Facebook Pixel Code
About Sickkids
About SickKids

Rulan Parekh, MD, MS, FRCP(C), FASN

The Hospital for Sick Children
Staff Physician
Nephrology

Research Institute
Associate Chief Clinical Research
Research Institute

Senior Scientist, Child Health Evaluative Sciences
Research Institute

University of Toronto
Professor
Faculty of Medicine, Department of Paediatrics

Program Director
Division of Nephrology, Department of Medicine

Associate Professor
Dalla Lana School of Public Health, Department of Epidemiology

Other Positions

University Health Network
Nephrology
Staff Physician


Phone: 416-813-7654
Fax: 416-813-6271
Email: rulan.parekh@sickkids.ca

For more information, visit:

Parekh Lab

Brief Biography

Dr. Parekh is a Clinician Scientist and Professor of Medicine and Paediatrics at the University of Toronto, the Hospital for Sick Children and University Health Network. The focus of Dr. Parekh’s research is to study risk factors both clinical and genetic leading to progression of chronic kidney and cardiovascular disease. She has published over 90 peer reviewed manuscripts and book chapters, and has mentored over 25 postdoctoral fellows and students. She leads both NIH and Canadian Institute of Health Research sponsored observational studies in kidney disease including: “Predictors in Arrhythmic and Cardiovascular Disease in End Stage Renal Disease (PACE)”, a new cohort study in dialysis patients to identify risk factors for sudden cardiac death;   the “ Insight into Nephrotic Syndrome: Genes, Health and Therapeutics (INSIGHT)”, a cohort study of childhood nephrotic syndrome; a pediatric solid organ transplant cohort; and is also site PI for the Family Investigation of Nephropathy in Diabetes (FIND).  She is a co-investigator on the Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network and leads the aims to study genetic risk, specifically APOL1, for chronic kidney disease in West and East Africa. She has recently been inducted into the American Society of Clinical Investigation and Society for Pediatric Research.

Academic Background

Degrees, Diplomas, and Certification
1985-1989   Royal College of Surgeons Dublin, Ireland
1989-1991   Albany Medical College MD Albany, New York, USA
1997-1999   University of Michigan MS Ann Arbor, MI, USA Clinical Research Design and Biostatistics

Certification
1995    American Board of Internal Medicine
1995    American Board of Pediatrics
1999    American Board of Pediatrics, Subspecialty Pediatric Nephrology; Recertified 2006.
1999    American Board of Internal Medicine, Subspecialty Nephrology

CLINICAL TRAINING:
1991-1995    University of Michigan Combined Internal Medicine and Ann Arbor, MI, USA Pediatric Internship and Residency
1995-1999 University of Michigan Combined Medicine and Pediatric Ann Arbor, MI, USA Nephrology Fellowships

RESEARCH TRAINING:
1997-1999 University of Michigan Post Doctoral Research Fellow in Ann Arbor, MI, USA
1999 Johns Hopkins University Post Doctoral Research Fellow in Baltimore, MD, USA

External Funding

2014-2018 
CIHR-Operating Grant, Long-Term Survival in Childhood Solid Organ Transplants
Principal Investigator

2012-2017 
NIH/NHGRI, H3Africa Kidney Disease Research Network
Co-Investigator

2013-2018 
CIHR Program Grant, Canadian National Transplant Research Program: Increasing Donation and Improving Transplantation Outcomes
Co-Investigator

2014- 2015      
CIHR-Catalyst Grant: e-Health Innovations, Teens Taking Charge – Managing my Transplant Online: A Feasibility Study.
Co-Investigator

Achievements

Honors and Awards

2008 Inducted into Society of Pediatric Research

2009 Inducted into the American Society of Clinical Investigation

2014 National Kidney Foundation of Maryland Award in recognition of outstanding scientific achievement

2014 C. Phillips Rance Award of Merit, Division of Nephrology, The Hospital for Sick Children

Publications

Selected

  1. Kao WHL, Klag MJ, Meoni LA, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Tandon A, Powe NR, Fink NE, Sadler JH, Weir MR, Adler S, Divers J, Iyengar SK, Freedman BI, Kimmel PL, Kamp K, Kohn OF, Leehey DJ, Nicholas S, Pahl M, Schelling JR, Sedor JR, Thornley-Brown D, Winkler CA, Smith MW, Parekh RS on behalf of the Family Investigation of Nephropathy and Diabetes (FIND) Research Group.  MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008 Oct;40(10):1185-92. Epub 2008 Sep 14. PMID: 18794854.
  2. Sozio SM, Coresh J, Jaar BG, Fink NE, Plantinga LC, Armstrong PA, Longenecker JC, Sharrett AR, Powe NR, Parekh RS. Inflammatory markers and risk of cerebrovascular events in patients initiating dialysis. (2011) Clinical Journal of the American Society of Nephrology, 6 (6), pp. 1292-1300.
  3. Hussain N, Zello JA, Vasilevska-Ristovska J, Banh TM, Patel VP, Patel P, Battiston CD, Hebert D, Licht CP, Piscione TD, Parekh RS . The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome. . BMC Nephrol. 2013 Jan 26;14:25. PMID: 23351121
  4. Foster MC, Coresh J, Fornage M, Astor BC, Grams M, Franceschini N, Boerwinkle E, Parekh RS, Kao WH.  Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans.  J Am Soc Nephrol. 2013 Jun 13. PMID: 23766536
  5. Estrella MM, Wyatt CM, Pearce CL, Li M, Shlipak MG, Aouizerat BE, Gustafson D, Cohen MH, Gange SJ, Kao WH, Parekh RS. Host APOL1 genotype is independently associated with proteinuria in HIV infection. Kidney Int. 2013 May 29. PMID: 23715117
  6. Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT Jr, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ; AASK Study Investigators; CRIC Study Investigators. APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med. 2013 Dec 5;369(23):2183-96. Epub 2013 Nov 9. PMID: 24206458
  7. Scialla JJ, Kao W H L, Crainiceanu C, Sozio SM, Oberai PC,  Shafi T, Coresh J, Powe NR, Laura C Plantinga LC, BG, and Parekh RS. Biomarkers of Vascular Calcification Are Associated with Mortality in Patients with End-Stage Renal Disease, Clin J Am Soc Nephrol. 2014 Jan 23. PMID:24458076
  8. Estrella, M, Li, M, Tin, A Abraham, A, Shilpak, M, Hussain, S, Palella, F, Martinson, J, Parekh, RS, Kao, WH.  The Association Between APOL1 Risk Alleles and Longitudinal Kidney Function Differs by HIV RNA Suppression Status.  Clin Infec Dis. 2014 Oct. 3. PMID: 25281610.