About Sickkids
About SickKids
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Uri Tabori , MD

The Hospital for Sick Children
Staff Oncologist
Haematology/Oncology

Research Institute
Scientist
Genetics & Genome Biology

Principal Investigator
The Arthur and Sonia Labatt Brain Tumour Research Centre

University of Toronto
Assistant Professor
Paediatrics

Assistant Professor
Institute of Medical Sciences


Phone: 416-813-7654 ext. 1503
Fax: 416-813-8024
e-mail: uri.tabori@sickkids.ca

For more information, visit:

Tabori Lab

Brief Biography

2003-2006 - Research and Clinical Fellowship. The Hospital for Sick Children, Toronto, Canada.
2002-2003 - Staff, Pediatric Hematology and Oncology. The Chaim Sheba Medical Center, Tel-Hashomer and Sourasky Medical Center, Tel-Aviv, Israel

2002 - Passed, in excellence, the Israeli Pediatric Hematology and Oncology Board Examination. Registered specialist in Pediatric Hematology and Oncology.

1999 - 2002 - Fellowship, Pediatric Hematology and Oncology. The Chaim Sheba Medical Center, Tel-Hashomer, Israel.

1999 - Passed, in excellence, the Israeli Pediatrics Board Examination. Registered Specialist in Pediatrics.

1995 - 1999 - Residency, Department of Pediatrics, Sorasky Medical Center, Tel-Aviv, Israel.

1994 - 1995 - Rotating Internship, Sorasky Medical Center, Tel-Aviv, Israel.

1987 - 1993 - Hadassah School of Medicine, Hebrew University, Jerusalem, Israel. Degree of MD.

Clinical Care Activities

Dr. Uri Tabori maintains an active clinical practice in the treatment of children with cancer, focusing particularly on those with brain tumours. Based on his clinical and research interests, he participates in the development of systems for early detection and intervention in individuals determined to be at high-risk of developing brain tumours. This includes patients with neurofibromatosis type 1 and 2, Li-Fraumeni syndrome and mismatch repair genes.

Research Interests

1) The role of telomere maintenance in paediatric neuronal tumours. In collaboration with other laboratories in the Brain Tumour Research Centre (BTRC) and the Research Institute, Dr. Tabori’s laboratory is examining the role of telomerase inhibition in glioma and neuroblastoma stem cells.

2) Uncovering the mechanisms that govern the spontaneous growth arrest of paediatric low grade gliomas. Dr. Tabori’s laboratory is investigating the pathways that control this unique phenomenon. Understanding the phenotype of these fascinating tumours will enable us to potentially reverse the high-grade tumours into treatable ones.

3) The role of radioresistance and sensitivity in determining survival and long-term radiation side effects in children with brain tumours. Using novel techniques to measure radiation response in tumour and blood cells from patients and in collaboration with the SickKids neuropsychological team, Dr. Tabori hopes to determine which tumours will be resistant to radiation therapy and which patients are specifically sensitive to radiation and will need dose modifications to avoid the severe long-term neuro-cognitive effects.

4) The genetic profile of paediatric gliomas. Dr. Tabori’s laboratory is investigating the role of several tumour suppressor genes, in which germline mutations predispose these children to early onset brain tumours, in brain tumour initiation and progression.

External Funding

The Terry New Investigator Award
Exhaustion of tumor initiating cells by targeting their self‐renewal capacity with telomerase inhibition.

The comprehensive cancer centre
Determination of the extent and role of monoallelic gene expression in low and high grade brain tumours.
Tabori U., Malkin D.

B.r.a.i.n.child Canada
1. Prediction of tumour resistance and normal brain sensitivity to cranial irradiation in paediatric brain tumours. Tabori U.

2. Genetic determinants of predisposition to childhood brain tumour initiation and progression. Tabori U., Malkin D.

3. Establishment of a comprehensive genetic bank for children with brain tumours. Tabori U.

Ontario Institute of Cancer Research
Combined telomerase inhibition and drug screen as novel therapies for tumour initiating cells in paediatric nervous system tumours. Tabori U., Dirks P.B., Kaplan D.

Pediatric Brain Tumour Foundation U.S.A
Predictors of functional and neuro-cognitive outcomes in long term survivors of paediatric low-grade gliomas.
Tabori U., Mabbott D., Rubin J.

Canadian Institutes for Health Research
Prognostic and therapeutic implications for telomere maintenance and telomerase inhibition in paediatric high-grade gliomas.
Tabori U.

The Brain Tumor Society
The biologic and prognostic role of replicative and oncogene induced senescence in paediatric low grade gliomas.
Tabori U., Jabado N., Macdonald T., Hawkins C.

Achievements

2010-2014
Canadian Institute of Health Research, New Investigator Award

2010-2013 
The Terry Fox Foundation, New investigator Award.

2010 
Eureka! International course of translational medicine (awarded for new investigators), Sicily, Italy

2006
1st Prize, 18th Annual Pediatric Resident/Fellow Research Competition. Winnipeg, Manitoba.

3rd Prize, Department of Paediatrics Resident and Fellows Research Day competition, The Hospital for Sick Children

Young investigator award: The Canadian Neuro-Oncology society.

Merit Award, American Society of Clinical Oncology Annual Meeting.

2005
Research for Trainees Competition (RESTRACOMP) Fellowship Award, Research Institute, The Hospital for Sick Children

1st Prize, Department of Paediatrics Resident and Fellows Research Day competition, The Hospital for Sick Children

2004
1st Prize, Department of Paediatrics Resident and Fellows Research Day competition, The Hospital for Sick Children

Scholar-in-Training Award, American Association for Cancer Research, Special Conference: The Role of Telomeres and Telomerase in Cancer.

2003-2005
Research Fellowship (Salary Award), Canadian Friends of Tel Aviv University/The Hospital for Sick Children Medical Exchange Program

Publications

A list of Dr.Uri Tabori's peer reviewed publications is available on pubmed »»