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About Sickkids
About SickKids

Dat Tran, MD, M.Sc.

The Hospital for Sick Children
Staff Physician
Infectious Diseases

University of Toronto
Assistant Professor

Phone: 416-813-6268
Email: dat.tran@sickkids.ca

Brief Biography

Dr. Dat Tran received his medical degree from the University of Toronto in 1993 and completed his paediatric residency from 1993 to 1997 and an infectious diseases fellowship from 1998 to 2000 at The Hospital for Sick Children (SickKids). He subsequently obtained training in clinical epidemiology and biomedical informatics at OHSU from 2000 to 2004 and received an M.Sc. in biomedical informatics. Tran then returned to SickKids in 2004 to join the Division of Infectious Diseases.

Research Interests

Tran's research focuses on understanding host, viral and environmental factors associated with severe influenza infection in children. His research group is conducting a study that aims to identify common genetic variants associated with severe disease in otherwise healthy children infected with influenza viruses. Insights into the genetic basis for variation in influenza severity may facilitate development of new preventive and therapeutic strategies.

Their future goal is to develop risk prediction models that integrate host, viral and environmental factors that will form the basis for tailored management approaches.

External Funding

Genetic predictors of severe respiratory illness from pandemic H1N1 influenza infection.  Tran D, Paterson A: Public Health Agency of Canada (2010-2011)

The mechanism and immunological correlates of severe respiratory illness following 2009 H1N1 pandemic influenza virus infection.  Sharma S, Haeryfar SMM, Hancock REW, Sahai BM, Tran D (Co-PIs), Alexander M, Gubbay JB, Halperin SA, Lin F, Loeb MB, McGeer AJ, Palaniyar N, Paterson AD (Co-Investigators): CIHR (2009-2010)

Severe influenza in children: Genetic determinants and related epidemiology.  Tran D, Paterson A, Beyene J, Richardson S, Schuh S, Roifman C: SickKids Foundation (2008-2010)

Genetic determinants of influenza severity in children: A pre-pandemic community-based feasibility study.  Tran D, Beyene J, Bitnun A, Ipp M, Paterson A, Richardson S: CIHR (2008-2009)

Genetic epidemiology of influenza: A multinational pediatric initiative.  Tran D, Paterson A, Beyene J, Tellier R, Lewinsohn D, Cheng F, Chokephaibulkit K: CIHR: International Opportunities Program (2007-2008)

A pilot study of genetic determinants of severe influenza in children.  Tran D, Paterson A, Beyene J, Richardson S, Schuh S: University of Toronto: Dean's Fund - New Staff Grant (2007)


Thampi N, Bitnun A, Banner D, Rowe T, Kelvin DJ, Richardson SE, Parkin P, Tran D. Influenza-associated encephalopathy with elevated antibody levels to pandemic (H1N1) 2009 influenza.  J Child Neurol 2011: Jan 26.

Longtin J, Patel S, Eshaghi A, Lombos E, Higgins R, Alexander D, Olsha R, Doyle J, Tran D, Sarabia A, Lee C, Bastien N, Li Y, Low D, Boivin G, Gubbay J. Neuraminidase-inhibitor resistance testing for pandemic influenza A (H1N1) 2009 in Ontario, Canada. J Clin Virol 2011: Jan 18.

Hawkes M, Schuh S, Ipp M, Bitnun A, Richardson SE, Parkin PC, Stephens D, Tran D. Natural history of pandemic H1N1 2009 influenza infection in healthy pediatric outpatients. Acad Pediatr 2011: 11(1):66-74.

Gray TLV, Ooi CY, Tran D, Traubici J, Gerstle JT, Sung L. Gastrointestinal complications in children with acute myeloid leukemia.  Leuk Lymphoma 2010: 51(5):768-77.

Bettinger JA, Sauve L, Scheifele DW, Moore D, Vaudry W, Tran D, Halperin SA, Pelletier L. Pandemic influenza in Canadian children: A summary of hospitalized pediatric cases.  Vaccine 2010: 28(18):3180-4.

Hawkes M, Richardson SE, Ipp M, Schuh S, Adachi D, Tran D. Sensitivity of Rapid Influenza Diagnostic Testing for Swine-Origin 2009 A (H1N1) Influenza Virus in Children.  Pediatrics 2010: 125(3):639-44.

O'Riordan S, Barton M, Yau Y, Read SE, Allen U, Tran D. Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza.  Canadian Medical Association Journal 2010: 182(1):39-44.

Wang Q, Babyn P, Branson H, Tran D, Davilla J, Mueller EL. Utility of MRI in the follow-up of pyogenic spinal infection in children.  Pediatric Radiology 2009: 40(1):118-30.

Manlhiot C, Liang L, Tran D, Bitnun A, Tyrell PN, Feldman BM. Assessment of an infectious disease history preceding juvenile dermatomyositis symptom onset.  Rheumatology 2008: 47(4):526-9.

Hawkes M, Kitai I, Blaser S, Cohen E, Bitnun A, Fluss J, Tran D. Neuroimaging findings in isoniazid central nervous system toxicity, presumed intramyelinic edema.  European Journal Pediatric Neurology 2008: 12(6):512-5.