Tae-Hee Kim, PhD
Developmental & Stem Cell Biology
University of Toronto
Department of Molecular Genetics
For more information, visit:
- Scientist/Assistant Professor, Development and Stem cells, The Hospital for Sick Children/University of Toronto, Canada (2014-present)
- Instructor, Development and Stem cells, Dana-Farber Cancer Institute/Harvard Medical School, USA (2014)
- Post-doctoral Fellow, Development and Stem cells, Dana-Farber Cancer Institute/Harvard Medical School, USA (2011)
- PhD, Cell Biology and Genetics, Howard Hughes Medical Institute, Cornell University/Sloan Kettering Institute, USA (2006)
- M.Sc., Biology, University of Illinois at Urbana-Champaign, USA (1999)
- B.Sc., Biology, Sungkyunkwan University, South Korea (1996)
Our lab addresses two fundamentally important questions: (1) how different organs and cell types are generated from stem cells and maintained for proper function over a lifetime, and (2) how mechanisms of normal stem cell homeostasis may be altered in diseases such as cancer. Since the gastrointestinal tract rapidly self-renews throughout life and is a common target of deadly cancers, our lab studies the gut as a model system, applying the combined approaches of mouse genetics, epigenomic analyses, and stem cell and organoid cultures. We hope understanding stem cell homeostasis in gut development and disease will provide deeper insight into the relationship between normal development and mechanisms of disease, and help identify new therapeutic targets for lethal digestive tract cancers and regenerative medicine.
- 2016 - March of Dimes Basil O'Connor Starter Scholar Research Award
- 2014 - Catalyst Scholar in Regenerative Medicine
- 2012 - NIH Pathway to Independence Award (K99/R00)
- 2011 - North American NeuroEndocrine Tumor Society Early Career Development Award
Kim T-H*, Saadatpour A*, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC#, Shivdasani RA# . (2016). Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5+ intestinal stem cells (* equal contribution). Cell Reports. 16(8): 2053-2060.
Kim T-H# and Shivdasani RA# (# co-corresponding authors). (2016). Stomach development, stem cells and disease. Development. 143: 554-565.
Kim T-H, Li F, Ferreiro-Neira I, Ho L-L, Luyten A, Nalapareddy K, Liu XS, Verzi M, Shivdasani RA. (2014) Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. 506(7489):511-5. (Recommended by Faculty of 1000)
Kim T-H, Shivdasani RA. (2012) Intestinal stem cell niche: Famished Paneth cells, gluttonous stem cells. Current Biology. 22(14):R579-80.
Kim T-H, Escudero S, Shivdasani RA. (2012) Intact function of Lgr5-expressing stem cells in the absence of Paneth cells. Proceedings of the National Academy of Science-USA. 109(10):3932-7.
Zhang Y*, Kim T-H*, Niswander L. (2012) Phactr4 regulates directional migration of Enteric Neural Crest through PP1, integrin signaling and cofilin activity (* equal contribution). Genes & Development. 26(1):69-81. (Cover Article, Featured in perspectives Genes & Development 2012;26(1):1-5, Highlighted in Nature Cell Biology 2012;14:130, and Recommended by Faculty of 1000)
Kim T-H*, Kim B-M*, Mao J, Rowan S, Shivdasani RA. (2011) Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme (* equal contribution). Development. 138(15):3225-33.
Kim T-H, Shivdasani RA. (2011) Notch signaling in stomach epithelial stem cell homeostasis. Journal of Experimental Medicine. 208(4):677-88. (Cover Article)
Kim T-H, Shivdasani RA. (2011) Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. Journal of Biological Chemistry. 286:11427-33.
Kim T-H, Goodman J, Anderson K, Niswander L. (2007) Phactr4 regulates neural tube closure by controlling PP1, Rb phosphorylation and cell cycle progression. Developmental Cell. 13:87-102.
San Roman AK, Kim T-H, Shivdasani RA. (2015). The Alimentary Canal. The Atlas of Mouse Development (Kaufman)-supplement. Elsevier, United Kingdom: 77-84.
Kim T-H, Shivdasani RA. (2014). Basic science of Stomach Development. Translational Gastroenterology: Organogenesis to Disease. Wiley Backwell, United States: 43-56.