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About Sickkids
About SickKids

Herman Yeger, PhD

Research Institute
Senior Scientist
Developmental & Stem Cell Biology

University of Toronto
Professor
Laboratory Medicine & Pathobiology


Phone: 416-813-7654 ext. 205958
Fax: 416-813-5974
Email: hermie@sickkids.ca

Research Interests

  • Chemorefractory Neuroblastomas
  • Neuroendocrine tumours
  • Developmental Biology of Cancer
  • Lung development/pulmonary neuroendocrine cell system
  • Cystic Fibrosis
  • Regenerative medicine

Research Activities

  • Modulation of tumour cell growth, differentiation an cancer metabolism with natural inhibitors of cell survival and homeostasis
  • Developmental biology of the neuroendocrine system
  • Pathophysiology of lung and cystic fibrosis
  • Tissue engineering an external ear construct for treatment of microtia

Further Research Interest

  • Cancer stem cells and hypoxic tumour microenvironments

Publications

For a complete list of publications, please see PubMed

Islam SS, Mokhtari RB, Kumar S, Maalouf J, Arab S, Yeger H, Farhat WA. (2013) Spatio-temporal distribution of Smads and role of Smads/TGF-β/BMP-4 in the regulation of mouse bladder organogenesis. PLoS One. 8(4):e61340.

Das B, Kashino SS, Pulu I, Kalita D, Swami V, Yeger H, Felsher DW, Campos-Neto A. (2013) CD271+ bone marrow mesenschymal stem cells may provide a niche for dormant Mycobacterium tuberculosis. Science Translational Medicine. 5(170):170ra13.

Pan J, Yeger H, Ratcliffe P, Bishop T, Cutz E. (2012) Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice. Advances in Experimental Medicine and Biology. 758:149-55.

Cutz E, Pan J, Yeger H, Domnik MJ, Fisher JT. (2012) Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors. Seminar in Cell and Developmental Biology. 21:1084-95.

Kumar, S, Mokhtari RB, Yeger H, Baruchel S. (2012) Preclinical models for pediatric solid tumor drug discovery: current trends, challenges and the scopes for improvement. Expert Opinion on Drug Discovery. 7:1093-106.

Buttigieg J, Pan J, Yeger H, Cutz E. (2012) NOX2 (gp91phox) is a predominat O2 sensor ina human airway chemoreceptor cell line: biochemical, molecular and electrophysiological evidence. American Journal of Physiology - Lung Cellular and Molecular Physiology. 303:L598-607.

Das B, Bayat-Mokhtari R, Tsui M, Lotfi S, Tsuchida R, Felsher DW, Yeger H, (2012) HIF-2a suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells. Stem Cells 30:1685-95.

Antoon R, Yeger H, Loai Y, Islam S, Farhat WA. (2012) Impact of bladder-derived acellular matrix, growth factors, and extracellular matrix constitutents on the survival and multipotency of marrow-derived mesenchymal stem cells. Journal of Biomedical Materials Research Part A. 100:72-83.

Kumar S, Mokhtari RB, Sheikh R, wu B, Zhang L, Xu P, Man S, Dias OI, Yeger H, Kerbel RS, Baruchel S. (2011) Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clinical Cancer Research. 17: 5656-5667.

Smith KM, Datti A, Fujitani M, Grinsgtein N, Zhang L, Mrorozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, Wrana JL, Kaplan DR. (2010) Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Molecular Medicine.  2:371-84.

Loai Y, Yeger H, Coz C, Antoon R, Islam SS, Moore K, Farhat WA. (2010) Bladder tissue engineering: tissue regeneration and neovascularization of HA-VEGF-incorporated bladder acellular constructs in mouse and porcine animal models. Journal of Biomedical Materials Research Part A. 94:1205-15.

Gisselsson D, Mengelbier LH , Ora I , Yeger H, (2010) Genetic bottlenecks and the hazardous game of population reduction in cell line based research. Experimental Cell Research. 316:3379-86.

Intellectual Property

Novel Bladder Tissue Bioreactor for Treatment of Bladder Dysfunction & Disease
Corporate Ventures

Novel Bladder Tissue Scaffolds for Tissue Regeneration
Corporate Ventures