About Sickkids
About SickKids
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Michael Taylor , MD, PhD, FRCS(C)

The Hospital for Sick Children
Neurosurgeon
Neurosurgery

Research Institute
Principal Investigator
The Arthur and Sonia Labatt Brain Tumour Research Centre

Senior Scientist
Developmental & Stem Cell Biology

University of Toronto
Associate Professor
Departments of Surgery and Laboratory Medicine and Pathobiology


Phone: 416-813-7564 ext. 206427
Fax: 416-813-4975
e-mail: mdtaylor@sickkids.ca

For more information, visit:

Taylor Lab

Brief Biography

Dr. Taylor was born in Calgary, Alberta and was educated at The University of Western Ontario where he obtained his MD in 1994. He entered the University of Toronto Neurosurgery residency program in 1994. He then did a PhD in Molecular Pathology at the University of Toronto (1998-2002), and completed his residency training in 2003. In 2003 Michael was awarded a Detweiler Travelling Fellowship from the Royal College of Physicians and Surgeons of Canada for fellowship training in paediatric neurosurgery and paediatric neuro-oncology at St. Jude Children’s Research Hospital in Memphis Tennessee. Dr. Taylor also did a post-doctoral fellowship in the Department of Developmental Neurobiology at SJCRH.

Dr. Taylor joined The Hospital for Sick Children (SickKids), Division of Neurosurgery in 2004. He has an appointment in the Developmental & Stem Cell Biology Program at the SickKids Research Institute. He is a principal investigator at the Arthur and Sonia Labatt Brain Tumour Research Centre. He also has cross-appointments to the Departments of Surgery & Laboratory Medicine and Pathobiology at the University of Toronto. His research is supported by the Canadian Institutes of Health Research (CIHR), Genome Canada, National Cancer Institute of Canada, National Institutes of Health (USA), American Brain Tumor Association  and SickKids Foundation. He has published close to 100 peer reviewed publications. Dr. Taylor’s laboratory focuses on the genetics of paediatric medulloblastoma and ependymoma. Clinically, he has a special interest in paediatric neuro-oncology. 

Clinical Care Activities

Dr. Taylor is a paediatric neurosurgeon at SickKids. He does general paediatric neurosurgery, with a special focus on paediatric neuro-oncology.

Research Interests

Dr. Taylor is interested in the molecular genetics of medulloblastoma and ependymoma, two of the most common malignant paediatric brain tumours. Through a better understanding of the molecular biology of these tumours, we hope to devise novel, more effective treatment strategies.

Research Activities

The Taylor laboratory focuses on:

  1. Identification and characterization of mutations in established paediatric medulloblastomas.
  2. Using tools from functional genomics to determine how a normal cerebellar cell can be turned into a medulloblastoma cell.
  3. Identification and characterization of the mutations in established paediatric ependymomas.
  4. Using tools from functional genomics to determine how a normal radial glial cell can be turned into an ependymoma cell.

External Funding

  • Canadian Institutes of Health Research
  • Genome Canada
  • National Cancer Institute of Canada
  • National Institutes of Health - USA
  • SickKids Foundation
  • American Brain Tumor Association
  • B.R.A.I.N.child

Achievements

  • 2011 - George-Armstrong Peters Research Award for Research Excellence in Surgery
  • 2010 - Canadian Institutes for Health Research: Clinician Scientist Award: Phase II
  • 2010 - Gold Medal in Surgery - Royal College of Physicians and Surgeons of Canada
  • 2009 - Young Investigator Award in Biomedical Science - Canadian Cancer Society
  • 2008 - Canada's Top 40 Under 40 - Caldwell Partners
  • 2008 - Bernard Langer Surgeon-Scientist Award - University of Toronto
  • 2007 - Sontag Foundation Distinguished Scholar Award, USA 
  • 2005 - Schweizguth Prize - International Society of Paediatric Oncology (SIOP), Great Britain
  • 2004 - Paediatric Brain Tumor Foundation Award - Society for Neuro-Oncology, USA
  • 2004 - Best Individual Investigator Award - AANS/CNS Brain Tumor Satellite Symposium
  • 2004 - Peter A. Steck Memorial Award - M.D. Anderson Cancer Institute, USA
  • 2003 - Detweiler Traveling Fellowship Research Award - Royal College of Physicians and Surgeons of Canada
  • 2003 - Brainstar Award - Canadian Institutes of Health Research
  • 2002 - First Prize - The Gallie-Bateman Resident Research Award
  • 2002 - K.G. McKenzie Memorial Prize For Basic Science Neurosurgical Research

Publications

For a complete list of publications, please see PubMed

Mack SC, Witt H, Wang X, Milde T, Yao Y, Bertrand KC, Korshunov A, Pfister SM, Taylor MD. (2013) Emerging insights into the ependymoma epigenome. Brain Pathology. 23(2):206-9.

Dubuc AM, Remke M, Korshunov A, Northcott PA, Zhan SH, Mendez-Lago M, Kool M, Jones DT, Unterberger A, Morrissy AS, Shih D, Peacock J, Ramaswamy V, Rolider A, Wang X, Witt H, Hielscher T, Hawkins C, Vibhakar R, Croul S, Rutka JT, Weiss WA, Jones SJ, Eberhart CG, Marra MA, Pfister SM, Taylor MD. (2013) Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathologica. 125(3):373-84.

Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD. (2012) Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 488(7409):49-56.

Northcott PA, Korshunov A, Pfister SM, Taylor MD. (2012) The clinical implications of medulloblastoma subgroups. Nature Reviews: Neurology. 8(6):340-51.

Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov A, Li XN, Scherer SW, Cho YJ, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA, Largaespada DA, Collier LS, Taylor MD. (2012) Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature. 482(7386):529-33.

Ramaswamy V, Northcott PA, Taylor MD. (2011) FISH and chips: the recipe for improved prognostication and outcomes for children with medulloblastoma. Cancer Genetics. 204(11):577-88.

Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M, Jones DT, Northcott PA, Garzia L, Bertrand KC, Wittmann A, Yao Y, Roberts SS, Massimi L, Van Meter T, Weiss WA, Gupta N, Grajkowska W, Lach B, Cho YJ, von Deimling A, Kulozik AE, Witt O, Bader GD, Hawkins CE, Tabori U, Guha A, Rutka JT, Lichter P, Korshunov A, Taylor MD, Pfister SM. (2011) Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell. 20(2):143-57.

Northcott PA, Hielscher T, Dubuc A, Mack S, Shih D, Remke M, Al-Halabi H, Albrecht S, Jabado N, Eberhart CG, Grajkowska W, Weiss WA, Clifford SC, Bouffet E, Rutka JT, Korshunov A, Pfister S, Taylor MD. (2011) Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathologica. 122(2):231-40.

Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD. (2009) The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Research. 69(8):3249-55.

Northcott PA, Nakahara Y, Wu X, Feuk L, Ellison DW, Croul S, Mack S, Kongkham PN, Peacock J, Dubuc A, Ra YS, Zilberberg K, McLeod J, Scherer SW, Sunil Rao J, Eberhart CG, Grajkowska W, Gillespie Y, Lach B, Grundy R, Pollack IF, Hamilton RL, Van Meter T, Carlotti CG, Boop F, Bigner D, Gilbertson RJ, Rutka JT, Taylor MD. (2009) Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nature Genetics. 41(4):465-72.

Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdaleno S, Dalton J, Calabrese C, Board J, Macdonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. (2005) Radial glial cells are candidate stem cells of ependymoma. Cancer Cell. 8(4), 323-335

Taylor MD, Zhang X, Liu L, Hui CC, Mainprize TG, Scherer SW, Wainwright B, Hogg D, Rutka JT. (2004) Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. Oncogene. 23(26):4577-83. 

Taylor MD
, Liu L, Raffel C, Hui CC, Mainprize TG, Agatep R, Chiappa S, Zhang X, Gao L, Lowrance A, Hao A, Goldstein A, Stavrou T, Scherer SW, Dura WT, Wainwright B, Rutka JT, Hogg D. (2002) Mutations of suppressor of fused predispose to medulloblastoma. Nature Genetics. 31(3): 306-310.