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About Sickkids
About SickKids

Rosanna Weksberg, MD, PhD

The Hospital for Sick Children
Staff Physician
Clinical and Metabolic Genetics

Co-director and Staff Geneticist
Cancer Genetics Program

Research Institute
Senior Associate Scientist
Genetics & Genome Biology

University of Toronto
Molecular and Medical Genetics


Phone: 416-813-6386
Email: rweksb@sickkids.ca

For more information, visit:

Weksberg Lab
Cancer Genetics Program

Brief Biography

Dr. Rosanna Weksberg is actively involved in many University of Toronto and national initiatives in genetics and epigenetics. Her research interfaces between clinical genetics assessments on patients and molecular genetic approaches to understanding imprinting and epigenetic lesions in the development of genetic syndromes and sporadic cancers.

Research Interests

  • Genomic imprinting
  • Overgrowth syndromes
  • Epigenetics
  • Assisted Reproductive Technologies

Research Activities

Epigenetics, Genomic Imprinting and Human Disease . Weksberg's research program centres on the epigenetic analysis of individuals with growth and neurodevelopmental disorders, such as Beckwith-Wiedemann syndrome (BWS), intrauterine growth restriction (IUGR) and Autism. Her team has recently utilized tissues of uniparental origin to identify new human imprinted genes. Their investigation of chromosome 11p15 in BWS patients has demonstrated that single locus imprinting alterations are associated with genome-wide epigenetic alterations.  Further, such genome-wide disruptions of epigenetic regulation are enhanced following infertility and the use of assisted reproductive technologies (ART). The mechanisms underpinning this observation are currently being explored in the lab.   


For a detailed list of Dr. Weksberg's publications, please visit PubMed.