About Sickkids
About SickKids

Katharina Manassis, MD, FRCP(C)

The Hospital for Sick Children
Psychiatrist and Director, Anxiety Disorders

Research Institute
Senior Associate Scientist
Neurosciences & Mental Health

University of Toronto
Department of Psychiatry

Phone: 416-813-7464
Fax: 416-813-5326
e-mail: katharina.manassis@sickkids.ca

Research Interests

Understanding and treating childhood anxiety disorders and associated conditions

Research Activities

Understanding and treating childhood anxiety disorders and their comorbidities.

My research goals are: 1) to elucidate the cognitive, familial, and genetic mechanisms underlying childhood anxiety and its comorbidities; and 2) to test the effectiveness of cognitive behavioural treatments for these disorders to reduce the morbidity associated with childhood anxiety.

Etiological studies I have led examined: attachment and behavioral inhibition as risk factors in offspring of anxious parents; familial and psychological risks for impaired functioning in anxious children; linguistic and cognitive antecedents of selective mutism; and cognitive factors associated with comorbid ADHD and anxiety disorders. I have also collaborated on genetic studies of generalized anxiety and obsessive compulsive disorder. In order to more closely examine child cognitive behavioral therapy I have led randomized controlled trials in to research: the effect of parent involvement on anxious children’s outcomes; the benefits of group versus individual treatment for anxiety; the effect of parental involvement in treating early onset depression; and the effectiveness of school-based cognitive behavioral interventions for children at risk. Dissemination and translation of cognitive behavioral treatments for use in community settings is a current area of interest for me. To this end, I have developed and evaluated a school-based intervention for children at risk for anxiety and depression and a group supervision model for community practitioners learning child CBT.

External Funding

Dr. Manassis is currently funded by the Canadian Institutes of Health Research, the Social Sciences and Humanities Research Council, the Ontario Brain Institute, and Bell Canada for studies related to children's internalizing disorders, their treatment, and the translation of evidence-based treatments to community settings.


Manassis K (2012). Generalized anxiety disorder in the classroom. Child Adolesc Psychiatr Clin North America, 21(1):  93-103.

Manassis K (2012). Managing anxiety in relation to anaphylaxis in childhood: a systematic review. J Allergy Volume 2012 (2012), Article ID 316296, 7 pages

Nobel R, Manassis K (2012).Perfectionism in relation to outcome of school-based CBT for children. J Rational Emot Cog Behav Ther, 30(2): 77-90.  

Crawford M, Manassis K (2011). Anxiety, social skills, friendship quality, and peer victimization: an integrated model. J Anxiety Dis, 25:924-931.

Adler-Nevo N, Manassis K(2011). An adaptation of prolonged exposure therapy for single-incident trauma: A case series. J Cdn Acad Child Adolesc Psychiatry, 20: 127-133.

Guberman C, Manassis K(2011). Symptomatology and Family Functioning in Childhood Anxiety with Comorbid Depression. J Cdn Acad Child Adolesc Psychiatry, 20: 186-195.

AlGhamdi S, Manassis K (2011). Relationship between self-esteem and depressive symptoms: gender differences. J Cdn Acad Child Adolesc Psychiatry, 20: 203-207.

Manassis K, Wilansky-Traynor P, Farzan N, Kleiman V, Parker K, Sanford M (2010)The Feelings Club: A randomized controlled trial of school-based intervention for anxious and depressed children. Depress Anxiety, 27: 945-952.


Manassis K (2009) CBT with Children: A Guide for the Community Practitioner. Routledge, New York, N.Y.

Manassis K (2012) Problem-Solving with Children, Adolescents, and Families. Guilford,New York, N.Y.