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About Sickkids
About SickKids

Patrick McNamara, MB, BCh, BAO, MSc (PAeds)

The Hospital for Sick Children
Staff Neonatologist
Neonatology

Research Institute
Associate Scientist
Translational Medicine

University of Toronto
Professor
Paediatrics & Physiology

Chair Positions

Pediatric Academic Societies
Neonatal Hemodynamics Club
Chair

Canadian TNE Collaborative
Chair

Canadian Neonatal Resuscitation Program
Chair


Phone: 416-813-5773
Fax: 416-813-8295
Email: patrick.mcnamara@sickkids.ca

Brief Biography

Patrick McNamara obtained his MB BCh BAO from Queens University, Belfast in 1993. He obtained neonatal subspecialty accreditation in the North Thames training programme, London, UK (awarded 2001). He completed a two-year neonatal transport fellowship at The Hospital for Sick Children, Toronto, and was appointed on staff in July 2003.

Academic Background

Clinician Investigator

Research Interests

1. Hemodynamics and Hypoxic-Ischemic Encephalopathy
2. Patent Ductus Arteriosus Shunt Volume Assessment
3. Pulmonary Hypertension and Chronic Lung Disease

Publications

El-Khuffash AEK, Weisz D, McNamara PJ. Reflections on the changes in PDA Management in the last 10 years. Archives of Disease in Childhood 2016 Apr 26. [Epub ahead of print]

Weisz D, Martins FF, Nield LE, El-Khuffash AE, Jain A, McNamara PJ. Acetaminophen to avoid surgical ligation in extremely low gestational age neonates with persistent large patent ductus arteriosus. Journal of Perinatology 2016 Apr 7. [Epub ahead of print]

Resende MHF, More K, Nicholls D, Ting J, Jain A, McNamara PJ. The impact of a dedicated patent ductus arteriosus ligation team on neonatal health-care outcomes. Journal of Perinatology 2016: 36 (6): pp 463-468.

Yoshida S, Martines J, Lawn JE et al [McNamara PJ, named author]. Setting research priorities to improve global newborn health and prevent stillbirths by 2025. Journal of Global Health. 2016: 6 (1): 010508.

Ting JY, Resende M, More K, Nicholls D, Weisz DE, El-Khuffash A, Jain A, McNamara PJ. Predictors of respiratory instability in neonates undergoing patient ductus arteriosus ligation after the introduction of targeted milrinone treatment. The Journal of Thoracic and Cardiovascular Surgery 2016 Apr 14. [Epub ahead of print]

Giesinger R, McNamara PJ. Hemodynamic instability in the critically ill neonate: An approach to cardiovascular support based on disease pathophysiology. Seminars in Perinatology 2016: 40 (3): pp 174-188.

EL-Khuffash AF, James AT, Corcoran JD, Dicker P, Franklin O, Elsayed YN, Ting JY, Sehgal A,  Malikiwi A, Harabor A, Soraisham AS, McNamara PJ. A patent ductus arteriosus severity score predicts chronic lung disease or death before discharge. Journal of Pediatrics 2015: 167 (6): pp 1354-1361.

Shifrin Y, Sadeghi S, Pan Y, Jain A, McNamara PJ, Belik J.  Maternal-pup interaction disturbances induces a long lasting increase in pulmonary vascular resistance in rats. American Journal of Physiology. Lung Cellular and Molecular Physiology 2015: 309 (10): pp L1186-1198.

Sellmer A, Hjortdal VE, Bjerre J, Schmidt MR, McNamara PJ, Bech BH, Henriksen TB. N-terminal pro-B type natriuretic peptide as a marker of Bronchopulmonary Dysplasia or death in very preterm neonates: A cohort study. PLoS One 2015: 10 (10): pp e0140079.  

Lavoie PM, Strizke A, Ting J, Jabr M, Jain A, Kwan E,  Chakkarapani E, Brooks P, McNamara PJ, Brant R, Holsti L. A randomized controlled trial of the use of oral glucose with or without gentle facilitated tucking of infants during neonatal echocardiography. PLoS One 2015: 10 (10): pp e0141015. 

Kaliniti K, Schmolzer G, McNamara PJ. Neonatal Resuscitation beyond the delivery room. Does one rule fit all? Acta Paediatrica 2015: 104 (10): pp 971-973.

McNamara PJ, Jain A. Persistent pulmonary hypertension of the neonate. Advances in diagnosis and treatment. Seminar in Fetal and Neonatal Medicine 2015: 20 (4): pp 262-271.

Terrin G, Conte F, Oncel MY, Scipione A, McNamara PJ, Simons S, Sinha R, Erdeve O, Tekgunduz K, Dogan M, Kessel I, Hammerman C, Nadir E, Yurttutan S, Jasani B, Alan S, De Curtis M. Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis. Archives of Disease in Childhood. Fetal and Neonatal Edition 2016: 101 (2): pp F127-F136.

Lavoie PM, Stritzke A, Ting J, Jabr M, Jain A, Kwan E, Chakkarapani E, Brooks P, Brant R, McNamara PJ, Holsti L. Oral glucose during targeted neonatal echocardiography: is it useful? Archives of Disease in Childhood. Fetal and Neonatal Edition 2015: 100 (4): pp F374-375.

Gosal K, Dunlop K, Dhaliwal R, Ivanovska J, Kantores C, Desjardins JF, Connelly KA, McNamara PJ, Jain A, Jankov RP. Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology 2015: 52 (6): pp 717-727.

Gibbins S, Stevens B, Dionne K, Yamada K, Pillai Riddell R, McGrath P,  Asztalos E, O’Brien K, Beyene J, Whyte R, McNamara P, Johnston C.  Perceptions of health professionals on pain in extremely low gestational age (ELGA) infants: complexities of pain assessment and management. Qualitative Health Research 2015: 25 (6): pp 763-774.

James AT, Bee C, Corcoran JD, McNamara PJ, Franklin O, EL-Khuffash AF. Treatment of premature infants with pulmonary hypertension and right ventricular dysfunction with milrinone: A case series. Journal of Perinatology 2015: 35 (4): pp 268-273.

Grasemann H, Dhaliwal R, Ivanovska J, Kantores, McNamara PJ, Scott J, Belik J, Jankov RP. Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling and collagen deposition in neonatal rat lungs. American Journal of Respiratory Cell and Molecular Biology 2015: 308 (6): pp L503-L510.

Noori S, McNamara PJ, Jain A, Lavoie PM, Wickremasinghe A, Merritt TA, Solomon T, Sekar K, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, Poindexter BB, Brook M, Auchus RJ. Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation. Journal of Perinatology 2015: 35 (2): pp 123-127.

James AT, Corcoran JD, McNamara PJ, Franklin O, El-Khuffash AF. The effect of milrinone on right and left ventricular function when used as a rescue therapy for term infants with pulmonary hypertension. Cardiology in the Young 2015: pp 1-10.

Jain A, Mohamed A, El-Khuffash A, Connelly KA, Dallaire F, Jankov RP, McNamara PJ, Mertens L. A comprehensive echocardiographic protocol for assessing neonatal right ventricular dimensions and function in the transitional period: normative data and z scores. Journal of the American Society of Echocardiography 2014: 27 (12): pp 1293-1304.

James AT, Corcoran JD, Jain A, McNamara PJ, Mertens L, Franklin O, El-Khuffash A.  Assessment of myocardial performance in preterm infants less than 29 weeks gestation during the transitional period.  Early Human Development 2014: 90 (12): pp 829-835.

Weisz D, Jain A, McNamara PJ, El-Khuffash AEK.  Non-invasive cardiac output monitoring (NICOM) in Preterm Infants post patent ductus arteriosus (PDA) ligation: A comparison with echocardiography.  Neonatology 2014: 106 (4): pp 330-336.

Finan E, Sehgal A, McNamara PJ. Targeted neonatal echocardiography in Canada: Need for standardized training and quality assurance. Journal of Ultrasound in Medicine 2014: 33 (10): pp 1833-1841.

Sehgal A, Mehta S, Evans N McNamara PJ. Cardiac Sonography by the neonatologist: clinical usefulness and educational perspective. Journal of Ultrasound in Medicine 2014: 33 (8): pp 1401-1406.

El-Khuffash A, Jain A, Corcoran D, Shah PS, Hooper CW, Brown N,  Poole SD, Shelton EL, Milne GL, Reese J, McNamara PJ. Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: Evidence from murine and human studies. Pediatric Research 2014: 76 (3): pp 238-244.

Yoshida S,  Rudan I, Lawn JE, Wall S, Souza JP, Martines J, McNamara PJ, Bahl R. Newborn health priorities beyond 2015. Lancet 2014: 384 (9938): pp e27-29.

El-Khuffash AF, Jain A, Weisz D, Mertens L, McNamara PJ. Assessment and treatment of post patent ductus arteriosus ligation syndrome. Journal of Pediatrics 2014: 165 (1): pp 46-52.

Resende M, More K, Nicholls D, Ting J, McNamara PJ. Archives of Disease in Childhood. Fetal and Neonatal Edition 2014: 99 (Suppl 1): pp 46-47.

Weisz DE, McNamara PJ. Patent ductus arteriosus ligation and the adverse outcomes: causality or bias? Journal of Clinical Neonatology 2014: 3 (2): pp 67-75.

Weisz D, Poon W, James AJ, McNamara PJ. Low cardiac output secondary to a malpositioned umbilical venous catheter: value of targeted neonatal echocardiography. American Journal of Perinatology Reports 2014: 4 (1): pp 23-28.

Dunlop K, Gosal K, Kantores C, Ivanovska J, Dhaliwal R, Desjardins JF, Connelly KA, Jain A, McNamara PJ, Jankov RP. Therapeutic hypercapnia prevents inhaled nitric oxide-induced right ventricular systolic dysfunction in juvenile rats. Free Radical Biology & Medicine 2014: 69: pp 35-49.

Clyman R, Wickremasinghe A, Merrit TA, Solomon T, McNamara P, Jain A, Singh J, Chu A, Noori S, Sekar K, Lavoie PM, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, Demauro S, Poindexter B, Aucott S, Satpute M, Fernandez E, Auchus RJ, Patent Ductus Arteriosus Ligation/Hypotension Trial Investigators. Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones. Journal of Pediatrics 2014: 164 (6): pp 1449-1455.

McNamara PJ, Engelberts D, Finelli M, Sahni M, Adeli K, Kavanagh BP. Vasopressin improves survival rates in neonatal porcine model of asphyxial cardiac arrest. Pediatric Research 2014: 75 (6): pp 738-748.

Hochwald O, Jabr M, Osiovich H, Miller SP, McNamara PJ, Lavoie PM. Preferential cephalic redistribution of left ventricular cardiac output during therapeutic hypothermia for perinatal asphyxia. Journal of Pediatrics 2014: 164 (5): pp 999-1004.

Weisz DE, More K, McNamara PJ, Shah PS. PDA ligation and health outcomes: a meta-analysis. Pediatrics 2014: 133 (4): pp e1024-1046.

Mohamed A, Nasef N, Shah V, McNamara PJ. Vasopressin as a rescue therapy for refractory pulmonary hypertension in neonates: case series. Pediatric Critical Care Medicine 2014: 15 (2): pp 148-154.

Enomoto M, Jain A, Pan J, Shifrin Y, Van Vliet T, McNamara PJ, Jankov RP, Belik J. Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators. American Journal of Physiology – Lung Cellular and Molecular Physiology 2014: 306 (2): pp L207-L215.

Lee AH, Dhaliwal R, Kantores C, Ivanovska J, Gosal K, McNamara PJ, Letarte M, Jankov RP. Rho-kinase inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation.  American Journal of Respiratory Cell and Molecular Biology 2014: 50 (1): pp 61-73.

Sellmer A, Bjerre J, Schmidt MR, McNamara PJ, Hjortdal VE, HØst B, Bech BH, Henriksen TB. Morbidity and mortality in preterm neonates with patent ductus arteriosus on day 3. Archives of Disease in Childhood – Fetal and Neonatal Edition 2013: 98 (6): pp F505-F510.

 Leslie AT, El-Khuffash A, Jain A, Keyzers M, Rogerson S, McNamara PJ. Evaluation of cerebral electrical activity and cardiac output after patent ductus arteriosus ligation in preterm infants. Journal of Perinatology 2013: 33 (11): pp 861-866.

Jain A, McNamara PJ.  Persistent pulmonary hypertension of the newborn: Physiology, hemodynamic assessment and novel therapies. Current Pediatric Reviews 2013: 9 (1): pp 55-66.

El-Khuffash A, Herbozo C, Jain A, Lepointe A, McNamara PJ.  Targeted neonatal echocardiography (TnECHO) service in a Canadian neonatal intensive care unit: a 4-year experience. Journal of Perinatology 2013: 33 (9): pp 687-690.

Kirpalani H, Millar D, Lemyre B, Yoder BA, Chiu A, Roberts RS, McNamara PJ, NIPPV Study Group. A trial comparing noninvasive ventilation strategies in preterm infants. The New England Journal of Medicine 2013: 369 (7): pp 611-620.

El-Khuffash A, Jain A, McNamara PJ.  Ligation of a patent ductus arteriosus in preterm infants: understanding the physiology.  Journal of Pediatrics 2013: 162 (6): pp 1100-1106.

El-Khuffash A, McNamara PJ, Lapointe A, Jain A.  Adrenal function in preterm infants undergoing patent ductus arteriosus ligation.  Neonatology 2013: 104 (1): pp 28-33.

McNamara PJ, Jain A.  Patent ductus arteriosus treatment in preterm babies. Time to consider shunt volume.  Journal of Perinatology 2013: 33 (3): pp 248-249.

McNamara PJ, Shivananda SP, Sahni M, Freeman D, Taddio A. Pharmacology of milrinone in persistent pulmonary hypertension of the newborn.  Pediatric Critical Care Medicine 2013: 14 (1): pp 74-84.

Intellectual Property

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