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About Sickkids
About SickKids

Zulfikarali Verjee, Ph.D., D. Clin. Chem, FCACB

The Hospital for Sick Children
Clinical Biochemist
Clinical Biochemistry

University of Toronto
Assistant Professor
Department of Laboratory Medicine and Pathobiology


Phone: 416-813-5910
Fax: 416-813-6257
Email: zulfikarali.verjee@sickkids.ca

Research Interests

  • Therapeutic Drug Monitoring in Paediatrics
  • Measurement of Free Drugs in Body Fluids
  • Drug levels in Breast Milk: Analysis and Interpretation
  • Screening for Drug Overdose and Adverse Reaction in Emergency Toxicology with particular reference to Drugs of Abuse, Date Rape Drugs and some Herbal medication
  • Advances in Analytical Methods for Immunosuppressive Drugs, azathiopurine metabolites and new anticonvulsants

Research Activities

Research and Development activities are centered around the new approaches to Therapeutic Drug Monitoring of Immunosuppressive Drugs cyclosporine, tacrolimus, sirolimus and mycophenolic acid using the Tandem Mass Spectrometry.

Future applications of Tandem Mass Spectrometry to screening for drug overdoses in Emergency Medicine

High Pressure Liquid Chromatography methods for the quantitation of Azathioprine and metabolites in patients with Inflammatory Bowel Disease

Immuoassay: Issues related to Cross reactivities, misdiagnoses and interpretation

Identification of unknown compounds by routine HPLC methods.

Publications

Myla E. Moretti, Michael Sgro, David W. Johnson, Reg S. Sauve, Mary J. Woolgar,Anna Tadio, Zul Verjee, Esther Giesbrecht, Gideon Koren and Shinya Ito. Cyclosporine excretion into breast milk Transplantation, 75, 2144-2146, 2003

Steven J. Soldin, Edward Wang, Zulfikarali Verjee Ronald J.Elim Phenytoin Overview-metabolite Interference in Some Immunoassays could be clinically important: Results of a College of American Pathologists Study. Archives of Pathology and Laboratory Medicine, 127, 1623-1625, 2003

Eran Kozer, Zul Verjee, Svetlana Emelianova and Gideon Koren. A patient with seizures and a positive drug screen: Three wrongs don’t make a right The Canadian Journal of Clinical Pharmacology, 10, 63-66, 2003

Eran Kozer, Dennis Scolnik, Whitty M. Agamata, Shelly K. Weiss, Zulfikarali H. Verjee and Gideon Koren Utility of Antiepileptic Drug Monitoring in the Pediatric Emergency Department. Therapeutic Drug Monitoring, 25, 17-21, 2003

Myla E. Moretti, Gideon Koren, Zulfikarali Verjee and Shinya Ito. Monitoring Lithium in Breast Milk: An individualized Approach for breast-feeding mothers Therapeutic Drug Monitoring, 25, 364-366, 2003

Sylvie Lebel, Yoshiko Nakamachi, Alan Hemming, Zul Verjee, M.James Phillips, and Katryn Furuya Glycine Conjugation of Para Aminobenzoic Acid (PABA): A pilot study of a novel Prognostic test in acute liver failure in children Journal of Pediatric Gastroenterology and Nutrition, 36, 62-71, 2003