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About Sickkids
About SickKids

Gelareh Zadeh, MD, PhD, FRCS (C)

Research Institute
Adjunct Scientist
Cell Biology

Scientist
The Arthur and Sonia Labatt Brain Tumour Research Centre

University of Toronto
Assistant Professor of Surgery
Faculty of Medicine

Other Positions

University Health Network
Targeting and Amplification of Radiation Response (STARR) Facility
Faculty

Acoustic Neuroma Association
Medical Director


Phone: 416-813-6688
Email: gelareh.zadeh@sickkids.ca
Alternate Contact: 416-603-5679

Brief Biography

Dr. Zadeh completed her Royal College Fellowship in Neurosurgery and PhD in molecular biology of brain tumour angiogenesis at the University of Toronto in 2006. From 2006-2008, she was awarded a Cancer Care Ontario Fellowship to complete radiobiology training at University College London. During this time she was a consultant neurosurgeon at Queen Square, University College London, UK, as a lead neuro-oncology neurosurgeon. In 2008, she returned as a CIHR Clinician-Scientist and neurosurgeon to the Toronto Western Hospital and University of Toronto.

Clinical Activities

Her clinical and research focus is in neuro-oncology, with specialization in skull base surgery, vestibular schwannomas and specifically minimally invasive endoscopic approaches to anterior skull base and sellar/parasellar lesions. Dr. Zadeh's practice also includes treatment of adult glioneuronal neoplasms, meningiomas and intraventricular tumours. She has focused subspecialty multidisciplinary clinics for management of brain metastases, pituitary/skull base and neurofibromatosis clinic at University Health Network. She has an active radiosurgery practice. Her clinical translational research focuses on understanding adverse radiation effects following radiation therapy and radiosurgery of CNS pathology.

Research Interests

My laboratory research is focused on gaining a better understanding of the molecular regulators of tumour angiogenesis and tumour microenvironment in response to ionizing radiation (IR) in order to improve the therapeutic benefit of radiation therapy for brain tumours.  

Central Hypothesis:  Ionizing radiation modulates molecular regulators of tumour angiogenesis

We have inter-related research aims and experimental strategies to investigate our hypothesis: 

  • Identifying the mechanisms and sequence of therapeutics targeting tumour angiogenesis concurrent with IR is crucial to improve the overall therapeutic response in glioblastoma multiforme (GBMs). We use various strategies to target angiogenesis: using novel strategies such as radiation activated angiogenic and anti-angiogenic genes of interest and use of pharmaceutical compounds, such as SUNITINIB, VEGFTRAP.
  • Understanding the molecular mechanisms that regulate endothelial progenitor cells contribution in response to IR in both normal and tumour related vasculature. Our goals are to determine the temporospatial response of bone marrow progenitor cells (BMPC) following IR in normal subcutaneous and intracranial tissue, determine the temporospatial response of BMPC following IR in subcutaneous and intracranial models of GBM, determine the temporospatial response of subpopulation of  BMPC, specifically endothelial progenitor cells (EPC), pericyte progenitor cells (PPC) and monocytes, following IR

Translational research focuses on identifying the molecular and genetic signatures that drive and distinguish benign intracranial tumours to behave aggressively. We also focus on understanding the molecular mechanisms of brain metastases and genetic signatures that distinguish a brain metastatic tumour from primary systemic cancer, such as breast or lung cancer.

External Funding

  • Terry Fox New Investigator Award, 2012-2-15
    PI: Zadeh G., $600,000
  • Canadian Institutes of Health Research (CIHR), 2012-2016.
    Role of HK2 in regulating brain tumor neovascularization and response to therapy.
    PIs: Zadeh G., Hawkins C.; Collaborator: Agnihotri S. $560,000
  • Canadian Institutes of Health Research (CIHR), 2012-2015.
    Role of Bone Marrow Derived Progenitor Cells in Brain Tumor Neovascularization.
    PI: Zadeh G. Collaborator: Hill R.
    $385,251
  • Canadian Institutes of Health Research (CIHR), 2012-2017.
    Targeting Thrombospondin-1 in medulloblastoma.
    Co-PI: Zadeh G.  PI: Huang A.
    $762,872
  • Ontario Institute of Cancer Research (OICR): Clinical Trial, Phase II, 2010-2013.
    Role of Nilotinib on inhibiting growth of vestibular schwannoma.
    PI: Zadeh G. Collaborators: Laperriere N., Mason W.
    $538,000
  • Allied Health Research Award, 2012-13.
    Neuropsychological outcomes after anterior skull base surgery a comparison study of a balance cohort operated with an endonasal or transcranial approach.
    PI: Zadeh G.
  • Canadian Research Soceity (CRS), 2011-12.
    Brain Tumor Microenvironmental Influences on Response to Therapy.
    PI: Zadeh G.
    $75,000
  • Brain Tumor Foundation of Canada, 2011-12.
    Identifying genetic profile of bone invading meningiomas.
    PI: Zadeh G.
    $50,000
  • b.r.a.i.n.child Grant, 2011-12.
    Differential Expression Profile of Bone Invading Meningiomas.
    PI: Zadeh G.
    $55,000
  • b.r.a.i.n.child Grant, 2010-11.
    Identifying biomarkers of response to anti-angiogenic therapy in combination with radiation therapy for malignant brain tumors.
    PI: Zadeh G.
    $50,000
  • b.r.a.i.n.child Grant, 2010-2011.
    Impact of Ionizing Radiation on Normal CNS.
    PI: Zadeh G.
    $30,000

Achievements

  • Lois H. Ross Resident Advocate Award, Professional Association of Internes and Residents of Ontario (PAIRO), 2012
  • Annual Clinician Scientist Award, American Society of Therapeutic Radiation Oncology (ASTRO), 2010
  • Alan R. Hudson Resident Teaching Award, University of Toronto, 2005
  • William Horsey Prize for Clinical Research, University of Toronto, 2004
  • Academy Award, American Acadmey of Neurological Surgeons, 2003
  • K.G. McKenzie Prize for Basic Science Research, Canadian Neurological Society, 2003
  • Thomas P. Morley Prize for Basic Science Research, University of Toronto, 2002, 2003

Publications

A list of Dr. Zadeh's publications can be found on PubMed