Jane McGlade, PhD
Associate Chief of Research, Faculty Development
The Arthur and Sonia Labatt Brain Tumour Research Centre
University of Toronto
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- Signal transduction
- Protein biochemistry
My research is directed towards understanding the regulation of signal transduction pathways, that control normal embryonic development and cellular function, and which are relevant to disease states such as cancer. Recently we have focused specifically on a family of intracellular adapter molecules that function to integrate, localize, and down regulate signal transduction cascades. My lab has identified new adapters such as GADS and MARS that function in antigen receptor signalling, and NUMB and LNX which regulate the activity of transmembrane receptors that determine cell fate during development.
Future research interests
Currently work in my laboratory focuses on the functional characterization of these molecules, as well as the on going discovery of new regulators of signal transduction pathways. In addition the lab studies the role of adaptors in directing protein ubiquitylation and vesicle trafficking.
Role of the SLAP adaptor proteins in ubiquitin dependent regulation of receptor tyrosine kinases.
2008-2013, Canadian Institutes of Health Research
The E3 ligase LNX2 in Wnt signaling, cell polarity and cancer.
2009-2014, Canadian Cancer Society Research Institute
Role of the CRB1-EPB41L5 complex in retinal degeneration.
2010-2013, Foundation Fighting Blindness-Canada
Function and regulation of Numb isoform expression in cancer.
2010-2015, Canadian Institutes of Health Research
Adapter Gene, Corporate Ventures