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About Sickkids
About SickKids

Theo Moraes, MD, PhD, FRCPC

The Hospital for Sick Children
Staff Respirologist
Respiratory Medicine

Research Institute
Scientist
Translational Medicine

University of Toronto
Assistant Professor
Department of Paediatrics


Phone: 416-813-2196
Fax: 416-813-5771
Email: theo.moraes@sickkids.ca

Brief Biography

Dr. Theo Moraes graduated from medical school in 1997 (Toronto) and then completed his paediatric residency (Kingston) and paediatric respirology fellowship (Toronto) before pursuing his PhD in the laboratory of Dr. Gregory Downey. His postdoctoral training was done in Dr. Tania Watts' lab in the area of T cell immunity to influenza infection.

Research Interests

The Moraes lab is broadly interested in respiratory epithelial cell biology. Many lung diseases directly impact respiratory epithelial function leading to profound illness, often in paediatric age group. By understanding these processes we hope to improve outcomes for these children.

The lab currently has a few major areas of focus. First, Respiratory Syncytial Virus (RSV), the most common cause of serious respiratory viral infection in children, is an active area of investigation. RSV primarily targets the respiratory epithelial cell for infection. We currently use a number of model systems including a mouse model and a well differentiated human airway epithelial cell culture system.

Second, we have a focus on cystic fibrosis (CF), the most common, fatal genetic disease in North America. While CF is a multi-organ disease, the primary lung defect is related to epithelial dysfunction. Our goal is to use our primary cell culture model to improve the management of CF for individual patients.

Third, the lab has a research focus on asthma.  Asthma is a complex disease however the lung epithelium is thought to play a key role in pathogenesis.

Dr. Moraes is a member of the Program for Individualized CF Therapy, a collaboration between Cystic Fibrosis Canada, SickKids Foundation and The Hospital for Sick Children to develop a nationally accessible resource that will accelerate the development of precision medicine for the treatment of each individual living with Cystic Fibrosis. More info: http://www.sickkids.ca/cysticfibrosiscentre/Individualized-Therapy

Dr. Moraes is also the Toronto Site Director for the CHILD Study (Canadian Healthy Infant Longitudinal Development), a prospective longitudinal birth cohort study that aims to advance knowledge about the genetic and environmental determinants of atopic diseases including asthma and allergy. More info: www.childstudy.ca

Achievements

  • Siminovitch-Salter Award, 2007
  • Canadian Child Health Clinician Scientist Program Postdoctoral Award, 2007
  • Canadian Institutes of Health Research Fellowship, 2005
  • Duncan L. Gordon Fellowship, 2002

Publications

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