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Sherman Lab
Interview with Dr. Sherman - July 2011

Brief Biography

Dr. Sherman is Professor of Paediatrics, Microbiology and Dentistry at The Hospital for Sick Children, University of Toronto where he has been a faculty member since 1984. Dr. Sherman is the recipient of a Tier 1 Canada Research Chair in Gastrointestinal Diseases (2001-2015). His research program is funded by support provided by the Canadian Institutes of Health Research (1985 – present) and the Crohn’s and Colitis Foundation of Canada (1986-1991, 1997-2000, 2001-2004, 2007-2010, 2011-2014).

Research Interests

Research interests focus on gastrointestinal epithelial cell responses to bacterial pathogens and their products.

• Shigatoxin - producing Escherichia coli
• Paediatric inflammatory bowel disease
• Prebiotics and probiotics
• Signal transduction

External Funding

• Canadian Institutes of Health Research
• Crohn’s and Colitis Foundation of Canada
• Institute Rosell-Lallemand Inc.

Canadian Institutes of Health Research (CIHR) Team Grant, 2007-2012.
"Immune regulation and biomarker development in pediatric and adult onset human autoimmune diseases" Amit Bar-Or, Principal Investigator.

Canadian Institutes of Health Research (CIHR), 2008-2013
Epithelial cell signalling responses to attaching - effacing pathogens

Achievements

1. Schwachman Lifeme Achievement Award, NASPGHAN, 2010
2. Associate Director, Institute of Medical Science, 2007 - 2008
3. Co-director CIHR training grant, Cell signalling in mucosal inflammation and pain, 2006 - 2008
4. Institute of Medical Science, Mel Silverman Mentorship Award, 2007
5. AHFMR Visiting Scientist to Alberta Award, 2003

Publications

Ho NK, Crandall I, Sherman PM.  Identifying mechanisms by which Escherichia coli O157:H7 subverts Interferon-γ mediated signal transducer and activator of transcription-1 activation. PLoS ONE. 2012;7(1): e30145. doi:10.1371/journal.pone.0030145

Gareau MG, Ho NK, Brenner D, Sousa AJ, Lebourhis L, Mak TW, Girardin SE, Philpott DJ, Sherman PM.  Enterohaemorrhagic, but not enteropathogenic, Escherichia coli infection of epithelial cells disrupts signalling responses to tumour necrosis factor-alpha.  Microbiology. 2011;157(Pt 10):2963-73

Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, Macqueen G, Sherman PM.  Bacterial infection causes stress-induced memory dysfunction in mice.  Gut. 2011 Mar;60(3):307-17.

Gareau MG, Sherman PM, Walker WA.  Probiotics and the gut microbiota in intestinal health and disease.  Nat Rev Gastroenterol Hepatol. 2010 Sep;7(9):503-14. Review.

Donato KA, Gareau MG, Wang YJ, Sherman PM.  Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling.  Microbiology. 2010 Nov;156(Pt 11):3288-97.

Wine E, Shen-Tu G, Gareau MG, Goldberg HA, Licht C, Ngan BY, Sorensen ES, Greenaway J, Sodek J, Zohar R, Sherman PM.  Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions.  Am J Pathol. 2010 Sep;177(3):1320-32.

Wine E, Ossa JC, Gray-Owen SD, Sherman PM.  Adherent-invasive Escherichia coli target the epithelial barrier.  Gut Microbes. 2010 Mar;1(2):80-84.

Lin FY, Gao Y, Li D, Sherman PM.  Development of microfluidic-based heterogeneous immunoassays.  Front Biosci (Schol Ed). 2010 Jan 1;2:73-84. Review.

Shen-Tu G, Schauer DB, Jones NL, Sherman PM.  Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching-effacing bacteria.  Lab Invest. 2010 Feb;90(2):266-81.

Gareau MG, Wine E, Reardon C, Sherman PM.  Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice.  J Infect Dis. 2010 Jan 1;201(1):81-91.

A detailed list of  Dr. Sherman's publications can be found on PubMed.