Janet Rossant , PhD, FRS, FRSC
Developmental & Stem Cell Biology
Chief of Research
University of Toronto
Departments of Molecular Genetics, Obstetrics and Gynaecology
Lombard Insurance Chair
Alternate Contact: Allison Gignac
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Dr. Janet Rossant is a Senior Scientist in the Developmental & Stem Cell Biology Program and Chief of Research at The Hospital for Sick Children, Toronto. She is also a University Professor, University of Toronto, and Professor in the Departments of Molecular Genetics, Obstetrics/Gynaecology and Paediatrics, University of Toronto. Her research interests centre on understanding the genetic control of normal and abnormal development in the early mouse embryo using both cellular and genetic manipulation techniques. Her interests in the early embryo have led to the discovery of a novel placental stem cell type, the trophoblast stem cell. She is Deputy Scientific Director of the Canadian Stem Cell Network and directs the Centre for Modelling Human Disease in Toronto, which is undertaking genome-wide mutagenesis in mice to develop new mouse models of human disease.
Dr. Rossant trained at the Universities of Oxford and Cambridge, United Kingdom and has been in Canada since 1977, first at Brock University and then at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, from 1985 to 2005. Dr. Rossant has been recognized for her contributions to science with many awards, including the Killam Prize for Health Sciences, the March of Dimes Prize in Developmental Biology, the Conklin Medal from the Society for Developmental Biology, and the CIHR Michael Smith Prize in Health Research, Canada’s most prestigious health research award. She is a Fellow of both the Royal Societies of London and Canada, and is a foreign Associate of the US National Academy of Science. She was most recently recognized in June, 2013, with the Ross G. Harrison Medal (lifetime achievement award) from the International Society of Developmental Biologists.
Dr. Rossant is actively involved in the international developmental and stem cell biology communities. Dr. Rossant has contributed to the scientific and ethical discussion on public issues related to stem cell research. She chaired the working group of the Canadian Institutes of Health Research on Stem Cell Research, which came up with guidelines for CIHR funded research in this area.
Areas of Specialty:
Dr. Rossant’s research program aims to understand the genetic underpinning of early lineage development in the mouse embryo in order to understand human embryo development and stem cell origins. Her particular interests lie in the specification of the lineages of the blastocyst, especially the trophoblast, the mechanisms of establishing the early axial patterning of the embryo and the signaling pathways involved in establishing and patterning the vasculature. Rossant also directs the Centre for Modeling Human Disease, which is a major collaborative effort to undertake genome-wide mutagenesis in the mouse.
- Stem cell research
- Molecular genetics
- Developmental biology
- Stem Cell Network
- Genome Canada
For a complete list of publications, please see PubMed
Cockburn K, Biechele S, Garner J, Rossant J. (2013) The hippo pathway member nf2 is required for inner cell mass specification. Current Biology. 23(13):1195-201.
Biechele S, Cockburn K, Lanner F, Cox BJ, Rossant J. (2013) Porcn-dependent Wnt signaling is not required prior to mouse gastrulation. Development. 140(14):2961-71.
Wong AP, Rossant J. (2013) Generation of lung epithelium from pluripotent stem cells. Current Pathobiology Reports. 1(2):137-145.
Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T. (2013) Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 152(5):1008-20.
Hirate Y, Cockburn K, Rossant J, Sasaki H. (2012) Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos. Proceedings of the National Academy of Sciences, U S A. 109(50):E3389-90.
Wong AP, Bear CE, Chin S, Pasceri P, Thompson TO, Huan LJ, Ratjen F, Ellis J, Rossant J. (2012) Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nature Biotechnology. 30(9):876-82.
Stephenson RO, Rossant J, Tam PP. (2012) Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. Cold Spring Harbor Perspectives in Biology. 4(11).
Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T. (2012) Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Developmental Cell. 22(4):887-901.
- Novel Receptor Tyrosine Kinase (U.S. Patent No. 5,681,714) with Martin L. Breitman, Daniel J. Dumont, Terry P. Yamaguchi
- Trophoblast Stem Cell Line (Patent Application No. CA99/00867) with Tilo Kunath and Satoshi Tanaka