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About Sickkids
About SickKids

Mike Seed, MBBS, MRCPCH, FRCR

The Hospital for Sick Children
Division Head, Cardiology
Cardiology

Fetal Cardiologist
Fetal Cardiac Program

Cardiac Radiologist
Diagnostic Imaging

Research Institute
Associate Scientist
Research Institute

University of Toronto
Associate Professor
Paediatrics, Meidcal Imaging, and Obstetrics & Gynecology

Associate Member
Institute of Medical Science

Chair Positions

Hospital for Sick Children
Cardiology
BMO Financial Group Chair in Cardiology


Phone: 416-813-8135
Fax: 416-813-7547
Email: mike.seed@sickkids.ca
Alternate Contact: Sue Morton
Alternate Phone: 416-813-7654 x 202459
Alternate Email: sue.morton@sickkids.ca

For more information, visit:

Fetal MRI Research at SickKids

Brief Biography

Mike Seed did his medical training in the United Kingdom and undertook specialist training in paediatrics and radiology in Newcastle and Leeds before coming to SickKids to join the fellowship programs in paediatric cardiac imaging and paediatric cardiology.  He was appointed as a clinician investigator and staff cardiologist/radiologist at SickKids in 2011, and became Division Head of Cardiology, Labatt Family Heart Centre in August 2017.

Academic Background

Projects/ Initiatives:

  1. Impact of fetal congenital heart disease on brain development.
  2. Early detection and neuro-developmental impact of late onset intrauterine growth restriction (IUGR).

Specialty Training

  • July 2008 – June 2011               Clinical fellowship in Paediatric Cardiology - SickKids
  • July 2006 – June 2008               Clinical fellowships in Paediatric Body Imaging and Cardiac Imaging SickKids - Toronto
  • Sept. 2002 – Aug. 2007              Radiology – Yorkshire Deanery – Yorkshire – UK
  • Feb. 2000 – June 2002              Paediatric Basic Specialist Training – Northern Deanery - UK

Research Interests

The focus of Seed’s research has been imaging the fetal circulation with magnetic resonance imaging. Human fetal circulatory physiology has previously been difficult to study comprehensively, but is implicated in the development of the fetal pulmonary circulation and brain. Disorders of the fetal circulation due to congenital heart disease and placental insufficiency are associated with adverse neurodevelopmental outcomes and pulmonary vascular disease.  

The use of advanced imaging technology to characterize fetal hemodynamics offers great potential to understand the mechanisms and timing of brain and lung injury in high-risk fetuses. Dr. Seed and his collaborators aim to use this approach to inform the design and implementation of new strategies to prevent or minimize fetal brain and lung injury and improve subsequent neurodevelopmental and clinical outcomes. They use phase contrast MRI and MR oximetry to study blood flow and oxygen delivery to fetal organs in the normal fetal circulation and in placental and congenital heart disease.  

The hope is that combining these powerful new techniques with fetal echocardiography and advanced neonatal brain imaging techniques a new system can be implemented for monitoring at-risk pregnancies and evaluating new fetal interventions.

RESEARCH AWARDS

  • 2013 – Pediatric Heart Network for the National Institute for Health – New Scholar Award - “Impact of fetal brain oxygenation on brain development in congenital heart disease by MRI” (Principal Investigator)
  • 2011-2013 Labatt Innovations Fundholder for “Normal human fetal circulatory physiology by echocardiography and magnetic resonance imaging” (Principal Investigator)
  • 2013-14 CIHR – Bridge funding – Institute of Respiratory and Circulatory Health – “Early Identification of Cardiac Dysfunction in Obese Adolescents: Mechanisms and Modulation” (Co-investigator)

Publications

Chaturvedi R, Jaeggi E, Seed M, Van Arsdell G, Ryan G.  Fetal stenting of the atrial septum: technique and initial results in cardiac lesions with left atrial hypertension. International Journal of Cardiology. 2013;Mar 4th (epub)

Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study.  Seed M, FP van Amerom J, Yoo SJ, Nafisi B, Grosse-Wortmann L, Jaeggi E, Jansz MS and Macgowan CK.  J Cardiovasc Magn Reson 2012;14:79

Dynamic Imaging of the Fetal Heart Using Metric Optimized Gating.  Roy C, Seed M, van Amerom JFP, Al Nafisi B, Grosse-Wortmann L, Yoo SJ, Macgowan CK.  Magnetic Resonance In Medicine.  In Press

Chu L, Seed M, Howse E, Ryan G, Grosse-Wortmann L. Mesenchymal hamartoma: prenatal diagnosis by fetal MRI.  Pediatric Radiology 2011 Jun;41(6):781-784

 Jansz M, Seed M, van Amerom J.  Metric Optimized Gating for Fetal Cardiac MRI. Magnetic Resonance in Medicine. 2010 Nov;64(5):1304-1314

Yinon Y, Chitayat D, Blaser S, Seed M, Jaeggi E. Fetal Cardiac Tumours: A Single Center Experience of 40 Cases. Prenatal Diagnosis 2010;30:941-949 Grosse-Wortmann L, Roche SL, Yoo S-J, Seed M, Kantor P. Early changes in right ventricular function and their clinical consequences in childhood and adolescent dilated cardiomyopathy. Cardiology in the Young 2010 Apr;20(4):418-425

Seed M, Bradley T, Bourgeois J, Jaeggi E, Yoo SJ: Antenatal MR imaging of pulmonary lymphangiectasia secondary to hypoplastic left heart syndrome.  Pediatr Radiol 2009;39:747-749

Helm E, Silva C, Roberts H, Manson D, Seed M, Amaral J, Baby P: Computer-aided detection for the identification of pulmonary nodules in paediatric oncology patients: initial experience. Paediatr Radiol. 2009 Jul; 39(7):685-93.

Seed M.  Fetal Cardiac MRI.  In: Diagnostic Imaging of Fetal Anomalies – Third Edition.  Ed: Bulas, Kline-Fath, Bahardo-Singh.  Lippincott Williams and Wilkins.  (In Press) ]

Seed M.  Techniques in the Paediatric Thorax, Radiology integrated training Initiative – e-learning module – Royal College of Radiologists and Department of Health, 2006