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About Sickkids
About SickKids

Mathieu Lemaire, MSc, MDCM, PhD, FRCP(C), FAAP

The Hospital for Sick Children
Staff Nephrologist
Nephrology

University of Toronto
Assistant Professor
Department of Paediatrics

Assistant Professor
Department of Biochemistry (cross appointment)

Assistant Professor
Institute of Medicine (cross appointment)


Phone: 416-813-7654 x207566
Fax: 416-813-6271
Email: mathieu.lemaire@sickkids.ca

Brief Biography

Dr. Mathieu Lemaire is a Staff Nephrologist, Nephrology at The Hospital for Sick Children (SickKids). Dr. Lemaire finished his medical training at McGill University in 2004 and then moved to Toronto to learn paediatrics at SickKids. After completing his fellowship in Paediatric Nephrology in Toronto, he went to Yale University (New Haven, CT) to pursue a PhD in Investigative Medicine under the guidance of Dr. Richard P. Lifton, with a focus on the genetics of rare paediatric kidney diseases. Dr. Lemaire returned to the University of Toronto in 2014 as Assistant Professor of Paediatrics. He joined the Division of Nephrology at SickKids as a Staff Nephrologist, and the SickKids Research Institute as Scientist-Track Investigator.

Clinical Interests

  • Staff physician in the Division of Nephrology, SickKids
  • Renal electrolyte/acid-base disturbances (acquired or inherited tubulopathies)
  • Other renal genetic disorders
  • Glomerulonephritides

Academic Background

Degrees, Diplomas and Certifications

2014 PhD, Yale University, New Haven, Connecticut, USA
2009 LMCC, Paediatric Nephrology, Royal College of Physicians & Surgeons of Canada
2009 Residency/Fellowship, University of Toronto, The Hospital for Sick Children, Division of Nephrology, Toronto, Ontario, Canada
2008 Certificate Summer Program - Clinical Effectiveness, Harvard Medical School, Boston, Massachusetts, USA
2008 FRCP(C), Royal College of Physicians & Surgeons of Canada
2007 Residency, Paediatrics, University of Toronto, Toronto, Ontario, Canada
2004 LMCC, Medicine, Royal College of Physicians & Surgeons of Canada
2004 MDMC, McGill University, Montreal, Quebec, Canada
1999 MSc, McGill University, Montreal, Quebec, Canada
1997 BSc, McGill University, Montreal, Quebec, Canada

Research Interests

My main interest is to do translational research that pertains to rare paediatric kidney diseases using genomic tools for gene discovery, followed by careful functional dissection of candidate genes using cutting-edge microscopic, cell biology and biochemical methods.

  • We recently identified the first non-complement gene that causes a recessive form of atypical hemolytic-uremic syndrome (aHUS), diacylglycerol kinase epsilon. (DGKE; Lemaire et al., Nature Genetics, 2013).
  • We are working to tease out how DGKE loss-of-function causes thrombosis that is restricted to small calibre vessels of infant’s kidneys.

  • We are continuing to perform gene discovery on a variety of rare paediatric kidney diseases using whole-exome sequencing.

Currently, our main focus has been studying atypical HUS with the hope that our results will not only contribute to a better understanding, but will also translate into tangible changes in clinical care within a reasonable time frame.

Achievements

2010 Post-doctoral fellowship, KRESCENT/CIHR/CKF (3 years, $65,000/year)
2009 Post-doctoral fellowship, Howard Hughes Medical Institute ($45,000/year)
2007 Norman Saunders Award for Excellence in Clinical Paediatrics, The Hospital for Sick Children, Toronto
2006 Rockefeller/Evans International Health Fund - Elective Scholarship ($2,000)
2005 Rockefeller/Evans International Health Fund - Elective Scholarship ($2,000)

Publications

Journal Articles

  1. So, V., Jalan, D., Lemaire, M., Topham, M. K., Hatch, G. M., & Epand, R. M. (2016). Diacylglycerol kinase epsilon suppresses expression of p53 and glycerol kinase in mouse embryo fibroblasts. Biochim Biophys Acta, 1861(12 Pt A), 1993-1999.
  2. Epand, R. M., So, V., Jennings, W., Khadka, B., Gupta, R. S., & Lemaire, M. (2016). Diacylglycerol Kinase-ε: Properties and Biological Roles. Front Cell Dev Biol, 4, 112.
  3. Mele, C., Lemaire, M., Iatropoulos, P., Piras, R., Bresin, E., Bettoni, S. et al. (2015). Characterization of a New DGKE Intronic Mutation in Genetically Unsolved Cases of Familial Atypical Hemolytic Uremic Syndrome. Clin J Am Soc Nephrol, 10(6), 1011-1019.
  4. Lemaire M, Frémeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nürnberg G, Altmüller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nürnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. (2013) Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nat Genet. 45(5):531-6.
  5. Lemaire M, Islam QS, Shen H, Khan MA, Parveen M, Abedin F, Haseen F, Hyder Z, Cook RJ, Zlotkin SH. (2011) Iron-containing micronutrient powder (iMNP) provided to children with moderate-to-severe malnutrition increased hemoglobin but not infectious morbidity risk: A randomized, double-blind, placebo-controlled, non-inferiority safety trial. Am J Clin Nutr. 94(2):585-93.
  6. Lemaire M et al. (2010) Treatment of vancomycin intoxication using hemodialysis with a high-flux membrane: case report and review of the literature. Nephr. Dial. Transplant. Plus 3, 260-264.
  7. Lemaire M. et al. (2009) A novel disease-causing mutation in AVPR2: Q96H. Nephr. Dial. Transplant. Plus 1, 200-222 .
  8. Lemaire M, Diamond IR, Langer JC. (2009) Whole or parts—the fate of hemoperitoneum. Surgery. 146(5):947-9
  9. Zalunardo N, Lemaire M, Davids MR, Halperin ML. (2004) Acidosis in a patient with cholera: a need to redefine concepts. Quart. J. Med. 97(10):681-96.

Writings as Associate Scientific Advisor, Science Translational Medicine

  1. Lemaire M. Superheeroes and Villians of the Heart. Sci Transl Med 15 October 2014 6:258ec175. DOI:10.1126 scitranslmed.aaa0483
  2. Lemaire M. Human cells: Finally Open for Cancer Business. Sci Transl Med 3, September 2014 6:252ec150. DOI: 10.1126/scitranslmed.3010262.
  3. Lemaire, M. For IBD, Bugs and Genes Are the Name of the Game. Sci Transl Med 23, July 2014 6:246ec126. DOI:10.1126/scitranslmed.3009812.
  4. Lemaire, M. WANTED: Natural-Born Sickler. Sci Transl Med 11 June 2014. 6:240ec101. DOI:10.1126/scitranslmed.3009588.
  5. Lemaire M. PGE2—The Immune System Tamer. Sci Transl Med 30 April 2014. 6:234ec75. DOI:10.1126/scitranslmed.3009255.

Book Chapters

  1. Lemaire M. & Frémeaux-Bacchi V. Chapter 45: HUS, TTP & other thrombotic microangiopathies. In Genetic Diseases of the Kidney, 2nd Edition. Editors: Lifton R., Somlo S., Giebisch G., Seldin D., and Pollak M. Elsevier, (to be published ).
  2. Lemaire M. & Waters A. Chapter 4: Genetics: Basic Concepts and Testing. In Pediatric Kidney Disease (2016) Editors: Geary D.F., & Schaefer F. Mosby.
  3. Lemaire M., Radhakrishnan, S., & Licht C. Chapter 16: Fluid, Electrolytes and Acid-Base. In Hospital for Sick Children Handbook, 11th Edition. Editors: Dipchand A.I., Friedman J.N., Gupta, S., Bismilla Z., & Lam C. Elsevier, 2009.