Andrew N. Redington, MB, BS, MRCP (UK), MD, FRCP (UK), FRCP (C)
The Hospital for Sick Children
Physiology & Experimental Medicine
University of Toronto
BMO Financial Group
Chair in Cardiology
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Dr. Andrew Redington moved to Toronto from England in August, 2001 to take on the role of Head of Cardiology at The Hospital for Sick Children (SickKids).
Dr. Redington's research interests include ventricular function and cardiopulmonary physiology, mechano-electric interactions in congenital heart disease, and the pathophysiology of late postoperative functional decline. He has written more than 230 peer reviewed publications, more than 20 book chapters, and has co-edited six books. He is the editor of the congenital heart disease section of Current Medical Literature, and serves on the editorial boards of the Cardiology in the Young and Heart and Vessels.
Dr. Redington graduated from the University of London in 1981. He obtained his MRCP (UK) in Internal Medicine in 1984. In 1986 he was awarded a British Heart Foundation research scholarship and subsequently received his doctorate of medicine in 1988 (UK). He was appointed Consultant Paediatric Cardiologist at the Royal Brompton Hospital, London, in 1990 and was awarded a fellowship of the Royal College of Physicians in 1994 (UK). In 1998, he transferred his clinical and research teams to Great Ormond Street Hospital in London.
Clinical Care Activities
- Cardiac catheterization
- In-patient and out-patient care
Long-standing interest in the pathophysiology of congenital heart disease, with emphasis on assessment of right ventricular function, cardiopulmonary interactions, and right left heart interactions.
- Ventricular function and cardiovascular physiology
- Ischemic preconditioning
Present research concentrates on analysis of myocardial performance using the abnormalities imposed by congenital heart disease and its surgery as natural models of chronic 'heart failure'. Current research interests are in two major areas: the non-invasive assessment of myocardial contractility using tissue Doppler techniques, and the use of a novel remote ischemic preconditioning protocol to protect the myocardium and other organs from the ischemic insult of cardiopulmonary bypass and ischemia re-perfusion injury.
Additional areas of interest include: right left heart interactions and their measurement using conductance catheter technologies, and the assessment of oxygen consumption and mechanisms of hibernation as they may apply to post-operative intensive care.
Future Research Interests
- Development of non-invasive techniques for assessing myocardial performance.
- The use of innate mechanisms of protection (eg. ischemic preconditioning) during cardiac surgery.
Heart & Stroke Foundation
Cheung M, Kharbanda RK, Konstantinov I, Shimizu M, Frndova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van Arsdell GS, Redington AN: Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. Journal of the American College of Cardiology 2006: 47(11): pp 2277-82.
Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, Vogel M, Sorensen K, Redington AN, MacAllister R. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. Dec 3;106(23):2881-3, 2002.
Vogel M, Schmidt MR, Kristiansen SB, Cheung M, White PA, Sorensen K, Redington AN. Validation of myocardial acceleration during isovolumic contraction as a novel noninvasive index of right ventricular contractility: comparison with ventricular pressure-volume relations in an animal model. Circulation. Apr 9;105(14):1693-9, 2002.
Vogel M, Sponring J, Cullen S, Deanfield JE, Redington AN. Regional wall motion and abnormalities of electrical depolarization and repolarization in patients after surgical repair of tetralogy of Fallot. Circulation. Mar 27;103(12):1669-73, 2001.
Derrick GP, Narang I, White PA, Kelleher A, Bush A, Penny DJ, Redington AN. Failure of stroke volume augmentation during exercise and dobutamine stress is unrelated to load-independent indexes of right ventricular performance after the Mustard operation. Circulation. Nov 7;102(19 Suppl 3):III154-9, 2000.
Hsia TY, Khambadkone S, Redington AN, Migliavacca F, Deanfield JE, de Leval MR. Effects of respiration and gravity on infradiaphragmatic venous flow in normal and Fontan patients. Circulation. Nov 7;102(19 Suppl 3):III148-53, 2000.
Gatzoulis MA, Balaji S, Webber SA, Siu SC, Hokanson JS, Poile C, Rosenthal M, Nakazawa M, Moller JH, Gillette PC, Webb GD, Redington AN. Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study. Lancet. Sep 16;356(9234):975-81, 2000.
Cheung YF, Taylor MJ, Fisk NM, Redington AN, Gardiner HM. Fetal origins of reduced arterial distensibility in the donor twin in twin-twin transfusion syndrome. Lancet. Apr 1;355(9210):1157-8, 2000.