Facebook Pixel Code
About Sickkids
About SickKids

Ran Kafri, PhD, M.Sc.

Research Institute
Scientist
Cell Biology

University of Toronto
Assistant Professor
Molecular Genetics

Chair Positions
Canada Research Chair
Canada Research Chair in Quantitative Cell Biology


Phone: 416-813-7654 ext. 309092
Fax: 416-813-5028
Email: ran.kafri@sickkids.ca
Alternate Contact: Mary Ann Gueco
Alternate Phone: 416-813-7654 ext. 303045
Alternate Fax: 416-813-8456
Alternate Email: maryann.gueco@sickkids.ca

For more information, visit:

Kafri Lab

Research Interests

  • Cell growth and proliferation of animal cells
  • Development of ergodic rate analysis (ERA)
  • Dynamics of DNA double strand break repair
  • Evolution and utilization of genetic redundancy by cellular systems
  • Statistical models for molecular recognition, under the supervision of Doron Lancet
  • The effects of Macromolecular crowding on biochemical kinetics and protein folding, under the supervision of Amnon Horovitz
  • Crystallographic studies of ribosomal structure, under the supervision of Ada Yonath
  • The derivation of a novel type of biosensors based on color sensitive, artificial membranes, in the laboratory of Raz Jelineck

Achievements

7/2010 – 6/2012 Charles A. King Trust Postdoctoral Research Fellowship,
Harvard Medical School
Award:  $92,000 USD

4/2007 – 9/2010 Human Frontier Science Program Organization, HFSP Fellowship
Award:  $160,688 USD

Publications

Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW.  Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature 2012:494 (7438):480-3.

Karanam K, Kafri R (equal contribution with Karanam), Löwer A, Lahav G. Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.  Mol. Cell 2012:47(2):320-9.

Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK.  Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.  Science 2012:336(6084): 1040-4.  

Juang YT, Peoples C, Kafri R, Kyttaris VC, Sunahori K, Kis-Toth K, Fitzgerald L, Ergin S, Finnell M, Tsokos GC.  A systemic lupus erythematosus gene expression array in disease diagnosis and classification: a preliminary report. Lupus 2011:20(3): 243-9.  

Kafri R, Markovitch O, Lancet D.  Spontaneous chiral symmetry breaking in early molecular networks. Biol. Direct 2010:5:8.

Tzur A, Kafri R (equal contribution with Tzur), LeBleu VS, Lahav G, Kirschner MW.  Cell growth and size homeostasis in proliferating animal cells. Science 2009: 325(5937):167-71.

Kafri R, Springer M, Pilpel Y. Genetic redundancy: new tricks for old genes. Cell 2009: 136(3):389-92.

Kafri R, Dahan O, Levy J, Pilpel Y.  Preferential protection of protein interaction network hubs in yeast: evolved functionality of genetic redundancy.  Proc. Natl. Acad. Sci. 2008:105(4):1243-8.  

Kafri R, Levy M, Pilpel Y.  The regulatory utilization of genetic redundancy through responsive backup circuits Proc. Natl. Acad. Sci. 2006:103(31):11653-8.  

Kafri R, Bar-Even A, Pilpel Y. Transcription control reprogramming in genetic backup circuits. Nat. Genet. 2005:37(3):295-9.