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About Sickkids
About SickKids

Rae S.M. Yeung, MD, PhD, FRCPC

The Hospital for Sick Children
Staff Physician
Rheumatology

Research Institute
Senior Scientist
Cell Biology

University of Toronto
Professor
Dept. of Paediatrics, Immunology and Institute of Medical Science


Phone: 416-813-8883
Fax: 416-813-4989
Email: rae.yeung@sickkids.ca

For more information, visit:

Yeung Lab Website

Brief Biography

Dr. Rae Yeung is presently Professor of Paediatrics, Immunology and Medical Science at the University of Toronto, and a Senior Scientist in Cell Biology Research at The Hospital For Sick Children (SickKids). She attended the University of Toronto where she obtained her Medical Degree. Subsequently, she trained in Paediatrics and was Chief Resident at SickKids prior to completing her PhD in Immunology at the Ontario Cancer Institute under the supervision of Dr. Tak Mac. Following her PhD studies, Dr. Yeung returned to clinical training and trained in Paediatric Rheumatology at  SickKids and subsequently came on staff in 1999.  

The goal of Dr. Yeung’s research is to understand the mechanisms governing autoimmunity, specifically the mechanisms involved in initiating and sustaining the immune response in Childhood Arthritis and Rheumatic Diseases. Dr. Yeung uses Kawasaki disease as an experimental model for studying Autoimmunity. Basic science findings have been translated into clinical correlates, which in turn are leading to new therapeutic interventions to improve the outcome in children affected with Kawasaki Disease. Lessons learned in immunobiology have been applied to studies in Childhood Arthritis, where Dr. Yeung is leading both national and international efforts to understand the biologic basis for heterogeneity in Childhood Arthritis.

Dr. Yeung is currently Chair and Principal Investigator of (UCAN) Understanding Childhood Arthritis Network and Chair of the Scientific Committee of the International Kawasaki Disease Genetics Consortium, in addition Dr. Yeung was the founding Chair of (CAPRI) Canadian Alliance of Paediatric Rheumatology Investigators.

Dr Yeung’s research is supported by The Arthritis Society, the Canadian Arthritis Network (CAN), the Heart and Stroke Foundation of Canada (HSF), and the Canadian Institutes of Health Research (CIHR) and the Ministry of Economic Development and Innovation, Province of Ontario and the Arthritis and Autoimmunity Research Centre. Currently, Dr. Yeung holds an Investigator Award from the Arthritis Society of Canada. Dr. Yeung is the recipient of the American College of Rheumatology Henry Kunkel Young Investigator Award (2009) and the Canadian Rheumatology Association Young Investigator Award (2004).

Research Interests

• Kawasaki Disease Pathogenesis
• Biologic Basis of Clinical Heterogeneity in Childhood Arthritis
• Determinants of Risks and Outcomes in Childhood Autoimmune Disease
• Collaborative research networks to enhance translational research in rare diseases

Research Activities

The central theme of Dr. Yeung’s research program is to understand the molecular and cellular mechanisms governing autoimmunity towards discovery of molecular tools for improved disease diagnosis, treatment, outcomes and prevention. Specifically, studying the mechanisms responsible for initiating and sustaining the immune response in autoimmunity.

Kawasaki Disease (KD):  KD is the most common cause of multi-system vasculitis in childhood. The vessels most commonly damaged are the coronary arteries, making KD the number one cause of acquired heart disease in children from the industrialized world. Dr. Yeung uses KD as an experimental model for studying autoimmunity and has applied her findings to study Childhood Arthritis. Exposure to an environmental agent in a genetically susceptible host is common to systemic autoimmune diseases, making KD a prototypic disease model. She studies the molecular mechanisms responsible for inflammation and vessel breakdown and is also actively involved in clinical care of affected children.

Juvenile Idiopathic Arthritis (JIA):  To foster research, improve efficiencies and combine resources to study rare diseases, Dr. Yeung helped develop a national research network (CAPRI-Canadian Alliance of Paediatric Rheumatology Investigators), and served as the inaugural Chair, helping to lead four Canada-wide, multi-disciplinary group grants to study childhood arthritis, continuing my thematic studies on immune activation in childhood autoimmunity.  Developing a robust national research infra-structure to support translational research including: a standardized data collection system for clinical phenotyping, processing and storage of biologic specimens, communications website, partnership funding for trainee support, and a strong organizational structure to develop guidelines, monitor research and tackle issues related to science, education, publication and knowledge translation and exchange. Dr. Yeung’s laboratory currently houses the national tissue repository.

Developing platforms and tools to improve research efficiency and magnify impact:  One of the largest obstacles to international collaboration is uniformity of data collection, analysis and assay performance. Site of sample collection is one of the most important factors responsible for differences in multi-center biomarker studies, likely due to differences in biologic data handling. The need for standardized operating procedures and core resources for analysis are critical first steps to ensure high quality translational research. Dr. Yeung established an international research consortium to address this challenge.  Together, representing over 50 countries and 300 sites, to jointly endorse the UCAN (Understanding Childhood Arthritis Network) initiative. UCAN’s goal is to discover novel genetic, biologic and phenotypic markers to define Childhood Arthritis in the broadest sense.  

External Funding

Genome Canada and Ontario Genomics - 2018 – 2022 (R Yeung PI and Project Leader)
UCAN CURE: Precision decisions for childhood arthritis

The Arthritis Society – 2018 – 2021 (R Yeung co-PI)
The Biologic Basis of Co-existent Uveitis and Arthritis in Children

Canadian Institutes of Health Research/Canada-Netherlands Personalized Medicine in Immune Mediated Inflammatory Musculoskeletal Disease Network – 2017 – 2022 (R Yeung Principal investigator and project leader)
UCAN CAN-DU: Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Diseases

Shire (formerly Baxalta) – 2017 – 2020 (R Yeung co-I)
Radiogenomics: Personalized Imaging of Arthropathy in Boys with Hemophilia in China

CARRA – 2017 – 2018 (R Yeung co-I)
Improving Care for Children with Autoinflammatory Diseases

The Arthritis Foundation – 2015 – 2019 (R Yeung PI)
Precision Decisions to STOP-JIA

Canadian Institutes of Health Research – 2014 – 2019 (R Yeung co-I)
NADPH oxidase function in the pathogenesis of pediatric IBD and JIA

Achievements

2018                            
The Janet Rossant Research Innovation Prize
The Hospital for Sick Children, Research Institute

2017                            
Fellow, Henry Kunkel Society 
Rockefeller University

2016                            
Physician Scientist Award
The Hospital for Sick Children, University of Toronto

2013                            
Endowed Research Chair 
The Hak-Ming and Deborah Chiu Chair in Pediatric Translational Research                                    
The Hospital for Sick Children, University of Toronto

2009                            
Henry Kunkel Young Investigator Award 
American College of Rheumatology, Philadelphia, PA, USA

The Royal College Professional Development Grant
Royal College of Physicians and Surgeons of Canada                            

Dafna Gladman Award 
University of Toronto, Faculty of Medicine

2007 - 2012                
Investigator Award 
The Arthritis Society of Canada

2004                            
Canadian Rheumatology Association Young Investigator Award 
Canadian Rheumatology Association Distinction

2001 - 2006                 
New Investigator Award
The Arthritis Society of Canada/Canadian Institutes of Health Research – Salary Award

1997 - 2001                 
Junior Research Scholarship
The Arthritis Society of Canada Research Award – Salary Award

1996                            
First Prize - Annual Ogryzlo Day Research Competition
University of Toronto, Rheumatic Diseases Unit

Doctor of Philosophy
Department of Immunology, University of Toronto Credential

1995                            
Fellowship
The Arthritis Society of Canada, Research Award

1994                            
Richard Miller Award
Department of Immunology, University of Toronto

1991 - 1995                 
Fellowship
Medical Research Council of Canada Fellowship Research Award

Clinician Scientist Award
The Hospital For Sick Children Research Award 

Publications

PA-denotes Principal Author; SRI-Senior Responsible Investigator; CPA-Co-Principal Author; C-Collaborator (name of trainee under direct supervision underlined)

Watanabe Duffy KN, Lee J, Guzman J, Barrowman N, Morishita K, Spiegel LR, Stringer E, Gibbon M, Yeung RSM, Tucker LB, Oen K, Duffy CM, ReACCh Out Investigators.  The Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh Out) Cohort: prospective determination of the incidence of new onset uveitis in juvenile idiopathic arthritis.  Arthritis Care and Research.  Arthritis Care Res (Hoboken). 2018 Oct 15. doi: 10.1002/acr.23783  C

Response to letter to the editor by: Aeschlimann FA, Barra L, Alsolaimani R, Benseler SM, Hebert D, Khalidi N, Laxer RM, Noone D, Pagnoux C, Twilt M, Yeung RSM: Presentation and disease course of childhood- versus adult-onset Takayasu Arteritis.

Aeschlimann FA, Barra L, Alsolaimani R, Benseler SM, Hebert D, Khalidi N, Laxer RM, Noone D, Pagnoux C, Twilt M, Yeung RSM: Presentation and disease course of childhood- versus adult-onset Takayasu Arteritis 2018 Aug 12. doi: 10.1002/art/.40690 (epub ahead of print) SRI

Grotenhuis HB, Aeschlimann FA, Hui W, Slorach C, Yeung RSM, Benseler S, Bradley TJ, Grosse-Wortmann L: Increased arterial stiffness in a cohort of pediatric Takayasu arteritis patients in Toronto adversely effects left ventricular mechanics. Journal of Clinical Rheumatology 2018 May 19. doi: 10.1097/RHU.0000000000000824 (epub ahead of print) C

Da Silveira Cavalcante L, Branch DR, Duong TT, Yeung RSM, Acker JP, Holovati JL: The immune-stimulation capacity of liposome-treated red blood cells.  Journal of Liposome Research. J Liposome Res. 2018 Sep; 28(3):173-181. PMID: 28276279.

Shivamurthy V, Guzman J, Huber A, Boire G, Oen K, Duffy KW, Yeung RSM et al on behalf of the ReACCh-Out investigator: Feasibility of applying the flare definition using the ACR core set variables in juvenile idiopathic arthritis in routine practice: results from the ReACCh-Out Cohort.  Journal of Rheumatology. J Liposome Res. 2018 Sep;28(3):173-181. doi: 10.1080/08982104.2017.1295991. Epub 2017 Mar 9.  C

Dhanranjani A, Yeung RSM:  Controversies in management of acute Kawasaki Disease.  Current Opinion in Rheumatology. Curr Opin Rheumatol. 2017 Sep; 29(5):547-552. PMID: 28661936.  SR

Oen K, Yeung RSM, Ellsworth J, Tse S, Scuccimarri R, Chedeville G, Morishita K, Guzman J, Cabral D, Rosenberg A, Feldman B, Silverman E, Chetaille  Anne-L, Dancey P, Benseler S, Huber A, Miettunen P, Boire G, Larche M, Spiegel L, Schneider R, Laxer RM, Turvey S, Houghton K, Duffy K, Campillo S, Lang B, Ramsey S, Stringer E, LeBlanc C, Johnson N, Schmeling H, Bruns A, Shiff N, Berard R, Levy D, Duffy C, Tucker L:  Early Disease Course In A Prospective Juvenile Idiopathic Arthritis Cohort. Annals of Rheumatic Disease. (in press)  CPA

Downie ML, Manlhiot C, Latino GA, Collins TH, Chahal N, Yeung RSM, McCrindle BW: Factors associated with development of coronary artery aneurysms after Kawasaki disease are similar for those treated promptly and those with delayed or no treatment. Int J Cardiol. 2017 Jun 01; 236:157-161. PMID: 28089146 co-SRI 

Kipkeu BJ, Shyian ML, da Silveira Cavalcante L, Duong TT, Yeung RSM, Binnington B, Branch DR, Acker JP, Holovati JL: Evaluation of the functional properties of cryopreserved buffy coat-derived monocytes for monocyte monolayer assay. Transfusion 2018: 58(8):2027-2035. C

Okihiro A, Hasija R, Fung L, Cameron B, Feldman BM, Laxer R, Schneider R, Silverman E, Spiegel L, Yeung RSM, Tse SML: Development of neoplasms in pediatric patients with rheumatic disease exposed to anti-tumor necrosis factor therapies: a single Centre retrospective study.  Pediatric Rheumatology Online Journal 2018: 16(1):17.  C

Arthur VL, Shuldiner E, Remmers EF, Hinks A, Grom A, Foel D, Martini A, Gattorno M, Ozen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT Mellins ED, Russo R, Len C, Oliveira S, Yeung RSM, Rosenberg AM, Wedderburn LR, Anton J, Haas J-P, Rosen-Wolff A, Minden K, Szymanski AM, INCHARGE consortium, Thomson W, Kastner DL, Woo P, Ombrello MJ: IL1RN variation influences both disease susceptibility and response to human recombinant IL-1RA therapy in systemic juvenile idiopathic arthritis.  Arthritis and Rheumatology 2018 Apr 2. doi: 10.1002/art.40498. [Epub ahead of print]  C

Hinks A, McMarion MC, Cobb J, Comeau ME, Sudman M, Ainsorth HC, Bowes J, Juvenile Arthritis Consortium for Immunochip, Becker ML, Bohnsack JF, Haas JP, Lovell DJ, Mellins ED, Nelson JL, Nordal E, Punaro M, Reed AM, Rose CD, Rosenberg AM, Rygg M, Smith SL, Stevens AM, Videm V, Wallace CA, Wedderburn LR, Yarwood A, Yeung RSM, Langefeld CD, Thompson SD, Thomson W, Prahalad S: The genetic profile of rheumatoid factor-positive polyarticular juvenile idiopathic arthritis (JIA) resembles that of adult rheumatoid arthritis (RA).  Arthritis and Rheumatology 2018: 70(6): 957-962.  C

Manlhiot C, Mueller B, O’Shea S, Majeed H, Bernknopf B, Labelle M, Westcott K, Heming B, Chahal N, Birken CS, Yeung RSM, McCrindle BW: Environmental epidemiology of Kawasaki Disease: linking disease etiology, pathogenesis and global distribution?  PLOS ONE 2018: 13(2):e0191087.  Co-SRI

Oen K, Guzman J, Dufault B, Tucker LB, Shiff NJ, Watanabe DK, Lee JJ, Feldman BM, Berard RA, Dancey P, Huber AM, Scuccimarri R, Cabral DA, Morishita KA, Ramsey SE, Rosenberg AM, Boire G, Benseler SM, Lang B, Houghton K, Miettunen PM, Chedeville G, Levy DM, Bruns A, Schmeling H, Haddad E, Yeung RSM, Duffy CM, Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators: Health-related quality of life in an inception cohort of children with Juvenile Idiopathic Arthritis: a longitudinal analysis.  Arthritis Care Research 2018: 70(1):134-144.  co-SRI

Shiff NJ, Tupper S, Oen K, Guzman J, Lim H, Lee CH, Bryce R, Huber AM, Boire G, Dancey P, Feldman B, Laxer R, Miettunen P, Schemling H, Watanabe DK, Levy DM, Turvey S, Bolaria R, Bruns A, Cabral DA, Campillo S, Chedeville G, Feldman DE, Haddad E, Houghton K, Johnson K, Jurencak R, Lang B, Larche M, Morishita K, Ramsey S, Roth J, Schneider R, Scuccimarri R, Spiegel L, Stringer E, Tse SM, Yeung RSM, Duffy CM, Tucker LB: Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort. Pain 2018: 159(1):57-66. co-SRI

Noone D, Yeung RSM, Hebert D: Outcome of kidney transplantation in pediatric patients with ANCA-associated glomerulonephritis: a single-center experience.  Pediatric Nephrology 2017: 32(12):2343-2350. C

Aeschlimann FA, Eng SWM, Sheikh S, Laxer RM, Hebert D, Noone D, Twilt M, Pagnoux C, Benseler SM, Yeung RSM: Childhood Takayasu arteritis: disease course and response to therapy.  Arthritis Research and Therapy.  Arthritis Research and Therapy 2017: 19(1):255.  SRI

Guzman J, Kerr T, Ward LM, Ma J, Oen K, Rosenberg AM, Feldman BM, Boire G, Houghton K, Dancey P, Scuccimarri R, Bruns A, Huber AM, Watanabe Duffy K, Shiff NJ, Berard RA, Levy DM, Stringer E, Morishita K, Johnson N, Cabral DA, Larche M, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille AL, Haddad E, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey SE, Roth J, Campillo S, Benseler S, Chedeville G, Schneider R, Tse SML, Bolaria R, Gross K, Feldman D, Cameron B, Jurencak R, Dorval J, LeBlanc C, St Cyr C, Gibbon M, Yeung RSM, Duffy CM, Tucker LB: Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort.  Pediatric Rheumatology Online Journal 2017: 15(1):68.  co-SRI

Aeschlimann FA, Yeung RSM, Laxer RM, Hebert D, Cooper A, Chami R, Noone D: A toddler presenting with pulmonary renal syndrome.  Case Reports in Nephrology and Dialysis 2017: 7(2)73-80.  C

Bonetto C, Trotta F, Felicetti P, Alarcon GS, Santuccio C, Bachtiar NS, Brauchli Pernus Y, Chandler R, Girolomoni G, Hadden RD, Kucuku M, Ozen S, Pahud B, Top K, Varrrichio O, Wise RP, Znoni G, Zivkovic S, Bonhoeffer J, Brighton Collaboration Vasculities Working Group: Vasculitis as an adverse event following immunization – systematic literature review.  Vaccine 2016: 34(51):6641-6651.  C

Downie ML, Manlhiot C, Collins TH, Chahal N, Yeung RSM, McCrindle BW: Factors associated with development of coronary artery aneurysms after Kawasaki disease are similar for those treated promptly and those with delayed or no treatment.  International Journal of Cardiology 2017: 236:157-161.  co-SRI

Felicetti P, Trotta F, Bonetto C, Santuccio C, Pernus YB, Burgner D, Chandler R, Girolomoni G, Hadden RDM, Kochar S, Kukucu M, Monaco G, Ozen S, Pahud B, Phuong L, Bachtiar NS, Teeba A, Top K, Varrichio F, Wise RP, Zanoni G, Zivkovic S, Bonhoeffer J, The Brighton Collaboration Vasculitis Working Group: Spontaneous reports of vasculitis as an adverse event following immunization: a descriptive analysis across three international databases.  Vaccine 2017: 34(51):6634-6640.  C

Kahr WH, Pluthero FG, Elkadri A, Warner N, Drobac M, Chen CH, Lo R, Li L, Li R, Li Q, Thoeni C, Pan J, Leung G, Lara-Corrales I, Murchie R, Cutz E, Laxer RM, Upton J, Roifman CM, Yeung RSM, Brumell JH, Muise AM: Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease.  Nature Communications 2017: 8:14816.  C

Morishita K, Moorthy L, Lubieniecka J, Twilt M, Yeung RSM, Toth M, Shenoi S, Ristic G, Nielsen S, Li S, Lee T, Lawson E, Kostic M, Klein-Gitelman M, Huber A, Hersh A, Foell D, Elder M, Eberhard B, Dancey P, Charuvanij S, Benseler S, Cabral D: Early outcomes in children with antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).  Arthritis and Rheumatology 2017: 69(7): 1470-1479.  C

Dhanrajani A, Yeung RSM: Revisiting the role of steroids and aspirin in the management of acute Kawasaki disease.  Current Opinion in Rheumatology 2017: 29(5):547-552.  SRI

Phuong LK, Bonetto C, Buttery J, Pernus YB, Chandler R, Felicetti P, Goldenthal KL, Kukucu M, Monaco G, Pahud B, Shulman ST, Top KA, Trotta F, Ulloa-Gutierrez R, Varricchio F, de Ferranti S, Newburger JW, Dahdah N, Singh S, Bonhoeffer J, Burgner D,  The Brighton Collaboration Vasculitis Working Group: Kawasaki Disease and immunization: a systematic review.  Vaccine 2017: 35(14):1770-1779.  C

Da Silveira Cavalcante L, Branch DR, Duong TT, Yeung RSM, Acker JP, Holovati JL:  The immune-stimulation capacity of liposome-treated red blood cells.  Journal of Liposome Research 2017: 9:1-9.  C

Hinks A, Bowes J, Cobb J, Ainsworth HC, Marion MC, Comeau ME, Sudman M, Han B, Juvenile Arthritis Consortium for Immunochip, Becker ML, Bohnsack JF, de Bakker PIW, Haas JP, Hazen M, Lovell DJ, Nigrovic PA, Nordal E, Punnaro M, Rosenberg AM, Rygg M, Smith SL, Wise CA, Videm V, Wedderburn LR, Yarwood A, Yeung RSM, Prahalad S, Langefeld CD, Raychaudhuri S, Thompson SD, Thomson W: Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.  Annals of Rheumatic Diseases.  Epub ahead of print doi: 10.1136/annrheumdis-2016-210025.   C

Ombrello MJ, Arthur VL, Remmers EF, Hinks A, Tachmazidou I, Grom A, Foell D, Martini A, Gattorno M, Ozen S, Prahalad S, Zeft AS, Bohnsack JF, Illowite NT, Mellins ED, Russo R, Len C, Hilario MOE, Oliveira S, Yeung RSM, Rosenberg A, Wedderburn LR, et al Langefeld CD, Thompson S, Zeggini E, Kastner DL, Woo P, Thomson W: Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic: clinical and therapeutic implications.  Annals of Rheumatic Diseases 2017: 76(5):906-913.  C

Barnabe C, Toepfer D, Marotte H, Hauge EM, Scharmga A, Kocijan R, Kraus S, Boutroy S, Schett G, Keller KK, deJong J, Stok KS, Finzel S, Yeung RSM and members of the SPECTRA collaboration: Definition for rheumatoid arthritis erosions imaged with high resolution peripheral quantitative computed tomography and interreader reliability for detection and measurement.  The Journal of Rheumatology 2016: 43(10)1935-1940.  C

Nagaraj S, Finzel S, Stok KS, Barnabe C, members of the SPECTRA collaboration (Yeung RSM member) collaboration: High-resolution peripheral quantitative computed tomography imaging in the assessment of periarticular bone of metacarpophalangeal and wrist joints.  The Journal of Rheumatology 2016: 43(10)1921-1934.  C         

Aeschlimann FA, members of the SPECTRA collaboration (Yeung RSM member) collaboration: TNF vs IL-1 targeted treatment in Kawasaki Disease.  Current Treatment Options in Rheumatology. 2016: 2:283-295.  SRI

Alphone MP, Duong TT, Shumitzu C, Hoang TL, McCrindle BW, Franco A, Schurmans S, Philpott DJ, Hibberd ML, Burns J, Kuijpers TW, Yeung RSM: Inositol-Triphosphate 3-Kinase C mediates inflammasome activation and treatment response in Kawasaki disease. Journal of Immunology 2016: 197(9): 3481-3489.  SRI

Shimizu C, Eleftherohorinou H, Wright VJ, Kim J, Alphone MP, Perry JC, Cimaz R, Burgner D, Dahdah N, Hoang LT, Khor CC, Salgado A, Tremoulet AH, Davila S, Kuijpers TW, Hibberd ML, Johnson TA, Takahashi A, Tsunoda T, Kubo M, Tanaka T, Onouchi Y, Yeung RSM, Coin LJM, Levin M, Burns JC on behalf of the International Kawasaki Disease Genetic Consortium: Genetic variation in the SLC8A1 calcium signaling pathway is associated with susceptibility to Kawasaki disease and coronary artery abnormalities.  Circulation Cardiovascular Genetics 2016: 9(6): 559-568.  C

Aeschlimann FA, Grosse-Wortmann L, Benseler SM, Laxer RM, Hebert D, Yeung RSM: Arterial dissection in childhood Takayasu Arteritis: not as rare as thought.  Pediatric Rheumatology Online Journal 2016: 22:14(1): 56.  SRI

Yeung RSM, S Albani, Feldman BM, Mellins E, Prakken B, Wedderburn L: Enhancing translational research in pediatric rheumatology through standardization. Nature Reviews Rheumatology 2016: 12(11): 684-690.  PA

Guzman J, Oen K, Huber AM, Watanabe Duffy K, Boire G, Shiff N, Berard RA, Levy DM, Stringer E, Scuccimarri R, Morishita K, Johnson N, Cabral DA, Rosenberg AM, Larche M, Dancey P, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille AL, Haddad E, Houghton K, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey SE, Bruns A, Roth J, Campillo S, Benseler S, Chedeville G, Schneider R, Tse SM, Bolaria R, Gross K, Feldman B, Feldman D, Cameron B, Jurencak R, Dorval J, LeBlanc C, St Cyr C, Gibbon M, Yeung RSM, Duffy CM, Tucker LB, ReACCh-Out investigators: The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort.  Annals of the Rheumatic Diseases 2016: 75(6): 1092-8. C

Cui A, Quon G, Rosenberg A, Yeung RSM, Morris QD: Gene expression deconvolution for uncovering molecular signatures in response to therapy in juvenile idiopathic arthritis. PLoS ONE 2016: May 31: 11(5):e0156055.  Co-SRI   Co-supervisor

Sieberts SK,  Zhu F, García-García J, Stahl E, Pratap A, Pandey G, Pappas D, Aguilar D, Anton B, Bonet J, ksi R, Fornés O, Guney E, Li H, Marín MA, Panwar B, Planas-Iglesias J, Poglayen D, Cui J, O Falcao A, Suver C, Hoff B, Balagurusamy VSK, Dillenberger D, Chaibub Neto S, Norman T, Aittokallio T, Azencott C, Bellón V, Boeva V, Bunte K, Chheda H, Cheng L, Corander J, Dumontier M, Goldenberg A, Gopalacharyulu P, Hajiloo M, Hidru D, Jaiswal A, Kaski S, Khalfaoui B, li Khan SA, Kramer ER, Marttinen P, Mezlini AM, Molparia B, Pirinen M, Saarela J, Samwald M, Stoven V, Tang H, Tang J, Torkamani A, Vert JP, Wang B, Wang T, Wennerberg K, Wineinger NE, Xiao G, Xie Y, Yeung RSM, Zhan X, Zhao  C, Calaza M, Elmarakeby H, Heath LS, Long Q, Moore JD, Opiyo SO, Savage RS, Zhu J, Greenberg J, Kremer J, Michaud K, Barton A, Coenen M, Mariette X, Miceli C, Shadick N, Weinblatt M, de Vries N, Tak PP, Gerlag D, Huizinga TWJ, Kurreeman F, Allaart C, Bridges Jr SL, Criswell L, Moreland L, Klareskog L, Saevarsdottir S, Padyukov L, Gregersen PK, Friend S, Plenge R, Stolovitzky G, Oliva B, Guan Y, Mangravite LM, Rheumatoid Arthritis Challenge Consortium. Nature Communications 2016: 7:12460.   C            

Downie ML, Manlhiot C, Latino GA, Collins TH, Chahal N, Yeung RSM, McCrindle BW: Variability in response to intravenous immunoglobulin in the treatment of Kawasaki disease.  Journal of Pediatrics 2016: 179:124-130.e1.   co-SRI  

Cabral DA, Canter DL, Muscal E, Nanda K, Wahezi DM, Spalding SJ, Twilt M, Benseler SM, Campillo S, Charuvanij S, Dancey P, Eberhard BA, Elder ME, Hersh A, Higgins G, Huber AM, Khubchandani R, Kim S, Klein-Gitelman M, Kostic M, Lawson E, Lee T, Lubieniecka JM, McCurdy D, Moorth LN, Morishita KA, Nielsen SM, O’Neil KM, Reiff A, Ristic G, Robinson AB, Sarmineto A, Shenoi S, Toth MB, Van Mater H, Wagner-Weiner L, Weiss JE, White AJ, Yeung RSM, ARChiVe Investigators Network within the PedVas Initiative: Comparing presenting clinical features in 48 children with microscopic polyangiitis (MPA) against 183 having granulomatosis with polyangiitis (GPA). An ARChiVe study.  Arthritis and Rheumatology 2016: 68(10):2514-26.  C                 

Zeft AS, Burns JC, Yeung RSM, McCrindle BW, Newburger JW, Dominguez SR, Anderson MS, Arrington C, Shulman ST, Yoon J, Tewelde H, Mix C, Pope CA: Kawasaki disease and exposure to fine particulate air pollution.  Journal of Pediatrics 2016: 177: 179-183.e1.  C

Niaki OZ, Clarke AE, Ramsey-Goldman R, Yeung RSM, Hayward K, Oen K, Duffy CM, Rosenberg A, O’Neil KM, von Scheven E, Schanberg L, Labrecque J, Tse S, Hasija R, Lee JL, Bernatsky S: Malignancy incidence in 5,294 Juvenile Arthritis Patients.  RMD Open, May 2016: May 2:2(1):e000212.  C

Chan MO, Petty RE, Guzman J on behalf of the ReACCh-Out Investigators: A family history of psoriasis in a first-degree relative in children with JIA: to include or exclude?  Journal of Rheumatology 2016: May 43(5):944-7.  C

Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas J-P, Martini A, Gattorno M, Ozen S, Prahalad S, Zeft AS, Bohnsack JF, Mellins ED, Ilowite NT, Russo R, Len C, Hilario MOE, Oliveira S, Yeung RSM, Rosenberg A, Wedderburn LR, Anton J, Schwarz T, Hinks A, Bilginer Y, Park J, Cobb J, Satorius C, Han B, Baskin E, Duerr R, Achkar JP, Kamboh MI, Kaufman K, Kottyan LC, Pinto D, Scherer SW, Alarcon-Riquelme ME, Docampo E, EStivill X, Gul A, British Society of Pediatric and Adolescent Rheumatology (BSPAR) study group, Childhood Arthritis Prospective Study (CAPS) group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) group, Biologically Based Outcome Predictors in JIA (BBOP) group, de Bakker PIW, Raychaudhuri S, Langefeld CD, Thompson SD, Zeggini E, Thomson W, Kaster DL, Woo P on behalf of the International Childhood Arthritis Genetics INCHARGE Consortium: HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. Proceedings of the National Academy of Sciences 2015: 29: 112(52) 15970-5.  C

Guzman J, Oen K, Tucker LB, Huber AM, Shiff N, Boire G… Yeung RSM et al: Degenerative joint disease.  Annals of the Rheumatic Diseases 2016: 74(10)1854-1860.  C

Soliman M, Laxer R, Manson D, Yeung RSM, Doria AS: Imaging of systemic vasculitis in childhood. Pediatric Radiology 2015: 45(8): 1110-25.   C

Guzman J, Oen K, Huber AM, Duffy KW, Boire G, Shiff N, Berard RA, Levy DM, Stringer E, Succimarri R, Morishita K, Johnson N, Cabral D, Rosenberg AM, Larche M, Dancey P, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille A-L, Haddad E, Houghton K, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey SE, Bruns A, Roth J, Campillo S, Benseler S, Chedeville G, Schneider R, Tse SML, Bolaria R, Gross K, Feldman B, Feldman D, Cameron B, Jurencak R, Dorval J, LeBlanc C, St Cyr C, Gibbon M, Yeung RSM, Duffy C, Tucker LB, for the ReACCh-Out investigators:  The Risk and Nature of Flares in Juvenile Idiopathic Arthritis: Results from the ReACCh-Out Cohort.  Annals of Rheumatic Diseases 2015: 0: 1-7. C      

Guzman J, Oen K, Tucker LB, Huber AM, Shiff N, Boire G, Scuccimarri R, Berard R, Tse SM, Morishita K, Stringer E, Johnson N, Levy DM, Duffy KW Cabral DA, Rosenberg AM, Larche M, Dancey P, Petty RE, Laxer RM, Silverman E, Miettunen P, Chetaille AL, Haddad E, Houghton K, Spiegel L, Turvey SE, Schmeling H, Lang B, Ellsworth J, Ramsey S, Bruns A, Campillo S, Benseler S, Chedeville G, Schneider R, Yeung RSM, Duffy CM for the ReACCh-Out investigators: The Outcomes of Juvenile Idiopathic Arthritis in Children Managed with Contemporary Treatments: Results from the ReACCh-Out cohort.  Annals of Rheumatic Disease 2014: 74:(10) 1854-1860.  Co-SRI             

Berard R, Tomlinson G, Li X, Oen K, Rosenberg A, Feldman B, Yeung RSM, Bombardier C: Description of active joint count trajectories in juvenile idiopathic arthritis. Journal of Rheumatology 2014: 41(12): 2466-73.   co-SRI  Direct supervisor

Eng SW, Duong TT, Rosenberg AM, Morris Q, Yeung RSM:  The Biologic Basis for Clinical Heterogeneity in Childhood Arthritis on behalf of the REACCH OUT and BBOP Research Consortia. Arthritis and Rheumatology 2014: 66(12): 3463-75.  SRI

Duvvuri B, Duvvuri VR, Wang C, Chen L, Wagar LE, Jamnik V  Wu J, Yeung RSM, Grigull J, Watts TH, Wu GE.   The human immune system recognizes neopeptides derived from mitochondrial DNA deletions.  Journal of Immunology 2014: 192(10): 4581-91.  C

Scuccimarri R, Yeung RSM: Kawasaki Disease: High Index of Suspicion Needed in a Febrile Child.  Paediatrics and Child Health 2014: 19(5): pp 239-40.  SRI

Ringold S, Weiss PF, Colbert RA, DeWitt EM, Lee T, Oen K, Prahalad S, Schneider R, Shenoi S, Vehe RK, Kimura Y, Juvenile Idiopathic Arthritis Research Committee of the Childhood Arthritis and Rheumatology Alliance.  Childhood Arthritis and Rheumatology Alliance consensus treatment plans for new-onset polyarticular juvenile idiopathic arthritis. Arthritis Care and Research 2014: 66(7): pp 1063-72.  C

Niedra E, Chahal N, Manlhiot C, Yeung RSM, McCrindle BW: Atorvastatin Safety in Kawasaki Disease Patients with Coronary Artery Aneurysms.  Pediatric Cardiology 2014:  35(1): pp 89-92.  C

LeBlanc CMA, Lang L, Bencivenga A, Chetaille AL, Dancey P, Dent P, Miettunen P, Oen K, Rosenberg A, Roth J, Scuccimarri R, Tse SML, Benseler S, Cabral DA, Campillo S, Chedeville G, Duffy C, Duffy KW, Haddad E, Huber AM, Laxer R, Levy D, Johnson N, Ramsey S, Shiff N, Schmeling H, Scheneider R, Stringer E, Yeung RSM, Tucker LB.  Access to Biologic Therapies in Canada for Children with Juvenile Idiopathic Arthritis.  Journal of Rheumatology 2012: 39: 9: pp 1875-9.  C

Luca N, Yeung RSM: Epidemiology and management of Kawasaki Disease.  Pediatric Drugs 2012: 72: 8: pp 1029-38.  SRI 

Banks L, Lin YT, Chahal N, Manlhiot C, Yeung RSM, McCrindle BW: Factors Associated with Low Moderate-to-Vigorous Physical Activity Levels in Pediatric Patients with Kawasaki Disease.  Clinical Pediatrics 2012: 51: 9: pp 828-834.  C

Chahal N, Somji Z, Manlhiot C, Clarizia N, Ashley J, Yeung RSM, McCrindle B:  Rate, Associated Factors and Outcomes of Recurrence of Kawasaki Disease in Ontario, Canada.  Pediatrics International 2012: 54: 3: pp 383-7.  C

Manlhiot C, Christie E, McCrindle BW, Rosenberg H, Chahal N, Yeung RSM: Complete and Incomplete Kawasaki Disease: two sides of the same coin. European Journal of Pediatrics 2012: 171: 4: pp 657-662. SRI

Millar K, Manlhiot C, Yeung RSM, Somji Z, McCrindle BW: Corticosteroid administration for patients with coronary artery aneurysms after Kawasaki disease may be associated with impaired regression.   International Journal of Cardiology 2012: 154: 1: pp 9-13.  C

Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright V, Yeung RSM, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, Hibberd ML on behalf of the Hong Kong-Shanghai, Korean, Taiwan, U.S. and International, Kawasaki Disease Genetics Consortiums. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.  Nature Genetics. 2011: 43: 12: pp 1241-6.  

Sleeper LA, Minich LL, McCrindle BM, Li JS, Mason W, Colan SD, Atz AM, Printz BF, Baker A, Vetter VL, Newburger JW: Evaluation of Kawasaki disease risk –scoring systems for intravenous immunoglobulin resistance. Pediatric Heart Network Investigators. Journal of Pediatric 2011: 158: 5: pp 831-835.e3.   C

Blankier S, McCrindle BM, Ito S, Yeung RSM:  The role of atorvastatin in regulating the immune response in a model of Kawasaki Disease.  Clinical and Experimental Immunology 2011: 164: 2: pp 193-201.  SRI   

Alvira CM, Guignabert C, Kim YM, Wang L, Duong T, Yeung RSM, Li DY, Mecham RP, Rabinovitch M: Inhibition of transforming growth factor-beta worsens elastin degradation in a murine model of Kawasaki disease.  American Journal of Pathology 2011: 178: 3: pp 1210-20.  C  Patents

Tak W. Mak, Rae S.M. Yeung. “An Animal Model of Septic Shock.”  United States Patent # A-275, 1998.