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About Sickkids
About SickKids

Philip Sherman, MD, FRCP(C), FAAP

The Hospital for Sick Children
Staff Gastroenterologist
Gastroenterology, Hepatology and Nutrition

Research Institute
Senior Scientist
Cell Biology

University of Toronto
Professor of Paediatrics, Microbiology, Nutritional Sciences and Dentistry
Dept. of Paediatrics

Chair Positions
Canada Research Chair
Gastrointestinal Disease

Other Positions
CIHR, Scientific Director
Institute of Nutrition, Metabolism and Diabetes (CIHR-INMD)


Phone: 416-813-7733
Fax: 416-813-4972
Email: philip.sherman@sickkids.ca
Alternate Contact: Ivette Milanes Abreus
Alternate Email: ivette.milanesabreus@sickkids.ca

For more information, visit:

Sherman Lab
Interview with Dr. Sherman - July 2011

Brief Biography

Dr. Sherman is a Staff Gastroenterologist, Gastroenterology, Hepatology and Nutrition at SickKids as well as a Senior Scientist, Cell Biology at the SickKids Research Institute. Dr. Sherman is also a Professor of Paediatrics, Microbiology (Laboratory Medicine & Pathobiology), Nutritional Sciences and Dentistry at the University of Toronto, where he has been a faculty member since 1984. Dr. Sherman is the recipient of a Tier 1 Canada Research Chair in Gastrointestinal Diseases (2001-2022). His research program is funded by support provided by the Canadian Institutes of Health Research (1985-present).

Research Interests

Dr. Sherman's research interests focus on gastrointestinal epithelial cell responses to bacterial pathogens and their products.

  • Paediatric inflammatory bowel disease
  • Prebiotics and probiotics
  • Signal transduction

External Funding

  • Canadian Institutes of Health Research
    • Canadian Institutes of Health Research, 2014-2018. 
      Epithelial cell signaling responses to attaching-effacing intestinal pathogens
    • Canadian Institutes of Health Research. 2013-2018. 
      Impact of emergency department probiotic treatment of paediatric gastroenteritis: randomized controlled trial, Stephen Freedman, Principal Investigator
    • Canadian Institutes of Health Research. 2013-2016. 
      Impact of feeding type and nutrient fortification on the gut microbiome of very low birth weight infants, Deborah O’Connor & Sharon Unger, Principal Investigators

Achievements

  • Scientific Director, CIHR Institute of Nutrition, Metabolism and Diabetes – 2009-2017
  • Physician Research Award for Career Excellence – 2014
  • Canadian Association of Gastroenterology Fellow – 2014
  • Shwachman Lifeme Achievement Award, NASPGHAN – 2010
  • Associate Director, Institute of Medical Science – 2007-2008
  • Co-director CIHR training grant, Cell signalling in mucosal inflammation and pain – 2006-2008
  • Institute of Medical Science, Mel Silverman Mentorship Award – 2007

Publications

For a complete list of publications, please see PubMed.

M. Desilets, X. Deng, C. Rao, A. Ensminger, D. Krause, P. Sherman, S. Gray-Owen. Genome-based definition of an inflammatory bowel disease-associated adherent-invasive Escherichia coli (AIEC) pathovar. Inflammatory Bowel Diseases, 2016;22:1-12.

L. Vong, C. Yeung, L. Pinnell, P. Sherman. Adherent-invasive Escherichia coli exacerbates antibiotic-associated intestinal dysbiosis and neutrophil extracellular trap activation. Inflammatory Bowel Diseases, 2016;22:42-54.

C. Sima, Q. Cheng, J. Rautava, C. Levesque, P. Sherman, M. Glogauer. Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis. Journal of Periodontal Research, 2016;51: 237-249.

A. Assa, J Butcher, J. Li, A. Elkadri, P. Sherman, A. Muise, A. Stintzi, D. Mack. Mucosa-associated ileal microbiota in new-onset pediatric Crohn’s disease. Inflammatory Bowel Diseases, 2016;22:1553-1539.

A. LoVecchio, J Dias, J. Berkley, C. Boey, M. Cohen, S. Cruchet, E. Salazar-Lindo, B. Sandhu, P. Sherman, T. Shimizu, A. Guarino. Comparison of recommendations in clinical practice guidelines for acute gastroenteritis in children. Journal Pediatric Gastroenterology and Nutrition, 2016;63:226-235.

K. Johnson-Henry, T. Abrahamsson, R. Wu, P. Sherman. Probiotics, prebiotics, and synbiotics for the prevention of necrotizing enterocolitis. Advances in Nutrition, 2016;15:928-937.

T. Lakraj, K. Johnson-Henry, P. Sherman, S. Goodman, A. Segall, D. Foster. Novel antimicrobial peptide prevents Citrobacter rodentium infection in C57BL/6 mice by enhancing acid-induced pathogen killing. Microbiology UK (formerly Journal of General Microbiology), 2016;162:1641-1650.

R. Wu, M. Abdullah, P. Maatanen, A. Pilar, E. Scruten, K. Johnson-Henry, S. Napper, C. O’Brien, N. Jones, P. Sherman. Protein kinase C-delta signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function. Scientific Reports, 2017;18;7:40820.

R. Wu, M. Jeffrey, K. Johnson-Henry, J. Green-Johnson, P. Sherman. Impact of prebiotics, probiotics and gut-derived metabolites on host immunity. LymphoSign Journal, 2017; 4(1):1-24.

B. Li, C. Lee, T. Filler, A. Hock, R.Y. Wu, Q. Li, S. Chen, Y. Koike, W. Ip, L. Chi, E. Zani-Ruttenstock, P. Määttänen, T. Gonska, P. Delgado-Olguin, A. Zani, P.M. Sherman, A. Pierro. Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair. Scientific Reports, 2017;11;7:46616.