Shi-Joon Yoo, MD, PhD
The Hospital for Sick Children
University of Toronto
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Dr. Yoo is a cardiac radiologist and leads the Division of Cardiac Imaging. He is a professor of the Departments of Medical Imaging and Paediatrics at the University of Toronto. His main clinical and research activities are MR and CT applications in children with cardiovascular disease and fetal echocardiography. He has developed a unique training program for cardiac imaging where both radiology and cardiology fellows collaborate closely together in a harmonious and productive manner. Recently he has introduced 3D printing or rapid prototyping technology to the program. This technique allows preoperative simulation of the surgical procedures in patients with complex congenital heart disease.
- Cardiovascular MRI and Fetal Echocardiography in Children
- Clinical research in MRI assessment of pulmonary circulation
- Clinical research in MRI assessment of right ventricular function
- MR evaluation of pulmonary and abdominal circulation after single ventricle repair
- 3D plastic printing of cardiovascular model from MRI or CT image data
Future Research Interests
- MRI assessment of vascular physiology
- Establishment of an image data archive of congenital heart diseases
Clinical Care Activities
- Cardiovascular MRI
- Cardiovascular CT
- Plain radiography
- Fetal echocardiography
Presidential Recognition Award. Society for Pediatric Radiology 2005. In recognition of the individual whose energy and reativity have made a significant impact on the work of the Society and its service to its members.
Yoo S-J, Lim TH, Park IS, et al. MR Anatomy Of Ventricular Septal Defect In Double Outlet Right Ventricle With Situs Solitus And Atrioventricular Concordance.
Radiology 181:501-505, 1991
Yoo S-J, Nickanen D, Freedom RM, Burrows PE, Moes CAF, Benson L..Retrobronchial Vertical Vein In Totally Anomalous Pulmonary Venous Connection To The Innominate Vein : Specific Occurrence In Right Isomerism. American Journal of Cardiology. 71:1198-1203, 1993
Yoo S-J, Seo JW, Park IS, Hong CY, Kim SH, Song MG, Lee HJ, Lim TH. MR Imaging Of The Hearts With Twisted Atrioventricular Connection : So-Called Criss-Cross Heart. Radiology. 188:109-113, 1993
Yoo S-J, Burrows PE, Moes CA, MacDonald C, Williams WG, Houde C, McCrindle BW, Freedom RM, Benson L.Evaluation Of Coronary Arterial Patterns In Complete Transposition By Laid-Back Aortography. Cardiology in the Young 6:149-155, 1996
Yoo S-J, Lee Y-H, Kim ES, Ryu HM, Kim MY, Choi H-K, Cho KS, Kim A. Three-Vessel View Of The Fetal Upper Mediastinum: An Easy Means Of Detecting Abnormalities Of The Ventricular Outflow Tracts And Great Arteries During Obstetric Screening. Journal of Ultrasound in Obstetrics and Gynecology 9:173-182, 1997
Yoo S-J, Lee Y-H, Ryu HM, Joo MS, Cheon JK, Park KW. Unusual Fate Of Vesicoallantoic Cyst With Non-Visualization Of Fetal Urinary Bladder In A Case With Patent Urachus. Journal of Ultrasound in Obstetrics and Gynecology 9:422-424, 1997
Yoo S-J, Kim YM, Bae EJ, Sohn S, Ko JK, Park IS. Rare Variants Of Divided Right Ventricle With Sequestered Apical Trabecular Component. International Journal of Cardiology. 60:249-255, 1997
Yoo-S-J, Park KW, Cho SY, Sim JS, Hhan KS. Definitive Diagnosis Of Intestinal Volvulus In Utero. Journal of Ultrasound in Obstetrics and Gynecology 13:200-203, 1999
Yoo S-J, Lee YH, Kim ES, Ryu HM, Kim MY, Yang JH, Chun YK, Hong SR. Tetralogy Of Fallot In The Fetus: Findings At Targeted Sonography. Journal of Ultrasound in Obstetrics and Gynecology 14:29-37, 1999
Yoo S-J, Min JY, Lee YH. Normal Pericardial Fluid In The Fetus: Color And Spectral Doppler Analysis. Ultrasound Obstet Gynecol 2001;18:248-252
Song MS, Yoo S-J, Smallhorn JF, Mullen JBM, Ryan G, Hornberger LK. Bilateral Congenital Diaphragmatic Hernia: Diagnostic Clues At Fetal Sonography. Ultrasound Obstet Gynecol 2001;17:255-258
Kim YM, Yoo S-J, Kim TH, Park IS, Kim WH, Lee JY, Han MY. Three-dimensional computed tomography in children with compression of the central airways complicating congenital heart disease. Cardiol Young. 2002 Jan; 12(1):44-50
Nield LE, Qi X, Yoo S-J, Valsangiacomo ER, Hornberger LK, Wright GA. MRI-based blood oxygen saturation measurements in infants and children with congenital heart disease. Pediatr Radiol. 2002 Jul;32(7):518-22.
Jaeggi ET, Fouron JC, Hornberger LK, Proulx F, Oberhansli I, Yoo S-J, Fermont L.. Agenesis of the ductus venosus that is associated with extrahepatic umbilical vein drainage: prenatal features and clinical outcome. Am J Obstet Gynecol. 2002 Oct;187(4):1031-7
Kang IS, Redington AN, Benson LN, Macgowan C, Valsangiacomo ER, Roman K, Kellenberger CJ, Yoo S-J. Differential regurgitation in branch pulmonary arteries after repair of tetralogy of Fallot: a phase-contrast cine magnetic resonance study. Circulation. 2003;107:2938-2943
Valsangiacomo ER, Barrea C, Macgowan CK, Smallhorn JF, Coles JG, Yoo S-J. Phase-contrast MR assessment of pulmonary venous blood flow in children with surgically repaired pulmonary veins. Pediatr Radiol. 2003;33:607-613
Murray CP, Yoo S-J, Babyn PS. Congenital extrahepatic portosystemic shunts. Pediatr Radiol. 2003;33:614-620.
Yoo SJ, Min JY, Lee YH, Roman K, Jaeggi E, Smallhorn J. Fetal sonographic diagnosis of aortic arch anomalies. Ultrasound Obstet Gynecol. 2003;22:535-546.
Roman KS, Kellenberger CJ, Farooq S, Macgowan CK, Gilday DL, Yoo SJ. Comparative imaging of differential pulmonary blood flow in patients with congenital heart disease: magnetic resonance imaging versus lung perfusion scintigraphy. Pediatr Radiol. 2005 Mar;35(3):295-301.
Kellenberger CJ, Macgowan CK, Roman KS, Al-Habshan F, Benson LN, Redington AN, Yoo SJ. Hemodynamic evaluation of the peripheral pulmonary circulation by cine phase-contrast magnetic resonance imaging. J Magn Reson Imaging. 2005 Dec;22(6):780-7.
Grosse-Wortmann L, Al-Otay A, Goo HW, Macgowan CK, Coles JG, Benson LN, Redington AN, Yoo SJ. Anatomical and functional evaluation of pulmonary veins in children by magnetic resonance imaging. J Am Coll Cardiol 2007;49:993-1002.
Cho JY, Min JY, Lee YH, McCrindle B, Hornberger LK, Yoo SJ. Diameter of the normal fetal thymus on ultrasound. Ultrasound Obstet Gynecol 2007; 29: 634-648
Jaeggi E, Chitayat D, Golding F, Kim P, Yoo SJ. Prenatal diagnosis of topsy-turvy heart. Cardiol Young. 2008 Jun;18(3):337-42.
Grosse-Wortmann L, Macgowan CK, Vidarsson L, Yoo SJ. Late gadolinium enhancement of the right ventricular myocardium: is it really different from the left ? J Cardiovasc Magn Reson. 2008 May 8;10(1):20.
Grosse-Wortmann L, Yun TJ, Al-Radi O, Kim S, Nii M, Lee KJ, Redington A, Yoo SJ, van Arsdell G. Borderline hypoplasia of the left ventricle in neonates: insights for decision-making from functional assessment with magnetic resonance imaging. J Thorac Cardiovasc Surg. 2008 Dec;136(6):1429-36.
Grosse-Wortmann L, Al-Otay A, Yoo SJ. Aortopulmonary collaterals after bidirectional cavopulmonary connection or Fontan completion. Quantification with MRI. Circ Cardiovasc Imaging 2009;:219-225
Jansz MS, Seed M, van Amerom JF, Wong D, Grosse-Wortmann L, Yoo SJ, Macgowan CK. Metric optimized gating for fetal cardiac MRI. Magn Reson Med. 2010 Nov;64(5):1304-14
Yivon Y, Chitayat D, Blaser S, Seed M, Amsalem H, Yoo SJ, Jaeggi ET. Fetal cardiac tumors: a single-center experience of 40 cases. Prenat Diagn. 2010 Oct;30(10):941-9
Lee KJ, Yoo SJ, Holtby H, Grant B, Mroczek D, Wong D, Grosse-Wortmann L, Benson LN, Chaturvedi RR. Acute effects of the ACE inhibitor enalaprilat on the pulmonary, cerebral and systemic blood flow and resistance after the bidirectional cavopulmonary connection. Heart. 2011 Aug;97(16):1343-8.
Windram J, Grosse-Wortmann L, Shariat M, Greer ML, Crawford MW, Yoo SJ. Cardiovascular MRI without sedation or general anesthesia using a feed-and-sleep technique in neonates and infants. Pediatr Radiol. 2012 Feb;42(2):183-7
Sun AM, Alhabshan F, Cheung M, Bronzetti G, Redington AN, Benson LN, Macgowan C, Yoo SJ. Delayed onset of tricuspid valve flow in repaired tetralogy of Fallot: An additional mechanism of diastolic dysfunction and interventricular dyssynchrony. J Cardiovasc Magn Reson. 2011 Aug 24;13(1):43.
Grosse-Wortmann L, Drolet C, Dragulescu A, Kotani Y, Chaturvedi R, Lee KJ, Mertens L, Taylor K, La Rotta G, van Arsdell G, Redington A, Yoo SJ. Aortopulmonary collateral flow volume affects early postoperative outcome after Fontan completion: A multimodality study. J Thorac Cardiovasc Surg. 2012 Dec;144(6):1329-36.
Lee W, Yoo SJ, Roche SL, Kantor P, van Arsdell G, Park EA, Redington A, Grosse-Wortmann L. Determinants and functional impact of restrictive physiology after repair of tetralogy of Fallot: New insights from magnetic resonance imaging. Int J Cardiol. 2012;167:1347-53
Grosse-Wortmann L, Dragulescu A, Drolet C, Chaturvedi R, Kotani Y, Mertens L, Taylor K, La Rotta G, van Arsdell G, Redington A, Yoo SJ. Determinants and clinical significance of flow via the fenestration in the Fontan pathway: A multimodality study. Int J Cardiol. 2012 Sep 30;168(2):811-7.
Seed M, van Amerom JF, Yoo SJ, Al Nafisi B, Grosse-Wortmann L, Jaeggi E, Jansz MS, Macgowan CK. Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study. J Cardiovasc Magn Reson. 2012 Nov 26;14:79.
Roy CW, Seed M, van Amerom JF, Al Nafisi B, Grosse-Wortmann L, Yoo SJ, Macgowan CK. Dynamic imaging of the fetal heart using metric optimized gating. Magn Reson Med. 2013;70:1598-607
Fratz S, Chung T, Greil GF, Samyn MM, Taylor AM, Valsangiacomo Buechel ER, Yoo SJ, Powell AJ. Guidelines and protocols for cardiovascular magnetic resonance in children and adults with congenital heart disease: SCMR expert consensus group on congenital heart disease. J Cardiovasc Magn Reson. 2013 Jun 13;15:51.
Woerner C, Cutz E, Yoo SJ, Grasemann H, Humpl T. Pulmonary veno-occlusive disease in childhood. Chest. 2014 ;146:167-74
Yoo SJ, Prsa M, Schantz D, Grosse-Wortmann L, Seed M, Kim TK, Wald R, Chaturvedi R. MR assessment of abdominal circulation in Fontan physiology. Int J Cardiovasc Imaging. 2014;30:1065-72
Prsa M, Sun L, van Amerom J, Yoo SJ, Grosse-Wortmann L, Jaeggi E, Macgowan C, Seed M. Reference Ranges of Blood Flow in the Major Vessels of the Normal Human Fetal Circulation at Term by Phase Contrast Magnetic Resonance Imaging. Circ Cardiovasc Imaging. 2014;4:663-70
Iwamoto Y, Inage A, Tomlinson G, Lee KJ, Grosse-Wortmann L, Seed M, Wan A, Yoo SJ. Direct measurement of aortic regurgitation with phase-contrast magnetic resonance is inaccurate: proposal of an alternative method of quantification. Pediatr Radiol. 2014 Jun 18. [Epub ahead of print].