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About Sickkids
About SickKids

Simon Ling, MB, ChB, MRCP(UK)

The Hospital for Sick Children
Division Head
Gastroenterology, Hepatology and Nutrition

University of Toronto
Associate Professor
Paediatrics


Phone: 416-813-8757
Fax: 416-813-6531
Email: simon.ling@sickkids.ca
Alternate Contact: Karen Danois
Alternate Email: karen.danois@sickkids.ca

Brief Biography

Dr. Simon Ling graduated in medicine from the University of Edinburgh, Scotland and trained in paediatric gastroenterology in Glasgow, Scotland and the Hospital for Sick Children, Toronto. He worked initially as Consultant at the Royal Hospital for Sick Children, Glasgow, and was then appointed to SickKids and the University of Toronto in 2003.  Dr Ling has served as Head of the Division of Gastroenterology, Hepatology and Nutrition since 2015, and previously as Director of the Paediatric Gastroenterology Training Program from 2009 - 2014. He received the Department of Paediatrics’ Richard Rowe Award for Clinical Excellence in Paediatric Medical Care in 2013.

Areas of Specialty

Dr. Ling’s subspecialty interest is paediatric liver disease.  He also maintains a broad interest and experience in paediatric gastroenterology and endoscopy.

Research Interests

Dr Ling’s clinical research activities aim to improve our ability to predict the progression of chronic liver disease and its complications in children, focusing on children at risk of variceal bleeding, children with cystic fibrosis liver disease (CFLD), and children with chronic viral hepatitis B and C. He collaborates in the CFLD Research Network and the Hepatitis B Research Network (HBRN).

Publications

Selected recent publications, for a complete list, please see PubMed

 

Acute variceal bleeding causes significant morbidity. (May 2018). Carneiro de Moura M, Chen S, Kamath BM, Ng VL, Ling SC. J Pediatr Gastroenterol Nutr.

Cystic fibrosis related liver disease: research challenges and future perspectives. (October 2017). Debray D, Narkewicz MR, Bodewes F, Housset C, de Jonge HR, Jonker JW, Kelly D, Ling SC, Poynard T, Sogni P, Traunder M, Witters P, Baumann U, Wilschanski M, Verkade HJ. J Pediatr Gastroenterol Nutr. 65(4): 443-448.

Health-related quality of life in pediatric patients with chronic hepatitis B living in the United States and Canada. (May 2017). Schwarzenberg SJ, Ling SC, Cloonan YK, Lin HH, Evon DM, Murray KF, Rodriguez-Baez N, Rosenthal P, Teckman J, Schwarz KB for the Hepatitis B Research Network (HBRN).  J Pediatr Gastroenterol Nutr. 64(5):760-769.

Normal ranges for splanchnic, thoracoabdominal and cerebral blood flow volumes in fasting and post-prandial states using phase-contrast MRI in healthy children and young adults. (May 2017). Muthusami P, Joon Yoo S,  Thind N, Windram J,  Schantz D,  Prsa M, Caro-Dominguez P, Seed M, Grosse-Wortmann L,  Chaturvedi R, Ling SC, Chavhan GB. Radiology. 285(1): 231-241.

Platelet count, spleen length, and platelet count-to-spleen length ratio for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis. (April 2017). Colli A, Gana JC, Yap J, Adams-Webber T, Rashkovan N, Ling SC, Casazza G. Cochrane Database Syst Rev.

Features of severe liver disease with portal hypertension in patients with cystic fibrosis. (August 2016). Stonebraker J, Ooi C, Pace R, Corvol H, Knowles M, Durie P, Ling SC. Clinical Gastroenterol Hepatol. 14(8):1207-1215.

Angiogenesis and portal-systemic collaterals in portal hypertension. (June 2016). Gana  JC, Serrano CA, Ling SC. Annals of Hepatology. 15(3):303-313.

Primary prophylaxis of variceal bleeding in children and the role of the mesorex bypass  Summary of the Baveno VI pediatric satellite symposium. (April 2016). Shneider B, de Ville de Goyet J, Leung D, Srivastava A, Ling SC, Duche M, McKiernan P, Superina R, Squires R, Sarin S, de Franchis R, Mazariegos G.  Hepatology. 63(4):1368-80.

Randomized Controlled Trial of Entecavir versus Placebo in Children with HBeAg-positive Chronic Hepatitis B. (February 2016). Jonas MM, Chang M-H, Sokal E, Schwarz KB, Kelly D, Kim KM, Ling SC, Rosenthal P, Oraseanu D, Reynolds L, Thiry A, Ackerman P. Hepatology. 63(2):377-87.

Children with chronic hepatitis B in the United States and Canada. (December 2015). Schwarz KB, Cloonan YK, Ling SC, Murray KF, Rodriguez-Baez N, Schwarzenberg SJ, Teckman J, Ganova-Raeva L, Rosenthal P, Hepatitis B Research Network. J Pediatr. 167(6):1287-1294.e2.

Baseline ultrasound and clinical correlates in children with cystic fibrosis(CF) from the prospective cohort in the CF Liver Disease Network. (October 2015). Leung DH, Ye W, Molleston JP, Weymann A, Ling SC, Paranjape SM, Romero R, Schwarzenberg SJ, Palermo J, Alonso EM, Murray KF, Marshall BC, Sherker AH, Siegel MJ, Krishnamurthy R, Harned R, Karmazyn B, Magee JC, Narkewicz MR for CFLD NET. J Pediatr. 167(4):862-868.e2.

Capsule endoscopy for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis. (October 2014). Colli A, Gana JC, Turner D, Yap J, Adams-Webber T, Ling SC, Casazza G. Cochrane Database Systematic Reviews. (10):CD008760.

Enteral energy and macronutrients in end-stage liver disease. (August 2014). Mouzaki M, Ng V, Kamath BM, Selzner N, Pencharz P, Ling SC. J Parenter Enteral Nutr. 38(6):673-68.

Predicting outcomes for children awaiting liver transplantation – is serum sodium the answer? (May 2014). Ling SC, Avitzur Y. Hepatology. 59(5):1678-80.

Measurement of hepatic venous pressure gradient is feasible and safe in children. (November 2013). Woolfson J, John P, Kamath B, Ng VL, Ling SC. J Pediatr Gastroenterol Nutr. 57(5):634-7.

Congenital portosystemic shunt: characterization of a multi-system disease. (June 2013). Sokollik C, Bandsma RHJ, Gana JC, van den Heuvel M, Ling SC. J Pediatr Gastroenterol Nutr. 56(6):675-81.

Chronic hepatitis B virus (HBV) infection in children: 25 years' experience. (April 2013). Popalis C, Yeung LT, Ling SC, Ng VL, Roberts EA. J Viral Hepatitis. 20(4):e20-6.

Recommendations for the assessment of non-extremity venous thromboembolism outcomes: Pediatric and Neonatal Haemostasis and Thrombosis SSC Working group communication. (March 2013). Rajpurkar M, Sharathkumar A, Williams S, Lau K, Ling SC, Chan A. J Thromb Hemostasis. 13(3):477-80.

 Advances in the evaluation and management of portal hypertension in children. (November 2012). Ling SC. Semin Liver Dis 2012; 32(4): 288-297.

Portal Hypertension in children: expert pediatric opinion on the report of the Baveno V Consensus Workshop on methodology of diagnosis and therapy in portal hypertension. (August 2012). Shneider BL, Bosch J, De Franchis R, Emre SH, Groszmann RJ, Ling SC, Lorenz JM, Squires Jr. RH, Superina RA, Thompson AE, Mazariegos GV. Pediatric Transplantation. 16(5): 426-437

A Clinical Prediction Rule and Platelet Count Predict Esophageal Varices in Children. (December 2011). Gana JC, Turner D, Mieli-Vergani G, Davenport M, Miloh T, Avitzur Y, Yap J, Morinville V, Brill H, Ling SC. Gastroenterology 2011; 141(6): 2009-16.

Variation in care for children with esophageal varices: a study of physicians, patients and families approaches and attitudes. (June 2011). Gana JC, Valentino P, Morinville V, O’Connor C, Ling SC. Journal of Pediatric Gastroenterology Nutrition. 52: pp 751-755.