About Sickkids
About SickKids

Seema Mital, MD, FACC, FAHA, FRCP(C)

The Hospital for Sick Children
Head of Cardiovascular Research
Cardiology

Interim Section Head Heart Function Program
Cardiology

Staff Cardiologist - Heart Function and Transplant Program
Cardiology

Research Institute
Senior Scientist
Genetics & Genome Biology

University of Toronto
Professor
Paediatrics

Chair Positions
Heart and Stroke Foundation
Chair in Cardiovascular Science


Phone: 416-813-7418
Fax: 416-813-5857
e-mail: seema.mital@sickkids.ca

For more information, visit:

Brief Biography

Dr. Seema Mital received a bachelor’s degree in medicine and surgery in 1989 from Bombay University. She completed her paediatric residency at Wayne State University in 1996 and a fellowship in paediatric cardiology in 1999 from Columbia University in New York. Mital served as Assistant Professor at Columbia University, Morgan-Stanley Children’s Hospital of New York, until 2007 when she joined SickKids as a Staff Cardiologist. She is currently Head of Cardiovascular Research and Interim Section Head of Heart Failure at SickKids, Professor of Paediatrics at the University of Toronto and a Senior Scientist at the SickKids Research Institute. She is also the Heart and Stroke Foundation of Ontario Chair of Cardiovascular Science, and the Scientific Co-Lead of the Ted Rogers Centre for Heart Research.

Mital has a strong translational research program. She has extensive experience in the genetics/genomics of congenital heart disease and heart failure, personalized medicine and clinical trials. She established the SickKids Heart Centre Biobank, a multi-centre biorepository of children and adults with childhood onset heart disease for genomics research, one of the largest international repositories of its kind. She is the Scientific Co-lead of the Ted Rogers Centre for Heart Research Cardiac Precision Medicine Program established in November 2014. Her research interests include genomics, pharmacogenomics and stem cell applications to model childhood heart disease and discover new therapies.

Mital is active nationally and internationally. She is a Principal Investigator of the CIHR-funded Canadian National Transplant Research Program, and the NIH-funded Pediatric Heart Network. She serves on the Leadership Committee of the Functional Genomics and Translational Biology Council of the American Heart Association, American Heart Association National Peer Review Steering Committee, and the Heart and Stroke Foundation of Ontario Research Advisory Committee. She is the incoming Vice-Chair of the American Heart Association Council on Cardiovascular Disease in the Young. She is the Section Editor (Cardiology) for Pediatric Research.

Clinical Care Activities

  • Paediatric heart failure and heart transplantation

Research Interests

  • Next Generation Sequencing to study the genetic and environmental basis of congenital heart disease and cardiomyopathies in children and adults
  • Cardiac precision medicine and pharmacogenetic and personalized medicine approaches in children with heart disease
  • Stem cell regulation in cardiac malformations and use of reprogrammed human induced pluripotent stem cells for disease modeling and drug discovery
  • Molecular basis of right ventricular adaptation and failure
  • Clinical trials in childhood heart disease

Research Activities and Funding

  • iPS cells to model vascular disease in patients with Williams-Beuren syndrome, CIHR (Co-PI)
  • Canadian National Transplant Research Program: Increasing Donation and Improving Transplantation Outcomes, CIHR Program Grant (Co-PI, and Project Lead).
  • NIH/NLHBI Pediatric Heart Network, NIH (Co-PI)
  • Novel approaches to the prediction, diagnosis and treatment of cardiac late effects in survivors of childhood cancer, CIHR Team grant (Co-PI and Genomics Lead)
  • Mechanistic interrogation of bicuspid aortic valve-associated aortopathy, Leducq Foundation Network Grant (Co-PI)
  • Exome sequencing for RV remodeling after tetralogy of Fallot repair. HSFC Research Fellowship Award to Manickaraj AK (Supervisor)
  • Non-invasive monitoring of pediatric kidney allograft injury to improve diagnosis and patient outcomes, CIHR (Co-inv)
  • A pharmacogenetic trial of tacrolimus after paediatric transplantation, SickKids TRMC Catalyst Grant (PI)
  • Zebrafish and Human iPS cell Modeling of Cardiac Regeneration: Phenotype to Therapeutics. SickKids TRMC Catalyst Grant (Co-PI)
  • Ted Rogers Cardiac Precision Medicine Program, Ted Rogers Centre for Heart Research (Scientific Co-Lead)

Achievements

Leadership, Committees, Awards

  • 2001-2011 Steering Committee Member, NIH/NHLBI Pediatric Heart Network
  • 2004-2010 Editorial Board of Reviewers, Journal of Cardiovascular Pharmacology
  • 2005-2011 Executive Committee Member, Section of Cardiology and Cardiothoracic Surgery, American Academy of Pediatrics
  • 2004-2010 Editorial Board of Reviewers, Journal of Cardiovascular Pharmacology 2011 Chair, NHLBI Pediatric Heart Network Biospecimens Committee
  • 2011-2016 Leadership Committee Member, American Heart Association Functional Genomics and Translational Biology Council (CVDY Liaison)
  • 2011-present Clinical Investigation – D, CIHR Grant Review Committee member
  • 2011 Section Editor, Cardiology, Pediatric Research
  • 2011 Associate Editor, Congenital Heart Disease Journal
  • 2013 Member, Adult Congenital and Pediatric Cardiology Council, American College of Cardiology
  • 2013-NIH Working Group Member, New Targets for Heart Failure in Children
  • 2013-2014 Member, American Heart Association Science Advisory and Coordinating Committee (SACC)
  • 2014-2021 Executive Committee, Ted Rogers Centre for Heart Research
  • 2014-2016 Member, American Heart Association National Peer Review Steering Committee
  • 2014-2016 Member, Heart and Stroke Foundation of Ontario Research Advisory Committee
  • 2015 American Heart Association Spring - Collaborative Science Award Committee
  • 2014-2015 Member, American Heart Association Council on Cardiovascular Disease in the Young Nominating Committee
  • 2015-2017 Vice-Chair, American Heart Association Council on Cardiovascular Disease in the Young

Trainee awards (Supervisor Mital)

  • Young Investigator Award, Basic Research in Cardiology, American Academy of Pediatrics 2002, 2003, 2007
  • APS-SPR Student Research Award 2007
  • Heart and Stroke Foundation of Canada Research Fellowship Award 2013-15
  • 2014 Douglas Davidson Scholarship in Genetics, University Senate Scholarship 2014
  • SickKids Summer Research Program Poster Presentation Awards 2010, 2015
  • Outstanding abstract, Global Cardio-oncology Meeting 2015

Publications

D’Alessandro LCA, Al Turki S,  Manickaraj AK, Manase D, Mulder BJM, Bergin L, Rosenberg HC, Mondal T, Gordon E, Lougheed J, Smythe J, Devriendt K, UK10K Consortium, Bhattacharya S, Watkins H, Bentham J, Bowdin S, Hurles ME, Mital S. Exome Sequencing Identifies Rare Variants in Multiple Genes in Atrioventricular Septal Defect. Genetics in Medicine 2015 (Epub ahead of print)

Bhatt AB, Foster E, Kuehl K, Alpert J, Brabeck S, Crumb S, Davidson WR Jr, Earing MG, Ghoshhajra BB, Karamlou T, Mital S, Ting J, Tseng ZH. Congenital Heart Disease in the Older Adult: A Scientific Statement from the American Heart Association. Circulation 2015; 131(21): 1884-931

Khattak S, Brimble E, Zhang W, Zaslavsky K, Hendry J, Ross PJ, Mital S, Salter MW, Osborne LR, Ellis J. Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome. Molecular Brain 2015;8(1):77

Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Chih Jin S, Deanfield J, Giardini A, Porter G, Kim R, Bilguvar K, Lopez F, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Gelb BD, Goldmuntz E, Brueckner M, Lifton RP, Seidman CE, Chung WK. Genetic Causes for Congenital Heart Disease with Neurodevelopmental and Other Deficits. Science  2015;4:1262-1266

Manase D. D'Alessandro LCA, Manickaraj AK, Turki SA, Hurles ME, Mital S. High Throughput exome coverage of clinically relevant cardiac genes. BMC Genomics  2014 Dec 11;7(1):67

Buske O*, Kumar A*, Mital S, Ray P, Brudno M. Identification of deleterious synonymous variants in human genomes. Bioinformatics 2014 Aug 1;29(15):1843-50 (COL)

Reddy S*, Fung A*, Manlhiot C, Tierney ESS, Chung WK, Blume E, Kaufman BD, Goldmuntz E, Colan S, Mital S. Adrenergic receptor genotype influences heart failure severity and ß-blocker response in children with dilated cardiomyopathy. Pediatric Res 2014 Nov 19 (Epub ahead of print) (SRA)

Burns KM, Byrne BJ, Gelb BD, Kuhn B, Leinwand LA, Mital S, Pearson GD, Rodefeld M, Rossano JW, Stauffer BL, Taylor MD, Towbin JA, Redington AN. New targets for pediatric heart failure: Report from a National Heart Lung and Blood Institute Working Group. Circulation 2014 July 1; 130(1): 79-86

Turki SA*, Manickaraj AK*, Mercer CL*, Gerety S*, Hitz M-P, Lindsay S, D'Alessandro LCA, Swaminathan GJ, Bentham J, Arndt A-K, Breckpot J, Low J, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer H-H, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O’Kelly IM, Salmon AP, Bu’Lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klassen S, Bhattacharya S, DeVriendt K, FitzPatrick D, UK10K, Wilson DI, Mital S†, Hurles ME†. Rare variants in NR2F2 cause congenital heart defects in humans. Am J Hum Genet. 2014 Apr 3;94(4):574-8 (* Co-first authors; † Co-corresponding authors)

Newburger J, Sleeper L, Pearson G, Mahle W, Chen S, Dunbar-Masterson C, Mital S, Williams I, Ghanayem N, Goldberg C, Jacobs J, Krawczeski C, Lewis A, Pasquali S, Pizarro C, Gruber P, Atz A, Khaikin S, Gaynor WJ, Ohye R. Transplant-free survival and interventions at 3 years in the Single Ventricle Reconstruction Trial. Circulation 2014 Apr 4. [Epub ahead of print] (COL)

Mahmut N*, Gagliardi M, Kinnear C, Zhang C, Chitayat D, Shannon P, Jaeggi E, Tabori U, Keller G, Mital S. Fetal Reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation. Am J Pathol. 2013 Sep;183(3):720-34 (SRA)

Fung A*, Manlhiot C, Naik S*, Rosenberg H, Smythe J, Lougheed J, Mondal T, Chitayat D, McCrindle BW, Mital S. Impact of prenatal risk factors on congenital heart disease in the current era. J Amer Heart Assoc 2013; May 31;2(3):e000064 (SRA) *Accompanying editorial: RB Hinton

Cordell HF, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Riveron JG, Setchfield K, Thornborough C, Breckpot J, Soemedi R, Martin R, Engelen KV, Moorman AFM, Zwinderman AH, Barnett P, Koopman TT, Adriaens ME, Varro A, George AL Jr, Remedios CD, Bishopric NH, Bezzina CR, O’Sullivan J, Gewillig M, Bu’Lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook DJ, Mulder BJM, Mital S, Postma AV, Lathrop MG, Farrall M, Goodship JA, Keavney B. Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet. 2013 May 26;45(7):822-4 (COL)

Cordell HJ, Topf A, Mamasoula C, Postma AV, Bentham J, Zelenika D, Heath S, Blue G, Cosgrove C, Riveron JG, Darlay R, Soemedi R, Wilson IJ, Ayers KL, Rahman TJ, Hall D, Mulder BJM, Zwinderman AH, van Engelen K, Brook JD, Setchfield K, BuLock FA, Thornborough C, O’Sullivan J, Stuart AG, Parsons J, Bhattacharya S, Winlaw D, Mital S, Gewillig M, Breckpot J, Devriendt K, Moorman AFM, Rauch A, Lathrop GM, Keavney BD and Goodship JA. Genome-wide association study identifies a locus on 12q24 associated with tetralogy of fallot. Hum Mol Genet. 2013 Apr 1;22(7):1473-81 (COL)

Kinnear C*, Chang WY*, Khattak S*, Hinek A, Thompson T, Rodrigues DC, Kennedy K, Mahmut N, Pasceri P, Stanford WL, Ellis J, Mital S. Modeling and rescue of the vascular phenotype of Williams-Beuren syndrome in patient induced pluripotent stem cells. Stem Cells Transl Med 2013; 2 (1): 2-15 (SRA)

Alkon J*, Friedberg MK, Manlhiot C, Manickaraj AK*, Kinnear C, McCrindle BW, Benson LN, Addonizio LJ, Colan SD, Mital S. Genetic variations in hypoxia response genes influence hypertrophic cardiomyopathy phenotype. Pediatr Res 2012; 72 (6); 583-92 (SRA)

Papaz T, Safi M, Manickaraj AK*, Ogaki C, Breaton-Kyryliuk J, Burill L, Dodge C, Chant-Gambacort C, Walter L-L, Rosenberg H, Mondal T, Smythe J, Lougheed J, Bergin L, Gordon E, Chitayat D, Oechslin E, Mital S. Factors Influencing participation in a population-based biorepository for childhood heart disease. Pediatrics 2012; 130 (5); e1198-205 (SRA)

Jeewa A*, Manickaraj AK*, Mertens L, Manlhiot C, Kinnear C, Mondal T, Smythe J, Rosenberg H, Lougheed J, McCrindle BW, Redington AN, Van Arsdell G, Mital S. Genetic determinants of right ventricular remodeling after tetralogy of Fallot repair. Pediatr Res 2012 Oct; 72(4):407-13 (SRA) *Accompanying commentary: Russell MW, Wilder NS.

Mital S, Chung WK, Colan SD, Sleeper LA, Manlhiot C, Arrington CB, Cnota JF, Graham EM, Mitchell ME, Goldmuntz E, Li JS, Levine JC, Lee TM, Margossian R, Hsu DT for the Pediatric Heart Network Investigators. Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle. Circulation 2011 Jun; 123: 2353-2362 (PA) (***Circulation Editors’ Pick: Most read articles highlighting cardiovascular drugs and pharmacology. Circulation 2012;125:e396-e405***)

Hsu DT, Zak V, Mahony L, Sleeper LA, Atz A, Levine JC, Barker PC, Ravishankar C, McCrindle BW, Williams RV, Altmann K, Ghanayem NS, Margossian R, Chung WK, Border WL, Pearson GD, Stylianou MP, Mital S. Enalapril in infants with single ventricle: results of a multicenter randomized trial. Circulation 2010;122(4):333-40 (SRA) (***Circulation Editors’ Pick: Most read articles highlighting cardiovascular drugs and pharmacology and pediatric cardiology in last 2 years. Circulation 2012;125:e396-e405; Circ 2012; 126: e285-e293***)

Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro C, Kanter KR, Jaggers J, Jacobs JP, Dent CK, Pike N, McCrindle BW, Virzi L, Gaynor JW, for the Pediatric Heart Network Investigators. Outcomes of the Norwood Procedure in Infants randomized to a modified Blalock-Taussig versus right ventricle-to-pulmonary artery shunt. N Engl J Med. 2010 May 27;362(21):1980-1992 (COL)

Stevens K, Hakonarson H, Kim C, Doevendans P, Mital S, Raue J, Glessner J, Coles J G, Moreno V, Granger A, Gruber S B, Gruber P J. Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. PlosOne 2010; May 26;5(5):e10855 (COL)

Auerbach SA(, Manlhiot C, Reddy S*, Richmond ME, Gruber D, McCrindle BW, Deng L, Chen JM, Addonizio LJ, Chung WK, Mital S. Recipient genotype is a predictor of outcomes after pediatric cardiac transplantation. J Am Coll Cardiol 2009;53 1909-1917 (SRA)

A detailed list of Dr. Mital's publications is available on PubMed.