For more information, visit:

• Mital Lab
• Transatlantic Alliance
• Heart Centre Biobank

Brief Biography

Dr. Seema Mital began her education at Bombay University and was awarded a bachelor’s degree in medicine and surgery in 1989. This was followed with an MD in Pediatrics at Bombay University in 1992, and an MD in Pediatrics from Wayne State University in 1996. Finally, she received an MD in Pediatric Cardiology in 1999 from Columbia University, New York. Dr. Mital served as Faculty (Assistant Professor) in Columbia University, Morgan-Stanley Chidren’s Hospital of New York, until 2007 when she joined SickKids as Staff Cardiologist.

Clinical Care Activities

• Paediatric heart failure and heart transplantation

Research Interests

• Genome-wide approach to study the genetic and environmental basis of heart disease in children and adults:
• Genetic determinants of outcomes in congenital heart disease and cardiomyopathy
• Pharmacogenetic and personalized medicine approaches in children with heart disease
• Stem cell regulation in cardiac malformations and use of reprogrammed human induced pluripotent stem cells for disease modeling and drug discovery
• Molecular basis of right ventricular adaptation and failure

Research Activities

• Established an Ontario province-wide heart centre biobank to study the genetic and environmental basis of heart disease in children and adults.
• Multicenter study of genetic determinants of outcomes in heart disease through the Pediatric Heart Network.
• Cardiac differentiation of pluripotent stem cells for disease modeling and drug discovery
• Cardiac biomarker discovery using stem cell approaches in heart disease (MRI-GL2)
• International Network for training and education in genomics of heart disease (MRI-ISOP)

External Funding

Principal Investigator, Ontario Ministry of Research and Innovation International Strategic Opportunities Program, “GenomeHeart: An International Network to Study Cardiac Malformations”

Co-Investigator, Ontario Research Fund - Global Leadership Round in Genomics & Life Sciences Competition (GL2 Competition), “Cardiovascular Biomarker Discovery in Disease and Development through Predictive Precision Proteomics” (CBD3P3)

Principal Investigator, Roma and Marvin Auerback Endowment in Developmental Biology and Congenital Heart Research

Principal Investigator, NIH/NLHBI Pediatric Heart Network (UO1 HL068288) ancillary study: “Genetic polymorphisms in pediatric cardiomyopathy”

Site PI: NIH/NLHBI Pediatric Heart Network (UO1 HL068288, 2006-11): "Single ventricle reconstruction-2 Trial"

Researcher, Ontario Initiative in Personalized Stem Cell Medicine, Biorepository component

Principal Investigator, Labatt Family Heart Centre Biobank, an Ontario province wide biobanking network in heart disease

Principal Investigator, SickKids Transplant Centre Biobank

Achievements

• 2010 Guest Editor, Review Series, Update in Pediatric Cardiovascular Pharmacology, Journal of Cardiovascular Pharmacology
• 2009-10 Chair, Peer Review Committee (Cardiac Biology/Regulation), American Heart Association
•  2008-11 Chair, Program Committee, Cardiovascular Disease in the Young, American Heart Association
• 2009 Co-Chair, American Heart Association International Congress 2009, on “Genetics/Genomics of Heart Disease”
•  2009 Chair, Peer Review Committee (Cardiac Biology/Regulation), American Heart Association 
• 2007 Roma and Marvin Auerback Professor of Developmental Cardiology and Congenital Heart Disease Research
• 2001-11 Steering Committee Member, NIH/NHLBI Pediatric Heart Network
• 2005-11 Executive Committee Member, Section of Cardiology and Cardiothoracic Surgery, American Academy of Pediatrics
• 2004-10 Editorial Board of Reviewers, Journal of Cardiovascular Pharmacology

Trainee Awards

• 2007 APS-SPR Student Research Award awarded to Rafael Cortes for research performed at Columbia University (Sponsor: Mital)
• 2007 Young Investigator Award awarded to Scott Auerbach, Section of Cardiology, American Academy of Pediatrics (Sponsor: Mital)
• 2003 Young Investigator Award awarded to Juan Carlos Osorio, Basic Research in Cardiology, American Academy of Pediatrics (Sponsor: Mital)
• 2002 Young Investigator Award awarded to Ashwin Prakash, Basic Research in Cardiology, American Academy of Pediatrics (Sponsor: Mital)
• 2001 Young Investigator Award Finalist (Juan Carlos Osorio) Basic Research in Cardiology, American Academy of Pediatrics (Sponsor: Mital)

Publications

Hsu DT, Zak V, Mahony L, Sleeper LA, Atz A, Levine JC, Barker PC, Ravishankar C, McCrindle BW, Williams RV, Altmann K, Ghanayem NS, Margossian R, Chung WK, Border WL, Pearson GD, Stylianou MP, Mital S. Enalapril in Infants with Single Ventricle: Results of a multicenter randomized trial. Circulation 2010 July 12 (Epub ahead of print)

Stevens K, Hakonarson H, Kim C, Doevendans P, Mital S, Raue J, Glessner J, Coles J G, Moreno V, Granger A, Gruber S B, Gruber P J. Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. PLoS One. 2010 May 26;5(5):e10855

Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro C, Kanter KR, Jaggers J, Jacobs JP, Dent CK, Pike N, McCrindle BW, Virzi L, Gaynor JW, for the Pediatric Heart Network Investigators. Outcomes of the Norwood Procedure in Infants randomized to a modified Blalock-Taussig versus right ventricle-to-pulmonary artery shunt. N Engl J Med. 2010 May 27;362(21):1980-1992

Williams RV, Ravishankar C, Zak V, Evans F, Atz AM, Border WL, Levine J, Li JS, Mahony L, Mital S, Pearson GD, Prakash A, Hsu DT. Pediatric Heart Network Infant Single Ventricle Trial: Birth weight and prematurity in the screened population. Congenital Heart Disease 2010; 5: 96-103

Minich LL, Atz AM, Colan SD, Sleeper LA, Mital S, Jaggers J, Margossian R, Prakash A, Li JS, Cohen MS, Lacro RV, Klein GL, Hawkins JA. Partial and Transitional Atrioventricular Septal Defect Outcomes: Does Age at Repair Matter? Annals of Thoracic Surgery 2010; 89:530-536

Marelli A, Beauchesne L, Mital S, Therrien J, Silversides CK. Canadian Cardiovascular Society 2009 Consensus Conference on Management of Adults with Congenital Heart Disease: Introduction. Can J Cardiol 2010;26(3): e65-e69

Auerbach SA, Manlhiot C, Reddy S, Richmond ME, Gruber D, McCrindle BW, Deng L, Chen JM, Addonizio LJ, Chung WK, Mital S. Recipient Genotype is a Predictor of Outcomes after Pediatric Cardiac Transplantation. J Am Coll Cardiol 2009;53 1909-1917

Kaufman BD, Desai M, Osorio JC, Mosca RS, Chen JM, Ferrante AW, Mital S. Genomic profiling of left and right ventricular hypertrophy in congenital heart disease. J Card Failure 2008; 14(9):760-7
Hsu DT, Mital S, Ravishankar C, Margossian R, Li JS, Sleeper LA, Williams RV, Levine JC, McCrindle BW, Atz AM, Serevedio D, Mahony L. Rationale and design of a trial of angiotensin converting enzyme inhibition in infants with single ventricle. American Heart Journal 2009 Jan; 157(1):37-45

Osorio JC, Cheema FH, Martens TP, Mahmut N, Kinnear C, Duque AM, Bonney W, Homma S, Liao JK, Mital S. Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor. Canadian J Physiol Pharmac 2008; 86(9): 633-42

Kaufman BD, Auerbach S, Reddy S, Manlhiot C, Deng L, Prakash A, Printz BF, Gruber D, Papavassiliou DP, Hsu DT, Sehnert AJ, Chung WK, Mital S. RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy. Hum Genet. 2007 Dec;122(5):515-23 Abstract

Gonzalez AM, Osorio JC, Manlhiot C, Gruber D, Homma S, Mital S. Hypertrophy signaling during peripartum cardiac remodeling. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3008-13 Abstract

Mital S. Value of surveillance biopsy in pediatric heart transplantation. Pediatric Transplantation 2007;11(3):233-5

Mital S. The right ventricle in congenital heart disease: is the right ventricle just a "weaker" left ventricle? Archives des Maladies du Coeur et des Vaisseaux Dec 2006; 99(12):1246-51

Reddy S, Osorio JC, Duque AM, Kaufman BD, Phillips AB, Chen JM, Quaegebeur J, Mosca RS, Mital S. Failure of right ventricular adaptation in children with tetralogy of fallot. Circulation 2006; 114: I-37-42 Abstract

Osorio JC, Reddy S, Cusmai G, Thaker H, Chen JM, Quaegebeur J, Mosca RS, Mital S. Vascular endothelial growth factor deficiency: a potential cause of left ventricular hypoplasia. Circulation 2006;114(18):II584, A2792

Evans RW, Williams GE, Baron HM, Deng MC, Eisen HJ, Hunt SA, Khan MM, Kobashigawa JA, Marton EN, Mehra MR, Mital S. The economic implications of noninvasive molecular testing for cardiac allograft rejection. Amer J Transplantation 2005; 5: 1553-1558 Abstract

Mital S, Liao JK. Statins and the myocardium. Seminars in Vascular Medicine. 2005; 4 (4): 377-384 

Reddy S, Matsuoka N, Gruber D, Kaufman BD, Masood T, Lamour JM, Chung WK, Mital S. Adrenergic receptor polymorphisms influence progression of dilated cardiomyopathy in children. Circulation 2005;112(17):II-515 (A2463)

Abraham SS, Osorio JC, Homma S, Wang JT, Thaker H, Liao JK, Mital S. Simvastatin preserves cardiac function in genetically determined cardiomyopathy. J Cardiovasc Pharmac 2004; 43 (3): 454-461 Abstract

Mital S, Loke KE, Chen JM, Mosca RS, Quaegebeur JM, Addonizio LJ, Hintze TH. Mitochondrial respiratory abnormalities in patients with end-stage congenital heart disease. J Heart Lung Transplant 2004; 23 (1): 72-79 Abstract

Kaufman BD, Deng L, Chung WK, Prakash A, Printz B, Gruber D, Lamour JM, Hsu DT, Addonizio LJ, Mital S. RAAS gene polymorphisms influence cardiac remodeling in children with hypertrophic cardiomyopathy. Circulation 2004; 110 (17) Suppl III; 2081

Dr. Mital's publications on PubMed »»