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About Sickkids
About SickKids

Daune MacGregor, MD

The Hospital for Sick Children
Staff Neurologist

University of Toronto
Professor of Pediatrics (Neurology)

Phone: 416-813-7721
Fax: 416-813-6334
Email: daune.macgregor@sickkids.ca

Brief Biography

Dr. Daune MacGregor is a Paediatric Neurologist at The Hospital for Sick Children, Toronto, Canada. She completed her medical training at the University of Saskatchewan graduating cum laude in 1971. She then trained in Paediatrics and Neurology in Toronto at the Hospital for Sick Children and did postgraduate studies in Developmental Neurology at The Hospital for Sick Children Great Ormond Street, London, England and the Children’s Hospital Medical Center at Harvard University in Boston, Massachusetts. She is currently a staff neurologist in the Department of Paediatrics at The Hospital for Sick Children. She was appointed a Full Professor of Paediatrics and Neurology at the University of Toronto in 1995.

Her current research interests are in the study of cerebral vascular disorders including stroke and headache, neurodevelopmental disorders including spina bifida and acquired brain injury in children. Dr. MacGregor is a past president of the Canadian Association of Child Neurologists. She is currently completing a Masters of Business Administration.

Areas of Specialty:

Cerebrovascular disorders, headache, head\ache, developmental disabilities.

Academic Background

University of Saskatchewan

Clinical Fellowship, Developmental Paediatrics and Mental Retardation
Children’s Hospital Medical Center, Harvard Medical School and Great Ormand Stre

Research Interests

  • Childhood stroke, cerebrovascular disorders, recovery following head injury.

Research Activities

  • stroke prevention in sickle cell anemia
  • Canadian Paediatric Ischemic Stroke Registry
  • hydrocephalus: MRI morphometric & cognitive correlations.
  • pharmacological treatment of migraine
  • neurobehavioural outcome of head injury in children
  • acute disseminated encephalomyelitis
  • predictors of neurodevelopmental outcome after neonatal cardiopulmonary bypass
  • encephalitis in childhood
  • administration and leadership activities in academic health sciences centers


2010     Paediatric Academic Leadership – Clinical Practitioner Award, Paediatric Chairs of Canada

2009     OHA Health Achieve Leading Practices Award:  Transition to Rehab-Going with the ‘Flo’. 2009

2009     Council Award, The College of Physicians and Surgeons of Ontario.  

2007     Community Citizenship Award, Bank of Montreal.  

2007     7 Year Volunteer Long Service Award, Bloorview Childrens Hospital Foundation  

2007     Nominated for the 2007 Council Award of the College of Physicians and Surgeons of Ontario

2005     Selected for inclusion in the Academic Keys Who's Who in Medical Sciences Education.  

2005     5 Year Volunteer Service Award as Board of Directors Member, Bloorview Childrens Hospital Foundation.  

2005     Runner Up - Continuing Education Award for Excellence in Course Coordination.  Developmental Paediatric Update; Department of Developmental Paediatrics, University of Toronto.  


Elbers JM, Bitnun A, Richardson SE, Ford-Jones EL, Tellier R, Wald RM, Petric M, Kolski H, Heurter H, MacGregor D: A 12-Year Prospective Study of Childhood Herpes Simplex Encephalitis: Is There a Broader Spectrum of Disease? Pediatrics 2007: 119 (2):399-407.  SRA

Hune SYC, DeVeber GA, MacGregor DL, Dirks PB, Yu HWH, Soman TB, Allen A, Golomb NR: Nursing Issues in Caring for Children with Moyamoya Vasculopathy and Their Families.  Journal of Neuroscience Nursing 2007: 39 (1):33-39.  Col

Kirton A, Schechter T, Brandao L, Chan A, Williams S, MacGregor D, Pontigon A, DeVeber G: Hemorrhagic Transformation of Arterial Ischemic Strokes in Children.  Stroke 2007: 38(2):581. Col

O'Brodovich H, Beyene J, Tallett S, MacGregor D, Rosenblum ND: Performance of a Career Development and Compensation Program at an Academic Health Science Center.  Pediatrics 2007: 119:e791-e797.  Col

Amin R, Ford-Jones L, Richardson SE, MacGregor D, Tellier R, Heurter H, Fearon M, Bitnun A: Acute Childhood Encephalitis and Encephalopathy Associated with Influenza:  A Prospective 11-Year Review.  Pediatric Infectious Disease Journal 2008: 27(5):390-395.  Col

Kirton A, DeVeber G, Pontigon A, MacGregor D, Shroff M: Presumed Perinatal Ischemic Stroke:  Vascular Classification Predicts Outcomes.  Annals of Neurology 2008: 63 (4): 436-43.  Col

Mahant S, Patel R, Campbell M, MacGregor DL, Friedman JN: Reducing Inappropriate Hospital Use on a General Pediatric Inpatient Unit.  Pediatrics 2008: 121 (5): e1068-e107.  Col

Kavadas F, Bitnun A, Heurter H, MacGregor D, Ford-Jones L: Acute Neurological Events Associated with Influenza Vaccination:  Are the WHO Criteria for Assessing Causality Adequate? Scandinavian Journal of Infectious Diseases 2008: 40 (6-7): 565-70.  Col

Tam E, Widjaja E, Blaser S, MacGregor D, Satodia P, Moore A: Occipital Lobe Injury and Cortical Visual Outcomes After Neonatal Hypoglycemia.  Pediatrics 2008: 122,( 3): 507-512.  Col

Hung RM, MacGregor DL: Management of Pediatric Migraine: Current Concepts and Controversies.  Indian Journal of Pediatrics 2008:75 (11):1139-1148.  SRA

Domi T, Edgell D, McCrindle B, Wiliams W, Chan A,MacGregor D, Kirton A, DeVeber G: Frequency, Predictors and Neurological Outcome of Vaso-occlusive Strokes Associated with Cardiac Surgery in Children.  Pediatrics 2008: 122(6):1292-1298.  Col

MacGregor DL: Shaken Baby Syndrome:  The Quest for Evidence.  Developmental Medicine and Child Neurology 2008: 50 (1): pp 8.  PA

Domi T., Edgell David S, McCrindle Brian W Williams, William G, Chan, Anthony K, MacGregor Daune L., Kirton, Adam, DeVeber Gabrielle A.: Frequency, predictors, and neurologic outcomes of vaso-occlusive strokes associated with cardiac surgery in children; Pediatrics. 2008: 122(6); 1292-8 Col

Domi T, DeVeber G, Shroff M, Kouzmitcheva E,MacGregor DL, Kirton A: Corticospinal Tract Pre-Wallerian Degeneration. A Novel Outcome Predictor for Pediatric Stroke on Acute MRI.  Stroke 2009: 01-08 Col

Rafay MF, Pontigon AM, Chiang J, Adams M, Jarvis A, Silver F, MacGregor D, DeVeber GA: Delay to diagnosis in acute pediatric arterial ischemic stroke.  Stroke 2009: 40(1):58-6.  Col

Tan M, Armstrong D, Birken C, Bitnun A, Caldarone CA, Cox P, Kahr W, Macgregor D, Askalan R: Bacterial Endocarditis in a Child Presenting with Acute Arterial Ischemic Stroke: Should Thrombolytic Therapy be Absolutely Contraindicated? Stroke 2009: 51(2):151-154.  Col

Tan MA, Armstrong D, MacGregor DL, Kirton A.  Late complications of vertebral artery dissection in children: pseudoaneurysm, thrombosis, and recurrent stroke. J Child Neurology 2009: 24(3):354-60. Col

MacGregor D, Bruce-Barrett C, Parker S, Blais I, Wong E, MacMillan S:  Innovation in Managing the Referral Process at a Canadian Paediatric Hospital.  Health Care Quarterly 2009:12 (3):72-79. PA

Tan M, DeVeber G, Kirton A, Vidarsson L, MacGregor D, Shroff M: Low Detection Rate of Craniocervical Arterial Dissection in Children Using Time-of-Flight (TOF) Magnetic Resonance Angiography (MRA):  Causes and Strategies to Improve Diagnosis.  Journal of Child Neurology 2009:04-07Col

Westmacott R, MacGregor D, Askalan R, DeVeber G: Late emergence of cognitive deficits following unilateral neonatal stroke.  Stroke 2009: 40 (6):2012-9. Col

Westmacott R, Askalan R, MacGregor D, DeVeber G: Cognitive Outcome Following Unilateral Stroke in Childhood:  The Effects of Age at Stroke and Lesion Location.  Developmental Medicine and Child Neurology 2009:08-20 Col

Rea D, Brandsema J, Armstrong D, Parkin P,MacGregor D, DeVeber G, Askalan R: Cerebral Arteriopathy in Children with Neurofibromatosis Type 1. Pediatrics 2009: 08-24 Col

Jewell D, Fletcher JM, Mahy CE, Hetherington R,Macgregor D, Drake JM, Salman MS, Dennis M.  Upper Limb Cerebellar Motor Function in Children with Spina Bifida. Childs Nervous System 2009:10-13.  Epub Col

Chan V, McCabe J, MacGregor DL: Botox Treatment for Migraine and Chronic Daily Headache in Adolescents.  Journal of Neuroscience Nursing 2009: 41(5): 235-243. SRA

Dennis M, Salman MS, Jewell D, Hetherington R, Spiegler BJ, MacGregor DL, Drake JM, Humphreys RP, Gentili F:  Upper Limb Motor Function in Young Adults with Spina Bifida and Hydrocephalus.  Childs Nervous System 2009: 25(11):1447-53. Col

Rea David,Brandsema John F., Armstrong Derek, Parken, Patricia C. DeVeber Gabrielle, MacGregor Daune, Logan William J, Askalan Rand: Cerebral arteriopathy in children with neurofibromatosis type 1: Pediatrics.2009:124(3): e476-83 Col

Tan Marilyn A., DeVeber Gabrielle, Kirton Adam, Vidarsson Logi, MacGregor Daune, Shroff Manohar; Low detection rate of carniocervical arterial dissection in children using time-of-flight magnetic resonance angiography; causes and strategies to improve diagnosis; Journal of Child Neurology. 2009: 24(10):1250-7 Col

MacGregor Daune, Parker Sandra, MacMillin, Sharon Blais Irene, Wong, Eugene, Robertson, Chris J. Bruce-Barrett, Cindy; Innovation in managing the referral process at the Canadian pediatric hospital. Healthcare Quarterly 2009: 12(3):72-9 SRA  

Westmacott R, MacGregor Daune, Askalan, Rand, DeVeber, Gabrielle; Late emergence of cognitive deficits after unilateral neonatal stroke. Stroke. 2009: 40(6); 2012-9Col

Jewell Derryn, Fletcher, Jack M. Mahy, Caitlin, E V. Hetherington, Ross, MacGregor Daune, Drake, James M. Salman Michael S., Dennis Maureen; Upper limb cerebellar motor function in children with spina bifida;Childs Nervous System; 2010: 26(1):67-73 Col

Moharir M, Shroff M, Stephens D, Chan A, MacGregor D, Mikulis D, Adams M,

DeVeber G: Anticoagulants in Pediatric Cerebral Sinovenous Thrombosis: Safety and Outcomes.  Annals of Neurology 2010:67(5):590-599.Col

Stavropoulos J, MacGregor D, Yoon G:  Mosaic Microdeletion 18q21 as a Cause of Mental Retardation.  European Journal of Medical Genetics 2010: 53(6):396-399. Col

Williams, T., Westmacott, R., Dlamini, N. Granite, L., Dirks, P. Askalan, R. MacGregor, D. Moharir, M. and DeVeber, G. Intellectual Ability and Executive Function in Pediatric Moyamoya Vasculopathy.  Developmental Medicine and Child Neurology, 2011 54(1), 30-37.

Bruce-Barrett C, Hodinott A, Manicat-Emo A, Flaming T,MacGregor D, Hogan I, Carew C, Cox S and Kitch T:  Kids in Transition: The Rehab Experience, Healthcare Quarterly, 14 Special Issue (3) 2011:77-82 SRA


Friefeld Sharon J., Westmocott, Robyn. MacGregor Daune, DeVeber, Gabrielle A: Predictors of quality of life in pediatric survivors of arterial ischemic stroke and cerebral sinovenous thrombosis. Journal of Child Neurology 2011: 26 (9): 1186-92 Col

Moharir, Mahendranath D., Shroff, Manohar, Pontigon Ann-Marie, Askalan, Rand. Yau, Ivanna, MacGregor Daune, DeVeber, Gabrielle A.; A prospective outcome study of neonatal cerebral sinovenous thrombosis: Journal of Child Neurology. 2011:26(9):1137-44

Elbers J.Viero, S MacGregor D, DeVeber G, Moore, Aideen M.; Placental pathology in neonatal stroke. Pediatrics 2011:127 (3); e722-9 Col

Ferrari, Sharon, Vozzolo, Ben, Daneman Denis,MacGregor Daune; Feasibility of physician peer assessment in an academic health sciences centre. Healthcare Quarterly 2011: 14(1):50-5 SRA

Kirton, Adam; Laughlin, Suzanne; Pontigon Ann-Marie; Finkelstein, Yaron;  MacGregor, Daune; Chan, Anthony; DeVeber, Gabrielle; Brandao, Leonardo; Safety of Anticoagulants in Children with Arterial Ischemic Stroke; Blood 2011: 361-535 Col

Williams, T., Westmacott, R., Dlamini, N. Granite, L., Dirks, P. Askalan, R. MacGregor, D. Moharir, M. and DeVeber, G. Intellectual Ability and Executive Function in Pediatric Moyamoya Vasculopathy.  Developmental Medicine and Child Neurology, 2011:54 (1) 30-37 Col

Kitchen, Lisa, Friefeld, Sharon, MacGregor, Daune; Curtis, Rosalind; Allen, Anita, Yau, Ivanna, Askalan, Rand, Moharir, Mahendranath, Domi, Trish, DeVeber, Gabrielle :The Pediatric Stroke Outcome Measure: A Validation and Reliability Study;  Stroke-(2012) Col

Manlhiot, Cedric, Sananes, Renee, McCrindle, Brian W., MacGregor, Daune: Neurodevelopmental Outcomes Following Open Heart Surgery in Infants Before 3 Months of Age. The Annals of Thoracic Surgery; (ATS/2011/323725) (in press) Col

MacGregor DL, et al: Head Injury in Children and Adolescents; International Child Neurology Review Series (MacGregor DL, Kulkarni A, Dirks P, Rumney P, eds).  MacKeith Press, London, U.K. 2007.  SRA

Menascu S, MacGregor DL: Mild closed head injury.  In:  Head Injury in Children and Adolescents; International Child Neurology Review Series (MacGregor DL, Kulkarni A, Dirks P, Rumney P, eds).  MacKeith Press, London, U.K. 2007.  SRA

Weiss S, Ramachandran-Nair R., MacGregor DL: Sleep and metabolism.  In:  Head Injury in Children and

Adolescents (MacGregor DL, Kulkarni A, Dirks P, Rumney P, eds).  International Child Neurology Review  Series, MacKeith Press, London, U.K. 2007.  SRA

MacGregor DL: Is my child ready for school.  In:  Current Management in Child Neurology,     Fourth Edition  Maria, Bernard L., eds).  BC Decker, Shelton, CT 2009:  258-262.  PA

MacGregor DL: Book Review on "Seizures and Epilepsy in Children - A Practical Guide".  Indian   Pediatrics 2009: 46:77-78.  PA

 MacGregor, Daune L, Trauma to the Posterior Fossa in Cerebellar Disorders of Childhood : Clinics and Developmental Medicine No. 191 – 192 (eds: E. Boltshauser and J. Schmahmann), pp 397 – 391, MacKeith Press, London, UK 2012

 MacGregor D.L, Steinlin M., Sejersen T, M, Chang Wang: Dizziness and Vertigo. In Acute Pediatric Neurology (Sejersen,T.M.,Wang, C.eds) Springer Science, 2012 (in press)