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About Sickkids
About SickKids

Paul Pencharz, MB, ChB, PhD, FRCP(C)

The Hospital for Sick Children
Staff Gastroenterologist
Gastroenterology, Hepatology and Nutrition

Research Institute
Senior Scientist Emeritus
Translational Medicine

University of Toronto
Professor
Depts. of Nutritional Sciences & Paediatrics

Other Positions

Canadian Institutes of Health Research Training Program
Clinical Nutrition Research
Director


Phone: 416-813-6171
Fax: 416-813-4972
Email: paul.pencharz@sickkids.ca

Brief Biography

Paul Pencharz has chaired the Canadian Paediatric Society’s Nutrition Committee and served as a liaison member of the American Academy of Pediatric’s Committee on Nutrition. He is a member of a United Nations Panel whose task is to revise the FAO/WHO/UNU Guidelines for Protein Requirements. He lists 71 research trainees over the past 32 years, from Europe, Israel, Australia and North America; several of whom are now senior investigators and/or Department Chairs. He has won awards for his research from the Canadian Society for Nutritional Sciences, the Clinical Research Society of Toronto, the March of Dimes, the Nutrition Award of the American Academy of Pediatrics (2002) and the Osborne-Mendel Award of the American Society for Nutritional Sciences (2002).

Research Interests

  • Protein metabolism
  • Amino acid metabolism
  • Protein requirements
  • Amino acid requirements
  • Body composition
  • Energy metabolism
  • Isotope ratio mass spectrometry
  • Quadropole mass spectrometry
  • Stable isotopes

Research Activities

Amino acid requirements throughout the life cycle and effect of disease on energy metabolism. My primary research interest is in the amino acid requirements of children (from birth through childhood) and adults. In a piglet model we have shown that intravenous feeding (TPN) markedly reduced the need for some amino acids. These observations are now being verified in TPN fed human neonates. We have developed a non-invassive method of indicator amino acid oxidation to be able to determine essential amino acid requirements in children.

Other areas of interest include the following:

  • Neonatal protein and energy metabolism
  • The effect of cystic fibrosis-related diabetes mellitus on protein metabolism
  • Splanchnic uptake of amio acids
  • Phenylalanine requirements of children with PKU

External Funding

Canadian Institutes of Health Research
- two operating grants
- principal applicant on a training grant

Achievements

Dr. Pencharz was awarded the Crampton Award of McGill University which is for excellence in Nutritional Science (2004), the McHenry Award of the Canadian Society for Nutritional Sciences for life-time contributions to nutrition in Canada (2004), Physician Research Award for Career Excellence of the University of Toronto, Department of Paediatrics (2007) and he was awarded Fellow of the American Society for Nutrition for contributions to nutrition (2008).

In 2004 Dr. Pencharz was awarded the Crampton Award of McGill University which is for excellence in Nutritional Sciences and the McHenry Award of the Canadian Society for Nutritional Sciences for life-time contributions to nutrition in Canada.

Publications

Courtney-Martin G, Chapman KP, Mooore AM, Kim JH, Ball RO, Pencharz PB. Total sulphur amino acid requirement and metabolism in the parenterally fed postsurgical human neonates. Am J Clin Nutr 88:115-124, 2008

Elango R, Ball RO, Pencharz PB. Indicator amino acid oxidation: concept and application. J Nutr 138:243-246, 2008

Rafii M, McKenzie JM, Roberts SA, Steiner G, Ball RO, Pencharz PB. The in vivo regulation of phenylalanine hydroxylation using enrichment in Apo-B 100. Am J Physiol 294:E475-479, 2008

Urschel KL, Rafii M, Pencharz PB, Ball RO. A multi-tracer stable isotope quantification of the effects of arginine intake on whole-body arginine metabolism in neonatal piglets. Am J Physiol 293:E811-818, 2007

Humayun MA. Elango R, Moehn S, Ball RO, Pencharz PB. Application of the indicator amino acid oxidation technique for the determination of metabolic availability of sulphur amino acids from casein versus soy protein isolate in adult men. J Nutr 137:1874-1879, 2007