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About Sickkids
About SickKids

Jiri Vajsar, MD, MSc, FRCP (C)

The Hospital for Sick Children
Clinical Director

Research Institute
Project Director
Neurosciences & Mental Health

University of Toronto
Associate Professor, Neurology

Phone: 416-813-5668
Fax: 416-813-6334
Email: jiri.vajsar@sickkids.ca

Brief Biography

Areas of Specialty:

Neuromuscular disorders

Having completed his MSc program in neurophysiology at the University of Ottawa and then his postgraduate training at the University of Toronto, Dr. Vajsar joined the Division of Neurology at SickKids in 1993. Dr. Vajsar is involved in ongoing neuromuscular research projects and also collaborates on patient management for peripheral nerve and brachial plexis and is the director of the EMG Laboratory at SickKids.

Academic Background

Fellowship, Child Neurology
Children's Hospital of Eastern Ontario, University of Ottawa

Fellowship, Neurophysiology
Children's Hospital of Eastern Ontario, University of Ottawa

Research Interests

Clinical aspects of neuromuscular diseases

Research Activities

A) Autoimmune neuromuscular disorders:

  1. Development of novel treatment strategies in acute and chronic inflammatory demyelinating polyneuropathies.
  2. Evaluation of long-term outcome of children with Guillain-Barre syndrome.
  3. Investigations in the use of new laboratory techniques in the diagnosis of acute and chronic inflammatory polyneuropathies. (e.g. somatosensory evoked potentials, electromyography and MRI).
  4. Development of novel treatment strategies in the treatment of polymyositis and juvenile myasthenia gravis.

B) Research in myopathies and muscular dystrophies:

  1. Ultrastructural characterization of myopathies and muscular dystrophies using immunolabelling techniques and clinical correlations based on the results of the ultrastructural studies.
  2. Therapeutic studies: Randomized, double-blinded, crossover trial in the use of creatine monohydrate in the treatment of muscular dystrophies.

Future Research Interests

  1. development of novel therapeutic strategies in neuromuscular disorders
  2. characterization, etiology and diagnosis of degenerative diseases of muscle and nerve


Award for Distinguished Lecturers. South Korean Child Neurology Association. 1994

Nominated for: Department of Pediatrics Award for Clinical Excellence. 1998

Clinical Care Activities

Treatment of autoimmune neuromuscular disorders with continuing interest in the diagnosis and treatment of children with degenerative muscle and nerve disease.


Jay V, Vajsar J: The dystrophy of Duchenne. Lancet 2000: 357: pp 550-552.

Jay V, Vajsar J,: Immunohistochemistry in the diagnosis of muscular dystrophy. American Society of Clinical Pathologists. Surgical Pathology II 2000: 24: pp 69-85.

Kolski H, Vajsar J, Kim PCW: Thorasoscopic thymectomy in juvenile myasthenia gravis. Journal of Pediatric Surgery 2000: 35: pp 768-770.

Mullaney P, Vajsar J, Smith R, Buncic J: The natural history and ophthalmic involvement in childhood myasthenia gravis at The Hospital for Sick Children. Ophthalmology 2000: 107: pp 504-510.

Vajsar J, Ackerley C, Chitayat DA, Becker LE: Basal lamina abnormality in the skeletal muscle of Walker-Warburg syndrome. Pediatric Neurology 2000: 22: pp 139-143.

Kolski H, Vajsar J, Kim P: Video-assisted thoracoscopic thymectomy in juvenile myasthenia gravis. Journal of Child Neurology 2001: 16: pp 569-573.

Sine SM, Shen X-M, Wang H-L, Ohno K, Lee, W-Y, Tsujino A, Brengmann J, Bren N, Vajsar J, Engel AG: Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating. Journal of General Physiology 2002: 120: pp 483-496.