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About Sickkids
About SickKids

Thomas Walters, MBBS, MSc, FRACP

The Hospital for Sick Children
Staff Gastroenterologist
Gastroenterology, Hepatology and Nutrition

Research Institute
Project Investigator
Research Institute

University of Toronto
Assistant Professor
Paediatrics


Phone: 416-813-7734
Fax: 416-813-6531
Email: thomas.walters@sickkids.ca
Alternate Contact: Suzanne Shek
Alternate Email: suzanne.shek@sickkids.ca

Brief Biography

Graduated from medicine at the University of Western Australia, Dr. Walters completed his training in Paediatric Gastroenterology at the Hospital for Sick Children, University of Toronto, with a fellowship in Paediatric Inflammatory Bowel Disease and post-graduate training in Clinical Epidemiology.  Currently Co-Director of the SickKids’ Paediatric Inflammatory Bowel Diseases Programme in Toronto, he has a broad range of clinical research interests related to the aetiology, manifestations and outcomes in children and adolescents with IBD.  He has extensive experience in developing data management systems and collection platforms; and is the founding Director of the Data Co-ordinating Centre for both PRO-KIIDS, a multi-centre Paediatric IBD Research Network fully funded by the Crohns and Colitis Foundation of America, NEOPICS, an international collaborative originating from SickKids Toronto investigating IBD in the very young, and IMAGEKIDS, an international multi-centre study developing standardized reporting tools for MR enterography in Paediatric IBD.

Areas of Specialty

Dr. Walters’s subspecialty interest is paediatric inflammatory bowel disease.  He also maintains a broad interest and experience in paediatric gastroenterology and endoscopy.

Research Interests

Dr. Walters’s clinical research interests are broadly focused around the inflammatory bowel diseases, particularly on projects related to phenotyping, genetics and longitudinal therapeutic outcomes.  He is a recognized expert in the analysis of growth impairment related to IBD.   His combined background in clinical epidemiology, biostatistics, database design and management has resulted in him leading the development of a number of data platforms in North America and internationally that support numerous ongoing multicenter clinical research endeavours in Paediatric IBD.  He is the founding and ongoing Director of the Data Co-ordinating Centre for the recently established Canadian Children Inflammatory Bowel Diseases Network: A Joint partnership with CIHR and the CHiLD Foundation.

Publications

For a complete list of publications, please see PubMed

Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs an immunomodulator in children with Crohn's disease. (2014) Walters TD, Kim M, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, Leleiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS. Gastroenterology. 146 (2): 383-391.

Infliximab-induced psoriasis and psoriasiform skin lesions in pediatric Crohn disease and a potential association with IL-23 receptor polymorphisms. (2013) Sherlock ME, Walters TD, Tabbers MM, Frost K, Zachos M, Muise A, Pope E, Griffiths AM. Journal of Pediatric Gastroenterology and Nutrition. 56 (5): 512-518.

MR enterography in children: Principles, technique, and clinical applications. (2013) Chavhan GB, Babyn PS, Walters TD. The Indian Journal of Radiology and Imaging. 23 (2): 173-178.

IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. (2013) Moran CJ, Walters TD, Guo CH, Kugathasan S, Klein C, Turner D, Wolters VM, Bandsma RH, Mouzaki M, Zachos M, NEOPICS, Langer JC, Cutz E, Benseler SM, Roifman CM, Silverberg MS, Griffiths AM, Snapper SB, Muise AM. Inflammatory Bowel Diseases. 19 (1): 115-123.

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. (2012) Muise AM, Xu W, Guo CH, Walters TD, Wolters VM, Fattouh R, Lam GY, Hu P, Murchie R, Sherlock M, Gana JC, NEOPICS, Russell RK, Glogauer M, Duerr RH, Cho JH, Lees CW, Satsangi J, Wilson DC, Paterson AD, Griffiths AM, Silverberg MS, Brumell JH. Gut. 61(7): 1028-1035.

Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis. (2011) Muise AM, Walters TD, Xu W, Shen-Tu G, Guo CH, Fattouh R, Lam GY, Wolters VM, Bennitz J, van Limbergen J, Renbaum P, Kasirer Y, Ngan BY, Turner D, Denson LA, Sherman PM, Duerr RH, Cho J, Lees CW, Satsangi J, Wilson DC, Paterson AD, Griffiths AM, Glogauer M, Silverberg MS, Brumell JH. Gastroenterology. 141(2): 633-641.

Validating Crohn's disease activity indices for use in assessing postoperative recurrence. (2011) Walters TD, Steinhart AH, Bernstein CN, Tremaine W, McKenzie M, Wolff BG, McLeod RS.  
Inflammatory Bowel Diseases. 17(7): 1547-1556.

Assessment of knowledge in adolescents with inflammatory bowel disease using a novel transition tool. (2011) Benchimol EI, Walters TD, Kaufman M, Frost K, Fiedler K, Chinea Z, Zachos M. Inflammatory Bowel Disease. 17(5): 1131-1137.

Primary prophylaxis of variceal hemorrhage in children with portal hypertension: a framework for future research. (2011) Ling SC, Walters TD, McKiernan P, Schwarz K, Garcia-Tsao G, Shneider B. Journal of Pediatric Gastroenterology and Nutrition. 52(3): 254-261.

Safety and efficacy of maintenance infliximab therapy for moderate-to-severe Crohn's disease in children: REACH open-label extension. (2011) Hyams J, Walters TD, Crandall W, Kugathasan S, Griffiths A, Blank M, Johanns J, Lang Y, Markowitz J, Cohen S, Winter H, Veereman-Wauters G, Ferry G, Baldassano R. Current Medical Research and Opinion. 27(3): 651-662.