Michael Moran, PhD
University of Toronto
Department of Molecular Genetics
Banting and Best Department of Medical Research
Canada Research Chair
Princess Margaret Hospital, Ontario Cancer Institute
University Health Network
Dr. Moran completed his PhD in Biochemistry at the National Cancer Institute of Canada’s Cancer Research Laboratory at the University of Western Ontario in 1987. He was an NCIC Fellow at Mount Sinai Hospital (1986-1990), and then joined the University of Toronto in 1990 in the Banting and Best Department of Medical Research, and the Department of Molecular and Medical Genetics. He was an NCIC Scientist from 1991-97 and an MRC/Canadian Institutes for Health Research Scientist from 1997-2002.
Moran has served on various granting agency study sections related to cancer, and consulted and collaborated with pharmaceutical and biotechnology companies in the area of drug discovery. He helped found the companies Ocata Proteomics and MDS Proteomics, and served as Chief Scientific Officer.
Moran’s research focus, publications, and invited seminars have addressed the intracellular signaling networks that control growth, survival, and spreading of tumours, and how drugs may be designed to target key components in these molecular networks. His group uses proteomics technologies including mass spectrometry and bioinformatics to identify and characterize proteins activated in cancers, and to determine drug mechanisms of action.
- Canadian Cancer Society Research Institute
- Canadian Foundation for Innovation
- Leukemia and Lymphoma Society
- Canadian Institutes of Health Research
Wei Y, Vellanki RN, Coyaud E, Ignatchenko V, Li L, Krieger JR, Taylor P, Tong J, Pham NA, Liu G, Raught B, Wouters BG, Kislinger T, Tsao MS and Moran MF (2015) CHCHD2 is Co-amplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration. Molecular Cancer Research 13, 1119-1129.
St-Germain JR, Taylor P, Zhang W, Li Z, Ketala T, Moffat J, Neel BG, Trudel S and Moran MF (2015) Differential regulation of FGFR3 by PTPN1 and PTPN2. Proteomics 15, 419-433.
Pandey A and Moran MF (2015) Signal Transduction. Proteomics 15, 179-182.
Jin LL, Wybenga-Groot LE, Tong J, Taylor P, Minden MD, Trudel S, McGlade CJ and Moran MF (2015) Tyrosine phosphorylation of the Lyn SH2 domain modulates its binding affinity and specificity. Molecular and Cellular Proteomics 14, 695-706.
Zhang W, Wei Y, Ignatchenko V, Li L, Sakashita S, Pham NA, Taylor P, Tsao MS, Kisilinger T and Moran MF (2014) Proteomic profiles of human lung adeno and squamous cell carcinoma using super-SILAC and label-free quantification approaches. Proteiomics 14, 795-803.
Tong J, Taylor P and Moran MF (2014) Proteomic analysis of the EGFR interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Molecular and Cellular Proteomics 13, 1644-1658.
Li L, Wei Y, To C, Zhu CQ, Tong J, Pham NA, Taylor P, Ignatchenko V, Ignatchenko A, Zhang W, Wang D, Yanagawa N, Li M, PIntilie M, Liu G, Muthuswamy L, Shepherd FA, Tsao MS, Kislinger T and Moran MF (2014) Integrated Omic analysis of lunch cancer reveals metabolism proteome signatures with prognostic impact. Nature Communications 5, 5469.
Ernst A, Awakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, and Sidhu SS (2013) A strategy for modulation of enzymes in the ubiquitin system. Science 339, 590-595.
Bocchinfuso DG, Taylor P, Ross E, Ignatchenko A, Ignatchenko V, Kislinger T, Pearson BJ and Moran MF (2012) Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms. Molecular and Cellular Proteomics 11, 681-691.
Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Ostman A, Moran MF and Neel BG (2011) Global proteomic assessment of the classical protein-tyrosine phosphatome and redoxome. Cell 146. 826-840.