About Sickkids
About SickKids
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Philip Sherman , MD, FRCP(C), FAAP

The Hospital for Sick Children
Staff Gastroenterologist
Gastroenterology, Hepatology and Nutrition

Research Institute
Senior Scientist
Cell Biology

University of Toronto
Professor of Paediatrics, Microbiology and Dentistry
Dept. of Paediatrics

Chair Positions
Canada Research Chair
Gastrointestinal Disease

Other Positions
CIHR, Scientific Director
Institute of Nutrition, Metabolism and Diabetes (CIHR-INMD)


Phone: 416-813-7733
Fax: 416-813-4972
e-mail: philip.sherman@sickkids.ca

For more information, visit:

Sherman Lab
Interview with Dr. Sherman - July 2011

Brief Biography

Dr. Sherman is Professor of Paediatrics, Microbiology and Dentistry at The Hospital for Sick Children, University of Toronto where he has been a faculty member since 1984. Dr. Sherman is the recipient of a Tier 1 Canada Research Chair in Gastrointestinal Diseases (2001-2017). His research program is funded by support provided by the Canadian Institutes of Health Research (1985 – present) and the Crohn’s and Colitis Foundation of Canada (1986-1991, 1997-2000, 2001-2004, 2007-2010, 2011-2014).

Research Interests

Research interests focus on gastrointestinal epithelial cell responses to bacterial pathogens and their products.

  • Shigatoxin - producing Escherichia coli
  • Paediatric inflammatory bowel disease
  • Prebiotics and probiotics
  • Signal transduction

External Funding

  • Canadian Institutes of Health Research
  • Crohn’s and Colitis Foundation of Canada
  • Institute Rosell-Lallemand Inc.

Canadian Institutes of Health Research (CIHR) Team Grant, 2007-2012.
"Immune regulation and biomarker development in pediatric and adult onset human autoimmune diseases" Amit Bar-Or, Principal Investigator.

Canadian Institutes of Health Research (CIHR), 2008-2013
Epithelial cell signalling responses to attaching - effacing pathogens

Achievements

  1. Schwachman Lifeme Achievement Award, NASPGHAN, 2010
  2. Associate Director, Institute of Medical Science, 2007 - 2008
  3. Co-director CIHR training grant, Cell signalling in mucosal inflammation and pain, 2006 - 2008
  4. Institute of Medical Science, Mel Silverman Mentorship Award, 2007
  5. AHFMR Visiting Scientist to Alberta Award, 2003

Publications

Shen-Tu G, Kim H, Liu M, Johnson-Henry K, Sherman PM.  Protein kinase C mediates enterohemorrhagic Escherichia coli O157:H7-induced attaching and effacing lesions.  Infect Immun. 2014 Feb 3. [Epub ahead of print]

.Vong L, Lorentz RJ, Assa A, Glogauer M, Sherman PM.  Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps. J Immunol. 2014 Feb 15;192(4):1870-7. doi: 10.4049/jimmunol.1302286. Epub 2014 Jan 24.

Abrahamsson TR, Sherman PM. Multifaceted effects of human milk oligosaccharides.  J Infect Dis. 2014 Feb 1;209(3):323-4.

Ho NK, Henry AC, Johnson-Henry K, Sherman PM. Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection. Can J Gastroenterol. 2013;27(5):281-5. Review.

Ossa JC, Ho NK, Wine E, Leung N, Gray-Owen SD, Sherman PM.  Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells.   Cell Microbiol. 2013 Mar;15(3):446-57.

Ho NK, Ossa JC, Silphaduang U, Johnson R, Johnson-Henry KC, Sherman PM. Enterohemorrhagic Escherichia coli O157:H7 shiga toxins inhibit gamma interferon-mediated cellular activation.  Infect Immun. 2012 Jul;80(7):2307-15. doi: 10.1128/IAI.00255-12.

Rodrigues DM, Sousa AJ, Johnson-Henry KC, Sherman PM, Gareau MG. Probiotics are effective for the prevention and treatment of Citrobacter rodentium-induced colitis in mice. J Infect Dis. 2012 Jul 1;206(1):99-109. doi: 10.1093/infdis/jis177.

Gareau MG, Ho NK, Brenner D, Sousa AJ, Lebourhis L, Mak TW, Girardin SE, Philpott DJ, Sherman PM. Enterohaemorrhagic, but not enteropathogenic, Escherichia coli infection of epithelial cells disrupts signalling responses to tumour necrosis factor-alpha.  Microbiology. 2011 Oct;157(Pt 10):2963-73. doi: 10.1099/mic.0.051094-0. Epub 2011 Jul 28. PMID:  21798984

Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, Macqueen G, Sherman PM.  Bacterial infection causes stress-induced memory dysfunction in mice.  Gut. 2011 Mar;60(3):307-17.

Gareau MG, Sherman PM, Walker WA. Probiotics and the gut microbiota in intestinal health and disease.  Nat Rev Gastroenterol Hepatol. 2010 Sep;7(9):503-14. doi: 10.1038/nrgastro.2010.117. Review.

Donato KA, Gareau MG, Wang YJ, Sherman PM.  Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling.  Microbiology. 2010 Nov;156(Pt 11):3288-97.

Shen-Tu G, Schauer DB, Jones NL, Sherman PM.  Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching-effacing bacteria.   Lab Invest. 2010 Feb;90(2):266-81.

Gareau MG, Wine E, Reardon C, Sherman PM. Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice. J Infect Dis. 2010 Jan 1;201(1):81-91. doi: 10.1086/648614. PMID: 19961304

A detailed list of  Dr. Sherman's publications can be found on PubMed.