Margot Taylor, PhD
The Hospital for Sick Children
Director of Functional Neuroimaging
Neurosciences & Mental Health
University of Toronto
Professor of Medical Imaging
Depts. of Paediatrics and Psychology
- frontal lobe and executive function development
- effect of emotions on face processing and attention
- neuroimaging in preterm neonates and prediction of outcome
My research investigates the neural bases of cognitive development. Areas of study include development of frontal lobe or executive functions and social cognition using various protocols adapted for children. Current studies use functional MRI and MEG, as well as structural MRI, and include normative series and clinical populations (children with autism and children born very preterm. The research will determine the neural bases, temporal and spatial aspects of the development of abilities, including emotional recognition, working memory, inhibition, set-shifting, and how these cognitive skills emerge with typical and atypical development. We are also following very preterm born infants from birth to determine the impact of very early brain development on later cognitive outcome.
Working memory in children with autism.
Taylor, M.J., Smith, M.L., Lerch, J.P., Anagnostou, E. CIHR CHI, 2010-2015, 1st year: $132,064; total :$ 660,318.
Typical and atypical development of frontal lobe systems and the maturation of social cognitive function. Taylor, M.J., Pang, E.W., Doesburg, S., Anagnostou, E. . CIHR BSC, jan 2012-2016; 5-yr grant application, 1st year: $151,692 (total $766,896).
Application of Non-invasive Magnetoencephalography (MEG) for Objective Assessment of Post Traumatic Stress Disorder (PTSD): A Pilot Study. Taylor, M.J., Pang, E.W DRDC, 2012 - 2013. $248,340
Canadian Institutes of Health Research (CIHR)
Predicting Neurobehavioural outcome in preterm neonates.
Taylor MJ, Whyte H, Moore A, Shroff M, Raybaud C, Donner EJ, Frisk V. 2008-2012CIHR CHI, 2008-2012. $185,962 1st year, for a 5-year grant (total $929,129)
Centre for the Investigation of Neuroplasticity and Developmental Disorders. Canadian Foundation for Innovation (CFI).
Snead OC, Taylor MJ, Salter M, Josselyn S, Westall C, Dennis M, Tannock R, Sled J, Cheyne D, Campbell M. 2006-2011.
Developmental investigation of memory capacity using functional neuroimaging.
NSERC Discovery Grant, Taylor, MJ. 2009-2014, Total: $150,000; $30,000/yr .
Sussman, D., Leung, R.C. Vogan, V.M., Lee, W., Trelle, S., Lin, S.Y., Cassel, D., Chakravarty, M.M., Lerch, J.P., Anagnostou, E., Taylor, M.J. The Autism Puzzle: Diffuse but not pervasive neuroanatomical features in children with ASD. NeuroImage: Clinical, 2015, in press.
Dunkley, B.T., Sedge, P.A., Doesburg, S.M., Grodecki, R.J., Jetly, R., Shek, P.N., Taylor, M.J., Pang, E.W. Theta, mental flexibility and PTSD: connecting in the parietal cortex. PloS One, 2015, in press.
Young, J.M., Powell, T.L., Morgan, B.R., Card, D., Smith, M.L., Sled, J.G., Taylor, M.J. Deep grey matter growth predicts neurodevelopmental outcomes in very preterm children. NeuroImage, in press, jan 2015.
Dunkley, B.T, Da Costa, L., Doesburg, S.M, Robertson, A., Pang, E.W., Taylor, M.J. Low-frequency amplitude coupling distinguishes mild traumatic brain injury. NeuroImage: Clinical, 2015, 7: 611-621.
Duerden E.G., Taylor, M.J., Lee, M., McGrath, P.A., Davis, K.D., Roberts, S.W. Decreased sensitivity to thermal stimuli in adolescents with autism spectrum disorder: Relation to symptomatology and cognitive ability. J. of Pain, 2015, in press.
Nossin-Manor, R., Card, D., Raybaud, C., Taylor, M.J., Sled, J.G. Cerebral maturation in the early preterm period - A magnetization transfer and diffusion tensor imaging study using voxel-based analysis. Neuroimage, 2015, 112, 30-42.
Stiver M.L., Kamino, D., Guo, T., Thompson, A., Duerden, E.G., Taylor, M.J., Tam, E.W.Y. Maternal postsecondary education associated with improved cerebellar growth after preterm birth. J. of Child Neurology, 2015, in press.
Leung, R.C., Vogan, V.M., Powell, T.L., Anagnostou, E., Taylor, M.J. The role of executive functions in social impairment in ASD. Child Neuropsychology, 2015 in press
Ibrahim, G.M. Morgan, B.R., Doesburg, S.M., Taylor, M.J., Pang, E.W., Rutka, J.T., Snead, O.C. Atypical language laterality is associated with large-scale disruption of network integration in children with medically-intractable localization-related epilepsy. Cortex, 2015; 65C:83-88.
Leung, R.C., Pang, E.W., Cassel, D., Brian J.A., Smith, M.L., Taylor, M.J. Early neural activation during facial affect processing in adolescents with Autism Spectrum Disorder. NeuroImage: Clinical, 2014, 7:203-12.
Powell, T.L., Vogan, V. M., Arsalidou, M., Taylor, M.J. Controlled interference and assessments of developmental working memory capacity: Evidence from the letter and colour matching tasks. Child Development Research, 2014, in press.
Leung, R.C., Ye, A.X., Simeon M. Wong, S.M., Taylor, M.J. Doesburg, S.M. Reduced connectivity during emotional face processing in adolescents with autism. Molecular Autism, 2014, 5(1):51.
Mišić, B., Doesburg, S.M., Fatima, Z., Vidal, J., Vakorin, V.A., Taylor, M.J., McIntosh, A.R. Coordinated information generation and mental flexibility: large-scale network disruption in children with autism. Cerebral Cortex, 2014, Apr 25. [Epub ahead of print]
da Costa, L., Robertson, A., Bethune, A., MacDonald, M.J., Shek, P.N., Taylor, M. J., Pang, E.W. Delayed and disorganized brain activation detected with magnetoencephalography after mild traumatic brain injury. J. Neurology, Neurosurgery & Psychiatry, 2014, Oct 16. doi: 10.1136/jnnp-2014-308571. [Epub ahead of print].
Bangel, K., Batty, M., Ye, A.X., Meaux, E., Taylor, M.J., Doesburg, S.M. Reduced beta band connectivity during number estimation in autism. NeuroImage: Clinical, 2014, 6:202-13.
Vara, A.S., Pang, E.W., Vidal, J., Anagnostou, E., Taylor M.J. Neural mechanisms of inhibitory control continue to mature in adolescence. Developmental Cognitive Neuroscience, 2014, 10:129–139.
Dunkley, B.T., Doesburg, S.M., Sedge, P.A., Grodecki, R.J., Shek, P.N., Pang, E.W., Taylor, M.J. Resting state hippocampal connectivity correlates with symptom severity in post-traumatic stress disorder. Neuroimage: Clinical, 2014, 5:377-384.
Ye, A.X. Leung, R.C., Schäfer, C.B., Taylor, M.J. Doesburg, S.M. Atypical resting coherence in autism spectrum disorder. Human Brain Mapping, 2014, 35(12):6049-66.
Vogan, V.M., Morgan, B.R., Lee, W., Smith, M.L. Taylor, M.J. The neural correlates of working memory in children and adolescents with ASD and the effects cognitive load. J. Neurodevelopmental Disorders, 2014, 6:19.
Pang, E.W., Sedge, P.A., Grodecki, R.J., Robertson, A., MacDonald, M.J., Jetly, R., Shek, P.N., Taylor, M.J. Colour or shape: examination of neural processes underlying mental flexibility in posttraumatic stress disorder. Translational Psychiatry, 2014, 4, e421.
Ibrahim, G.M., Morgan B.R., Lee, W., Smith, M.L. Donner, E., Wang, F., Beers, C., Federic, P., Taylor, M.J., Doesburg, S.M., Rutka, J.T., Snead, O.C.III. Impaired development of intrinsic connectivity networks in children with medically-intractable focal epilepsy. Human Brain Mapping, 2014, 35(11):5686-5700.
Taylor, M.J., Doesburg, S.M., Pang, E.W. Neuromagnetic vistas into typical and atypical development of frontal lobe functions. Frontiers: Human Neuroscience, June 2014, vol 8, article 453.
Ibrahim, G.M. Cassel, D. Morgan, B.R., Smith, M.L., Otsubo, H., Ochi, A., Taylor, M.J., Rutka, J.T., Snead, O.C., Doesburg, S.M. Resilience of developing brain networks to interictal epileptiform discharges is associated with cognitive outcome. Brain, 2014, 137(Pt 10):2690-702.
Schäfer, C.B., Morgan, B.R., Ye, A.X., Taylor, M.J., Doesburg, S.M. Oscillations, networks and their development: MEG connectivity changes with age. Human Brain Mapping, 2014, 35(10):5249-5261.
Todd, R.M., Taylor, M.J., Cassel, D., Robertson, A., Doesburg, S.M., Lee, D.H., Shek, P., Pang, E.W. Attending differently vs. attending more: Temporal-spatial activation patterns and perceptual encoding of affective salience. PLoS One, 2014, 9( 4), e93753.
Mišić, B., Mills, T. Vakorin, V.A., Taylor, M.J., McIntosh, A.R. Developmental trajectory of face processing revealed by integrative dynamics. JoCN, 2014, 26(10):2416-30.
Oh, A., Vidal, J., Taylor, M.J., Pang, E.W. Neuromagnetic correlates of intra- and extra-dimensional set-shifting. Brain & Cognition, 2014, 86 (2014) 90–97.
Meaux, E., Taylor, M.J., Pang, E.W., Vara, A.S., Batty, M. Neural substrates of numerosity estimation in autism. Human Brain Mapping, 2014, 35(9):4362-85.
Vara, A.S., Pang, E.W., Doyle-Thomas, K.A., Vidal, J., Taylor M.J., Anagnostou, E. Is inhibitory control a "No-go" in adolescents with ASD? Molecular Autism, 2014, 5:6.
Duerden EG, Card D, Roberts SW, Mak-Fan KM, Chakravarty MM, Lerch JP, Taylor MJ. Self-injurious behaviours are associated with alterations in the somatosensory system in children with autism spectrum disorders. Brain Structure & Function, 2014, 219(4):1251-61.
Doesburg, S.M., Vidal, J., Taylor, M.J. Reduced connectivity during set-shifting in children with autism. Frontiers: Human Neuroscience, 2013 Nov 14; 7:785.
Taylor, M.J. Structure and function in the premature brain: how to connect? Neuroradiology, 2013, 55(S2):55-64.
Duerden, E.G., Taylor, M.J., Soorya, L., Wang, T., Fan, J., Anagnostou, E. Neural correlates of response inhibition of socially relevant stimuli in adults with autism spectrum disorders. Brain Research, 2013, 1533:80-90.
Lee, W., Morgan, B.R., Shroff, M.M., Sled, J.G., Taylor, M.J. The development of regional functional connectivity in preterm infants into early childhood. Neuroradiology, 2013, 55 Suppl 2:105-11.
Duerden, E.G., Taylor, M.J., Miller, S.P. Brain development in infants born preterm: looking beyond injury. Seminars in Pediatric Neurology, 2013, 20:65-74.
Hopf, L., Quraan, M.A., Cheung, M.J., Taylor, M.J., Ryan, J.D., Moses, S.N. Hippocampal lateralization and memory in children and adults. J. International Neuropsychological Society, 2013, 19(10):1042-52.
Chau ,V., Taylor, M.J., Miller, S.P. Visual function in preterm children: how MR techniques can help see the prognosis better? Documenta Ophthalmologica, 2013, 127 (1) 41-55.
Duerden E.G., Lax, I.D., Card, D., Donner, E.J., Taylor, M.J. Alterations to frontostriatal pathways in children born very preterm. Develop Medicine Child Neurology, 2013 55(10):952-8.
Arsalidou, M., Pascual-Leone J., Johnson J., Morris, D., Taylor, M.J. A balancing act of the brain: Activations and deactivations driven by cognitive load. Brain & Behavior, 2013, 3(3):273-85.
Duerden, E.G. Arsalidou, M., Lee, M., Taylor, M.J. Lateralization of affective processing in the insula. Neuroimage, 2013, 78:159-75
Bayless, S.J., Nagata, Y., Mills, T., Taylor, M.J. MEG measures of covert orienting and gaze processing in children. Brain Topography, 2013, 26(4):616-626.
Card, D., Nossin-Manor, R., Moore, A.M., Raybaud, C., Sled, J.G., Taylor, M.J. Brain metabolite concentrations associated with illness severity scores and white matter abnormalities in very preterm infants. Pediatric Research, 2013, 74(1):75-81.
Arsalidou, M., Agostino, A., Maxwell, S., Taylor, M.J. “I can read these colours” Orthographic manipulations and the development of the colour-word Stroop. Frontiers in Psychology, 2013, 3:594.
Nossin-Manor R., Card, D., Morris, D., Noormohamed, S., Shroff, M.M. Whyte, H.E.A. Taylor, M.J., Sled, J.G. Quantitative MRI in the very preterm brain: Assessing tissue organization and myelination using magnetization transfer, diffusion tensor and T1 imaging. NeuroImage, 2013, 64:505-16.
Lax, I.D., Duerden E.G., Chakravarty, M., Donner, E.J., Lerch, J.P., Taylor, M.J. Neuroanatomical consequences of very preterm birth in middle childhood. Brain Structure & Function, 2013, 218:575–585.
Doyle-Thomas KA, Duerden EG, Taylor MJ, Lerch JP, Soorya LV, Wang AT, Fin J, Hollander E, Anagnostou E. Effects of age and symptomatology on cortical thickness in autism spectrum disorders. Research in Autism Spectrum Disorders. 2013, 7(1):141-150.
Hung, Y., Smith, M.L. Taylor, M.J. Functional dissociation in hippocampal-prefrontal working memory systems. Cortex, 2013, 49:961-967.
Arsalidou, M., Duerden, E.G., Taylor, M.J. The centre of the brain: Topographical model of functions of the basal ganglia. Human Brain Mapping, 2013, 34:3031–3054.
Doyle-Thomas KA, Kushki A, Duerden EG, Taylor MJ, Lerch JP, Soorya LV, Wang AT, Fan J, Anagnostou E. The effect of diagnosis, age, and symptom severity on cortical surface area in the cingulate cortex and insula in Autism Spectrum Disorders. Journal of Child Neurology. 2013, 28(6):729-36.
Mak-Fan, K.M., Morris, D., Vidal, J., Anagnostou, E., Roberts, W., Taylor, M.J. White matter and development in children with an Autism Spectrum Disorder (ASD). Autism, 2013;17(5):541-57.