About Sickkids
About SickKids

Earl Silverman, MD, FRCPC

The Hospital for Sick Children
Staff Rheumatologist
Rheumatology

Research Institute
Senior Associate Scientist
Physiology & Experimental Medicine

University of Toronto
Professor
Departments of Paediatrics and Immunology


Phone: 416-813-6249
Fax: 416-813-4989
e-mail: earl.silverman@sickkids.ca

Brief Biography

Dr. Earl Silverman is a Staff Rheumatologist at The Hospital for Sick Children (SickKids) and is Director of the Paediatric Lupus Clinic. He is also a Senior Associate Scientist in the Physiology & Experimental Medicine program at SickKids Research Institute. At the University of Toronto, Silverman is a Professor of Paediatrics & Immunology at the University of Toronto. His appointments are in the Department of Paediatrics, Immunology and the Institute of Medical Sciences. In 2008 Silverman was named the inaugural holder of the Ho Family Chair in Paediatric Autoimmunity at SickKids.

Silverman has received various honours including an Assistantship and an Associateship from the Arthritis Society of Canada. He is currently the only Canadian Advisor to the Arthritis Panel at the U.S. Food and Drug Administration. He coordinates the Northern Paediatric Clinic which travels throughout Northern Ontario. Dr. Silverman is an Associate Editor at the Journal of Rheumatology responsible for the paediatric section of the journal. Dr. Silverman has continually held peer reviewed research grants from both the Arthritis Society and Medical Research Council of Canada, now the Canadian Institutes of Health Research (CIHR).

Silverman's major interest is in outcomes in paediatric systemic lupus erythematosus (SLE) and the etiology of neonatal lupus erythematosus (NLE). He is currently the paediatric investigator on a Canadian-wide study of paediatric and adult onset SLE. He is a member of many national and international organizations for studying paediatric rheumatic diseases including the Childhood Arthritis and Rheumatology Research Alliance, the Paediatric Rheumatology Collaborative Study Group, the Paediatric Rheumatology International Trials Organization, the Canadian Network for Improved Outcome in Systemic Lupus Erythematosus, the Paediatric Rheumatology Basic Science Research Group, the Lupus section of the American College of Rheumatology and the Canadian Rheumatology Research Consortium. He has sat on multiple national and international review panels and has reviewed for these agencies which include the Canadian Institutes of Health Research (CIHR), the Arthritis Society of Canada, the Kidney Foundation of Canada and the National Institute of Health Research (NIHR) in the United States.

Research Interests

  • Paediatric systemic lupus erythematosus
  • Neonatal lupus erythematosus
  • Therapies in paediatric rheumatic diseases

Research Activities

  • Development of atherosclerosis in paediatric SLE and paediatric rheumatic diseases
  • Clinical and pathogenetic studies of neonatal lupus erythematosus (NLE)
  • Trials and novel therapies in juvenile idiopathic arthritis and paediatric SLE

Future Research Interests

  • Development of therapeutic strategies to prevent premature atherosclerosis in paediatric rheumatic diseases
  • Development novel biomarkers in paediatric SLE and paediatric rheumatic diseases

External Funding

The Role of Chronic Inflammation and Systemic Lupus Erythematosus-related Factors in the Development of Premature Atherosclerosis in Paediatric SLE.
Silverman ED, Bargman J, Bradley T, Beyene J: The Heart and Stroke Foundation of Canada (2006 - 2009)

Towards Understanding the Mechanism of Congenital Heart Block.
Hamilton RH, Gross G, Silverman ED: Canadian Institutes of Health Research (2006 - 2009)

International Study: The Efficacy of Monoclonal anti-TNF Antibody in JRA. Extension Phase.
Silverman ED (Site PI): Centocor Corporation ($110,000 2004 - 2010)

Publications

Hiraki LT, Benseler SM, Tyrrell PN, Hebert D, Harvey E, Silverman ED: Clinical and laboratory characteristics and long-term outcome of pediatric systemic lupus erythematosus. Journal of Pediatrics 2008: 152:4: pp 550-556.

Avcin T, Benseler S, Tyrrell PN, Cucnik S, Silverman E: A follow-up study of antiphospholipid antibodies and associated neuropsychiatric manifestations in 137 children with systemic lupus erythematosus. Arthritis Care & Research 2008: 59:2: pp 206-213.

Brunner HI, Gladman DD, Ibanez D, Urowitz MD, Silverman ED: Difference in disease features between childhood-onset and adult systemic lupus erythematosus (SLE). Arthritis and Rheumatism 2008: 58:2: pp 556-562.

Jacob CO, Reiff A, Armstrong DL, Myones BL, Silverman ED, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Nocton JJ, Solomon A, Zidovetzki R: Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform. Arthritis and Rheumatism 2007: 56:12: pp 4164-4173.

Tyrrell P, Beyene J, Benseler S, Sarkissian T, Silverman ED: Predictors of lipid abnormalities in children with new onset systemic lupus erythmatosus. Journal of Rheumatology 2007: 34:10: pp 2112-2118.

Hiraki LT, Hamilton J and Silverman ED: Measuring permanent damage in pediatric systemic lupus erythematosus. Lupus 2007: 16:8: pp 657-662.

Saurenmann R, Rose JB, Tyrrell PN, Feldman B, Laxer RM, Schneider R, Silverman ED: Epidemiology of juvenile idiopathic arthritis in a multi-ethnic cohort: ethnicity as a risk factor. Arthritis and Rheumatism 2007: 56:6: pp 1974-1984.

Compeyrot-Lacassagne S, Tyrrell PN, Atenafu E, Doria AS, Stephens D, Gilday D, Silverman ED: Prevalence and etiology of low bone mineral density in juvenile systemic lupus erythematosus. Arthritis and Rheumatism 2007: 56:6: pp 1966-1973.

Benseler SM and Silverman ED: Neuropsychiatric involvement in pediatric systemic lupus erythematosus. lupus 2007: 16:8: pp 564-571.

Avcin T, Silverman ED: Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome. Lupus 2007: 16:8: pp 627-633.

Akikusa JD, Schneider R, Harvey EA, Hebert D, Thorner PS, Laxer RM, Silverman ED: Clinical features and outcome of pediatric Wegener's granulomatosis. Arthritis and Rheumatism 2007: 57:5: pp 837-844.

Boros C, Silverman ED, Spence D, Blaser S: Hydrocephalus and macrocephaly: new manifestations of neonatal lupus erythematosus. Arthritis and Rheumatism 2007: 57:2: pp 261-266.

Benseler SM and Silverman ED: Systemic lupus erythematosus. Rheumatic Disease Clinics of North America 2007: 33:3: pp 471-498.

Silverman ED: Pediatric systemic lupus erythematosus. Future Medicine/Future Rheumatology 2007: 2:1: pp 23-50.

Saurenmann RK, Levin AV, Feldman BM, Rose JB, Laxer RM, Schneider R, Silverman ED: Prevalence, risk factors, and outcome of uveitis in juvenile idiopathic arthritis. Arthritis and Rheumatism 2007: 56:2: pp 647-657.

Sarkissian T, Beyenne J, Feldman B, McCrindle B, Silverman ED: Longitudinal examination of lipid profiles in pediatric systemic lupus erythematosus. Arthritis and Rheumatism 2007: 56:2: pp 631-638.

Aviv RI, Benseler SM, DeVeber G, Silverman ED, Tyrrell PN, Tsang LM, Armstrong D: Angiography of primary CNS vasculitis of childhood (cPACNS): conventional angiography (CA) versus magnetic resonance angiography (MRA) at presentation. American Journal of Neuroradiology 2007: 28:1: pp 9-15.

Saurenmann T, Schneider R, Silverman ED, Laxer RM, Levin AV: Risk of new-onset uveitis in patients with juvenile idiopathic arthritis treated with anti-TNF agents. Journal of Pediatrics 2006: 149:6: pp 833-6.

Saurenmann RK, Levin AV, Rose JB, Parker S, Rabinovitch T, Tyrrell PN, Feldman BM, Laxer RM, Schneider R, Silverman, ED: Tumour necrosis factor alpha inhibitors in the treatment of childhood uveitis. Rheumatology (Oxford) 2006: 45:8: pp 982-9.

Avcin T, Schneider R, Tse S, Silverman ED: Macrophage Activation syndrome as the presenting manifestation of rheumatic diseases in childhood. Journal of Pediatrics 2006: 148:5: pp 683-6.