Jose Luis Perez-Velazquez, PhD
Neurosciences & Mental Health
University of Toronto
Department of Paediatrics and the Institute of Medical Science
Jose Luis Perez Velazquez was born in Zaragoza, Spain. He undertook undergraduate studies in Chemistry at the University of Zaragoza and Biochemistry at the University of Madrid. In 1992, he obtained his PhD from the Department of Molecular Physiology and Biophysics at Baylor College of Medicine. In 1997, Perez Velazquez was granted a Doctorate in Chemistry by the Spanish Ministry of Culture. He has worked in Toronto since 1992, initially at Toronto Western Hospital. He joined The Hospital for Sick Children in 2001.
My interests lie in seeking an understanding of the relation between brain function and behaviour. I was originally trained as a biochemist and, after doing much work on molecular aspects of neuroscience, I understood that to better understand the relation between brain and behaviour I would have to change levels of description. I began performing more "holistic" approaches and thus studied neurophysiology and dynamical system theory that we are now applying to brain recordings.
One of our key research themes is the investigation of the patterns of coordinated activity in brain networks, associated with some pathologies and cognitive functions. During the past few years my colleagues and I have determined a few specific dynamical regimes in brain activity - epilepsy in particular. Research is done in collaboration with clinicians at SickKids and other hospitals and, we have begun to use magnetoencephalographic (MEG) recordings to determine brain coordination dynamics. We are extending our work on brain pathologies, so that in addition to continuing work on epilepsy, we have started work on brain dynamics resulting from traumatic brain injury, autism and schizophrenia. These experimental studies are complemented with more theoretical investigations using dynamical system theory to elaborate frameworks that capture the essence of cellular interactions in the brain and their relation to behaviour.
The Brain-Behaviour Continuum― The subtle transition between sanity and insanity. J.L. Perez Velazquez & M.V. Frantseva, Imperial College Press/World Scientific (2011)
Coordinated Activity in the Brain: Measurements and Relevance to Brain Function and Behaviour. J.L. Perez Velazquez & R. Wennberg, eds. Springer Verlag (2009)
Finding simplicity in complexity: general principles of biological and nonbiological organization. J. L. Perez Velazquez. Journal of Biological Physics, 35, 209-221, 2009
Decreased brain coordinated activity in autism spectrum disorders during executive tasks: reduced long-range synchronization in the fronto-parietal networks. J.L. Perez Velazquez, F. Barcelo, Y. Hung, Y. Leshchenko, V. Nenadovic, J. Belkas, V. Raghavan, J. Brian, L. Garcia Dominguez. International Journal of Psychophysiology, 73, 341-349, 2009
Brain, behaviour and mathematics: are we using the right approaches? J. L. Perez Velazquez. Physica D 212, 161-182 (2005)