Facebook Pixel Code
About Sickkids
About SickKids

Margot Taylor, PhD

The Hospital for Sick Children
Director of Functional Neuroimaging
Diagnostic Imaging

Research Institute
Senior Scientist
Neurosciences & Mental Health

University of Toronto
Professor of Medical Imaging
Depts. of Paediatrics and Psychology


Phone: 416-813-7654, ext. 306321
Fax: 416-813-7362
e-mail: margot.taylor@sickkids.ca
Alternate Contact: Julie Lu
Alternate Phone: 416-813-5175
Alternate e-mail: julie.lu@sickkids.ca

Research Interests

  • frontal lobe and executive function development
  • effect of emotions on face processing and attention
  • neuroimaging in preterm neonates and prediction of outcome

Research Activities

My research investigates the neural bases of cognitive development. Areas of study include development of frontal lobe or executive functions and social cognition using various protocols adapted for children. Current studies use functional MRI and MEG, as well as structural MRI, and include normative series and clinical populations (children with autism and children born very preterm. The research will determine the neural bases, temporal and spatial aspects of the development of abilities, including emotional recognition, working memory, inhibition, set-shifting, and how these cognitive skills emerge with typical and atypical development. We are also following very preterm born infants from birth to determine the impact of very early brain development on later cognitive outcome.

External Funding

Grants in submission

Identifying brain dysmaturation in very preterm neonates associated with autism.  Church, P.T., Banihani, R., Anagnostou, E., Kelly, E., Ly, L., Taylor, M.J.  submitted to PSI, May 12th, 2016. $165,790 for two years

Awards and Grants Received

Understanding the thoughts and emotions of others: neuroimaging measures of typical and atypical development.  Taylor, M.J., Pang, E.W., Smith, M.L., Anagnostou, E.  CIHR-BSB 2015-2020.  5yr grant.  1st year $129,703 (total $648,513).

Longitudinal follow-up study of a military PTSD patient cohort using magnetoencephalography. Taylor, M.J., Pang, E.W., Dunkley, B.T.  CIMVHR, 2015-2017, total  $270,810.91

Cognitive functions in children born very preterm; relation to brain structure and function from birth through childhood.  Taylor, M.J., Sled, J.G., Whyte, H.E., Miller, S.P., Shroff, M.M., Smith, M.L. CIHR-BSC, 2014-2019.  5yr grant, 1st year $164,340 (total $821,701).

Neonatal intensive care and brain development of the preterm neonate.  CoPIs: Miller, S.P., Grunau, R., Taylor, M.J., Co-Applicants: Synnes, A., Ly, L., Poskitt, K., Brant, R., Sled, J.G. Whyte, H.E. CIHR-CHI 2014-2020.  6yr grant, 1st year $184,036 (total: $1,104,216).

Typical and atypical development of frontal lobe systems and the maturation of social cognitive function.  Taylor, M.J., Pang, E.W., Doesburg, S., Anagnostou, E.  CIHR BSC, jan 2012-2017; 5-yr grant, 1st year: $151,692 (total $766,896).

Application of non-invasive magnetoencephalography (MEG) for objective assessment of Post Traumatic Stress Disorder (PTSD) A Pilot Study.  Taylor, M.J., Pang, E.W.  DRDC, August 2012 - Dec. 2013.  $248,340

Working memory in children with autism.  Taylor, M.J., Smith, M.L., Lerch, J.P., Anagnostou, E.  CIHR CHI, 2010-2015,  1st year: $132,064; total :$ 660,318.

Typical and atypical development of frontal lobe systems and the maturation of social cognitive function. Taylor, M.J., Pang, E.W., Doesburg, S., Anagnostou, E. . CIHR BSC, jan 2012-2016; 5-yr grant application, 1st year: $151,692 (total $766,896).

Application of Non-invasive Magnetoencephalography (MEG) for Objective Assessment of Post Traumatic Stress Disorder (PTSD): A Pilot Study. Taylor, M.J., Pang, E.W  DRDC, 2012 - 2013.  $248,340

Canadian Institutes of Health Research (CIHR)
Predicting Neurobehavioural outcome in preterm neonates.
Taylor MJ, Whyte H, Moore A, Shroff M, Raybaud C, Donner EJ, Frisk V. 2008-2012CIHR CHI, 2008-2012.  $185,962 1st year, for a 5-year grant (total $929,129)

Centre for the Investigation of Neuroplasticity and Developmental Disorders. Canadian Foundation for Innovation (CFI).
Snead OC, Taylor MJ, Salter M, Josselyn S, Westall C, Dennis M, Tannock R, Sled J, Cheyne D, Campbell M. 2006-2011.

Developmental investigation of memory capacity using functional neuroimaging. 
NSERC Discovery Grant, Taylor, MJ.  2009-2014, Total:  $150,000; $30,000/yr .

Publications

2016

Kouptsova, J.E., Leung, R.C., Taylor, M.J.  Stimulus exposure duration alters implicit processing of neutral and emotional faces. Neuroscience, nov., 2016, in press

Vakorin, V.A., Doesburg, S.M, Leung, R.C., Vogan, V.M., Anagnostou, E., Taylor, M.J.  Developmental trajectories of resting neuromagnetic rhythms and network synchrony in typical and autistic populations.  Annals of Neurology, 2016, in press.

Young, J.M., Morgan, B.R., Whyte, H.E.A., Lee, W., Smith, M.L., Sled, J.G., Taylor, M.J.  Early longitudinal development of white matter tracts and outcomes in very preterm children.  Cerebral Cortex, 2016, epub ahead of print doi: 10.1093/cercor/bhw221

Ibrahim, G.M., Morgan, B.R, Vogan, V.M., Leung, R.C., Anagnostou, E., Taylor, M.J.  Mapping the network of neuropsychological impairment in children with autism spectrum disorder: A graph theoretical analysis. JADD, 2016, in press.

Duerden, E.G., Lee, M., Chow; S., Sato, J., Mak-Fan, K., Taylor, M.J.  Neural correlates of reward processing in typical and atypical development.  Child Neurology, 2016, in press.

Dunkley, B.T, Pang, E.W., Sedge, P.A., Grodecki, R.J., Jetly, R., Doesburg, S.M, Taylor, M.J.  Alpha hypersynchrony and atypical memory processes in soldiers with post-traumatic stress disorder.  J. Neuroimaging in Psychiatry & Neurology (JNPN), 2016, in press http://dx.doi.org/10.17756/jnpn.2016-007

Vakorin V.A., Doesburg, S.M., Da Costa, L., Jetly, R., Pang, E.W., Taylor, M.J.  Detecting mild traumatic brain injury using resting state magnetoencephalographic connectivity.  PLoS Computational Biology, 2016, in press

Mossad, S., AuCoin-Power, M., Urbain, C.M., Smith M.L., Taylor, M.J.  Thinking about the thoughts of others; temporal and spatial neural activation during false belief reasoning.  NeuroImage, 2016, 134:320-327.

Ameis, S.H., Lerch J.P., Taylor, M.J. .… Anagnostou, E.  A diffusion tensor imaging study in children with ADHD, ASD, OCD and matched controls: Distinct and non-distinct white matter disruption and dimensional brain-behavior relationships.  American Journal of Psychiatry, 2016, 173:1213–1222.

Sussman, D., Pang, E.W., Jetly, R., Dunkley, B.T, Taylor, M.J.  Neuroanatomical features in soldiers with post-traumatic stress disorder.  BMC Neuroscience, 2016, Mar 31; 17:13.

Wilkinson, A.A., Simic, N., Fndrova, H., Taylor, M.J., … Dennis, M., Schachar, R., Hutchison, J.  Serum biomarkers help predict attention problems in critically ill children with traumatic brain injury.  Pediatric Critical Care Medicine, 2016, 17(7):638-648.

Young, J.M., Morgan, B.R., Moore, A.M., Whyte, H.E.A., Smith, M.L., Taylor, M.J.  Associations of perinatal clinical and magnetic resonance imaging measures with developmental outcomes in children born very preterm.  Journal of Pediatrics, 2016,170, 90-96.

Sussman, D., Leung, R.C., Chakravarty, M.M. Lerch, J.P., Taylor, M.J.  The developing human brain: Age-related changes in cortical, subcortical and cerebellar anatomy.  Brain & Behavior, 2016, (4):e00457.

Vogan, V.M., Morgan, B.R., Leung, R.C., Anagnostou, E., Doyle-Thomas, K., Taylor, M.J.  Widespread white matter differences in children and adolescents with Autism Spectrum Disorder.  JADD, 2016, 17, 19-27.

Urbain, C.M., Vogan, V.M., Ye, A.X., Pang, E.W., Doesburg, S.M., Taylor, M.J.  Desynchronization of fronto-temporal networks during working memory processing in children with autism.  Human Brain Mapping, 2016, 7(1):153-164.

Pavaine*, J., Young*, J.M., Morgan, B.R., Raybaud, C., Shroff, M.M., Taylor, M.J.  Diffusion tensor imaging based assessment of white matter tracts and visual motor outcomes in very preterm neonates.  Neuroradiology, 2016, 58(3), 301-310.

Pang, E.W., Dunkley, B.T, Doesburg, S.M., Da Costa, L., Taylor, M.J.  Reduced brain connectivity and mental flexibility in mild traumatic brain injury.  Annals of Clinical and Translational Neurology, 2016, 3(2), 124-131.

Mišić, B., Dunkley, B.T., Sedge, P.A., da Costa, L., Fatima, Z., Berman, M.G., Doesburg, S.M., McIntosh, A.R, Grodecki, R., Jetly, R., Pang, E.W., Taylor, M.J.  Posttraumatic stress constrains the dynamic repertoire of neural activity.  J. Neurosci., 2016, 36(2):419-431.

Leung, R.C., Vogan, V.M., Powell, T.L., Anagnostou, E., Taylor, M.J.  The role of executive functions in social impairment in ASD.  Child Neuropsychology, 2016, 22: 336-344.

Pang, E.W., Valica, T., MacDonald, M., Taylor, M.J. Brian, J., Lerch, J.P., Anagnostou, E.  Abnormal brain dynamics underlie speech production in children with autism spectrum disorder.  Autism Research, 2016, 9(2), 249-261.

Vogan, V.M., Morgan, B.R, Powell, T.L., Smith, M.L., Taylor, M.J.  The neurodevelopmental differences of increasing verbal working memory demand in children and adults.  Developmental Cognitive Neuroscience, 2016, 17:19-27.

Dunkley, B.T, Pang, E.W., Sedge, P.A., Jetly, R., Doesburg, S.M., Taylor, M.J.  Threatening faces evoke fear circuitry hypersynchrony in soldiers with post-traumatic stress disorder.  Helyion, 2016, 2(1), e00063.

Lee, W., Al Dossary, H., Raybaud, C., Young, J.M., Morgan, B.R., Whyte, H.E.A., Sled, J.G., Taylor, M.J., Shroff, M.M.  Longitudinal cerebellar growth following very preterm birth.  J Magn Reson Imaging, 2016, 43(6):1462-73.

2015

Dunkley, B.T, Doesburg, S.M, Jetly, R., Sedge, P.A., Pang, E.W. Taylor, M.J.  Characterising intra-and inter-intrinsic network synchrony in combat-related post-traumatic stress disorder.  Psychiatry Research: Neuroimaging, 2015, 234(2):172-81.

Ye, A.X., AuCoin-Power, M. Taylor, M.J. Doesburg, S.M.  Disconnected neuromagnetic networks in children born very preterm.  NeuroImage: Clinical, 2015, 9, 376-384.

Ibrahim, G.M. Morgan, B.R., Smith, M.L., Kerr, E., Donner, E.J., Go, C., Doesburg, S.M., Taylor, M.J., Widjaja, E., Rutka, J.T., Snead, O.C.  Thalamocortical connectivity is enhanced following hemispherectomy for intractable lateralized epilepsy. Epilepsy & Behavior, 2015, 51:281-285.

Urbain, C.M., Pang, E.W., Taylor, M.J.  Spatiotemporal signatures of working memory brain processes in autism. Translational Psychiatry, 2015, 5:e617.

Todd, R.M., MacDonald, M.J., Sedge, P.A., Robertson, A., Jetly, R., Taylor, M.J., Pang, E.W.  Soldiers with PTSD see a world full of threat: MEG reveals enhanced tuning to combat-related cues.  Biological Psychiatry, 2015, 78(12):821-829.

Sussman, D., Leung, R.C. Vogan, V.M., Lee, W., Trelle, S., Lin, S.Y., Cassel, D., Chakravarty, M.M., Lerch, J.P., Anagnostou, E., Taylor, M.J.  The Autism Puzzle: Diffuse but not pervasive neuroanatomical features in children with ASD.  NeuroImage: Clinical, 2015, in press.

Dunkley, B.T., Sedge, P.A., Doesburg, S.M., Grodecki, R.J., Jetly, R., Shek, P.N., Taylor, M.J., Pang, E.W.  Theta, mental flexibility and PTSD: connecting in the parietal cortex.  PloS One, 2015, in press.

Young, J.M., Powell, T.L., Morgan, B.R., Card, D., Smith, M.L., Sled, J.G., Taylor, M.J.  Deep grey matter growth predicts neurodevelopmental outcomes in very preterm children.  NeuroImage, in press, jan 2015.

Dunkley, B.T, Da Costa, L., Doesburg, S.M, Robertson, A., Pang, E.W., Taylor, M.J.  Low-frequency amplitude coupling distinguishes mild traumatic brain injury.  NeuroImage: Clinical, 2015, 7: 611-621.

Duerden E.G., Taylor, M.J., Lee, M., McGrath, P.A., Davis, K.D., Roberts, S.W.  Decreased sensitivity to thermal stimuli in adolescents with autism spectrum disorder: Relation to symptomatology and cognitive ability.  J. of Pain, 2015, in press.

Nossin-Manor, R., Card, D., Raybaud, C., Taylor, M.J., Sled, J.G.  Cerebral maturation in the early preterm period - A magnetization transfer and diffusion tensor imaging study using voxel-based analysis.  Neuroimage, 2015, 112, 30-42.

Stiver M.L., Kamino, D., Guo, T., Thompson, A., Duerden, E.G., Taylor, M.J., Tam, E.W.Y.  Maternal postsecondary education associated with improved cerebellar growth after preterm birth.  J. of Child Neurology, 2015, in press.

Leung, R.C., Vogan, V.M., Powell, T.L., Anagnostou, E., Taylor, M.J.  The role of executive functions in social impairment in ASD.  Child Neuropsychology, 2015 in press

Ibrahim, G.M. Morgan, B.R., Doesburg, S.M., Taylor, M.J., Pang, E.W., Rutka, J.T., Snead, O.C.  Atypical language laterality is associated with large-scale disruption of network integration in children with medically-intractable localization-related epilepsy.  Cortex, 2015; 65C:83-88.

2014

Leung, R.C., Pang, E.W., Cassel, D., Brian J.A., Smith, M.L., Taylor, M.J.  Early neural activation during facial affect processing in adolescents with Autism Spectrum Disorder.  NeuroImage: Clinical, 2014, 7:203-12.

Powell, T.L., Vogan, V. M., Arsalidou, M., Taylor, M.J.  Controlled interference and assessments of developmental working memory capacity: Evidence from the letter and colour matching tasks.  Child Development Research, 2014, in press.

Leung, R.C., Ye, A.X., Simeon M. Wong, S.M., Taylor, M.J. Doesburg, S.M.  Reduced connectivity during emotional face processing in adolescents with autism.  Molecular Autism, 2014, 5(1):51.

Mišić, B., Doesburg, S.M., Fatima, Z., Vidal, J., Vakorin, V.A., Taylor, M.J., McIntosh, A.R.  Coordinated information generation and mental flexibility: large-scale network disruption in children with autism.  Cerebral Cortex, 2014, Apr 25. [Epub ahead of print]

da Costa, L., Robertson, A., Bethune, A., MacDonald, M.J., Shek, P.N., Taylor, M. J., Pang, E.W.  Delayed and disorganized brain activation detected with magnetoencephalography after mild traumatic brain injury.  J. Neurology, Neurosurgery & Psychiatry, 2014, Oct 16. doi: 10.1136/jnnp-2014-308571. [Epub ahead of print].

Bangel, K., Batty, M., Ye, A.X., Meaux, E., Taylor, M.J., Doesburg, S.M.  Reduced beta band connectivity during number estimation in autism.  NeuroImage: Clinical, 2014, 6:202-13.

Vara, A.S., Pang, E.W., Vidal, J., Anagnostou, E., Taylor M.J.  Neural mechanisms of inhibitory control continue to mature in adolescence.  Developmental Cognitive Neuroscience, 2014, 10:129–139.

Dunkley, B.T., Doesburg, S.M., Sedge, P.A., Grodecki, R.J., Shek, P.N., Pang, E.W., Taylor, M.J.  Resting state hippocampal connectivity correlates with symptom severity in post-traumatic stress disorder.  Neuroimage: Clinical, 2014, 5:377-384.

Ye, A.X. Leung, R.C., Schäfer, C.B., Taylor, M.J. Doesburg, S.M.  Atypical resting coherence in autism spectrum disorder.  Human Brain Mapping, 2014, 35(12):6049-66.

Vogan, V.M., Morgan, B.R., Lee, W., Smith, M.L. Taylor, M.J.  The neural correlates of working memory in children and adolescents with ASD and the effects cognitive load.  J. Neurodevelopmental Disorders, 2014, 6:19.

Pang, E.W., Sedge, P.A., Grodecki, R.J., Robertson, A., MacDonald, M.J., Jetly, R., Shek, P.N., Taylor, M.J.  Colour or shape: examination of neural processes underlying mental flexibility in posttraumatic stress disorder.  Translational Psychiatry, 2014, 4, e421.

Ibrahim, G.M., Morgan B.R., Lee, W., Smith, M.L. Donner, E., Wang, F., Beers, C., Federic, P., Taylor, M.J., Doesburg, S.M., Rutka, J.T., Snead, O.C.III.  Impaired development of intrinsic connectivity networks in children with medically-intractable focal epilepsy.  Human Brain Mapping, 2014, 35(11):5686-5700.

Taylor, M.J., Doesburg, S.M., Pang, E.W.  Neuromagnetic vistas into typical and atypical development of frontal lobe functions.  Frontiers: Human Neuroscience, June 2014, vol 8, article 453.

Ibrahim, G.M. Cassel, D. Morgan, B.R., Smith, M.L., Otsubo, H., Ochi, A., Taylor, M.J., Rutka, J.T., Snead, O.C., Doesburg, S.M.  Resilience of developing brain networks to interictal epileptiform discharges is associated with cognitive outcome.  Brain, 2014, 137(Pt 10):2690-702.

Schäfer, C.B., Morgan, B.R., Ye, A.X., Taylor, M.J., Doesburg, S.M.  Oscillations, networks and their development: MEG connectivity changes with age.  Human Brain Mapping, 2014, 35(10):5249-5261.

Todd, R.M., Taylor, M.J., Cassel, D., Robertson, A., Doesburg, S.M., Lee, D.H., Shek, P., Pang, E.W.  Attending differently vs. attending more: Temporal-spatial activation patterns and perceptual encoding of affective salience.  PLoS One, 2014, 9( 4), e93753.

Mišić, B., Mills, T. Vakorin, V.A., Taylor, M.J., McIntosh, A.R.  Developmental trajectory of face processing revealed by integrative dynamics.  JoCN, 2014, 26(10):2416-30.

Oh, A., Vidal, J., Taylor, M.J., Pang, E.W. Neuromagnetic correlates of intra- and extra-dimensional set-shifting.  Brain & Cognition, 2014, 86 (2014) 90–97.

Meaux, E., Taylor, M.J., Pang, E.W., Vara, A.S., Batty, M.  Neural substrates of numerosity estimation in autism.  Human Brain Mapping, 2014, 35(9):4362-85.

Vara, A.S., Pang, E.W., Doyle-Thomas, K.A., Vidal, J., Taylor M.J., Anagnostou, E.  Is inhibitory control a "No-go" in adolescents with ASD?  Molecular Autism, 2014, 5:6.

Duerden EG, Card D, Roberts SW, Mak-Fan KM, Chakravarty MM, Lerch JP, Taylor MJ.  Self-injurious behaviours are associated with alterations in the somatosensory system in children with autism spectrum disorders. Brain Structure & Function, 2014, 219(4):1251-61.

2013

Doesburg, S.M., Vidal, J., Taylor, M.J.  Reduced connectivity during set-shifting in children with autism.  Frontiers: Human Neuroscience, 2013 Nov 14; 7:785.

Taylor, M.J.  Structure and function in the premature brain: how to connect?  Neuroradiology, 2013, 55(S2):55-64.

Duerden, E.G., Taylor, M.J., Soorya, L., Wang, T., Fan, J., Anagnostou, E.  Neural correlates of response inhibition of socially relevant stimuli in adults with autism spectrum disorders.  Brain Research, 2013, 1533:80-90.

Lee, W., Morgan, B.R., Shroff, M.M., Sled, J.G., Taylor, M.J.  The development of regional functional connectivity in preterm infants into early childhood.  Neuroradiology, 2013, 55 Suppl 2:105-11.

Duerden, E.G., Taylor, M.J., Miller, S.P.  Brain development in infants born preterm: looking beyond injury.  Seminars in Pediatric Neurology, 2013, 20:65-74.

Hopf, L., Quraan, M.A., Cheung, M.J., Taylor, M.J., Ryan, J.D., Moses, S.N.  Hippocampal lateralization and memory in children and adults.  J. International Neuropsychological Society, 2013, 19(10):1042-52.

Chau ,V., Taylor, M.J., Miller, S.P.  Visual function in preterm children: how MR techniques can help see the prognosis better?  Documenta Ophthalmologica, 2013, 127 (1) 41-55.  

Duerden E.G., Lax, I.D., Card, D., Donner, E.J., Taylor, M.J.  Alterations to frontostriatal pathways in children born very preterm. Develop Medicine Child Neurology, 2013 55(10):952-8.

Arsalidou, M., Pascual-Leone J., Johnson J., Morris, D., Taylor, M.J.  A balancing act of the brain: Activations and deactivations driven by cognitive load.  Brain & Behavior, 2013, 3(3):273-85.

Duerden, E.G. Arsalidou, M., Lee, M., Taylor, M.J.  Lateralization of affective processing in the insula.  Neuroimage, 2013, 78:159-75

Bayless, S.J., Nagata, Y., Mills, T., Taylor, M.J.  MEG measures of covert orienting and gaze processing in children.  Brain Topography, 2013, 26(4):616-626.

Card, D., Nossin-Manor, R., Moore, A.M., Raybaud, C., Sled, J.G., Taylor, M.J.  Brain metabolite concentrations associated with illness severity scores and white matter abnormalities in very preterm infants.  Pediatric Research, 2013, 74(1):75-81.

Arsalidou, M., Agostino, A., Maxwell, S., Taylor, M.J.  “I can read these colours” Orthographic manipulations and the development of the colour-word Stroop.  Frontiers in Psychology, 2013, 3:594.

Nossin-Manor R., Card, D., Morris, D., Noormohamed, S., Shroff, M.M. Whyte, H.E.A. Taylor, M.J., Sled, J.G. Quantitative MRI in the very preterm brain: Assessing tissue organization and myelination using magnetization transfer, diffusion tensor and T1 imaging.  NeuroImage, 2013, 64:505-16.

Lax, I.D., Duerden E.G., Chakravarty, M., Donner, E.J., Lerch, J.P., Taylor, M.J.  Neuroanatomical consequences of very preterm birth in middle childhood.  Brain Structure & Function, 2013, 218:575–585.

Doyle-Thomas KA, Duerden EG, Taylor MJ, Lerch JP, Soorya LV, Wang AT, Fin J, Hollander E, Anagnostou E.  Effects of age and symptomatology on cortical thickness in autism spectrum disorders.  Research in Autism Spectrum Disorders. 2013, 7(1):141-150.

Hung, Y., Smith, M.L. Taylor, M.J.  Functional dissociation in hippocampal-prefrontal working memory systems.  Cortex, 2013, 49:961-967.  

Arsalidou, M., Duerden, E.G., Taylor, M.J.  The centre of the brain: Topographical model of functions of the basal ganglia.  Human Brain Mapping, 2013, 34:3031–3054.

Doyle-Thomas KA, Kushki A, Duerden EG, Taylor MJ, Lerch JP, Soorya LV, Wang AT, Fan J, Anagnostou E.  The effect of diagnosis, age, and symptom severity on cortical surface area in the cingulate cortex and insula in Autism Spectrum Disorders. Journal of Child Neurology. 2013, 28(6):729-36.

Mak-Fan, K.M., Morris, D., Vidal, J., Anagnostou, E., Roberts, W., Taylor, M.J.  White matter and development in children with an Autism Spectrum Disorder (ASD). Autism, 2013;17(5):541-57.