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About Sickkids
About SickKids

Daniel Roth, MD MSc PhD

The Hospital for Sick Children
Staff Physician
Paediatric Medicine

Research Institute
Scientist
Child Health Evaluative Sciences

University of Toronto
Assistant Professor - Status Only
Institute of Health Policy, Management & Evaluation


Phone: 416-813-7654 ext. 328807
Fax: 416-813-7654 ext. 308763
Email: daniel.roth@sickkids.ca
Alternate Contact: Nadine Francis
Alternate Phone: 416-813-7654 ext. 309265
Alternate Fax: 416-813-7654 ext. 308763
Alternate Email: nadine.francis@sickkids.ca

For more information, visit:

http://www.sickkids.ca/PaediatricMedicine/index.html

Brief Biography

Daniel Roth received his MD in 2002 from the University of British Columbia (Vancouver, British Columbia). He completed a paediatric residency (2002-06) and MSc (2006) at the University of Alberta (Edmonton, Alberta). In 2011, he earned a PhD in global public health and human nutrition at The Johns Hopkins Bloomberg School of Public Health (Baltimore, Maryland). Dr. Roth is a clinician-scientist and assistant professor in the Division of Paediatric Medicine, Department of Paediatrics at The Hospital for Sick Children and University of Toronto.  His research focuses on maternal and child health in low income settings.

Academic Background

2002    MD University of British Columbia

2003    MSc, Medical Science (Paediatrics), University of Alberta

2011    PhD, Human Nutrition, Department of International Health, The John Hopkins Bloomberg School of Public Health

Research Interests

  • Global maternal-child health and nutrition.
  • Nutrition-infection relationships.
  • Vitamin D status during pregnancy and early infancy, with a particular focus on its determinants and consequences in South Asia.
  • Application of pulse oximetry to the first-level management of sick young infants in developing countries.
  • Calcium supplementation during pregnancy for the prevention of hypertensive diseases of pregnancy, preterm birth and neonatal mortality in resource-poor settings where dietary calcium intakes are low.
  • Prevention, diagnosis and treatment of neonatal sepsis and infant lower respiratory tract infections in resource-limited settings.

His current major research focus is to test the hypothesis that improvements in vitamin D status during pregnancy reduce the risk of adverse maternal-infant health outcomes in resource-poor settings. Current clinical studies are ongoing in Dhaka, Bangladesh.  

Publications

1. Dimitris M, Perumal N, Craig-Barnes H, Leadley M, Mahmud AA, Baqui A, Roth DE. Effect of weekly high-dose vitamin D3 supplementation on serum cholecalciferol concentrations in pregnant women. J Steroid Biochem Mol Biol 2016 Apr;158:76–81.

2. Roth DE, Gaffey MF, Smith-Romero E, Fitzpatrick T, Morris SK. Acute respiratory infection case definitions for young children: a systematic review of community-based epidemiologic studies in South Asia. Tropical Medicine and International Health 2015 Dec; 20(12):1607-20.

3. Perumal N, Bassani DG, Gaffey MF, Roth DE. World Health Organization child growth standards are often incorrectly applied to children born preterm in epidemiologic research. Journal of Nutrition 2015 Nov; 145(11):2429-39.

4. Emdin C, Mir F, Sultana S, Kazi M, Zaidi AKM, Dimitris MC, Roth DE. Utility and feasibility of integrating pulse oximetry into the routine assessment of young infants at first-level clinics in Karachi, Pakistan: a cross-sectional study. BMC Pediatrics 2015 Sep; 15:141.

5. Roth DE, Gernand AD, Morris SK, Pezzack B, Islam MM, Dimitris MC, Shanta SS, Zlotkin SH, Willan AR, Ahmed T, Shah PS, Murphy KE, Weksberg R, Choufani S, Shah R, Mahmud AA. Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. Trials 2015; 16:300.

6. Eckhardt C, Gernand A, Roth D, Bodnar L. Maternal vitamin D status and infant anthropometry in a U.S. multicenter cohort study. Annals of Human Biology 2015; 42(3):215-22.

7. Baqui AH, Saha SK, Ahmed ASM, Shahidullah M, Quasem I, Roth DE, Samsuzzaman AKM, Ahmed W, Bin Tabib SMS, Mitra DK, Begum N, Islam M, Ibne Moin M, Mullany LC, Cousens S, El Arifeen S, Wall S, Brandes N, Santosham M, Black RE. Safety and Efficacy of alternate Antibiotic Regimens for Outpatient Treatment of Suspected Serious Infections in Neonates and Young Infants in Bangladesh: A Randomized Controlled Trial. Lancet Global Health 2015 May;3(5):e279-87.

8. Roth DE, Pezzack B, Al Mahmud A, Abrams SA, Islam M, Aimone Phillips A, Baxter JB, Dimitris MC, Hawthorne KM, Ahmed T, Zlotkin SH. Bioavailability of enteric coated microencapsulated calcium during pregnancy: a randomized crossover trial in Bangladesh. American Journal of Clinical Nutrition 2014 Dec;100(6):1587-95.

9. Raqib R, Ly A, Akhtar E, Mily A, Perumal N, Al-Mahmud A, Agerberth B, Baqui AH, Roth DE. Prenatal vitamin D3 supplementation suppresses LL-37 peptide expression in ex vivo activated neonatal macrophages but not their killing capacity. British Journal of Nutrition 2014;112(6):908-15. doi:10.1017/S0007114514001512

10. Harrington J, Perumal N, Mahmud AA, Baqui A, Roth DE.  Vitamin D and fetal-neonatal calcium homeostasis:  findings from a randomized controlled trial of high-dose antenatal vitamin D supplementation.  Pediatric Research 2014 Sep;76(3):302-9. doi: 10.1038/pr.2014.83

11. Aimone Phillips AM, Zlotkin SH, Baxter JB, Martinuzzi F, Kadria T, Roth DE. Design and development of a combined calcium-iron-folic acid prenatal supplement to support implementation of the new World Health Organization (WHO) recommendations for calcium supplementation during pregnancy. Food and Nutrition Bulletin 2014; 35(2): 221-229.

12. Baxter J, Roth DE, Mahmud M, Islam M, Ahmed T, Aimone A, Zlotkin S. Tablets are Preferred and More Acceptable than Powdered Prenatal Calcium Supplements among Pregnant Women in Dhaka, Bangladesh. Journal of Nutrition 2014; 144(7):1106-12.

13. Bailey D, Perumal N, Yazdanpanah M, Mahmud AA, Baqui AH, Adeli K, Roth DE. Maternal-fetal-infant dynamics of the C3-epimer of 25-hydroxyvitamin D. Clinical Biochemistry 2014;47(9):816-22.