Facebook Pixel Code
About Sickkids
About SickKids

Lars Grosse-Wortmann, MD

The Hospital for Sick Children
Staff Cardiologist

Section Head, Cardiovascular Magnetic Resonance

University of Toronto

Phone: 416-813-7654 x 207308
Fax: (416) 813-7547
Email: lars.grosse-wortmann@sickkids.ca
Alternate Contact: Sue Morton
Alternate Phone: 416-813-7654 x 202459
Alternate Email: sue.morton@sickkids.ca

For more information, visit:

The Labatt Family Heart Centre

Brief Biography

Dr. Grosse-Wortmann received his medical degree from the University of Würzburg in Germany. Following training in pediatric cardiology in Aachen (Germany) and at the Hospital for Sick Children, he completed a two year clinical and research fellowship in cardiovascular MR, also in Toronto. He accepted a staff cardiologist position at Sickkids in 2008, and has been the Section Head of the Cardiovascular MR service since 2012. His clinical areas of expertise include echocardiography, the cardiology inpatient service, and his outpatient clinic. Dr. Grosse-Wortmann leads the connective tissue disorder clinic at SickKids. He is a Professor of Paediatrics with the University of Toronto. His research focuses on myocardial tissue characterization using imaging, heart muscle disorders as well as the pulmonary circulation in congenital heart disease. Outside of work, Grosse-Wortmann shares his love for the outdoors with his wife and two boys and enjoys tennis, canoeing, mountain-biking, and rock-climbing.

Clinical Care Activities

  • Magnetic Resonance Imaging
  • Echocardiography
  • General Cardiology
  • Outpatient Cardiology
  • Connective Tissue Disorder Clinic

Research Interests

  • Outcomes after congenital heart defect surgery
  • Cardiomyopathies
  • Myocardial tissue characterization
  • Myocardial mechanics
  • Pulmonary blood flow


Selected Peer-Reviewed Articles

  1. Kato A, Drolet C, Yoo SJ, Redington AN, Grosse-Wortmann L. Vicious circle between the progressive right ventricular dilatation and pulmonary regurgitation in patients after tetralogy of Fallot repair? Right heart enlargement promotes flow reversal in the left pulmonary artery. Journal of Cardiovascular Magnetic Resonance 2016: 18 (1): pp 34.
  2. Morgan CT, Mertens L, Grotenhuis H, Yoo SJ, Seed M, Grosse-Wortmann L. Understanding the mechanism for branch pulmonary artery stenosis after the arterial switch operation for transposition of the great arteries. European Heart Journal of Cardiovascular Imaging 2016: Epub March 2016.
  3. Riesenkampff E, Chen CK, Kantor PF, Greenway S, Chaturvedi RR, Yoo SJ, Greiser A, Dipchand AI, Grosse-Wortmann L. Diffuse myocardial fibrosis in children after heart transplantations: a magnetic resonance T1 mapping study. Transplantation 2015: 99 (12): pp 2656-2662.
  4. Etoom Y, Govindapillai S, Hamilton R, Manlhiot C, Yoo SJ, Farhan M, Sarikouch S, Peters B, McCrindle B, Grosse-Wortmann L. Importance of CMR within the task force criteria for the diagnosis of ARVC in children and adolescents. Journal of the American College of Cardiology 2015: 65 (10): 987 – 995
  5. Riesenkampff E, Messroghli DR, Redington AN, Grosse-Wortmann L. Myocardial T1 mapping in pediatric and congenital heart disease. Circulation – Cardiovascular Imaging 2015: 8 (2)
  6. Kozak MF, Redington A, Yoo SJ, Seed M, Greiser A, Grosse-Wortmann L. Diffuse myocardial fibrosis following tetralogy of Fallot repair: a T1 mapping cardiac magnetic resonance study. Pediatric Radiology 2014: 44 (4): pp 403-409
  7. Grosse-Wortmann L, Yoo SJ, van Arsdell G, Chetan D, Macdonald C, Benson B, Honjo O. Preoperative Total Pulmonary Blood Flow predicts Right Ventricular Pressure in Patients early after Complete Repair of Tetralogy of Fallot and Pulmonary Atresia with Major Aortopulmonary Collateral Arteries. Journal of Thoracic and Cardiovascular Surgery 2013: 146 (5): pp 1185-1190
  8. Grosse-Wortmann L, Drolet C, Dragulescu A, Kotani Y, Chaturvedi R, Lee KJ, Mertens L, Taylor K, La Rotta G, van Arsdell G, Redington A, Yoo SJ. Determinants and Clinical Significance of Flow via the Fenestration in the Fontan Pathway: A Multimodality Study. International Journal of Cardiology 2013: 168 (2): pp 811-817
  9. Lee W, Yoo SJ, Roche SL, Kantor P, van Arsdell G, Park EA, Redington A, Grosse-Wortmann L.  Determinants and functional impact of restrictive physiology after repair of tetralogy of Fallot: New insights from magnetic resonance imaging.  International Journal of Cardiology 2013: 167 (4): pp 1347-1353
  10. Kozak M, Yoo SJ, Mertens L, Ho A, Grosse-Wortmann L. Assessment of ductal blood flow in newborns with obstructive left heart lesions by cardiovascular magnetic resonance. Journal of Thoracic and Cardiovascular Surgery 2013: 15: pp 45
  11. Grosse-Wortmann L, Drolet C, Dragulescu A, Kotani Y, Chaturvedi R, Lee KJ, Mertens L, Taylor K, La Rotta G, van Arsdell G, Redington A, Yoo SJ. Aortopulmonary collateral flow volume affects early postoperative outcome after Fontan completion: a multimodality study. Journal of Thoracic Cardiovascular Surgery 2012: 144 (6): pp 1329-1336
  12. Meng H, Grosse-Wortmann L. Gadolinium in Pediatric Cardiovascular Magnetic Resonance Imaging: What we know and how we practice. Journal of Cardiovascular Magnetic Resonance 2012: 14 (1): pp 56
  13. Greenway SC, Yoo S-J, Baliulis G, Caldarone C, Coles J, Grosse-Wortmann L. Assessment of pulmonary veins after atrio-pericardial anastomosis by cardiovascular magnetic resonance.  Journal of Cardiovascular Magnetic Resonance 2011: 13 (1): pp 72
  14. Grosse-Wortmann L, Yoo SJ, Solomon M, Macgowan CK, Keshavjee S, Grasemann H. Cardiopulmonary magnetic resonance imaging in children after lung transplantation: Preliminary observations. The Journal of Heart and Lung Transplantation. 2011: 30 (11): pp 1294-1298
  15. Grosse-Wortmann L, Roche SL, Yoo SJ, Seed M, Kantor P.  Early changes in right ventricular function and their clinical consequences in childhood and adolescent dilated cardiomyopathy. Cardiology in the Young 2010: (4): pp 418-425
  16. Grosse-Wortmann L, Al-Otay A, Yoo SJ. Aortopulmonary collaterals after bidirectional cavopulmonary connection or Fontan completion: Quantification with magnetic resonance imaging. Circulation, Cardiovascular Imaging 2009: 2 (3): pp 219-225
  17. Grosse-Wortmann L, Al-Otay A, Goo, HW, Macgowan CK, Coles J, Benson LN, Redington AN, Yoo SJ. Anatomical and functional evaluation of pulmonary veins in children by magnetic resonance imaging. Journal of the American College of Cardiology 2007: 49 (9): pp 993-1002

Book Chapters

  1. Grosse-Wortmann L, Yoo SJ. Anatomic and Functional Assessment of the Pulmonary Circulation. IN: Principles and Practice of Cardiac Magnetic Resonance in Congenital Heart Disease: Form, function and flow (Editors: Mark A. Fogel). Wiley-Blackwell, Malden, Mass, USA 2010: pp 209-235.
  2. Grosse-Wortmann L, Yoo SJ. Functional Evaluation of the Pulmonary Circulation: With special emphasis on Magnetic Resonance Imaging. IN: Congenital Diseases in the Right Heart (Editors: Andrew N. Redington, Glen S. Van Arsdell, Robert H. Anderson). Springer-Verlag, London, UK 2009: pp 65-71.
  3. Grosse-Wortmann L, Lee W, Yoo SJ. Magnetic Resonance Imaging and Computed Tomography. IN: Paediatric Cardiology (Editors: Anderson R, Baker E, Penny D, Redington A, Rigby M, Wernovsky G). Churchill-Livingstone, Philadelphia, PA, USA 2009: pp 363-378.