Philip Sherman, MD, FRCP(C), FAAP
The Hospital for Sick Children
Gastroenterology, Hepatology and Nutrition
University of Toronto
Professor of Paediatrics, Microbiology and Dentistry
Dept. of Paediatrics
Canada Research Chair
CIHR, Scientific Director
Institute of Nutrition, Metabolism and Diabetes (CIHR-INMD)
Dr. Sherman is a Staff Gastroenterologist, Gastroenterology, Hepatology and Nutrition at SickKids as well as a Senior Scientist, Cell Biology at the SickKids Research Institute. Dr. Sherman is also a Professor of Paediatrics, Microbiology (Laboratory Medicine & Pathobiology), Nutritional Sciences and Dentistry at University of Toronto, where he has been a faculty member since 1984. Dr. Sherman is the recipient of a Tier 1 Canada Research Chair in Gastrointestinal Diseases (2001-2022). His research program is funded by support provided by the Canadian Institutes of Health Research (1985 – present).
Dr. Sherman's research interests focus on gastrointestinal epithelial cell responses to bacterial pathogens and their products.
- Paediatric inflammatory bowel disease
- Prebiotics and probiotics
- Signal transduction
- Canadian Institutes of Health Research
Canadian Institutes of Health Research, 2014-2018.
Epithelial cell signaling responses to attaching-effacing intestinal pathogens
Canadian Institutes of Health Research. 2013-2018.
Impact of emergency department probiotic treatment of paediatric gastroenteritis: randomized controlled trial, Stephen Freedman, Principal Investigator
Canadian Institutes of Health Research. 2013-2016.
Impact of feeding type and nutrient fortification on the gut microbiome of very low birth weight infants, Deborah O’Connor & Sharon Unger, Principal Investigators
- Scientific Director, CIHR Institute of Nutrition, Metabolism and Diabetes, 2009-2017
- Physician Research Award for Career Excellence - 2014
- Canadian Association of Gastroenterology Fellow – 2014
- Schwachman Lifeme Achievement Award, NASPGHAN, 2010
- Associate Director, Institute of Medical Science, 2007 - 2008
- Co-director CIHR training grant, Cell signalling in mucosal inflammation and pain, 2006 - 2008
- Institute of Medical Science, Mel Silverman Mentorship Award, 2007
For a complete list of publications, please see PubMed
M. Desilets, X. Deng, C. Rao, A. Ensminger, D. Krause, P. Sherman, S. Gray-Owen. Genome-based definition of an inflammatory bowel disease-associated adherent-invasive Escherichia coli (AIEC) pathovar. Inflammatory Bowel Diseases, 2016;22:1-12.
L. Vong, C. Yeung, L. Pinnell, P. Sherman. Adherent-invasive Escherichia coli exacerbates antibiotic-associated intestinal dysbiosis and neutrophil extracellular trap activation. Inflammatory Bowel Diseases, 2016;22:42-54.
C. Sima, Q. Cheng, J. Rautava, C. Levesque, P. Sherman, M. Glogauer. Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis. Journal of Periodontal Research, 2016;51: 237-249.
A. Assa, J Butcher, J. Li, A. Elkadri, P. Sherman, A. Muise, A. Stintzi, D. Mack. Mucosa-associated ileal microbiota in new-onset pediatric Crohn’s disease. Inflammatory Bowel Diseases, 2016;22:1553-1539.
A. LoVecchio, J Dias, J. Berkley, C. Boey, M. Cohen, S. Cruchet, E. Salazar-Lindo, B. Sandhu, P. Sherman, T. Shimizu, A. Guarino. Comparison of recommendations in clinical practice guidelines for acute gastroenteritis in children. Journal Pediatric Gastroenterology and Nutrition, 2016;63:226-235.
K. Johnson-Henry, T. Abrahamsson, R. Wu, P. Sherman. Probiotics, prebiotics, and synbiotics for the prevention of necrotizing enterocolitis. Advances in Nutrition, 2016;15:928-937.
T. Lakraj, K. Johnson-Henry, P. Sherman, S. Goodman, A. Segall, D. Foster. Novel antimicrobial peptide prevents Citrobacter rodentium infection in C57BL/6 mice by enhancing acid-induced pathogen killing. Microbiology UK (formerly Journal of General Microbiology), 2016;162:1641-1650.
R. Wu, M. Abdullah, P. Maatanen, A. Pilar, E. Scruten, K. Johnson-Henry, S. Napper, C. O’Brien, N. Jones, P. Sherman. Protein kinase C-delta signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function. Scientific Reports, 2016; Accepted for Publication.
R. Wu, M. Jeffrey, K. Johnson-Henry, J. Green-Johnson, P. Sherman. Impact of prebiotics, probiotics and gut-derived metabolites on host immunity. LymphoSign Journal, 2016; Accepted for Publication.