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About Sickkids
About SickKids

Margaret Rand, PhD

The Hospital for Sick Children
Senior Associate Scientist
Haematology/Oncology

Research Institute
Senior Associate Scientist
Translational Medicine

University of Toronto
Professor
Dept. of Laboratory Medicine & Pathobiology


Phone: 416-813-7764
Fax: 416-813-8243
Email: margaret.rand@sickkids.ca

Research Interests

  • Platelets, Bleeding Disorders and Thrombosis

Research Activities

Platelets play important roles in the formation of hemostatic plugs, which stop bleeding from injured blood vessels, and arterial thrombi, which are responsible for the clinical complications of atherosclerosis. My colleagues and I are interested in the biochemical mechanisms involved in platelet function and dysfunction. In one area of research, we are investigating hereditary and acquired disorders of platelet function and dysfunction. Another line of research involves studies of the reduced functions of stored platelets that are transfused into patients with low numbers of circulating platelets. Finally, we are examining effectors of platelet function in vivo, including those that may be involved in the clearance of platelets from the circulation.

Future Research Interests

We will be investigating polymorphisms in platelet membrane glycoproteins that can lead to an increased risk of bleeding complications, or of arterial thrombosis.

Publications

Rand ML, Wang H, Bang KWA, Packham MA, Freedman J: Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost 4:1621-1623, 2006.

Rand ML, Kuhle S: Platelets and platelet function testing in children. Prog Pediatr Cardiol 21:63-69, 2005.

Hedlund-Treutiger I, Revel-Vilk S, Blanchette VS, Curtin JA, Lillicrap D, Rand ML: Reliability and reproducibility of classification of children as "bleeders" versus "non-bleeders" using a questionnaire for significant mucocutaneous bleeding. J Pediatr Hematol Oncol 26:488-491, 2004.

Nurden AT, Breillat C, Jacquelin B, Combrie R, Freedman J, Blanchette VS, Schmugge M, Rand ML: Triple heterozygosity in the integrin IIb subunit in a patient with Glanzmann thrombasthenia. J Thromb Haemost 2:813-819, 2004.

Rand ML, Wang H, Bang KWA, Poon KSV, Packham MA, Freedman J: Procoagulant surface exposure and apoptosis in rabbit platelets with shortened survival or in senescent rabbit platelets. J Thromb Haemost 2:651-659, 2004.

Schmugge M, Dunn MS, Amankwah KS, Blanchette VS, Freedman J, Rand ML: The activity of the von Willebrand factor cleaving protease ADAMTS-13 in newborn infants. J Thromb Haemost 2:228-233, 2004.

Reynaud D, Clark D, Qiao N, Rand ML, Pace-Asciak CR: The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100. Thromb Res 112:245-248, 2003.

Schmugge M, Rand ML, Bang A, Mody M, Dunn MS, Amankwah KS, Blanchette VS, Freedman J: The relationship of von Willebrand factor binding to activated platelets from healthy neonates and adults. Pediatr Res 54:474-9, 2003.

Rand ML, Jakubowski JA, Fisher MJ, Chahil A, Kinlough-Rathbone RL, Packham MA: Inhibitory effects of the combination of a GPIIb/IIIa antagonist and ethanol on responses of human platelets to ADP, collagen, U46619 and SFLLRN. J Lab Clin Med 140:391-397, 2002.

Carcao MD, Blanchette VS, Stephens D, He L, Wakefield CD, Butchart S, Christie DJ, Rand ML: Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA-100 ). Br J Haematol 117:961-964, 2002.