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About Sickkids
About SickKids

Jeehye Park, PhD

Research Institute
Scientist
Genetics & Genome Biology

University of Toronto
Assistant Professor
Department of Molecular Genetics

Chair Positions
Canada Research Chair
Molecular Genetics & Neurodegenerative Diseases


Phone: 416-813-7670
Email: jeehye.park@sickkids.ca

Brief Biography

Education and Research Training

  • Postdoctoral fellow: Baylor College of Medicine & Howard Hughes Medical Institute (Dr. Huda Zoghbi laboratory)
  • PhD: Korea Advanced Institute of Science and Technology (Dr. Jongkyeong Chung laboratory)

Research Interests

  • Gene expression control in neurodevelopment
  • Molecular basis of neuronal aging
  • Genetic models for neurodevelopmental and neurodegenerative diseases
  • Molecular mechanism of brain diseases
  • Genome-wide genetic screens to identify therapeutic targets for brain disorders

Research Activities

  • Characterizing the role of RNA binding proteins in motor neuron development
  • Investigating the mechanisms of gene expression during motor neuron differentiation
  • Dissecting the molecular mechanism of amyotrophic lateral sclerosis (ALS) using genetic models
  • Conducting genome-wide genetic screens to identify therapeutic targets for ALS

Publications

Tan Q*, Yalamanchili HK*, Park J*, De Maio A, Lu H, Wan Y, White JJ, Bondar VV, Sayegh LS, Liu X, Gao Y, Sillitoe RV, Orr HT, Liu Z , Zoghbi HY. Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegenerative models. Hum Mol Genet (2016) DOI:10.1093/hmg/ddw337 *co-first authors

Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY. TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife (2016) DOI: 10.7554/eLife.19809.

Lasagna-Reeves CA, Rousseaux MW, Guerrero-Munoz MJ, Park J, Jafar-Nejad P, Richman R, Lu N, Sengupta U, Litvinchuk A, Orr HT, Kayed R, Zoghbi HY. A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1. Elife (2015) DOI: 10.7554/eLife.07558.

Park J*, Al-Ramahi I*, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Kang H, Lagalwar S, Duvick L, Lu H, Lee Y, Jafar-Nejad P, Sayegh LS, Malani N, Richman R, Liu X, Gao Y, Shaw CA, Arthur JC, Orr HT, Westbrook TF, Botas J, Zoghbi HY. Genetic screens reveal Ras/MAPK/MSK1 modulates Ataxin-1 levels and toxicity in SCA1. Nature (2013) 498: 325-331. *co-first authors

Song S*, Jang S*, Park J*, Bang S, Choi S, Kwon KY, Zhuang X, Kim E, Chung J. Characterization of phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) mutations associated with Parkinson’s disease in mammalian cells and Drosophila. J. Biol. Chem. (2013) 288: 5660-72. *co-first authors

Park J*, Kim Y*, Choi S*, Koh H, Lee SH, Kim JM, Chung J. Drosophila Porin/VDAC affects mitochondrial morphology. PLoS One (2010) 5(10):e13151. *co-first authors

Park J, Kim Y, Chung J. Mitochondrial dysfunction and Parkinson’s disease genes: insights from Drosophila. Dis. Model Mech. (2009) 2:336-40.

Park J, Lee G, Chung J. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochem. Biophys. Res. Commun. (2009) 378:518-23.

Kim Y*, Park J*, Kim S*, Song S, Kwon SK, Lee SH, Kitada T, Kim JM, Chung J. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. (2008) 377:975-80. *co-first authors

Park J*, Lee SB*, Lee S, Kim Y, Song S, Kim S, Bae E, Kim J, Shong M, Kim J, Chung J. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature (2006) 441:1157-61. *co-first authors

Cha GH*, Kim S*, Park J*, Lee E, Kim M, Lee SB, Kim JM, Chung J, Cho KS. Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc. Natl. Acad. Sci. USA (2005) 102:10345-50. *co-first authors

Park J*, Kim SY*, Cha GH*, Lee SB, Kim S, Chung J. Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene (2005) 361:133-9. *co-first authors

A full list of Park's publications is available through PubMed.