About Sickkids
About SickKids

Lisa Strug, PhD

Research Institute
Senior Scientist
Genetics & Genome Biology

Associate Director
The Centre for Applied Genomics

University of Toronto
Assistant Professor
Dalla Lana School of Public Health

Phone: 416-813-7654 ext. 301762
e-mail: lisa.strug@utoronto.ca

For more information, visit:


Research Interests

Statistical genetics; genetic epidemiology

Research Activities

I work on both applied and theoretical problems in the study of complex disease genetics. Examples include:

  • studying the genetics of rolandic epilepsy
  • genetic modifiers in cystic fibrosis
  • applications of evidential statistics in genetics
  • development of evidential methodology for analysis of genetic data


Non Peer-reviewed Publications

Invited Commentary
Pal, DK and Strug, LJ. The genetics of common epilepsies:  common or distinct? Lancet Neurol.  Epub.  PMID: 25087077.  2014.  

Peer-reviewed Publications

  1. Derkach A, Chiang T, Gong J, Addis L, Dobbins S, Tomlinson I, Houlston R, Pal DK, Strug LJ.  2014.  Association analysis using next generation sequence data from publicly available control groups:  The robust variance score statistics. Bioinformatics, 30: 2179-88, 2014.  
  2. Soave D, Miller M, Keenan K, Li W, Gong J, Ip W, Accurso F, Sun L, Rommens J, Sontag M, Durie P, Strug LJ.  Prenatal exocrine pancreatic disease causes cystic fibrosis-related diabetes:  A mendelian randomization study. Diabetes, 63(6): 2114-9. 2014.  
  3. Addis,L, Chiang, T, Clarke, T, Hardison, H, Kugler, S, Mandelbaum, D, Novotny, E, Wolf, S, Strug, LJ, Pal, DK.  Evidence for linkage of migraine in Rolandic Epilepsy families to known, 1q23.1-2 (FMH2), and novel, 17q22, loci.  Genes, Brain and Behaviour, 13: 333-40. 2014.
  4. Li, W, Soave, D, Miller, MR, Keenan, K, Lin, F, Gong, J, Chiang, T, Stephenson, A, Durie, P, Rommens, J, Sun, L, Strug, LJ.  Unraveling the Complex Genetic Model for Cystic Fibrosis:  Pleiotropic Effects of Gene Modifiers on Early CF-Related Morbidities. Human Genetics.  133: 151-61. 2014.  
  5. Lesca, G, Rudolf, G, Bruneau, N, Lozovaya, N, Labalme, A, Boutry-Kryza, N, Salmi, M, Tsintsadze, T, Addis, L, Motte, J, Wright, S, Tsintsadze, V, Michel, A, Doummar, D, Lascelles, K, Strug, L, de Bellescize, J, Vrielynck, P, Ville, D, Ryvlin, P, Arzimanoglou, A, Hirsch, E, Vincent, A, Pal, D, Burnashev, N, Sanlaville, D, Szepetowski, P.  GRIN2A mutations cause acquired epileptic aphasia (Landau-Kleffner syndrome) and related childhood focal epilepsies and encephalopathies with speech and language dysfunction. Nature Genetics.  28: 161-6. 2013.  
  6. Blackman, SM, Commander, CW, Watson, C, Arcara, K, Strug, LJ, Stonebraker, JR, Wright, FA, Rommens, JM, Sun, L, Pace, RG, Norris, SA, Durie, PR, Drumm, ML, Knowles, MR, Cutting, GR.  Genetic modifiers of cystic fibrosis-related diabetes. Diabetes 62: 3627-35. 2013.
  7. Crosbie, J, Arnold, P, Paterson, A, Swanson, J, Dupuis, A, Li, X, Shan, J, Goodale, T, Tam, C, Strug, LJ, Schachar, RJ. Response inhibition and ADHD traits:  Correlates and heritability in a community sample. Journal of Abnormal Child Psychology.  3: 497-507. 2013.
  8. Strug, LJ, Addis, L, Chiang, T, Baskurt, Z, Li, W, Clarke, T, Greenberg, DA, Hardison, HH, Kugler, SL, Mandelbaum, DE, Novotny, EJ, Wold, SM, Pal, DK.  The Genetics of Reading Disability in an Often Excluded Sample:  Novel Loci for Reading Disability in Rolandic Epilepsy Map to 1q42 and 7q21.  PLoS One 7:e40696. 2012.
  9. Sun, L, Rommens, JM, Corvol, H, Li, W, Li, X, Chiang, T, Lin, F, Dorfman, R, Busson, P, Parekh, R, Zelenika, D, Blackman, S, Corey, M, Doshi, V, Henderson, L, Naughton, K, O’Neal, WK, Pace, RG, Stonebraker, JR, Wood, SD, Wright, FA,Zielenski, J, Clement, A, Drumm, ML, Boelle, PY, Cutting, GR, Knowles, MR, Durie, PR, Strug, LJ.  Multiple apical plasma membrane constituents are associated with Meconium Ileus in Cystic Fibrosis.  Nature Genetics. 44: 562-9. 2012.
  10. Hodge, SE, Baskurt, Z, and Strug, LJ.  Using parametric multipoint lods and mods for linkage analysis requires a shift in statistical thinking.  Human Heredity. 72: 264-75. 2011.
  11. Taylor, C, Commander, CW, Collaco, JM, Strug, LJ, Li, W, Wright, FA, Webel, AD, Pace, RG, Stonebraker, JR, Naughton, K., Dorfman, R, Sanford, A, Blackman, SM, Berthiaume, Y, Paré, PD, Drumm, ML, Zielenski, J, Durie, P, Cutting, GR, Knowles, MR, Corey M. A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis genetic modifier studies. Pediatric Pulmonology. 46, 857-69. 2011.
  12. Wright, F, Strug, LJ, Doshi, V, Commander, C, Blackman, S, Sun, L, Berthiaume, Y, Cutler, D,  Li, W, Collaco, M, Corey, M, Dorfman, R, Goddard, K, Green, D, Kent, J, Lange, E, Lee, S, Cojocaru, A, Luo, J, Mayhew, G, Naughton, K, Pace, R, Pare, P, Rommens, J, Sandford, A, Stonebraker, J, Sun, W, Taylor, C, Vanscoy, L, Zou, F, Blangero, J, Zielenski, J , O’Neal, W, Drumm, M, Durie, P, Knowles, MR. and Cutting, G. Genome-wide association and linkage indetify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. Nature Genetics. 43: 539-546. 2011.  
  13. Li, W, Sun, L, Corey, M, Zou, F, Lee, S, Cojocaru, A, Taylor, C, Blackman, S, Stephenson, A, Sanford, A, Zielenski, J, Drumm, ML, Cutting, G, Knowles, MR, Durie, P, Wright, FA, Strug, LJ. Understanding the population structure of the North American Cystic Fibrosis Population.  Clinical Genetics. 79: 136-46. 2011.
  14. Pal, DK, Li, W, Clarke, T, Lieberman,,P, Strug, LJ. Pleiotropic Effects of the 11p13 locus on developmental verbal dyspraxia and EEG centrotemporal sharp waves. Genes, Brain and Behavior. 9: 1004-12. 2010.
  15. Hodge, SE, Strug, LJ.  What is the “Multiple Testing Problem” and what can we do about it?  Biomedical statistics and clinical epidemiology.  3(2): 71-75.  2010.  
  16. Strug, LJ, Hodge, SE, Chiang, T, Pal, DK, Corey, P, Rohde, C. A pure likelihood approach to the analysis of genetic association data:  an alternative to Bayesian and Frequentist analysis. European Journal of Human Genetics.  18:  933-41. 2010.  
  17. Strug, LJ, Suresh, R, Fyer, A, Talati, A, Adams, PB, Li, W, Hodge, SE, Gilliam, C, Weissman, MM. Panic Disorder is associated with the Serotonin Transporter Gene (SLC6A4) but not the promoter region (5-HTTLPR). Molecular Psychiatry. 15(2): 166-76. 2010.  
  18. Dorfman, R, Li, W, Sun, L, Lin, F, Wang, Y, Sandford, A, Pare, PD, McKay, K, Kayserova, H, Piskackova, T, Macek, M, Czerska, K, Sands, D, Tiddens, H, Margarit, S, Gabriela, R, Sontag, MK, Accurso, FJ, Blackman, S, Cutting, GR, Tsui, L, Corey, M, Durie, P, Zielenski, J, Strug, LJ. Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results.  Human Genetics. 1(26):763-778. 2009.
  19. Clarke, T, Baskurt, Z, Strug, LJ. and Pal, DK.  Evidence of shared genetic risk factors for migraine and Rolandic epilepsy. Epilepsia. 50(11):2428-33. 2009.
  20. Strug, LJ, Clarke, T, Chiang, T, Chien, M, Baskurt, Z, Li, W, Dorfman, R, Bali, B, Wirrell, E, Kugler, SL, Mandelbaum, DE, Wolf, SM, McGoldrick, P, Hardison, H, Novotny, EJ, Ju, J, Greenberg, DA, Russo, JJ, Pal, DK.  Centrotemporal sharp wave EEG trait in Rolandic epilepsy maps to Elongator Protein Complex 4. European Journal of Human Genetics. 17(9):1171-81. 2009.
  21. Hodge, SE, Rodriguez-Murillo, L, Strug, LJ, Greenberg, DA. Multipoint Lods Provide Reliable Linkage Evidence Despite Unknown Limiting Distribution: Type I Error Probabilities Decrease With Sample Size for Multipoint Lods and Mods. Genetic Epidemiology, 32: 800-815. 2008.
  22. Kavros, PM, Clarke, T, Strug, LJ, Halperin, JM, Dorta, NJ, Pal, DK. Attention impairment in rolandic epilepsy: Systematic review. Epilepsia, 49: 1570-80. 2008.  
  23. Kulger, SL, Bali, B, Lieberman, P, Strug, LJ, Gagnon, B, Murphy, PL, Clarke, T, Greenberg, DA, Pal, DK. An autosomal dominant genetically heterogeneous variant of rolandic epilepsy and speech disorder. Epilepsia 49: 1086-90. 2008.
  24. Pal, DK, Strug, LJ, and Greenberg, DA. Evaluating candidate genes in common epilepsies and the nature of evidence. Epilepsia, 49: 386-92. 2008.  
  25. Talati, A, Ponniah, K, Strug, LJ, Hodge, SE, Fyer, AJ, Weissman, MM.  Panic Disorder, Social Anxiety Disorder, and a possible medical syndrome previously linked to chromosome 13.  Biological Psychiatry, 63: 594-601. 2008.
  26. Clarke, T, Strug, LJ,  Murphy, PL, Bali, B, Carvalho, J, Foster, S, Tremont, G, Gagnon, BR, Dorta, N, Pal, DK. High Risk of Reading Disability and Speech Sound Disorder in Rolandic Epilepsy Families:  Case-Control Study.  Epilepsia, 48: 2258-65. 2007.  
  27. Bali, B, Kull, LL, Strug, LJ, Clarke, T, Murphy, P, Greenberg, DA, Pal, DK. Autosomal Dominant Inheritance of Centrotemporal Sharp Waves In Rolandic Epilepsy Families.  Epilepsia, 48: 2266-72. 2007.  
  28. Strug, LJ, Rohde, CA, Corey, PN. An introduction to evidential sample size calculations.  American Statistician, 61: 207-212. 2007.  
  29. Strug, LJ, Hodge, SE.  An alternative foundation for the planning and evaluation of linkage analysis.  II. Implications for multiple test adjustments.  Human Heredity, 61: 200-209. 2006.
  30. Strug, LJ, Hodge, SE. An alternative foundation for the planning and evaluation of linkage analysis.  I. Decoupling “Error Probabilities” from “Measures of Evidence”.  Human Heredity, 61: 166-188. 2006.
  31. Hodge, SE, Ban, Y, Strug, LJ, Greenberg, DA, Davies, TF, Concepcion, ES, Villanueva, R, Tomer, Y. Possible interaction between HLA-DRB1 and Thyroglobulin variants in Graves’ Disease.  Thyroid, 16: 351-355. 2006.
  32. Greenberg, DA, Zhang, J, Shmulewitz, D, Strug, LJ, Zimmerman, R, Singh, V, Marathe, S.  Construction of the model for the GAW 14 simulated data:  Genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium and ascertainment effects for a complex phenotype.  14th International Genetic Analysis Workshop (GAW) 2005.  BMC Genet, 6 Suppl 1:S3. 2005.  
  33. Schneiderman-Walker, J, Wilkes, DL, Strug, LJ, Lands, LC, Pollock, SL, Selvadurai, HC, Hay, J, Coates, AL, Corey, M.  Gender differences in habitual physical activity and lung function decline in children with Cystic Fibrosis.  The Journal of Pediatrics, 147: 321-326. 2005.  
  34. Greenberg, DA, Tzilianos, E, Strug, LJ, Marathe, S, Durner, M, Pal, DK, Alvin, G, Klotz, I, Dicker, E, Shinnar, S, Bromfield, EB, Resor, S, Cohen, J, Moshe, SL, Harden, C, Kang, H.  Malic Enzyme 2 (ME2) may underlie susceptibility to adolescent-onset Idiopathic Generalized Epilepsy.  American Journal of Human Genetics, 76: 139-146. 2005.  
  35. Clark, LN, Nicolai, A, Afridi, S, Harris, J, Mejia-Santana, H, Strug, LJ, Cote, LJ, Louis, ED, Andrews, H, Waters, C, Ford, B, Frucht, S, Fahn, S, Mayeux, R, Ottman, R, Marder, K. A pilot study of the β-Glucocerebrosidase `N370S’ allele and Parkinson’s Disease in subjects of Jewish ethnicity.  Movement Disorders, 20, 100-103. 2005.
  36. Katz, SL, Strug, LJ, Corey, M.  Disease severity in siblings with cystic fibrosis.  Pediatric Pulmonology, 37, 407-412. 2004.
  37. Strug, LJ, Sun, L, Corey, M.  The genetics of cross-sectional and longitudinal body mass index.  BMC Genetics, 4(Suppl 1): S14. 2003.
  38. Curriero, FC, Heiner, KS, Samet, JM, Zeger, SC, Strug, LJ, Patz, JA.  Temperature and mortality in 11 cities of the eastern United States.  American Journal of Epidemiology, 155, 80-87. 2002.