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About Sickkids
About SickKids

Anne Wheeler, PhD

Research Institute
Scientist
Neurosciences & Mental Health


Phone: 416-813-7654 ext. 309585
Email: anne.wheeler@sickkids.ca

For more information, visit:

The TBI Neuroimaging Lab

Brief Biography

Dr. Anne Wheeler completed her PhD in the Institute of Medical Science at the University of Toronto, where she focused on structural and functional imaging in the rodent brain, combining the mapping of brain networks with behavioural analysis. This was followed by a postdoctoral fellowship at the Centre for Addiction and Mental Health (CAMH) where she employed magnetic resonance brain imaging (MRI) to investigate network-based neuroimaging biomarkers in psychiatric disorders. She joined SickKids in 2015 as the new Catalyst Scholar in traumatic brain injury (TBI).

Research Interests

  • Circuits that support cognition in the healthy and injured brain
  • Neuroimaging based biomarkers in paediatric TBI
  • Vulnerable periods of neurodevelopment

Research Activities

Dr. Anne Wheeler is using brain imaging in patient populations and mouse models to look for biomarkers of TBI in order to identify brain damage, inform prognosis and monitor which treatments work. MRI based biomarkers, especially those derived from recent advanced acquisition methods, are able to detect subtle microscopic alterations in the brain. Wheeler’s research involves acquiring structural and functional longitudinal neuroimaging in a paediatric sample and the application of advanced processing and network analysis methods with the goal of identifying biomarkers that can function in a personalized medicine approach. These neuroimaging biomarkers will be combined with blood-based biomarkers and validated in animal models.

External Funding

  • 2013 NARSAD Young Investigator Grant, Brain and Behavior Research Foundation

Publications

Wheeler AL, Felsky D, Viviano JD, Stojanovski S, Ameis SH, Szatmari P, Lerch JP, Chakravarty MM, Voineskos AN (2017) “BDNF Dependent Effects on Amygdala-Cortical Circuitry and Depression Risk in Children and Youth” Cerebral Cortex Apr 6:1-11.
 
Nazeri A, Mulsant BH, Rajji TK, Levesque ML, Pipitone J, Stefanik L, Shahab S, Roostaei T, Wheeler AL, Chavez S, Voineskos AN (2016) “Gray Matter Neuritic Microstructure Deficits in Schizophrenia and Bipolar Disorder” Biological Psychiatry 2016 Dec 8. pii: S0006-3223(16)33066-9.
 
Voineskos AN, Felsky D, Wheeler AL, Rotenberg DJ, Szeszko P, Kennedy JL, Lencz T, Malhotra AK (2016) “Limited Evidence for Association of Genome-Wide Schizophrenia Risk Variants on Cortical Neuroimaging Phenotypes” Schizophrenia Bulletin Jul;42(4):1027-36.
 
Behdinan T, Foussias G, Wheeler AL, Stefanik L, Felsky D, Remington G, Rajji TK, Chakravarty MM, Voineskos AN (2015) “Neuroimaging Predictors of Functional Outcomes in Schizophrenia at Baseline and 6 month Follow-Up” Schizophrenia Research Dec;169(1-3):69-75.

Wheeler AL, Wessa M, Szeszko PR, Foussias G, Chakravarty MM, Lerch JP, DeRosse P,  Remington G, Mulsant BH, Linke J, Malhotra AK, Voineskos AN (2015) “Further Neuroimaging Evidence for the Deficit Subtype of Schizophrenia: A Cortical Connectomics Analysis” JAMA Psychiatry May 1;72(5):446-55.

Wheeler AL, Chakravarty MM, Lerch JP, Pipitone J, Daskalakis ZJ, Rajji TK, Mulsant BH, Voineskos AN (2014) “Disruption of prefrontal interhemisphereic structural coupling in schizophrenia related to working memory performance” Schizophrenia Bulletin Jul;40(4):914-24.

Wheeler AL, Creed MC, Voineskos AN, Nobrega JN (2014) “Changes in brain functional connectivity after chronic haloperidol in rats: a network analysis” International Journal of Neuropsychopharmacology Aug;17(8):1129-38.

Wheeler AL, Voineskos AN (2014) “A review of structural neuroimaging in schizophrenia: from connectivity to connectomics.” Frontiers in Human Neuroscience Aug 25;8:653.

Akers KG, Martinez-Canabal A, Restivo L, Yiu AP, De Cristofaro A, Hsiang H-L, Wheeler AL, Guskjolen A, Niibori Y, Shoji H, Ohira K, Richards BA, Miyakawa T, Josselyn SA, Frankland PW (2014) “Hippocampal neurogenesis regulates forgetting during adulthood and infancy” Science May 9;344(6184):598-602.

Ameis SH, Ducharme S, Albaugh MD, Hudziak JJ, Botteron KN, Lepage C, Zhao L, Khundrakpam B, Collins L, Lerch JP, Wheeler AL, Schachar R, Evans AC, Karama S (2014). “Cortical thickness, cortico-amygdalar networks, and externalizing behaviors in healthy children” Biological Psychiatry Jan 1;75(1):65-72.

Hamani C, Amorim B, Wheeler AL, Diwan M, Driesslein K, Diwan M, Covolan L, Butson C, Nobrega JN (2014) “Deep brain stimulation in rats: Different targets induce similar antidepressant-like effects but influence different circuits.” Neurobiology of Disease Aug 13;71C:205-214.

Wheeler AL, Lerch JP, Chakravarty M, Friedel M, Sled JG, Fletcher P, Josselyn SA, Frankland PW (2013) “Adolescent cocaine exposure causes enduring macroscale changes in mouse brain structure” Journal of Neuroscience 33(5):1797-1803.

Wheeler AL, Teixeira CM, Wang AH,, Xiong X, Lerch JP, McIntosh AR, Parkinson J, Frankland PW (2013) “Identification of a functional network for long-term fear memory in mice” PLoS Computational Biology (9(1): e1002853. doi:10.1371/journal.pcbi.1002853.

Turnbull J, Tiberia E, Pereira S, Zhao X, Pencea N, Wheeler AL, Yu WQ, Ivovic A, Naranian T, Israelian N, Draginov A, Piliguian M, Frankland PW, Wang P, Ackerley CA, Giacca A, Minassian BA (2013) “Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance”. Journal of Biological Chemistry Nov 29;88(48):34627-37.

Martinez-Canabal A, Wheeler AL, Sarkis D, Lerch JP, Lu W-Y, Buckwalter M, Wyss-Coray T, Josselyn SA, and Frankland PW (2013) "Chronic over-expression of TGF-B1 alters hippocampal structure and causes learning deficits" Hippocampus Dec;23(12):1198-211.

Stone SS, Teixeira CM, Zaslavsky K, Wheeler AL, Martinez-Canabal A, Wang AH, Sakaguchi M, Lozano AM, Frankland PW (2011) “Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory” Hippocampus 21(12):1348-62.
Wang SH, Teixeira CM, Wheeler AL, Frankland PW. (2009) “The precision of remote context memories does not require the hippocampus.” Nature Neuroscience 12(3):253-5.