecular Genetics


Phone: 416-813-7654 ext. 309092
Fax: 416-813-5028
Email: ran.kafri@sickkids.ca
Alternate Contact: Mary Ann Gueco
Alternate Phone: 416-813-7654 ext. 303045
Alternate Fax: 416-813-8456
Alternate Email: maryann.gueco@sickkids.ca

For more information, visit:

Kafri Lab

Research Interests

  • Cell growth and proliferation of animal cells
  • Development of ergodic rate analysis (ERA)
  • Dynamics of DNA double strand break repair
  • Evolution and utilization of genetic redundancy by cellular systems
  • Statistical models for molecular recognition, under the supervision of Doron Lancet
  • The effects of Macromolecular crowding on biochemical kinetics and protein folding, under the supervision of Amnon Horovitz
  • Crystallographic studies of ribosomal structure, under the supervision of Ada Yonath
  • The derivation of a novel type of biosensors based on color sensitive, artificial membranes, in the laboratory of Raz Jelineck

Achievements

7/2010 – 6/2012 Charles A. King Trust Postdoctoral Research Fellowship,
Harvard Medical School
Award:  $92,000 USD

4/2007 – 9/2010 Human Frontier Science Program Organization, HFSP Fellowship
Award:  $160,688 USD

Publications

Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW.  Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature 2012:494 (7438):480-3.

Karanam K, Kafri R (equal contribution with Karanam), Löwer A, Lahav G. Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.  Mol. Cell 2012:47(2):320-9.

Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK.  Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.  Science 2012:336(6084): 1040-4.  

Juang YT, Peoples C, Kafri R, Kyttaris VC, Sunahori K, Kis-Toth K, Fitzgerald L, Ergin S, Finnell M, Tsokos GC.  A systemic lupus erythematosus gene expression array in disease diagnosis and classification: a preliminary report. Lupus 2011:20(3): 243-9.  

Kafri R, Markovitch O, Lancet D.  Spontaneous chiral symmetry breaking in early molecular networks. Biol. Direct 2010:5:8.

Tzur A, Kafri R (equal contribution with Tzur), LeBleu VS, Lahav G, Kirschner MW.  Cell growth and size homeostasis in proliferating animal cells. Science 2009: 325(5937):167-71.

Kafri R, Springer M, Pilpel Y. Genetic redundancy: new tricks for old genes. Cell 2009: 136(3):389-92.

Kafri R, Dahan O, Levy J, Pilpel Y.  Preferential protection of protein interaction network hubs in yeast: evolved functionality of genetic redundancy.  Proc. Natl. Acad. Sci. 2008:105(4):1243-8.  

Kafri R, Levy M, Pilpel Y.  The regulatory utilization of genetic redundancy through responsive backup circuits Proc. Natl. Acad. Sci. 2006:103(31):11653-8.  

Kafri R, Bar-Even A, Pilpel Y. Transcription control reprogramming in genetic backup circuits. Nat. Genet. 2005:37(3):295-9.