About Sickkids
About SickKids

Philip Sherman, MD, FRCP(C), FAAP

The Hospital for Sick Children
Staff Gastroenterologist
Gastroenterology, Hepatology and Nutrition

Research Institute
Senior Scientist
Cell Biology

University of Toronto
Professor of Paediatrics, Microbiology and Dentistry
Dept. of Paediatrics

Chair Positions
Canada Research Chair
Gastrointestinal Disease

Other Positions
CIHR, Scientific Director
Institute of Nutrition, Metabolism and Diabetes (CIHR-INMD)

Phone: 416-813-7733
Fax: 416-813-4972
e-mail: philip.sherman@sickkids.ca
Alternate Contact: Ivette Milanes Abreus
Alternate e-mail: ivette.milanesabreus@sickkids.ca

For more information, visit:

Sherman Lab
Interview with Dr. Sherman - July 2011

Brief Biography

Dr. Sherman is Professor of Paediatrics, Microbiology and Dentistry at The Hospital for Sick Children, University of Toronto where he has been a faculty member since 1984. Dr. Sherman is the recipient of a Tier 1 Canada Research Chair in Gastrointestinal Diseases (2001-2017). His research program is funded by support provided by the Canadian Institutes of Health Research (1985 – present).

Research Interests

Research interests focus on gastrointestinal epithelial cell responses to bacterial pathogens and their products.

  • Shigatoxin - producing Escherichia coli
  • Paediatric inflammatory bowel disease
  • Prebiotics and probiotics
  • Signal transduction

External Funding

  • Canadian Institutes of Health Research
  • Institute Rosell-Lallemand Inc.

Canadian Institutes of Health Research, 2014-2018. 
Epithelial cell signaling responses to attaching-effacing intestinal pathogens

Canadian Institutes of Health Research. 2013-2018. 
Impact of emergency department probiotic treatment of pediatric gastroenteritis: randomized controlled trial, Stephen Freedman, Principal Investigator

Canadian Institutes of Health Research. 2013-2016. 
Impact of feeding type and nutrient fortification on the gut microbiome of very low birth weight infants, Deborah O’Connor & Sharon Unger, Principal Investigators


  1. Physician Research Award for Career Excellence - 2014
  2. Canadian Association of Gastroenterology Fellow – 2014
  3. Schwachman Lifeme Achievement Award, NASPGHAN, 2010
  4. Associate Director, Institute of Medical Science, 2007 - 2008
  5. Co-director CIHR training grant, Cell signalling in mucosal inflammation and pain, 2006 - 2008
  6. Institute of Medical Science, Mel Silverman Mentorship Award, 2007
  7. AHFMR Visiting Scientist to Alberta Award, 2003


For a complete list of publications, please see PubMed

Rautava J, Pinnell LJ, Vong L, Akseer N, Assa A, Sherman PM.  Oral microbiome composition changes in mouse models of colitis.  J Gastroenterol Hepatol. 2014 Sep 2. doi: 10.1111/jgh.12713. [Epub ahead of print]

Johnson-Henry KC, Pinnell LJ, Waskow AM, Irrazabal T, Martin A, Hausner M, Sherman PM. Short-chain fructo-oligosaccharide and inulin modulate inflammatory responses and microbial communities in Caco2-bbe cells and in a mouse model of intestinal injury.  J Nutr. 2014 Aug 20. pii: jn.114.195081. [Epub ahead of print]

Assa A, Vong L, Pinnell LJ, Avitzur N, Johnson-Henry KC, Sherman PM. Vitamin D deficiency promotes epithelial barrier dysfunction and intestinal inflammation. J Infect Dis. 2014 Apr 21. pii: jiu235. [Epub ahead of print]

Shen-Tu G, Kim H, Liu M, Johnson-Henry K, Sherman PM.  Protein kinase C mediates enterohemorrhagic Escherichia coliO157:H7-induced attaching and effacing lesions.  Infect Immun. 2014 Feb 3. [Epub ahead of print]

Vong L, Lorentz RJ, Assa A, Glogauer M, Sherman PM.  Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps. J Immunol. 2014 Feb 15;192(4):1870-7. doi: 10.4049/jimmunol.1302286. Epub 2014 Jan 24.

Abrahamsson TR, Sherman PM. Multifaceted effects of human milk oligosaccharides.  J Infect Dis. 2014 Feb 1;209(3):323-4.

Ho NK, Henry AC, Johnson-Henry K, Sherman PM. Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection. Can J Gastroenterol. 2013;27(5):281-5. Review.

Ossa JC, Ho NK, Wine E, Leung N, Gray-Owen SD, Sherman PM.  Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells.   Cell Microbiol. 2013 Mar;15(3):446-57.

Ho NK, Ossa JC, Silphaduang U, Johnson R, Johnson-Henry KC, Sherman PM. Enterohemorrhagic Escherichia coliO157:H7 shiga toxins inhibit gamma interferon-mediated cellular activation.  Infect Immun. 2012 Jul;80(7):2307-15. doi: 10.1128/IAI.00255-12.

Rodrigues DM, Sousa AJ, Johnson-Henry KC, Sherman PM, Gareau MG. Probiotics are effective for the prevention and treatment of Citrobacter rodentium-induced colitis in mice. J Infect Dis. 2012 Jul 1;206(1):99-109. doi: 10.1093/infdis/jis177.

Gareau MG, Ho NK, Brenner D, Sousa AJ, Lebourhis L, Mak TW, Girardin SE, Philpott DJ, Sherman PM. Enterohaemorrhagic, but not enteropathogenic, Escherichia coli infection of epithelial cells disrupts signalling responses to tumour necrosis factor-alpha.  Microbiology. 2011 Oct;157(Pt 10):2963-73. doi: 10.1099/mic.0.051094-0. Epub 2011 Jul 28. PMID:  21798984

Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, Macqueen G, Sherman PM.  Bacterial infection causes stress-induced memory dysfunction in mice.  Gut. 2011 Mar;60(3):307-17.

Gareau MG, Sherman PM, Walker WA. Probiotics and the gut microbiota in intestinal health and disease.  Nat Rev Gastroenterol Hepatol. 2010 Sep;7(9):503-14. doi: 10.1038/nrgastro.2010.117. Review.

Donato KA, Gareau MG, Wang YJ, Sherman PM.  Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling.  Microbiology. 2010 Nov;156(Pt 11):3288-97.

Shen-Tu G, Schauer DB, Jones NL, Sherman PM.  Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching-effacing bacteria.   Lab Invest. 2010 Feb;90(2):266-81.

Gareau MG, Wine E, Reardon C, Sherman PM. Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice. J Infect Dis. 2010 Jan 1;201(1):81-91. doi: 10.1086/648614. PMID: 19961304