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About Sickkids
About SickKids

Simon Ling, MB, ChB, MRCP(UK)

The Hospital for Sick Children
Division Head
Gastroenterology, Hepatology and Nutrition

University of Toronto
Associate Professor

Phone: 416-813-8757
Fax: 416-813-6531
Email: simon.ling@sickkids.ca
Alternate Contact: Karen Danois
Alternate Email: karen.danois@sickkids.ca

Brief Biography

Dr. Simon Ling graduated in medicine from the University of Edinburgh, Scotland and trained in paediatrics in the UK.  His training in paediatric gastroenterology in Glasgow, Scotland and the Hospital for Sick Children, Toronto, included a British Digestive Foundation Research Training Fellowship. Following two years as Consultant in Paediatric Gastroenterology at the Royal Hospital for Sick Children, Glasgow, Dr. Ling was appointed to SickKids and the University of Toronto in 2003 and became Director of the Paediatric Gastroenterology Training Program from 2009 - 2014. Dr. Ling has been recognized with the Fellow’s Award for Teaching and Mentorship in 2010 and 2011 and received the Department of Paediatrics’ Richard Rowe Award for Clinical Excellence in Paediatric Medical Care in 2013.

Areas of Specialty

Dr. Ling’s subspecialty interest is paediatric liver disease.  He also maintains a broad interest and experience in paediatric gastroenterology and endoscopy.

Research Interests

Dr. Ling’s clinical research interests include

  • Portal hypertension in children, including the Global Registry for Outcomes of Varices in Children (GROOVE).  Further details are available at www.groovestudy.org.
  • Cystic fibrosis liver disease, including collaboration in the CFLD research network (further details available at www.childrennetwork.org).
  • Hepatitis B infection in children, including collaboration in the Hepatitis B Research Network (further details available at www.hepbnet.org).


For a complete list of publications, please see PubMed

Ling SC, Pfeiffer A, Avitzur Y, Fecteau A, Grant D, Ng VL:  Long-term follow-up of portal hypertension after liver transplantation in children.  Pediatric Transplantation 2009: 13: pp 206-209.  

Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo C, Colombo JL, Debray D, Fernandez A, Lacaille F, Macek Jr. M, Rowland M, Salvatore F, Taylor CJ, Wainwright C, Wilschanski M, Zemková D, Hannah WB, Phillips MJ, Corey M, Zielenski J, Dorfman R, Wang Y, Zou F, Silverman LM, Drumm ML, Wright FA, Lange EM, Durie PR, Knowles MR:  Genetic modifiers of liver disease in cystic fibrosis.  Journal of the American Medical Association 2009: 302: pp 1076-1083.

Gana JC, Turner D, Roberts EA, Ling SC:  Derivation of a clinical prediction rule for the non-invasive diagnosis of varices in children.  Journal of Pediatric Gastroenterology and Nutrition 2010: 50: pp 188-193.

De Francis R, on behalf of the Baveno V Faculty:  Revising consensus in portal hypertension:  Report of the Baveno V Consensus Workshop on methodology of diagnosis and therapy in Portal Hypertension.  Journal of Hepatology 2010: 53: pp 762-768.  

Ling SC, Walters T, McKiernan P, Schwarz K, Garcia-Tsao G, Shneider B:  Primary prophylaxis of variceal hemorrhage in children with portal hypertension: a framework for future research. Journal of Pediatric Gastroenterology and Nutrition 2010: 52: pp 254-261.

Gana JC, Valentino P, Morinville V, O’Connor C, Ling SC:  Variation in care for children with esophageal varices: a study of physicians, patients and families approaches and attitudes.  Journal of Pediatric Gastroenterology Nutrition 2011: 52: pp 751-755.  

Gana JC, Turner D, Mieli-Vergani G, Davenport M, Miloh T, Avitzur Y, Yap J, Morinville V, Brill H, Ling SC.  A Clinical Prediction Rule and Platelet Count Predict Esophageal Varices in Children.  Gastroenterology 2011; 141(6): 2009-16.  

Shneider BL, Bosch J, De Franchis R, Emre SH, Groszmann RJ, Ling SC, Lorenz JM, Squires Jr. RH, Superina RA, Thompson AE, Mazariegos GV.  Portal Hypertension in children: expert pediatric opinion on the report of the Baveno V Consensus Workshop on methodology of diagnosis and therapy in portal hypertension.  Pediatric Transplantation 2012; 16(5): 426-437

Ling SC. Portal hypertension in children. Clinical Liver Disease 2012;1(5):139-142.  

Ling SC. Advances in the evaluation and management of portal hypertension in children.  Semin Liver Dis 2012; 32(4): 288-297.  

Popalis C, Yeung LT, Ling SC, Ng VL, Roberts EA.  Chronic Hepatitis B Virus (HBV) Infection in Children: 25 Years’ Experience.  J Viral Hepatitis 2013;20(4):e20-6.  

Sokollik C, Bandsma RHJ, Gana JC, van den Heuvel M, Ling SC.  Congenital portosystemic shunt: characterization of a multi-system disease.  J Pediatr Gastroenterol Nutr 2013;56(6):675-81.  

Woolfson J, John P, Kamath B, Ng VL, Ling SC.  Measurement of hepatic venous pressure gradient is feasible and safe in children.  J Pediatr Gastroenterol Nutr 2013;57(5):634-7.   

Ling SC, Avitzur Y.  Predicting outcomes for children awaiting liver transplantation – is serum sodium the answer?  Hepatology 2014;59(5):1678-80.  

Mouzaki M, Ng V, Kamath BM, Selzner N, Pencharz P, Ling SC.  Enteral energy and macronutrients in end-stage liver disease.  J Parenter Enteral Nutr 2014;38(6):673-68.  

Ling SC. Management of Adult Survivors of Biliary Atresia. Clinical Liver Disease 2014; 4(4):86-88.  

Colli A, Gana JC, Turner D, Yap J, Adams-Webber T, Ling SC, Casazza G. Capsule endoscopy for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis.  Cochrane Database Systematic Reviews 2014, 1;10:CD008760.

Rajpurkar M, Sharathkumar A, Williams S, Lau K, Ling SC, Chan A.  Recommendations for the assessment of non-extremity venous thromboembolism outcomes: Pediatric and Neonatal Haemostasis and Thrombosis SSC Working group communication.  J Thromb Hemostasis 2015;13(3):477-80.  

Leung DH, Ye W, Molleston JP, Weymann A, Ling SC, Paranjape SM, Romero R, Schwarzenberg SJ, Palermo J, Alonso EM, Murray KF, Marshall BC, Sherker AH, Siegel MJ, Krishnamurthy R, Harned R, Karmazyn B, Magee JC, Narkewicz MR for CFLD NET.  Baseline ultrasound and clinical correlates in children with cystic fibrosis(CF) from the prospective cohort in the CF Liver Disease Network.  J Pediatr (In press June 2015).  

Jonas MM, Chang M-H, Sokal E, Schwarz KB, Kelly D, Kim KM, Ling SC, Rosenthal P, Oraseanu D, Reynolds L, Thiry A, Ackerman P.  Randomized Controlled Trial of Entecavir versus Placebo in Children with HBeAg-positive Chronic Hepatitis B.  Hepatology (In press July 2015).  

Jiménez-Rivera C, Ling SC, Ahmed N, Yap J, Aglipay M, Barrowman N, Graitson S, Critch J, Rashid M, Ng VL, Roberts E, Brill H, Dowhaniuk JK, Bruce G, Bax K, Deneau M, Guttman O, Schreiber RA, Martin S, and Alvarez F.  Incidence and characteristics of autoimmune hepatitis.  Pediatrics (In press July 2015).