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About Sickkids
About SickKids

Norman Rosenblum, MD

The Hospital for Sick Children
Staff Nephrologist
Nephrology

Research Institute
Senior Scientist
Developmental & Stem Cell Biology

University of Toronto
Professor, Associate Dean, Physician Scientist Training
Depts. of Paediatrics, Physiology, Laboratory Medicine & Pathobiology

Chair Positions
Canada Research Chair
Developmental Nephrology


Phone: 416-813-7654 ext. 305667
Fax: 416-813-5252
Email: norman.rosenblum@sickkids.ca

For more information, visit:

Rosenblum Lab

Brief Biography

Dr. Norman Rosenblum is a paediatric nephrologist and senior scientist at The Hospital for Sick Children (Sickkids) and the Sickkids Research Institute.  

Dr. Rosenblum is an MD graduate of Dalhousie University. He completed his paediatric residency and fellowship in paediatric nephrology at the Children’s Hospital, Boston followed by a post-doctoral fellowship in the laboratory of Dr. Bjorn Olsen in the Department of Anatomy and Cell Biology, Harvard Medical School.  He has received  support for his research via grants from the Kidney Foundation of Canada and the Canadian Institutes of Health Research.  He is also the recipient of a Canada Research Chair, Tier 1 in Developmental Nephrology.  

Dr. Rosenblum is a professor of physiology, laboratory medicine and pathobiology in the Department of Paediatrics at the University of Toronto and is currently the scientific director of the CIHR Institute of Nutrition, Metabolism and Diabetes.

Research Interests

  • Kidney development
  • Branching morphogenesis and nephrogenesis
  • Lineage tracing and cell fate
  • Ex vivo and in vivo disease modeling
  • Congenital kidney-urinary tract malformation
  • Growth factor signaling

Research Activities

The major research focus in Dr. Rosenblum’s lab is the investigation into the molecular and cellular mechanisms that control renal development in humans and animal models. His laboratory is investigating the functions of signaling pathways controlled by sonic hedgehog, integrin-linked kinase and transforming growth factor β proteins during normal kidney formation and in renal malformation. 

Work resulting from these endeavours has demonstrated distinct functions for these effectors in controlling renal branching morphogenesis and nephron formation. Work in the Rosenblum lab has also investigated the cellular and molecular mechanisms that control urinary pacemaker cell function. Further, Dr. Rosenblum’s work focuses on the use of kidney organoids to model renal diseases. Dr. Rosenblum leads a North American six-centre study aimed at identifying genetic defects in human renal malformation.

Achievements

  • Kidney Foundation of Canada Medal for Research Excellence - 2011
  • Maureen Andrew Mentor Award, Society for Paediatric Research - 2010
  • Paediatric Academic Leadership-Clinical Investigator Award, Paediatric Chairs of Canada - 2009
  • New Member Outstanding Science Award, American Paediatric Society - 2006
  • Member, Editorial Board, Journal of the American Society of Nephrology - 2005 - present
  • Aventis Pasteur Research Award, Canadian Paediatric Society - 2004

Publications

For a complete list of publications, please see PubMed

Rowan CJ, Li L, Martirosyan H, Erwood  S, Hu D, Kim Y-K, Mulder J, Blake J,Chen L, Rosenblum ND. (2018) Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes nephrogenesis via TGFβsignaling. Development. 145(13).

Levin A, Adams E, Barrett BJ, Beanlands H, Burns KD, Chiu HH, Chong K, Dart A, Ferera J, Fernandez N, Fowler E, Garg AX, Gilbert R, Harris H, Harvey R, Hemmelgarn B, James M, Johnson J, Kappel J, Komenda P, McCormick M, McIntyre C, Mahmud F, Pei Y, Pollock G, Reich H, Rosenblum ND, Scholey J, Sochett E, Tang M, Tangri N, Tonelli M, Turner C, Walsh M, Woods C, Manns B. (2018) Canadians seeking solutions and innovations to overcome chronic kidney cisease (Can-SOLVE CKD): form and function. Canadian Journal of Kidney Health and Disease. 5:2054358117749530. doi: 10.1177/2054358117749530.

Iskander S, Feeney M, Yee K, Rosenblum ND. (2018) Protein kinase 2ß is expressed in neural crest-derived urinary pacemaker cells and controls pyeloureteric contraction. Journal of the American Society of Nephrology: JASN.  29(4):1198-1209.

Skinnider MA, Twa DDW, Squair JW, Rosenblum ND, Lukac CD on behalf of the Canadian MD/PhD Program Investigation Group. (2018) Predictors of sustained research Involvement among Canadian MD/PhD program graduates.  Medical Education. 52(5):536-545.

Sheybani-Deloui S, Chi L, Staite MV, Cain JE, Nieman BJ, Henkelman RM, Wainwright BJ, Potter SS, Bagli DJ, LorenzoAJ,  Rosenblum ND. (2018) Activated hedgehog GLI signaling causes congenital ureteropelvic junction obstruction.  Journal of the American Society of Nephrology. 29(2):532-544.

Strong MJ, Busing N, Goosney D, Harris KA, Horsley T, Kuzyk A, Lingard L, Norman WV, Rosenblum ND, Saryeddine T, Wang X. (2018) Training the physician scientist: recommendations of the Canadian Consensus Conference.  Academic Medicine: Journal of the Association of American Medical Colleges. 93(2):172-178.

Kim J, Jiwani T, Erwood S, Loree J, Rosenblum ND. (2018) Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15. Developmental Dynamics. 247(1):156-169.

Rowan CJ, Sheybani-Deloui S, Rosenblum ND.  (2017)  Origin and function of the renal stroma in health and disease. Results and Problems in Cell Differentiation. 60:205-229.

Skinnider MA, Squair JW, Twa DDW, Ji JX, Kuzyk A, Eisenberg MJ, Gagné E-R, HayGlass KT, Lewis JF, Margetts PJ, Underhill AD, Rosenblum ND, Raymond LA. (2017) Characteristics and outcomes of Canadian MD/PhD program graduates: a cross-sectional survey. CMAJ Open. 25;5(2):E308-E314.

Petrelli A, Prakken BJ, Rosenblum ND. (2016) Developing translational medicine professionals: the Marie Curie Actions model. Journal of Translational Medicine. 14:329-333.

Rosenblum ND. (2016) The path ahead for MD/PhD programs in Canada: commentary on Jones et al.. Clinical and Investigative Medicine. 39(4):E140-1.

Goldenberg N, Steinberg B, Rutka J, Chen R, Cabral V, Rosenblum ND, Kapus A, Lee W.  (2016) Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study. CMAJ Open.  4(3):E444-E447.

Ting K, Aitken KJ, Penna F, Samiei AN, Sidler M, Jiang J-X, Ibrahim F, Tolg C, Delgado-Olguin P, Rosenblum ND, Bagli DJ.  (2016) Uropathogenic E.coli (UPEC) infection induces proliferation through enhancer of zeste homologue 2 (EZH2). PLoS ONE.  11(3):e0149118.

Rosenblum ND, Kluijtmans M, ten Cate O. (2016) Professional identity formation and the clinician scientist: a paradigm for a clinical career combining two distinct disciplines. Academic Medicine.  91(12):1612-1617.

Blake J, Hu D, *# Rosenblum ND.  (2016)  Urogenital development in Pallister-Hall syndrome is disrupted in a cell lineage-specific manner by constitutive expression of GLI3 repressor. Human Molecular Genetics, 25(3):437-47.

Smeeton J, Dhir P, Hu D, Feeney MM, Chen L, Rosenblum ND. (2016)  Integrin-linked-kinase controls renal branching morphogenesis via dual specificity phosphatase 8. Journal of the American Society of Nephrology.  27(5):1465-77.

Dos SantosJ, Parekh RS, Hassouna T, Figueroa V, Zhang Y, Salei A,  Gonima P,  Vargas I, Piscione TD, Farhat W, Rosenblum ND.  (2015) A new grading system for the management of antenatal hydronephrosis in children. Clinical Journal of the American Society of Nephrology. (10):1783-90.

Sectish TC, Hay WW, Mahan JD, Mendoza FS, Spector ND, Stanton B, Szilagyi PG, Turner TL, Walker LR, and Slaw K on behalf of the Federation of Pediatric Organizations' Visioning Summit Working Groups and Planning Committee.  (2015) Blueprint for action: visioning summit on the future of the workforce in pediatrics. Pediatrics. 136(1):161-9.

Sarin S, Javidan A, Alexopoulou I, Svajger B, Boivin F, Chu S, Baradaran-Heravi A, Boerkoel CF, Rosenblum ND, Bridgewater D.  (2015)  Insights into the renal pathogenesis in Schimke-immuno-osseous dysplasia: a renal histological characterization and expression analysis. The Journal of Histochemistry and Cytochemistry.  63(1):32-44.

Ballios BG, Rosenblum ND.  (2014) Challenges facing physician scientist trainees: a survey of trainees in Canada’s largest undergraduate and postgraduate programs in a single centre. Clinical and Investigative Medicine.  37(5):E268-83.

Blake J, Rosenblum ND. ( 2014) Renal branching morphogenesis: morphogenetic and molecular mechanisms. Seminars in Cell and Developmental Biology. 36:2-12.

Levin A, Clase CM, Sood MM, Dicks E, Fortin MC, Hartwig S, Holden R, Lafrance JP, Molzahn A, Rosenblum ND, Samuel S, Soroka S.  (2014) Canadian Journal of Kidney Health and Disease: a unique launch of a unique journal. Canadian Journal of Kidney Health and Disease. 1:1. doi: 10.1186/2054-3581-1-1.

Cornfield DN, Lane R, Rosenblum ND, Hostetter M, Jobe A, Albertine K, Aschner J, Abman SH. (2014) Patching the pipeline: creation and retention of the next generation of physician - scientists for child health research. Journal of Pediatrics.  165(5):882-4.

Li W, Hartwig S, Rosenblum ND.  (2014)  Developmental origins and functions of stromal cells in the normal and diseased mammalian kidney. Developmental Dynamic. 243(7):853-63.

Sarin S, Li A, Boivin F, Lim J, Svajger B, Rosenblum ND, Bridgewater D. (2014) ?-Catenin overexpression in the metanephric mesenchyme leads to renal dysplasia genesis via cell-autonomous and non-cell-autonomous mechanisms.  American Journal of Pathology. 84(5):1395-410.