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About Sickkids
About SickKids

Vito Mennella, PhD

Research Institute
Scientist
Cell Biology

University of Toronto
Assistant Professor
Biochemistry


Phone: 416-813-7654 ext. 309267
Fax: 416-813-5028
Email: vito.mennella@sickkids.ca

External Email: vito.mennella@utoronto.ca
Alternate Contact: Mary Ann Gueco
Alternate Phone: 416-813-7654 ext. 303045
Alternate Fax: 416-813-8456
Alternate Email: maryann.gueco@sickkids.ca

For more information, visit:

http://biochemistry.utoronto.ca/person/vito-mennella/ 

Brief Biography

Dr. Vito Mennella is a Scientist in the Cell Biology research program at The Hospital for Sick Children (SickKids). Dr. Mennella received his B.Sc. from the University La Sapienza in Rome, Italy. He then worked as a research assistant at the National Institute of Health in Italy. After becoming a Fulbright Fellow, Dr. Mennella travelled to the U.S. to complete his M.Sc. and his PhD at Albert Einstein College of Medicine in New York in Dr. David Sharp’s lab. From there, Dr. Mennella joined the Howard Hughes Medical Institute lab (HHMI) of Dr. David Agard at the University of California San Francisco (UCSF) as a postdoctoral fellow. Dr. Mennella joined the Research Institute at SickKids in 2014.

Research Interests

  • Super-resolution Microscopy
  • Centrosome and cilia structure and function
  • Molecular mechanism of Ciliopathies and Microcephaly
  • Macromolecular complex architecture
  • Mechanism of organelle remodeling
  • Correlative Super-resolution-Electron Microscopy

Publications

Mennella, V., Agard, D.A., Huang, B. and Pelletier, L.  Amorphous no more: Subdiffraction organization of the pericentriolar material, Trends Cell Biol, 2014, (3):188-97.

Miao, J., Wong, C.L., Mennella, V., Michelot, A., Agard, D.A., Holt, L.J., Yates, J.R., Drubin, D.G. Cell cycle regulation of formin-mediated actin cable assembly. PNAS, 2013, 110(47):4446-55.

Arigovindan, M., Fung, J.C., Elnatan, D., Mennella, V., Chan, Y.H., Branlund, E., Sedat, J.W., Agard, D.A.  High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratio. PNAS, 2013, 110(43):17344-9.

Mennella, V., Keszthelyi, B., McDonald, K.L., Chhun, B., Kan, F., Rogers, G.C., Huang, B. and Agard, D.A.  Subdiffraction resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization. Nat Cell Biol, 2012, 14(11):1159-68.

Gopalakrishnan J., Mennella, V., Blachon, S., Zhai, B., Smith, A.H., Megraw, T.L., Nicastro, D., Gygi, S.P., Agard, D.A., Avidor-Reiss, T.  Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome.  Nat Commun, 2011, 2:359.

Mennella, V., Tan, D., Ansejo, A.B., Buster, D.W., Rath, U., Ao, M., Sosa, H. and Sharp, D. Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A. J Cell Biol, 2009, 186(4):481-90.

Tan, D., Asenjo, A.B., Mennella, V., Sharp, D.J, Sosa, H.  Kinesin-13s form rings around microtubules.  J Cell Biol, 2006, 175:25-31.

Mennella, V., Rogers, G.C., Rogers, S.L., Buster, D.W., Vale, R.D., Sharp, D.J.  Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Nat Cell Biol, 2005, 7(3):235-45.

Sharp, D.J., Mennella, V., Buster, D,W.  Klp10a and Klp59c: the dynamic duo of microtubule depolymerisation. Cell Cycle, 2005, 4(11):1482-5.

Flego, M., Mennella, V., Moretti, F., Poloni, F., Dupuis, M.L., Barca, S., Felici, F. and Cianfriglia, M.  Identification by phage display of the linear continuous Mab mrpr1 epitope the multidrug resistance associate protein (MRP1).  Biol Chem, 2003, 384(1):139-42.