- The polio epidemic hits. SickKids workshop staff manufacture more than 30 iron lungs for use throughout Ontario. Medical and nursing staff organize temporary treatment centres.
- Dr. John Ross studies lead poisoning in children, resulting in the prohibition of lead pigments in paints on children's toys and furniture.
- Dr. Alan Brown is named the first Professor of Paediatrics in the newly-established Department of Paediatrics at the University of Toronto.
- Dr. Gar Hamblin develops the Hospital's first "premature ambulance," a small wooden box with a mattress suspended in a wire basket over a hot water tank. It travels by taxi.
- Nutritional research by Drs. Alan Brown, Fred Tisdall and Theo Drake leads to the development of a new quick-to-prepare, low cost cereal that later becomes famous the world over as Pablum. The goal is improved nutrition. Also being developed at this time are Sunwheat Biscuits, a high-nutrition biscuit, and enriched bread.