The Hospital for Sick Children | hospital | News

MyEducation Passport helps students self-advocate

Tue, 15 May 2012 24:00:00 EDT

By Lucas Bailey

SickKids has released a new tool, MyEducation Passport, that gives young people a chance to express their detailed learning needs.

MyEducation Passport allows students (or their care providers) to fill out an on-line form that provides a quick summary outlining any learning disabilities and useful strategies. The form can be printed and stored in a pocket or wallet and produced whenever students want to remind themselves of their learning needs and provides them with easy-to-access information when meeting new teachers. The passport can also be emailed so students can provide a digital copy as needed.

“Usually this information is stored in a document that is several pages long,” said Dr. Miriam Kaufman, Adolescent Paediatrician and team lead in the Good 2 Go Transition Program. “Young people can’t easily refer to this, so the wallet-sized passport lets them take the information with them wherever they may need it.”

The idea for the MyEducation Passport came from Dr. Kaufman’s presentation on the MyHealth Passport at SickKids’ Psychology Day in February. After hearing how the health passport provides portable information on individual chronic medical conditions, Jill Haydicky, PhD candidate at the Ontario Institute for Studies in Education, asked if there was an equivalent for education needs.

Recognizing the benefit of the passport tool in education, Kaufman asked Haydicky to join a SickKids working group with the goal of making it easier for young people to understand their education information and communicate it to others.

The working group also included Andrea Regina, Psychology Clinical Fellow, Dr. Anna Gold, Psychologist, and Karen Sappleton, Social Worker. Working together, the team had the new version of the passport up and running within a month.

The MyEducation Passport has already received a positive response from school psychologists and OISE researchers. Roughly 70 passports have been generated, and another 30 have been created by health-care providers and educators checking out the program.

The Good 2 Go Transition Program works to prepare all youth with chronic health conditions leaving SickKids with the necessary skills and knowledge to succeed outside of a paediatric medical setting. Self-advocacy is an important skill for youths with chronic medical conditions and specialized learning needs. The MyEducation passport supports the self-advocacy goal by making it easier for students to get the most out of their education.

New outreach program encourages high school students to become ambassadors for organ donation

Mon, 14 May 2012 24:00:00 EDT

In a unique teen-focused GTA outreach program, three Toronto transplant centres are teaming up with young transplant recipients and Trillium Gift of Life Network to educate high school students about the lifesaving impact of organ and tissue donation.

SickKids Bravery Beads Program celebrates 10-year milestone

Mon, 14 May 2012 24:00:00 EDT

By Daniella Vasilovsky

Freedman receives Grand Challenges grant

Fri, 11 May 2012 24:00:00 EDT

By Lucas Bailey

Dr. Stephen Freedman, Associate Scientist in the SickKids Research Institute and a physician in the Division of Paediatric Emergency Medicine, has received funding through the Grand Challenges Explorations initiative. The funds will support a clinical trial involving children in the emergency departments at the Aga Khan University Hospital, Karachi, and the Aga Khan Maternal and Child Care Centre, Hyderabad, both located in Pakistan.

Created by the Bill & Melinda Gates Foundation, the Grand Challenges program enables individuals to test unorthodox ideas that address persistent health and development challenges.

Dr. Freedman is the co-principal investigator on a study focused on treating children with gastroenteritis (inflammation of the stomach and small intestine). The study will evaluate the use of ondansetron to enhance oral fluid tolerance, in the hope that it reduces the need for intravenous fluid administration. The total amount of the grant is US$100,000.

If the trial is successful, the research team will have the opportunity to receive a follow-on grant of up to US$1 million to evaluate the treatments use in remote settings where conventional treatments are unavailable.

“Grand Challenges Explorations encourages individuals worldwide to expand the pipeline of ideas where creative, unorthodox thinking is most urgently needed,” said Chris Wilson, Director of Global Health Discovery and Translational Sciences at the Bill & Melinda Gates Foundation. “We’re excited to provide additional funding for select grantees so that they can continue to advance their idea towards global impact.”

The grant program is open to anyone from any discipline and from any organization. Grand Challenges Explorations grants have been awarded to researchers in more than 44 countries.

The evolution of nursing

Thu, 10 May 2012 24:00:00 EDT

As we recognize our nurses this Nursing Week, we salute them for their continued commitment to children’s health and reflect on how this profession has evolved over the years.

In 1875, Elizabeth McMaster founded The Hospital for Sick Children (SickKids) to address a gap in the health care system. Almost half of recorded deaths at the time were in children under 10 years old. McMaster, who later became a nurse, recognized the need for specialized care for children and took action.

Today, nurses at SickKids remain committed to providing the best possible care to children and their families, but their role has evolved significantly since 1875. The traditional role of nursing has been considered at the bedside and while bedside nurses will always be essential to quality patient care, nurses also demonstrate leadership through their integral roles in research, education, technology, hospital management and global health. SickKids President & CEO, Mary Jo Haddad, began her career as a nurse. SickKids nurses continue to adapt to the complex and ever-changing health-care system, and strive to improve the health of children locally, provincially, nationally and internationally.

Thinking of working abroad? Think IHAw

Thu, 10 May 2012 24:00:00 EDT

Toronto is a great city – but if you work in health care and are dreaming of making an impact internationally, on May 15 you should be in the International Health Assignment Workshop (IHAw).

SickKids is a leader in paediatric nursing at national conference

Wed, 09 May 2012 24:00:00 EDT

Sarah Meadows and Angela Domingues at the SIckKids booth at the PedNIG conference.

By Lucas Bailey

This year, Nursing Week at SickKids was preceded by the first-ever national paediatric nursing conference, Canadian Nurses Partnering for Children’s Health. Hosted by the Pediatric Nurses Interest Group (PedNIG) and presented by SickKids, the conference ran May 4-5 at the Hyatt Hotel. More than 175 nurses and health-care professionals attended.

The goals of the conference included highlighting primary and preventive health care and promotion, supporting paedatric nursing research, and profiling innovation and technology in paediatric health care. The wide range of topics included rural nursing, pain management and access to specialized services for vulnerable children.

“The conference was a success,” said Ashley Harrison, SickKids RN and conference co-chair. “Our closing panel featured two parents discussing family-centred care, which left many nurses inspired and remembering why they had chosen the profession.”

Harrison also noted that there was considerable buzz about the revamping of the Canadian Association of Paediatric Nurses, a national nursing group. Inactive since 2005, CAPN held a national meeting at the conference to continue its revitalization efforts.

Here’s how some other members of the SickKids family were involved in the conference:

MaRS Innovation paves the way for innovative drug development partnership in China

Tue, 08 May 2012 24:00:00 EDT

MaRS Innovation (MI), The Hospital for Sick Children (SickKids) and NovoTek Therapeutics Inc. (NovoTek, Beijing/China) have announced a strategic partnership to co-develop, and bring to the Chinese market, a novel therapeutic cream aimed at reducing scar formation post surgery.

For many individuals, the development of excessive scar tissue growth after surgery is a reality and it can cause physical discomfort, and emotional and psychological stress. Each year, approximately 240 million surgeries are performed worldwide. Market research suggests an efficacious anti-skin-scarring therapeutic represents a multi-billion dollar opportunity. There are currently no clinically proven prescription therapeutics available for preventing excessive dermal scarring.

Recognizing the value of this promising treatment and the challenging financing environment for preclinical stage therapeutics, MI initiated a co-development licensing option agreement with NovoTek. NovoTek will be responsible for development and commercialization costs for the anti-scarring medication in the Chinese market. MI and SickKids will receive clinical development milestones payments from NovoTek, and MI will have access to all preclinical and clinical data generated by NovoTek to support future clinical development for strategic markets outside China, including the US, Canada, Brazil and Korea.

“With a proven track record in clinical development in China and with strong ties to the Ontario research community, we believe that NovoTek and its founder, Dr. Jubo Liu, are ideal partners for MaRS Innovation and SickKids to co-develop, and ultimately commercialize, the anti-scarring therapeutic in the Chinese marketplace and later on in other territories”, stated Rafi Hofstein, President and CEO, MI.

Dr. Benjamin Alman, Head of the Division of Orthopaedic Surgery and Senior Scientist, Program in Developmental and Stem Cell Biology at SickKids, discovered that a particular molecule known for its analgesic properties can effectively target myofibroblast cells – the cells responsible for producing scar tissue. From this finding, Dr. Alman and his team have successfully developed an alternative use for this molecule as an anti-scarring medication. They have formulated a topical cream containing this molecule which, when applied to a surgical wound, can reduce scarring, as demonstrated in gold standard preclinical models. Clinical trials are expected to begin in early 2013.

“We have a good understanding of which cells are responsible for producing scar tissue during the wound healing process,” says Dr. Alman. “What has been a real challenge is to stop those specific cells from making excessive amounts of scar tissue without negatively impacting the overall wound healing process; and this therapeutic cream appears to do exactly that.”

New iPhone app helps kids with cancer fight pain

Mon, 07 May 2012 24:00:00 EDT

FACTS

Researchers at The Hospital for Sick Children (SickKids) are always looking for new ways to improve pain management for cancer patients, and with the help of Cundari, a leading Toronto-based marketing communications agency; a pain diary app called “Pain Squad” was developed.
Pain Squad is an iPhone app that helps kids and teens with cancer track how intense their pain is, how long it lasts, where it hurts as well as what helps to treat it. They are also able to record how pain impacts their mood and daily activities, such as doing schoolwork, sleeping and interacting with others.
While there are many hurdles in pain treatment, inadequate assessment and a patient’s reluctance to report pain are among the biggest barriers. Adolescents with cancer were involved in the research and development of the app, providing feedback on content and user-friendliness.
Cundari created the Pain Squad theme to keep kids engaged and motivated to complete their pain surveys twice a day. Cundari sought the help of celebrities from two prime-time Canadian law enforcement shows, Rookie Blue and Flashpoint. Playing their crime- fighting characters, the actors performed in encouraging video clips that are unlocked as the kids win promotions to higher ranks. Patient-users join the Pain Squad as “Rookies” and progress through different levels. By completing more surveys they are promoted to higher ranks, such as “Sergeant” and “Captain”.
Pain Squad has just finished the third phase of testing to assess whether it’s easy for patients to use and understand. The app will soon be tested in three other Canadian paediatric oncology centres. The ultimate goal, explains Dr. Jennifer Stinson, lead researcher of the project, is to make the Pain Squad App available to all Canadian adolescents with cancer with the hope that improved pain monitoring will result in better pain management and improve the quality of life for these youths with cancer.

QUOTES

“We made it easier for kids and teens to track their pain symptoms by using technology that they’re familiar with. Keeping an iPhone pain diary is not only less work, but fun, too. Pain Squad is unique because while it helps patients keep track of their own symptoms, it also contributes to research by collecting data on cancer pain. Having solid information on the prevalence and severity of pain and the effectiveness of treatment will allow us to better manage pain and ultimately help improve the quality of life for our patients.” - Dr. Jennifer Stinson, Scientist and Nurse Practitioner in the Chronic Pain Program, SickKids
“Filling out a paper pain journal was like homework. The Pain Squad app is interactive and the more Olivia used it, the more rewards she got. It only takes a few minutes to complete but it gave Olivia a better understanding of and more control over her pain.”
- Sam and Gloria Santarelli, parents of Olivia Santarelli, 11, SickKids patient and study participant
“Over the past three years we've gone to great lengths to reinvent Cundari as not just a creative ad agency, but as a technologically creative agency. This application was a unique opportunity to showcase this. Our creative staff worked closely with our newly formed mobile software group to deliver an impressive end result.” He continues, “It just so happened that the project itself was also rewarding, professionally as Cundari's CTO, and personally as a parent.”
- Wayne Gomes, Chief Technology Officer (CTO), Cundari

BACKGROUND

Every year in Canada 1,400 children are diagnosed with cancer and must not only battle the disease itself, but also the pain associated with cancer and its treatment. Pain is a common and distressing symptom that affects a patient’s quality of life. To effectively manage pain, doctors and nurses rely on the patients to communicate how they are feeling. One way to do this is to have them fill out a detailed paper-based pain diary every day. The challenge is that after chemotherapy and radiation treatment, the last thing on these kids’ minds is completing a pain dairy.
This research was supported by a grant from C17 Children’s Cancer & Blood Disorders. The development of Pain Squad iPhone app was made possible thanks to the expertise of Cundari’s development and creative teams as well as the time and effort of the actors from the shows Rookie Blue and Flashpoint.

About The Hospital for Sick Children
The Hospital for Sick Children (SickKids) is recognized as one of the world’s foremost paediatric health-care institutions and is Canada’s leading centre dedicated to advancing children’s health through the integration of patient care, research and education. Founded in 1875 and affiliated with the University of Toronto, SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally. Its mission is to provide the best in complex and specialized family-centred care; pioneer scientific and clinical advancements; share expertise; foster an academic environment that nurtures health-care professionals; and champion an accessible, comprehensive and sustainable child health system. SickKids is proud of its vision for Healthier Children. A Better World. For more information, please visit www.sickkids.ca.

About Cundari
Cundari is one of Canada’s largest independently owned and operated communications agencies, applying thought leadership to the building of business solutions as the key benefit for client partners. Guided by the core philosophy "It's the thought that counts," Cundari, with offices in Toronto and Montreal, works in our two official languages across an array of disciplines such as research, strategic planning, brand identity, advertising, design, digital, experiential, direct and media planning. Established in 1980,The Cundari Group is proud to be entrusted with premiere brands including BMW, SUBWAY, TELUS, Northern Ontario Tourism, Blue Cross and Ivey School of Business, The University of Western Ontario. For more information visit www.cundari.com.

Contacts:

Caitlin McNamee-Lamb
The Hospital for Sick Children
416-813-7654, ext. 1436
caitlin.mcnamee-lamb@sickkids.ca

SickKids program helps children with reading disabilities

Fri, 04 May 2012 24:00:00 EDT

By Lucas Bailey

May 7-11 is Education Week in Ontario, and SickKids has much to celebrate, including a highly regarded Epilepsy Classroom, an amazing health information system, AboutKids Health, a large number of innovative minds such as those in Adolescent Medicine who have developed the new MyEducation Passport, and Empower™ Reading which has become a national success story and demonstrates SickKids’ commitment to social paediatrics.

Based on 30 years of research by Dr. Maureen Lovett, Director of the Learning Disabilities Research Program and Senior Scientist in Neurosciences and Mental Health, Empower™ uses a scientific approach that teaches children strategies for decoding and understanding words. Children who successfully finish the program move on to reading for meaning, information, and pleasure.

While the program was initially confined to laboratory classrooms, it is now commercially available to schools. The primary level of the decoding and spelling program was launched by five school boards in 2006. Three years later, the high school level rolled out, consisting of a decoding and spelling program and a comprehension and fluency program.

Revenue from sale of the program flows back into SickKids and helps to fund Lovett’s research on the causes and treatment of reading disabilities in children, youth, and adults. As well, the funds are used to develop, refine, and evaluate new interventions to allow struggling learners of all ages and circumstances to develop literacy skills.

This research into learning disabilities was championed by Dr. Bette Stephenson, a former education minister of Ontario. “She recognized the strong relationship between health and literacy, and offered support to the Hospital by providing two special education teachers from local school boards,” Lovett says.

“She encouraged us to develop a new program in learning disabilities, and Drs. John Stobo Prichard and Bill Logan, outgoing and incoming division heads of Neurology, decided that the greatest contributions we could make ultimately to better treatments for kids with learning disabilities would be through developing rigourous research in the area.”

Dr. Lovett was hired to start such a program with the hope that it would result in better understanding of what would work for children with learning disabilities.

Today, Empower™ has reached 19 school boards and benefitted more than 6,500 students at nearly 500 schools across Canada. Independent evaluations by these school boards have reported very positive results.

“We are delighted to see these outcomes in schools as it tells us that we have been able to successfully translate research into practice,” said Karen Steinbach, Program Coordinator, Learning Disabilities Research Program. “The LDRP has embodied SickKids’ commitment to be a hospital without walls.”

Borschel and Tabori honoured with Ontario Early Researcher Awards

Mon, 30 Apr 2012 24:00:00 EDT

The Government of Ontario announced the winners of Round VIII of the Ontario Early Researcher Awards (ERA), Monday, April 30 2012. SickKids is home to two of the awardees this year. Drs. Gregory Borschel and Uri Tabori of SickKids were among the 28 winners in the GTA recognized by the Honourable Brad Duguid, Minister of Economic Development and Innovation at an event at the University of Toronto.

Dr. Gregory Borschel, Associate Scientist, Physiology & Experimental Medicine and Plastic Surgeon at SickKids and Assistant Professor, Departments of Surgery and Biomaterials, and Biomedical Engineering at the University of Toronto, received the ERA funding in support of his project, Enhancing recovery following nerve injury. Nerve injuries are common but current treatments can leave patients with pain, paralysis and numbness. Borschel is investigating whether nerve regeneration can be improved using growth factors and electrical stimulation. If successful, these technologies could be applied in operating rooms worldwide.

Dr. Uri Tabori, Scientist, Genetics & Genome Biology and Staff Oncologist at SickKids and Assistant Professor in the Departments of Paediatrics and Institute of Medical Sciences at the University of Toronto is focused on improving treatment for childhood brain tumours. Through his research project, Prevention of tumor recurrence by targeting telomere dependent self-renewal capacity of neural tumor initiating cells, he is exploring a new way to treat brain tumours by exhausting the self-renewal of cancer stem cells. The approach could transform the lives of children with brain tumours – and could have applications for treating adult brain cancer as well.

“Drs. Borschel and Tabori are precisely the types of individuals who have the skills, ingenuity, knowledge and expertise to help Ontario innovate and move toward a knowledge-based economy,” commented Dr. Janet Rossant, Chief of Research at SickKids. “I congratulate them both on their early success and look forward to seeing their growth in the future.”

The ERA program helps promising, recently-appointed Ontario researchers build their research teams of undergraduates, graduate students, post-doctoral fellows, research assistants, associates and technicians. The goal of the program is to improve Ontario’s ability to attract and retain the best and brightest research talent.

SickKids researchers strive to be the next Rising Stars in Global Health

Fri, 27 Apr 2012 24:00:00 EDT

The challenges may be grand, but the solutions are even grander!

TDSB and SickKids Team Up To Support Child and Youth Mental Health

Fri, 27 Apr 2012 24:00:00 EDT

Connecting Students and TDSB staff to Mental Health Experts Through Technology

The Toronto District School Board (TDSB) and The Hospital for Sick Children (SickKids) have launched a first-of-its-kind partnership that will provide students and TDSB staff with better access to leading mental health and psychiatric services.

Dr. Darius Bägli’s mentoring earns him recognition from his peers and an award from the AUA Foundation

Thu, 26 Apr 2012 24:00:00 EDT

By Alena Boczek

The American Urology Association (AUA) Foundation and the urology community have recognized Dr. Darius Bägli as the 2012 Distinguished Mentor. This honour has been bestowed upon Dr. Bägli for his track record of mentoring numerous research scholars to impeccable standards. He was selected by a panel of his peers who wanted to acknowledge the respect and admiration he has earned from the entire urologic research community.

“Dr. Bägli is an incredibly deserving recipient of the Distinguished Mentor Award,” says Dr. Janet Rossant, Chief of Research. “He consistently displays an authentic generosity and creates a supportive environment for every individual in which he interacts. The AUA Foundation has selected a recipient who truly exemplifies the values this award represents.”

Dr. Bägli is a Senior Attending Paediatric Urologist and Associate Surgeon-In-Chief at The Hospital for Sick Children, and Senior Associate Scientist in the SickKid's Research Institute. He is also a Professor of Surgery at the University of Toronto. Dr. Bägli is currently investigating extracellular matrix biology as it pertains to wound healing and biomechanically-mediated injury in the lower urinary tract.

The Distinguished Mentor Award will be presented at the annual AUA Foundation Scholar Awards Breakfast on Monday May 21.

For more information on Dr. Bägli and his work, please see his Researchers in Profile interview.

Gender bias in autism

Thu, 12 Apr 2012 24:00:00 EDT

Researchers uncover a genetic glitch that affects boys, but not girls

TORONTO – Boys and girls are not affected equally when it comes to Autism Spectrum Disorder (ASD) – it affects four times more males than females. In their search to find genes linked to ASD, a team of international researchers led by The Hospital for Sick Children (SickKids) and McMaster University have uncovered a key genetic clue to explaining the gender bias. The study is published in the April 12 advance online edition of The American Journal of Human Genetics.

39 people who will change Ghana

Wed, 11 Apr 2012 24:00:00 EDT

Celebrating the Graduation of the first Paediatric Nurses in West Africa

A huge white tent cast some welcome shade on the black-robed graduates from the University of Ghana’s College of Health Science.

An investment in the future of paediatric cancer research at SickKids

Wed, 11 Apr 2012 24:00:00 EDT

Heather Bennett, Erica Scarf, Hon. Leona Aglukkaq, Myles Davis

By Alena Boczek

The Honourable Leona Aglukkaq, Canada’s Minister of Health, visited The Hospital for Sick Children (SickKids) to announce a $12 million investment in childhood cancer research. Over five years, the investment from The Government of Canada, through the Canadian Institutes of Health Research (CIHR), will support four new research teams in partnership with the Garron Family Cancer Centre at SickKids, C17 council, the Canadian Cancer Society, the Cancer Research Society, the Ontario Institute for Cancer Research and the Pediatric Oncology Group of Ontario.

Two of the research teams to receive this funding are led by SickKids principal investigators, Drs. Shinya Ito and Paul Nathan. Dr. Ito’s team will study how childhood leukemia treatment affects brain function, while Dr. Nathan’s team will research cardiotoxicity and evaluate the importance of genetic differences between individuals in determining who is at greatest risk of developing heart disease as a result of exposure to chemotherapeutic agents.

“As Canada’s leading paediatric academic health-care centre, SickKids sees firsthand the devastating impact cancer can have on children and their families,” says Mary Jo Haddad, SickKids President and CEO. “Through the funding from this important initiative, SickKids researchers can continue improving cancer treatments for Canada’s children and youth that will enhance the quality of life for paediatric cancer patients.”

For more information on this investment visit the CIHR website for the official news release and a detailed fact sheet.

SickKids-led study identifies multiple genes linked to differences in cystic fibrosis

Sun, 01 Apr 2012 24:00:00 EDT

TORONTO – Cystic fibrosis (CF) is a devastating disease caused by mutations in the CFTR gene. In Canada, one in every 3,600 children born has the disease.

Gideon Koren receives lifetime achievement award

Thu, 29 Mar 2012 24:00:00 EDT

Dr. Gideon Koren, Director of the Motherisk Program and Senior Scientist in Child Health Evaluative Sciences at The Hospital for Sick Children, has been awarded the 2012 Sumner Yaffe Lifetime Achievement Award in Pediatric Pharmacology.

Study suggests new way to treat chronic pain

Sun, 25 Mar 2012 24:00:00 EDT

Gene that encodes crucial pain receptor may be key to individualizing therapy for major health problem

Nearly one in five people suffer from the insidious and often devastating problem of chronic pain.

A Fine Day for Discovery

Fri, 23 Mar 2012 24:00:00 EDT

One fine day in 1989 a group of researchers, including Dr. Lap-Chee Tsui, a scientist at The Hospital for Sick Children (SickKids) at the time, discovered the genetic cause for Cystic Fibrosis (CF). On March 21, a fine day in 2012, Dr. Tsui, now Vice-Chancellor and President of the University of Hong Kong, celebrated his induction into the Canadian Medical Hall of Fame with a special event at SickKids.

Members of the Toronto research community celebrated the impact of the discovery on cystic fibrosis and genomics research. The cystic fibrosis gene discovery was the first time that a disease gene was identified, paving the way for the mapping of the human genome, which began in 1990.

SickKids President and CEO, Mary Jo Haddad gave opening remarks, welcoming Dr. Tsui back to SickKids as the guest of honour. She was followed by SickKids’ Dr. Stephen Scherer, a former trainee of Dr. Tsui’s and now a leader in genomics research, who discussed how that discovery significantly contributed to continued advancement in genomics. Invited guest Dr. Eric Sorscher, Director of the Gregory Flemming James Cystic Fibrosis Centre at the University of Alabama, then discussed how the 1989 discovery has greatly contributed to the advancements of CF research and treatment. SickKids’ Senior Scientist Dr. Johanna Rommens, who was part of the CF gene discovery team in 1989, talked about some of her recent research, including a paper that will be published shortly in Nature Genetics, which is further advancing our understanding of CF.

In a celebration of science and the impact of the CF gene discovery, both those who were present for the 1989 discovery, as well as the next generation of SickKids researchers were honoured to spend an afternoon with Dr. Tsui looking back to this remarkable discovery and the developments in research and treatment it has since enabled.

Dr. John Brumell: A rising star in the field of Cell Biology

Thu, 22 Mar 2012 24:00:00 EDT

By Alena Boczek

Addressing Global Child Health Priorities around the World

Wed, 21 Mar 2012 24:00:00 EDT

Dr. Joy Lawn from Cape Town, South Africa and a panel of speakers from the Canadian health-care community discuss ‘Inequities in Perinatal Health'

SickKids’ celebrated its 6th Annual Global Child Health Day as over 125 health-care professionals, researchers, development workers and community members interested in global child health gathered in the Daniels Hollywood Theatre on February 15, 2012.

Child Life brought the vacation to SickKids during this March Break!

Wed, 14 Mar 2012 24:00:00 EDT

Around the world in an afternoon

By Alena Boczek

Filling the gaps: New diagnostic tool reflects today’s diverse Canadian paediatric population

Mon, 12 Mar 2012 24:00:00 EDT

TORONTO – A major tool has been developed that will directly contribute to improved diagnosis and assessment of children and youth with medical concerns across Canada.

Building capacity for nursing and research in Qatar

Mon, 12 Mar 2012 24:00:00 EDT

Two recent educational events demonstrate the collaborative relationship between SickKids and Hamad Medical Corporation (HMC).

Held in January, the events focused on nursing leadership and child health research, both areas where SickKids and HMC are working hard to create a strong foundation for future growth.

The First Symposium for Pediatric Nursing Leaders was created to explore the many ways nursing leaders can take positive action through evidence-based best practices and research, and the benefits such action can have on patient care. Speakers at the symposium, which included nursing professionals from both SickKids and HMC, stressed the strong role nursing leaders can play in the development of a strong, collaborative and supportive nursing environment.

Margaret Keatings, Chief Interprofessional Practice and Chief Nurse Executive for SickKids, was impressed by the commitment to nursing leadership she saw at the symposium. “At SickKids, we’ve implemented a broad range of tools and resources to support our nursing leaders,” she says. “I was thrilled to be able to share what we’ve learned at the symposium, and to have the opportunity to support our partners in advancing their Nursing Leadership Model.”

The Second Annual Child Health Research Day was also a partnership between SickKids International and HMC. Open to researchers in HMC and across Qatar, it highlighted the importance of research in a world-class paediatric health organization.
The event was an opportunity to feature research projects as well as to connect researchers and focus on issues relevant to children’s health in Qatar. The theme was “Celebrating Collaborative Research”.

Dr. Allan Coates, Research Director for the Qatar Project, made the point that, while the First Annual Research Day was really a Sickkids endeavour with some help from Hamad Medical Corporation, the 2012 event was very much a Hamad endeavour with some help from SickKids. “This is a great example of building capacity and sustainability in Qatar,” he said. Coates looked forward to the presentations that would show case child health research done by Hamad investigators.

Cathy Seguin, SickKids’ Vice-President for International Affairs, says the two events illustrate the collaborative nature of the partnership with HMC. “It’s exciting to see how our work to establish a state-of-the-art children’s hospital in Qatar has blossomed to include learning experiences such as the nursing symposium and research day, which will enhance child health services for Qatar,” she says.

SickKids International began its five-year partnership with Hamad Medical Corporation in 2010.

Peter Gilgan, Founder, Mattamy Homes helps build future home of SickKids researchers with historic $40 million gift

Wed, 07 Mar 2012 24:00:00 EST

A transformational gift of $40 million donated by philanthropist and business leader Peter Gilgan, Founder and CEO of Mattamy Homes, was announced on March 7, 2012, at The Hospital for Sick Children (SickKids).

Researchers suggest WHO re-evaluate drinking water guideline for manganese

Wed, 29 Feb 2012 24:00:00 EST

TORONTO – Scientists are concerned about drinking water quality around the world after the World Health Organization (WHO) discontinued its drinking water guideline for manganese in 2011. In a recent commentary by an international team from The Hospital for Sick Children (SickKids), Norwich University and Better Life Laboratories, researchers identified more than 50 countries worldwide with drinking water or potential drinking water supplies exceeding the former recommended limit for manganese (400 micrograms per liter). The commentary, published online in February in Environmental Health Perspectives, suggests the WHO re-evaluate and re-instate its drinking water guideline for manganese.

Rethinking paediatric brain cancer

Wed, 15 Feb 2012 24:00:00 EST

Rethinking paediatric brain cancer

Canadian researchers find simple reason why some children die despite aggressive modern therapy for brain cancer

What does Valentine's Day mean to our patients?

Tue, 14 Feb 2012 24:00:00 EST

We caught up with some of our patients who wanted to deliver a special Valentine's Day message.

SickKids Scientist, Dr. Jennifer Stinson Honoured by the Canadian Pain Society

Wed, 08 Feb 2012 24:00:00 EST

By: Alena Boczek

Researchers say patients leave ER with poor understanding of how to care for themselves

Tue, 24 Jan 2012 24:00:00 EST

TORONTO – A visit to the Emergency Department (ED) can be a stressful and overwhelming experience for patients and families. Between diagnosis, test results, a treatment plan and medications, there is a lot of information to digest. While experts note that discharge education should begin with the initial assessment, it has often been an afterthought, leaving patients with unanswered questions and uncertainty about self-care.

Top 11 of 11

Fri, 20 Jan 2012 24:00:00 EST

The year 2011 was a banner year for SickKids. We received one award after another, continued construction on a building we could only have dreamt of five years ago, and raised an unprecedented amount of money to help children get better. Here are 11 of the top stories for 2011. See more news from 2011.

Bouffet, Egeler named inaugural holders of Garron Family Chairs in Childhood Cancer Research

Thu, 19 Jan 2012 24:00:00 EST

Dr. Eric Bouffet and Dr. Maarten Egeler appointed as inaugural holders of Garron Family Chairs in Childhood Cancer Research

By Daniel Puiatti

Maureen Dennis – “the leading child neuropsychologist in North America” – receives lifetime achievement award

Mon, 16 Jan 2012 24:00:00 EST

Maureen Dennis has been given the Lifetime Achievement Award from the International Neuropsychological Society. She will receive the award Feb. 15 during the annual meeting of the International Neuropsychological Society (INS) in Montreal.

SickKids researcher appointed Officer of the Order of Canada

Fri, 13 Jan 2012 24:00:00 EST

Dr. Alvin Zipursky has been appointed an Officer of the Order of Canada for his contributions to paediatrics in Canada and in developing countries.

SickKids scientists develop cutting-edge 3D structural model detailing cell’s molecular motors

Thu, 12 Jan 2012 24:00:00 EST

Researchers from The Hospital for Sick Children (SickKids) have determined the structure of an essential type of protein, called a rotary ATPase, found in all cells. Rotary ATPases are referred to as molecular motors because rotation of part of the protein causes it to pump protons across cell membranes. Until now, there were no structural models available of an intact rotary ATPase with the necessary resolution to understand how rotation of the rotary part of the protein can lead to protons being pumped across cell membranes. The study is published in the January 12 edition of Nature.

“Our research provides a new level of understanding of the mechanism of these motors, which has implications in diverse areas,” says Dr. John Rubinstein, Scientist in the Molecular Structure and Function Program at SickKids and Assistant Professor in the Departments of Biochemistry and Medical Biophysics at the University of Toronto, who conducted the study with SickKids PhD student Wilson Lau.

In this study, the scientists developed new techniques for electron cryomicroscopy (cryo-EM) – a form of electron microscopy where samples are studied at very low temperatures – to determine the 3D map of the rotary ATPase from the bacterium T. thermophilus at a subnanometer (better than one millionth of a millimeter) resolution. These techniques included developing methods to optimize images and creating new computer algorithms used to calculate the complete 3D structure from the images they obtained.

“The findings help us understand how cells manage their energy supply, how certain bacteria, viruses and toxins enter human cells and even how certain types of tumours acidify and invade the tissue that surrounds them,” says Rubinstein.

The research was supported by the Canadian Institutes of Health Research, an Ontario Graduate Scholarship, the Ministry of Research and Innovation and SickKids Foundation.

Imaging success

Wed, 04 Jan 2012 24:00:00 EST

SickKids and Holland Bloorview launch shared imaging system

Two Toronto paediatric hospitals recently made it easier for clinicians to treat patients.

Diagnostic images and reports can now be shared between The Hospital for Sick Children (SickKids) and Holland Bloorview Kids Rehabilitation Hospital through a shared diagnostic imaging system based on the SickKids PACS (Picture Archiving and Communication System) platform.

Dr. Stephen Scherer Inducted as AAAS Fellow

Thu, 22 Dec 2011 24:00:00 EST

By Daniel Puatti

HOT TOPIC: It’s no one’s fault: Speaking to kids about mental illness

Tue, 20 Dec 2011 24:00:00 EST

Approximately 20 per cent of Canadians will experience mental illness over the course of their lives. When a family member is diagnosed with mental illness, it can be difficult to explain what’s happening to a child. Dr. Sandra Mendlowitz, Psychologist in the Anxiety Program and Project Investigator at SickKids, and Assistant Professor in the Department of Child Psychiatry at the University of Toronto, has some advice for parents.

Qatar Update: Department of Paediatrics

Mon, 19 Dec 2011 24:00:00 EST

Baruchel recently awarded prestigious French order

Mon, 19 Dec 2011 24:00:00 EST

Philippe Zeller presents Dr. Sylvain Baruchel with the Chevalier de l ‘Ordre National de la legion D‘ honneur

Dr. Sylvain Baruchel was recently named a Chevalier de l ‘Ordre National de la legion D‘ honneur, the highest designation given by his native country, France and equivalent to the Order of Canada. The French Ambassador in Canada, Philippe Zeller presented Baruchel with this award. It was Zeller’s first official visit to Toronto. Baruchel, a physician, researcher and professor was given this award for his research and education in the fields of AIDS and cancer over the last 30 years and his work to improve the self esteem of teens living with cancer.

Founder of the innovative Tip of the Toes Foundation, Baruchel started an initiative to take teens with cancer on expeditions in the wilderness. Baruchel has also done work in France and in Canada to raise awareness and combat the stigmatization of patients with AIDS or cancer.

Santa's elves land on roof!

Thu, 15 Dec 2011 24:00:00 EST

Daniel Ethier meets the Leafs

The weather outside was not at all frightful – six degrees with 11 km/h winds and perfect for Santa’s elves to land their Griffon helicopters on the SickKids rooftop, pouring rain notwithstanding.

Qatar Update: Perioperative Services

Tue, 13 Dec 2011 24:00:00 EST

In 2010, SickKids began a historic five-year partnership with Hamad Medical Corporation (HMC) to create a state-of-the-art children’s hospital in Doha, Qatar. Read about the project and the SickKids staff experience, one of our major project milestones, research and nursing education and training.

A focused, high-performing perioperative team is essential for young patients and their families to have a positive surgical experience. In perioperative services, a multidisciplinary surgical team provides care for a patient during the immediate pre-operative/ pre-anesthesia, intra-operative and immediate post-operative periods.

Canada's Most Powerful Women: Top 100 Hall of Fame welcomes Mary Jo Haddad

Tue, 06 Dec 2011 24:00:00 EST

The Hospital for Sick Children (SickKids) is proud to announce that its President and CEO, Mary Jo Haddad, has been inducted into the Canada’s Most Powerful Women: Top 100 Hall of Fame.

Qatar Update: Nursing Education and Training

Mon, 05 Dec 2011 24:00:00 EST

In 2010, SickKids began a historic five-year partnership with Hamad Medical Corporation to create a state-of-the-art children’s hospital in Doha, Qatar. In 2010, SickKids began a historic five-year partnership with Hamad Medical Corporation to create a state-of-the-art children’s hospital in Doha, Qatar. Read about the project and the SickKids staff experience, one of our major project milestones and research.

Qatar Update: Research

Thu, 01 Dec 2011 24:00:00 EST

In 2010, SickKids began a historic five-year partnership with Hamad Medical Corporation to create a state-of-the-art children’s hospital in Doha, Qatar. Read about the project and the SickKids staff experience and one of our major project milestones.

SickKids photo book now on sale

Thu, 01 Dec 2011 24:00:00 EST

A History of Healing ($69.99) is a limited edition - purchase your copy at the 5 Fifty 5 Shop or online.

Leader in education will head Learning Institute

Tue, 29 Nov 2011 24:00:00 EST

Dr. Jonathan Kronick, MD, PhD, has been appointed as SickKids’ Chief of Education, effective February 6, 2012.

Dr. Kronick has been involved in education throughout his career. He received the Canadian Paediatric Society's 2011 Michel Weber Education Award which recognizes excellence in the field of education. He is currently a professor in the Department of Pediatrics at Dalhousie University in Halifax NS and served as Dalhousie’s Head of Pediatrics and as Chief of Pediatrics at IWK Health Centre from 2002 to 2010. He received both his medical and doctorate degrees at McMaster University and holds a master’s degree in psychology from the University of Waterloo. Dr. Kronick’s clinical work will be in the Division of Clinical and Metabolic Genetics.

“I am absolutely thrilled that Dr. Kronick has chosen to join SickKids,” said Mary Jo Haddad, President and CEO. “His experience and understanding of the paediatric academic health-care environment will be a wonderful asset as we continue to build our innovative and progressive Learning Institute, advancing the overall educational mission of SickKids.”

Dr. Kronick will replace Dr. Susan Tallett, who retired as Chief of Education in September. The Learning Institute is currently headed by Dr. Stanley Zlotkin, Vice President, Medical and Academic Affairs, who serves as Interim Chief, Education.

Qatar update: Project milestone

Mon, 21 Nov 2011 24:00:00 EST

And all the children in Ghana will be smiling

Mon, 21 Nov 2011 24:00:00 EST

A November 11 visit from Professor Aaron Lawson, Provost, College of Health Sciences, University of Ghana, and a special edition of the Global Health Discussion Forum, gave SickKids a unique opportunity to celebrate the many milestones achieved with its Ghanaian partners.

SickKids focuses international strategy

Fri, 18 Nov 2011 24:00:00 EST

Whether they live in Toronto or in Accra, all children deserve good health. SickKids knows achieving success in the global child health environment can be complex, and that it is a rapidly evolving area for care, research and education.

“As a leading paediatric health centre that serves a diverse community and attracts and trains professionals from around the world, SickKids is committed to having a meaningful impact on the health of children here and abroad,” says Cathy Séguin, vice-president, international affairs.

Five years ago, SickKids formalized its international activity into SickKids International (SKI). SKI’s purpose is to focus efforts abroad to optimize resources and promote positive change. In the last five years, SickKids, through SKI, has made great strides in our international work.

Staff from across the organization have worked on SickKids’ Qatar project, charged with creating a world-class paediatric health care centre in Doha. We have created and are now delivering a curriculum that will train paediatric nurses in Ghana. The Programme for Global Paediatric Research (PGPR) is facilitating work that will result in a huge impact in child mortality and morbidity rates caused by sickle cell disease, Kernicitus disease and others.

In September, the SickKids Board of Trustees approved a renewal plan for our international strategy for the next five years that will build on our current successes. There are three areas of focus: the Global Child Health Program, Business Development and the International Patient Office.

SickKids named Most Admired Corporate Culture

Thu, 17 Nov 2011 24:00:00 EST

The Hospital for Sick Children (SickKids) is thrilled to announce it has been named one of Canada’s 10 Most Admired Corporate Cultures for 2011.

Greater Toronto's Top Employers for 2012

Wed, 16 Nov 2011 24:00:00 EST

We are proud to announce that SickKids has been named one of Greater Toronto's Top Employers for 2012 by Mediacorp Canada, as well as being one of Canada’s Top 100 Employers for 2012.

Science Rocks!

Fri, 11 Nov 2011 24:00:00 EST

Café Scientifique weighs in on childhood obesity in Canada

SickKids scientists were the headliners at the Hard Rock Café Toronto on Tuesday, November 7, where community members gathered to take part in Café Scientifique: Tipping the Scales – Weighing the Health Impacts of Obesity on Canadian kids.

The community based discussion focused on the causes, prevention and treatment of childhood obesity. Dr. Catherine Birken kicked off the conversation with revealing statistics that obesity rates among Canadian children have almost tripled in the last 25 years, meaning approximately 26 per cent of kids aged 2-17 are overweight or obese, according to The Childhood Obesity Foundation. Through the TARGet Kids! program, her research group aims to identify prevalence, predictors, outcomes, and effective strategies for prevention of overweight and obesity in children under five.

Dr. Jill Hamilton added to the tune with her research on the health risks associated with obesity. She works to understand the physiology of children with obesity and the trajectory of weight gain. Hamilton also discussed a group of children who have suffered from a specific type of brain tumour called craniopharyngioma. About half of these kids develop very serious weight gain because the tumours are often located right near the appetite centre of the brain and the site that regulates body weight.

As soon as the speakers concluded, the moderator, Mohamed Awad, Couchiching Institute on Public Affairs managed the questions that flooded in until the end of the evening. This Café attracted a broad group of people who were engaged in the discussion and offered their varied perspectives on childhood obesity.

This Café Scienitifique reflects SickKids dedication to tackling childhood obesity and our ongoing commitment to Healthier Children. A Better World. By facilitating community based discussions, through Café Scientifique, SickKids engages in knowledge translation of child health issues.

Planning is underway for the next Café Scientifique to be held in the summer. Be sure to sign up for to receive notifications of our upcoming Café Scientifique’s by sending an email to: cafe.scientifique@sickkids.ca

By Daniel Puatti

National SickKids-led study finds new way to predict MS diagnosis in children

Wed, 09 Nov 2011 24:00:00 EST

TORONTO - Early MRI scans can help predict the diagnosis of multiple sclerosis (MS) in children, which may permit earlier initiation of treatment, according to a new national study. The study was led by The Hospital for Sick Children (SickKids) and was performed as a part of the Canadian Pediatric Demyelinating Disease Network, a 23-site study that includes all paediatric health-care facilities in Canada. The study is published in the November 7 advance online edition of Lancet Neurology.

SickKids psychiatrist honoured by children’s aid societies for protecting children from abuse and neglect

Wed, 09 Nov 2011 24:00:00 EST

Dr. Johanne Roberge receives her award from the Honorable Dr. Eric Hoskins, Minister of Child and Youth Services, during a ceremony that took place Nov. 8

Dr. Johanne Roberge, Director of the Psychiatry Emergency and Crisis Service at SickKids, has been recognized for her exceptional commitment to protecting vulnerable children from abuse and neglect.

Qatar Update: Project Overview and Staff Experience

Mon, 07 Nov 2011 24:00:00 EST

In 2010, SickKids began a historic five-year partnership with Hamad Medical Corporation to create a state-of-the-art children’s hospital in Doha, Qatar.

SickKids named one of Canada’s Top 40 Research Hospitals

Fri, 04 Nov 2011 24:00:00 EDT

Research Infosource released the inaugural list of Canada’s Top 40 Research Hospitals, and The Hospital for Sick Children (SickKids) is number three. The list, based on research income generation, highlights the important role that hospitals play in Canada's research ecosystem.

SickKids, third on the list, is the number one income generating paediatric research hospital in Canada. At SickKids, research discoveries in children’s health are guided by our vision Healthier Children. A Better World. Through collaboration, SickKids brings research from the bench to the bedside and into the backyard, making SickKids a leader in children’s health research and innovation.

“I am delighted that SickKids was named as one of the Top 40 Research Hospitals in Canada,” said Janet Rossant, SickKids Chief of Research. “The ranking reflects our collective success in attracting grant funding.”

The total research income for Canada's Top 40 Research Hospitals was $2.1 billion in the 2010 fiscal year, up 7.2 per cent from 2009. According to Canada's Top 40 Research Hospitals List 2011, research income includes all internal and external government and non-government sources.

Check out the full list of Canada's Top 40 Research Hospitals on the Research Infosource website.

More than 800 exceptional minds, one big room

Thu, 03 Nov 2011 24:00:00 EDT

On Tuesday, November 1, 2011 researchers and staff of the SickKids Research Institute gathered at the Metro Toronto Convention Centre to share cutting edge research and to celebrate the excellence of their peers at the 2011 Research Institute Retreat.

The 24th annual retreat kicked off with Mary Jo Haddad, CEO of SickKids, welcoming a conference room of over 820 researchers and staff. “This retreat is a great tradition, an opportunity for everyone in the Research Institute to come together for a day of learning and it is wonderful to see so many faces in the crowd,” said Haddad. “Together, we have reaffirmed the immense contributions that each of you bring to advancing children’s health in addition to setting some key strategic areas of research focus.”

This year’s retreat focused on the themes of cancer research, neuropsychiatric research and cardiac research. For the first time, trainees were included as invited speakers along with SickKids principal investigators, adding to the breadth of research presented during the sessions. Trainees also added to the day of science by presenting over 200 research posters during the poster session. Dr. Huda Y. Zoghbi from Baylor College of Medicine in Houston Texas was the 2011 Aser Rothstein keynote speaker, presenting her groundbreaking work on neurobiology and Rett Syndrome.

The retreat is not only an opportunity to celebrate our research excellence, but it is also a time to recognize accomplishments. Every year, awards are presented in recognition of individuals who contribute to the SickKids research community in extraordinary ways. This year Mark Hayes was awarded the Research Institute Citizenship Award for his generosity in facilitating the space and facilities needs of researchers. Each research program is also given an opportunity to recognize individual trainees. The 2011 Exceptional Trainee Award winners are:

Getting animated at SickKids

Thu, 03 Nov 2011 24:00:00 EDT

Gurjas Samra at the clay station

The National Film Board of Canada (NFB) visited SickKids on Oct. 27 to bring its Get Animated! workshop to kids spending time at the hospital. The already whimsical Bear Theatre was transformed into the hub of all things animation, with a clay animation station and a flipbook table. Two other tables had all the gear needed to create the animation magic.

Behaviour training, not meds, preferred therapy for preschoolers at risk of ADHD

Tue, 25 Oct 2011 24:00:00 EDT

The diagnosis and treatment of attention deficit hyperactivity disorder (ADHD) has increased significantly over the past 15 years. While the disorder is more commonly identified in children aged six to 10, recently there has been increased interest in the diagnosis and treatment of preschoolers at risk of ADHD.

Unhealthy habits in teens from lower socioeconomic households raises risk of heart disease

Sun, 23 Oct 2011 24:00:00 EDT

New research from The Hospital for Sick Children (SickKids) shows cardiovascular risk in teens with lower socioeconomic status is significantly influenced by sedentary lifestyle, poor nutrition, smoking and other health behaviours.

Next-generation Database of Genomic Variants launches

Wed, 19 Oct 2011 24:00:00 EDT

Version 2 of the Database of Genomic Variants (DGV) launches this week. DGV – also known as “the Toronto Database” – is a public resource that facilitates the translation of genomic information into new diagnostic, prognostic and therapeutic tools for improving health. DGV was initially created in 2004, as an initiative of The Centre for Applied Genomics (TCAG) at The Hospital for Sick Children (SickKids) and the University of Toronto’s McLaughlin Centre.

Dr. Lap-Chee Tsui inducted into Canadian Medical Hall of Fame

Wed, 19 Oct 2011 24:00:00 EDT

It was a landmark discovery at the time. Now, more than 20 years later, this remarkable moment in 20th century medical history is understood to be one of the most significant breakthroughs in human genetics in 50 years -- the discovery of the gene that causes cystic fibrosis.

Today, news that Dr. Lap-Chee Tsui, Adjunct Scientist, SickKids Research Institute, is being inducted into the Canadian Medical Hall of Fame in 2012 for his extraordinary contributions to science is taking many of us at SickKids back to that day in 1989.

SickKids opens cultural competence education to the world

Fri, 14 Oct 2011 24:00:00 EDT

The Hospital for Sick Children (SickKids) has launched a series of free educational tools designed to enhance cultural competence in health care.

SickKids Expert Alert: Year-round athletes at risk for adult-like injuries

Wed, 12 Oct 2011 24:00:00 EDT

As the professional hockey season begins, baseball players are almost heading into the off season, but for an increasing number of young athletes there are no breaks.

SickKids wins top employer designation

Fri, 07 Oct 2011 24:00:00 EDT

The Hospital for Sick Children (SickKids) is proud to have been named one of Canada’s Top 100 Employers for 2012 by Mediacorp Canada Inc.

Dr. David Malkin appointed Medical Director of POGO; Chair of Childhood Cancer Control at U of T

Fri, 07 Oct 2011 24:00:00 EDT

Dr. David Malkin has been appointed Medical Director of POGO (Pediatric Oncology Group of Ontario) and Chair in Childhood Cancer Control at the University of Toronto (U of T). He assumed his new roles August 1, 2011.

SickKids Expert Alert: Why do youth delay seeking help for mental illness?

Thu, 06 Oct 2011 24:00:00 EDT

Researchers at The Hospital for Sick Children (SickKids) try to understand the perspective of young people experiencing mental illness and why they delay seeking help. Despite efforts to increase awareness about mental health issues, the stigma and discrimination associated with mental illness prevent young people from seeking help.

Research reveals that other factors include the dynamic complexity of the roles of family, school, community, treatment system and illness experience in the path to mental health care. This problem calls for creative, innovative and provocative strategies.

Dr. Katherine Boydell, Health Systems Research Scientist in the Community Health Systems Resource Group at SickKids, is available to discuss some of the strategies – specifically the use of arts-based projects using dance and mural art installation to create awareness and understanding and open up a dialogue on mental health issues, particularly in secondary school settings.

Schachter awarded Austrian Cross of Honour for Science and Art First Class

Mon, 03 Oct 2011 24:00:00 EDT

Dr. Harry Schachter was recently awarded The Austrian Cross of Honour for Science and Art First Class, a prestigious state designation from his birth country, Austria. A world-leader in the field of glycobiology, Schachter was honoured for his scientific achievements in glycobiology and most notably for his collaboration with scientists at BOKU: University of Natural Resources and Life Sciences, Vienna. He was presented with the Cross at Glyco 21 held in Vienna from August 21 to 26, the 21st International Symposium on Glycoconjugates that brings together glycobiologists from around the world.

Schachter was born in Vienna in 1933. His father, a dentist, loved the arts and culture of the city, especially the opera. However, as a politically astute man, he foresaw the future for Jewish people in Vienna and moved his family out of the city he loved to Trinidad in September 1938. This was just a few weeks before Kristallnacht – the Night of Broken Glass, a night of terror for many of the remaining Jewish people in Europe.

Schachter did not return to Vienna until the 1980s. He was invited by Dr. Leopold März , a biochemist starting a Glycobiology Department at BOKU University, who eventually became Chancellor (“Rektor”) of the University. He sought Schachter’s advice and assistance in launching the new department. Over the years, Schachter and his wife Judy became very close friends of März and his wife and returned many times – both on personal visits and for professional collaboration. For Judy, who survived the war in Slovakia, hearing someone speaking German had become traumatizing. By being around Schachter’s professional connections and establishing personal friendships that trauma eventually faded away. Schachter continued his collaboration with BOKU and the field of glycolobiology in Austria throughout his career.

Although the Cross is awarded by the Austrian government, März played a large role in ensuring that Schachter’s name was put forward. In his presentation speech, Josef Glößl, the current Vice-Rektor of BOKU, not only spoke about Schachter’s science but also discussed the events in Austria starting in the late 1930s. Schachter and other Jewish scientists present at Glyco 21 were very touched by this acknolwedgement.

“They gave the award for my science, but I could not separate what happened in the 1930s from my receipt of this award,” said Schachter. “Glößl’s speech was very moving.”

Scientific Consortium awarded $34 million from the National Institutes of Health

Thu, 29 Sep 2011 24:00:00 EDT

The Toronto Centre for Phenogenomics, a research facility of The Hospital for Sick Children (SickKids), will benefit from grants awarded by the National Institutes of Health (NIH). The NIH announced $34million in grants to the DTCC Consortium, which is formed by the Toronto Centre for Phenogenomics, University of California Davis, Children’s Hospital Oakland Research Institute, and Charles River Laboratories. The money will be used to fund the Consortium’s participation in the second phase of the NIH Knockout Mouse Project (KOMP2).

“In this consortium, we have assembled world experts in mouse stem cell biology, genetics, breeding, and phenotype analysis, who are dedicated to ensuring the successful outcome of KOMP2, on-time and on-budget,” says Dr. Kent Lloyd from the University of California Davis, Principal Investigator and Project Director of the DTCC KOMP2 project.

Researchers use knockout mouse models because 94% of genes in mice have a similar gene in humans. A knockout mouse is a research model in which a specific gene has been disrupted. The resulting loss of the gene’s function can often be linked to a change in phenotype (observable characteristics such as appearance, behavior or biological function). These observations can help researchers determine which genes are linked to certain normal biological functions or disease. “To understand how our genes function normally and in disease, we will study the developmental problems and diseases in unique animal models that have different abnormal or mutated genes,” says Dr. Colin McKerlie, Senior Associate Scientist at SickKids and a Co-PI on the grant. “This will enable us to determine the effect of each mutation and whether the gene or the protein it produces could be a target for drugs or be used to diagnose disease. This support from NIH leverages our capabilities and project already funded by Genome Canada in Toronto to have truly international impact.”

KOMP2 is part of a global initiative to create a repository of knockout mouse lines and phenotype data which researchers will then use to develop better models of human diseases such as cancer, heart disease, neurological disorders, diabetes and obesity. The goal of the first phase of the global initiative was to create a mutation in embryonic stem cells for each of the approximately 21 ,000 protein-coding genes in the mouse genome, which would allow researchers to determine the role of each gene in normal physiology and development. KOMP1 successfully completed work on 8,500 genes and the majority of the remaining genes will be completed by scientists in Europe and Canada.

In KOMP2, 2,500 of the mouse embryonic stem cells created in the first phase will be used to establish and breed mouse lines which will then be phenotyped. All of the mouse lines and phenotype data will be accessible to researchers around the globe. Model creation and phenotyping expertise will be provided by the University of California Davis, Toronto Centre for Phenogenomics, and Children’s Hospital Oakland Research Institute; Charles River will provide large-scale production expertise for the mouse models.

Scientists identify two distinct genes that may have profound effect on power plants of the cell

Fri, 23 Sep 2011 24:00:00 EDT

In a new study led by The Hospital for Sick Children (SickKids), scientists identified two distinct genes that may help better understand a vital component of the mitochondria, or power plants of the cell: the assembly of iron-sulfur clusters. The study was published in the September 22 advance online edition of The American Journal for Human Genetics during mitochondrial disease awareness week.

For 30 years, researchers have been working to better understand mitochondrial diseases.

Mitochondrial diseases are a result of a genetic mutation that causes these energy-producing structures to fail to produce energy. Without this energy, the affected cells die and the body is no longer able to power its organs causing a variety of health problems such as muscle weakness, high acidity in the body and degeneration of the central nervous system.

Iron-sulfur clusters are an electron-conducting unit that generates energy to produce life and plays an essential role in mitochondria.

“There has been considerable interest in how iron-sulfur clusters are formed,” says Dr. Brian Robinson, Senior Scientist in Genetics & Genome Biology at SickKids. “It has been known that two cellular pathways, the NFU and ISCU pathways, are involved in iron-sulfur cluster assembly, but the ISCU pathway was thought to be more important.”

Scientists identified two distinct genetic defects in two families with mitochondrial disease. Both genes were found on the NFU pathway. The defective genes affected the process by which the iron-sulfur clusters were assembled in the mitochondria.

“The identification of the defective genes, NFU1 and BOLA3, on the NFU pathway suggests that this pathway is more important for the assembly of iron-sulfur assembly than we thought,” explains Robinson, who is also Professor in Biochemistry & Paediatrics at the University of Toronto. “Prior to this study, no defects had been identified on the NFU pathway. The discovery of these genes shows that there are more severe consequences for iron-sulfur cluster assembly on the NFU pathway.”

SickKids-led study shows simple technique using ordinary blood-pressure cuff may protect against stroke damage

Thu, 22 Sep 2011 24:00:00 EDT

TORONTO – An international research team led by The Hospital for Sick Children (SickKids) has found a new potential treatment to help reduce the severity of acute stroke. As a leading cause of death and long-term disability in the world, acute stroke is a serious brain injury that currently has only one standard therapy and a narrow window of time in which to use it.

Mary Jo Haddad, SickKids President and CEO, named one of Canada’s Top 25 Women of Influence

Tue, 20 Sep 2011 24:00:00 EDT

Mary Jo Haddad, SickKids President and CEO, has been named one of Canada’s inaugural Top 25 Women of Influence.

The Top 25 Women of Influence celebrates the achievements of 25 women across Canada in five industry categories: Business, Health Sciences, Professional Services, Public Sector and Non-Governmental Organizations. Haddad was recognized in the Health Sciences category. The categories were chosen because of the exceptional impact that women are having in these areas, and the need for increased recognition beyond those concentrations.

The Top 25 were chosen from a pool of hundreds of accomplished Canadian women and represent a diverse list of women who are leading the pack. The women chosen are “authentic leaders, extraordinary achievers and exceptional role models for other aspiring Canadian women.” Candidates were ranked by quantifiable and measureable data, on their influence in their current roles, industry and beyond.

“Mary Jo's influence on the advancement of the child health system is evident through the progress that has been made right here in Ontario”, says Robert Harding, Chair of The Hospital’s Board of Trustees. “Her leadership and passion for children's health is an inspiration to us all. This is a well-deserved award.”

Haddad and the other Top 25 women will be profiled in the winter issue of Women of Influence magazine.

Deep brain stimulation helps regenerate brain cells to improve brain’s RAM

Tue, 20 Sep 2011 24:00:00 EDT

TORONTO – While a cut on your hand will prompt new skin cells to grow over the wound and heal it, the brain has historically been considered an organ that does not regenerate. If brain cells were lost, they were thought to be gone forever; however, recent studies have suggested that this may not be the case. New research from The Hospital for Sick Children (SickKids) and the University Health Network shows promising results in regenerating neurons in the part of the brain responsible for memory and learning, which may ultimately have applications in neurocognitive diseases like Alzheimer’s. The study is published in the September 21 advance online edition of The Journal of Neuroscience.

Deep brain stimulation, which involves activating electrodes in a targeted area of the brain, has a proven track record of improving symptoms in people with movement disorders like Parkinson’s disease. The technique has been used in more than 60,000 patients. While a preliminary study has shown deep brain stimulation may slow or stop cognitive decline in Alzheimer’s patients, the mechanisms behind this observation remain poorly understood. The research team set out to further explore these mechanisms. The preliminary study was led by co-author Dr. Andres Lozano, Neurosurgeon and Senior Scientist at the Toronto Western Hospital Research Institute and Professor in the Department of Surgery at the University of Toronto.

Dr. Paul Frankland, Principal Investigator of the new study and Senior Scientist in the Neurosciences and Mental Health Program at SickKids, notes “we asked whether increasing the production of new neurons would have any impact on memory and learning. What we found was that we were able to facilitate memory formation.”

Using animal models, the scientists implanted electrodes into the entorhinal cortex, a region of the brain that connects with the hippocampus, where memories are formed. After stimulating the electrodes for an hour, the scientists noticed the production of new neurons in the hippocampus nearly doubled. This increase was observed about three to five days after the deep brain stimulation and lasted about a week. The new neurons that were produced during this period went on to develop and integrate into local circuitry like normal neurons.

Six weeks after the period of increased neuron production, the animal models were trained in a spatial task – finding a hidden platform in a water maze – and showed signs of enhanced memory as they navigated the maze.

To ensure that this improved memory was attributed to the production of the new neurons, and not due to other effects from the stimulation, the scientists used temozolomide (TMZ) to block creation of the new cells. They found that this prevented the memory enhancement, which confirmed that the new neurons are responsible for it.

“These findings are important to basic neuroscience in that they indicate that these new neurons produced by stimulation are integrated into the existing brain circuits and function normally alongside their older counterparts,” says Frankland, who is also Associate Professor in the Department of Physiology at the University of Toronto and Canada Research Chair in Cognitive Neurobiology. “This could be akin to adding RAM to your computer to expand its memory.”

SickKids Expert Alert: Bullying = a relationship breakdown

Thu, 15 Sep 2011 24:00:00 EDT

One of the most complex things kids must learn isn’t in a textbook

Both at home and at school, kids learn that C-A-T will always spell cat and 1+1 will always equal two. What often isn’t taught, though, is that when it comes to learning how to get along with others, the answer isn’t always the same. Building relationships is one of the most complex things a person can learn to do and yet we receive very little formal training for this task.

Bullying often occurs because of relationship problems. When we learn to read, write and calculate there are multiple opportunities for practice. Mistakes are made and we learn from them, but when social mistakes are made, instead of providing a learning opportunity, the response is often punitive. Just as kids need practice with their ABCs and 1-2-3s, they also need practice solving social problems, connecting with others and becoming positive leaders.

Dr. Debra Pepler, Psychologist in the Community Health Systems Resource Group at The Hospital for Sick Children (SickKids), is an expert in the field of bullying.

Pepler is also Distinguished Research Professor of Psychology at York University and co-leads PREVNet (Promoting Relationships and Eliminating Violence Network; www.prevnet.ca ) which has produced many tools for parents, teachers, and youth.

Below you’ll find a Q & A with Pepler about what to do if your child is being bullied, how to handle the situation if your child is doing the bullying, and much more.

Northbridge Financial Corporation Chair to tackle little known disease

Wed, 14 Sep 2011 24:00:00 EDT

By Daniel Puiatti

The rates of inflammatory bowel disease (IBD) are rising among children and adolescents, particularly in Ontario, and thanks to a $2 million donation from Northbridge Financial Corporation, SickKids now has a new chair to help tackle this relatively misunderstood and unknown spectrum of diseases, which includes Crohn’s disease and ulcerative colitis.

Taking great panes to build The Tower

Tue, 13 Sep 2011 24:00:00 EDT

By Daniel Puiatti

The Research & Learning Tower is undergoing another transformation this week. The outer glass ‘curtain walls’ are being installed on the second and third floors of the Tower on the corner of Bay and Elm Streets.

FASD Awareness Day

Fri, 09 Sep 2011 24:00:00 EDT

Nine months to abstain from alcohol

Can pregnant women drink alcohol? Fetal Alcohol Spectrum Disorder (FASD) experts don’t know if there is a safe amount at any point in the pregnancy. The safest choice is to not drink while pregnant.

HOT TOPIC: Fighting the sugar wave

Tue, 06 Sep 2011 24:00:00 EDT

It’s September. Kids are heading back to school and families are gearing up for their hectic morning and evening routines. It can be easy to grab a can of pop or juice box for a thirsty kid when you’re on the run. But is it the best choice?

“Water,” says Daina Kalnins, Manager of Clinical Dietetics and an Academic and Clinical Specialist Dietitian in Respiratory Medicine at SickKids. “Water is the best thirst quencher around.”

Kalnins recommends water and milk be the beverage of choice for children up to the age of ten. Young kids don’t need juice, she says. “It’s just empty calories from sugar. It fills their stomachs up, displacing their hunger for the healthy foods they need to grow.” Milk, on the other hand, gives kids the fat and calories they need. Fruit will provide kids with fibre missing from juice.

If parents offer juice, Kalnins stresses that moderation and education is key. “Parents shouldn’t focus on totally eliminating beverages such as juice and pop, but educating kids on how those types of drinks will make them feel,” says Kalnins. “Kids are surrounded by them. They’re going to be in situations, such as a parties, where there will be all sorts of goodies on offer. You want your child to make the choice to have just a little, and that’s it.”

It’s not an impossible task, she assures doubtful parents. Kalnins notes that a body gets used to what it is given. A child who is raised drinking primarily water and milk will tend to feel slightly ill if he or she overloads on sugary treats. “It may be uncomfortable for them, but it can be a real learning experience,” she says. “It helps kids learn to listen to their bodies.”

As for caffeine, Kalnins notes that Health Canada has recommendations for the amount that can be consumed daily. “It’s a stimulant. I think all parents should read about what caffeine is and what it does before they give it to a child. They might reach for the water instead.”

Sugar-free pop not recommended as substitute for water, Kalnins adds, and aspartame recommendations can also be found on the Health Canada website.

Healthy doesn’t have to be boring! Kalnins recommends some delicious alternatives to water:

International leader in child health joins SickKids

Tue, 06 Sep 2011 24:00:00 EDT

A leading international child health expert has set up office at The Hospital for Sick Children (SickKids) and will spend his academic leave in 2011-2012 with The Programme for Global Paediatric Research (PGPR) at SickKids.

Dr. Zulfiqar Bhutta, Founding Chair of the Division of Women and Child Health at Aga Khan University in Karachi, Pakistan, has set aside the year to work on a global action plan to eradicate childhood diarrhea which kills more than 1.25 million children a year.

Dr. Isaac Odame Leads Global Sickle Cell Disease Network

Thu, 01 Sep 2011 24:00:00 EDT

Dr. Isaac Odame knows sickle cell disease (SCD). He’s studied the genetic blood disorder for years. He was instrumental in creating Ontario’s newborn screening program, implemented in 2006. He’s seen the devastating impact it has on vulnerable children in the developing world, where it accounts for the deaths of up to 16 per cent of all African children under the age of five. He also knows that there are solutions at hand.

Dr. Isaac Odame fights Sickle Cell Disease in developing countries

Thu, 01 Sep 2011 24:00:00 EDT

SickKids wins gold for innovative business model

Wed, 31 Aug 2011 24:00:00 EDT

The Hospital for Sick Children’s (SickKids) commitment to innovation has been recognized by the Institute of Public Administration of Canada (IPAC) with a Gold Award in Innovative Management.

SickKids Expert Alert: Early + Math Skills = Success

Tue, 30 Aug 2011 24:00:00 EDT

Increased technology puts higher demands on kids' math skills

Not too long ago, early literacy indicated academic achievement. Today, it’s early numeracy that is considered a stronger predictor of success in school. The increase of technology and science-based professions has created a greater demand for math skills than there once was.

Researchers map pathway of infection for a common, potentially life-threatening respiratory virus

Thu, 18 Aug 2011 24:00:00 EDT

Finding ends five-decade search

Researchers at the University of Toronto, The Hospital for Sick Children (SickKids), St. Paul’s Hospital and the University of British Columbia have identified a new treatment target for a virus that causes severe lung infections and an estimated 10% of common colds.

The virus, called human respiratory syncytial virus or RSV, is the most common reason for hospitalization of infants and children under two years of age; currently there is no effective therapy or vaccine for it.

“This discovery provides an understanding of the mechanism through which RSV causes infection and offers a target molecule for development of new cell-based therapies,” said the study’s principal investigator Prof. Richard Hegele, Chair and Professor in U of T’s Department of Laboratory Medicine and Pathobiology who is also Chief of Paediatric Laboratory Medicine at SickKids.

The research is published in the current edition of the journal Nature Medicine.

The researchers found that RSV interacts with healthy cells by binding with a molecule located on the surface of those cells called nucleolin. By manipulating the function of nucleolin in cell culture, they were able to decrease RSV infection or increase susceptibility to it.

In mice, the researchers showed that disruption of lung nucleolin was associated with significantly reduced RSV infection, confirming that the molecule is a viable therapeutic target.

“While other factors may influence the frequency and severity of RSV infections, our results indicate that the presence of nucleolin on the cell surface is sufficient for RSV to successfully infect cells,” said Hegele. “We can now pursue strategies designed to block the interaction of RSV with cell surface nucleolin, the idea being to find approaches that will safely and effectively halt infection by preventing RSV from entering the cell in the first place.”

Researchers have been searching for a receptor for RSV for over five decades.

“This is a long-awaited and much-needed discovery that will help researchers develop new therapies for this disease, which has a large global burden, primarily affecting young children and other vulnerable populations,” said Dr. David Marchant, a research associate at UBC’s James Hogg iCAPTURE Centre at St. Paul’s Hospital, and co-lead on the study. “What is especially encouraging is that there is already a lot of ground work done in terms of understanding the biology of nucleolin to treat other ailments like cancer. The discovery of the RSV receptor combined with this knowledge could help deliver a potential therapeutic much faster.”

Increasingly, RSV is being recognized as a serious pathogen of the elderly for causing lung infections such as pneumonia. It is also a common cause of middle ear infections and can infect other organ systems, and has been implicated in the onset of asthma and allergy in children. Organ transplant recipients or other individuals whose immune systems are compromised are also at increased risk for serious RSV lung infections.

According to the World Health Organization, the global RSV disease burden is estimated at 64 million cases and 160,000 deaths each year. It is considered the single most important cause of severe respiratory illness in infants and young children.¹
The study was conducted by the following researchers: Richard G. Hegele (University of Toronto Department of Laboratory Medicine and Pathobiology, and The Hospital for Sick Children (SickKids)); Farnoosh Tayyari and David Marchant (James Hogg iCAPTURE Centre at St. Paul’s Hospital and UBC Department of Pathology and Laboratory Medicine); Theo J. Moraes (U of T and SickKids); Wenming Duan (SickKids); Peter Mastrangelo (U of T).

Funding for the study was provided by the Canadian Institutes of Health Research and the Heart and Stroke Foundation of British Columbia.

¹ World Health Organization 2009

Scientists identify two distinct subgroups in common childhood brain cancer

Mon, 15 Aug 2011 24:00:00 EDT

Discovery may impact aggressiveness of current treatments for some infants and children with posterior fossa ependymoma

Government of Ontario invests $75 million in The Research & Learning Tower

Mon, 15 Aug 2011 24:00:00 EDT

Glen Murray, Ontario Minister of Research and Innovation, shares the exciting news.

The Government of Ontario today announced that it is investing $75 million towards The Research & Learning Tower at SickKids.

Study finds new ADHD genes, links susceptibility with autism and other neuropsychiatric conditions

Wed, 10 Aug 2011 24:00:00 EDT

TORONTO – New research led by The Hospital for Sick Children (SickKids) and the University of Toronto has identified more genes in attention deficit hyperactivity disorder (ADHD) and shows that there is an overlap between some of these genes and those found in other neuropsychiatric conditions such as autism spectrum disorder (ASD). The study is published in the August 10 advance online edition of Science Translational Medicine.

Largest Canadian IBD study uncovers gene associated with ulcerative colitis

Tue, 02 Aug 2011 24:00:00 EDT

TORONTO – For as long as seven-year-old Jonathan Wexler can remember, he has taken sweet orange medicine every day to manage his ulcerative colitis symptoms. When he was only eight months old, Jonathan became the youngest patient to be diagnosed with ulcerative colitis, a form of inflammatory bowel disease (IBD), at The Hospital for Sick Children (SickKids).

SickKids innovators win international grant competition

Fri, 29 Jul 2011 24:00:00 EDT

Researchers look to improve maternal and neonatal survival in developing countries

A team of researchers from The Hospital for Sick Children (SickKids) has been successful in a global competition geared to finding the most innovative approaches for improving maternal and neonatal survival in rural regions of low-income countries.

The international grant competition, Saving Lives at Birth: A Grand Challenge for Development, was sponsored by the Bill and Melinda Gates Foundation, USAID, The World Bank, Norwegian Ministry of Foreign Affairs and Grand Challenges Canada. There were more than 600 original applicants. The finalists attended an awards ceremony in Washington, D.C., which was opened by U.S. Secretary of State Hillary Clinton. SickKids was one of 19 winners to receive a Grand Challenge award. These awards are geared to identifying roadblocks to solving critical global health issues.

The SickKids project, Prenatal calcium to prevent preeclampsia and pre-term birth in resource-poor rural settings, is a proposal to develop “Prenatal Sprinkles.” The original Sprinkles, a micronutrient powder developed to address vitamin and mineral deficiencies in infants and young children, was created at SickKids by Dr. Stanley Zlotkin. This new version is designed for use by pregnant women in low-income countries as a means of delivering microencapsulated calcium, iron and folic acid to address the long-standing critical health problems associated with two conditions: anemia in pregnancy, associated with premature birth, and preeclampsia associated with hypertension, a major cause of maternal and fetal death. Anemia is prevented by the use of iron and preeclampsia is prevented by the use of calcium. However, to date, combining iron and calcium has not been possible as the calcium interferes with iron absorption. The new product will contain pH-sensitive time-release microencapsulated iron and calcium to overcome this problem, thus enabling both nutrients to be safely delivered together. The grant will be used to develop and test “Prenatal Sprinkles.”

The SickKids team is comprised of Dr. Daniel Roth, Dr. Stan Zlotkin, Ashley Aimone (PhD student) and Dr. Diego Bassani, as well as collaborators from Johns Hopkins Bloomberg School of Public Health, Baylor College of Medicine and ICDDR,B (Bangladesh).

“Innovation at SickKids is a major priority and this project is an example of innovation in action,” said Zlotkin, Vice-President, Medical and Academic Affairs at SickKids and Professor of Pediatrics, Public Health Sciences and Nutritional Sciences at the University of Toronto.

“This award strengthens SickKids’ engagement in global health research,” said Roth, Staff Physician, Division of Paediatric Medicine at SickKids and Assistant Professor, Department of Paediatrics at the University of Toronto. “This grant will help solidify a research team at SickKids as well as nurture collaborations with other international institutions. Our hope is that our project will eventually contribute to lowering maternal and neonatal illness and mortality in low-resource regions of the world.”

Initial product testing is expected to begin in 12 to 18 months in Bangladesh.

New research questions automatic removal of children living in grow ops

Tue, 26 Jul 2011 24:00:00 EDT

TORONTO – Children living in drug-producing homes may not be exposed to the alarming health risk widely believed to exist, according to new research from the Motherisk Program at The Hospital for Sick Children (SickKids). The researchers found the majority of children removed from these homes were healthy and drug free. The research is published in the July 25 advance online edition of the Journal of Pediatrics.

New SickKids mobile app helps IBD patients transition to adult care

Mon, 25 Jul 2011 24:00:00 EDT

TORONTO – Parents tend to do most of the talking at their child’s doctor’s appointments. While the child is almost always present, their participation is often minimal. When it comes time to transition into adult care, the patient may feel unprepared to speak about their disease, let alone manage it on their own. Front-line staff at The Hospital for Sick Children (SickKids) recognized this problem among patients with inflammatory bowel disease (IBD) and took action.

SickKids researchers honoured with Early Researcher Awards

Mon, 25 Jul 2011 24:00:00 EDT

Today, the Hon. Glen Murray, Ontario’s Minister of Research & Innovation, recognized the Toronto researchers benefitting from this year’s Ontario Research Fund and Early Researcher Awards (ERA). Drs. Brian Ciruna and Jennifer Stinson from The Hospital for Sick Children (SickKids) were among those to receive Early Researcher Awards.

“We’re proud of the exceptional work our Toronto researchers do. Their contributions are making the world a better place, starting right here with new ideas and jobs, which fuel job creation and economic growth, and our government is proud to support them,” said Glen Murray, Minister of Research and Innovation.

Ciruna and Stinson are among 334 emerging researchers and their teams from 19 institutions across Ontario to receive Early Researcher Awards.

Ciruna, a Scientist in Developmental & Stem Cell Biology at SickKids and an Assistant Professor in the Department of Molecular Genetics at the University of Toronto, received his ERA funding for his project Determining the underlying cause of polycystic kidney disease. Polycystic kidney disease (PKD) affects one in 500 people. The current treatment options include dialysis or transplants, both of which are costly. At SickKids, Ciruna and his team are studying what causes PKD, which could, in turn, lead to new and more effective treatments.

Stinson, a Scientist in Child Health Evaluative Sciences and a Clinical Nurse Specialist/Nurse Practitioner in Anaesthesia at SickKids and Assistant Professor in the Department of Nursing at the University of Toronto, received her ERA funding for her project The use of e-health technologies to promote paediatric disease self-management. Children with chronic and life-threatening illnesses such as arthritis and cancer suffer from pain that is often under-appreciated and under-treated by doctors. Stinson and her team at SickKids are developing web-based technologies to help young people manage their own pain and improve their quality of life.

The Early Researcher Award (ERA) program helps promising, recently-appointed Ontario researchers build their research teams of undergraduates, graduate students, post-doctoral fellows, research assistants, associates and technicians. The goal of the program is to improve Ontario’s ability to attract and retain the best and brightest research talent.

For a full list of winners and to read the news release from the Ministry of Research & Innovation, visit their website.

Saving Lives at Birth: A Grand Challenge for Development

Mon, 25 Jul 2011 24:00:00 EDT

A team of researchers from The Hospital for Sick Children (SickKids) have been successful in a global competition geared to finding the most innovative approaches for improving maternal and neonatal survival in rural regions of low-income countries.

The international grant competition, Saving Lives at Birth: A Grand Challenge for Development, was sponsored by the Bill and Melinda Gates Foundation, USAID, The World Bank, Norwegian Ministry of Foreign Affairs and Grand Challenges Canada. There were more than 600 original applicants. The finalists attended an awards ceremony in Washington, D.C., which was opened by U.S. Secretary of State Hillary Clinton. SickKids was one of 19 winners to receive a Grand Challenge award. These awards are geared to identifying roadblocks to solving critical global health issues.

The SickKids project, Prenatal calcium to prevent preeclampsia and pre-term birth in resource-poor rural settings, is a proposal to develop “Prenatal Sprinkles.” The original Sprinkles, a micronutrient powder developed to address vitamin and mineral deficiencies in infants and young children, was created at SickKids by Dr. Stanley Zlotkin. This new version is designed for use by pregnant women in low-income countries as a means of delivering microencapsulated calcium, iron and folic acid to address the long-standing critical health problems associated with two conditions: anemia in pregnancy, associated with premature birth, and preeclampsia associated with hypertension, a major cause of maternal and fetal death. Anemia is prevented by the use of iron and preeclampsia is prevented by the use of calcium. However, to date, combining iron and calcium has not been possible as the calcium interferes with iron absorption. The new product will contain pH-sensitive time-release microencapsulated iron and calcium to overcome this problem, thus enabling both nutrients to be safely delivered together. The grant will be used to develop and test “Prenatal Sprinkles.”

The SickKids team is comprised of Dr. Daniel Roth, Dr. Stan Zlotkin, Ashley Aimone (PhD student) and Dr. Diego Bassani, as well as collaborators from Johns Hopkins Bloomberg School of Public Health, Baylor College of Medicine and ICDDR,B (Bangladesh).

“Innovation at SickKids is a major priority and this project is an example of innovation in action,” said Zlotkin, Vice-President, Medical and Academic Affairs at SickKids and Professor of Pediatrics, Public Health Sciences and Nutritional Sciences at the University of Toronto.

“This award strengthens SickKids’ engagement in global health research,” said Roth, Staff Physician, Division of Paediatric Medicine at SickKids and Assistant Professor, Department of Paediatrics at the University of Toronto. “This grant will help solidify a research team at SickKids as well as nurture collaborations with other international institutions. Our hope is that our project will eventually contribute to lowering maternal and neonatal illness and mortality in low-resource regions of the world.”

Initial product testing is expected to begin in 12 to 18 months in Bangladesh.

Here’s lookin’ at you, kids

Wed, 20 Jul 2011 24:00:00 EDT

SickKids teens create special memories in Old Hollywood

Glitz, glamour, red carpets and “paparazzi” created the scene at The Hospital for Sick Children (SickKids) Thursday evening and transformed an otherwise-routine evening into the world of Old Hollywood.
We experienced the After Hours Exclusive Teen Event through the eyes of two SickKids patients, Mary Feeney, 17, and Alex Salmon, 14.

Researchers identify gene linked to bleeding disorder

Mon, 18 Jul 2011 24:00:00 EDT

Never underestimate the power of the platelet. Platelets are blood cells that control clotting. If you are cut, platelets help stop the bleeding, and they are also intimately involved in the dangerous clots that cause heart attacks and strokes.

The Scientist magazine ranks SickKids #7 on international list of best places to work in academia

Thu, 07 Jul 2011 24:00:00 EDT

The award-winning life sciences magazine, The Scientist, announced the winners of its 9th annual Best Places to Work in Academia competition on July 1, 2011 and The Hospital for Sick Children (SickKids) was named #7 internationally.

SickKids is one of three Canadian centres to be honoured with this award; Dalhousie University ranked fourth and the University of Alberta ranked eighth.

Readers of The Scientist were invited to complete an online survey and assess their workplace based on job satisfaction, peers, infrastructure and environment, research resources, pay, management and policies, teaching and mentoring and lastly, tenure and promotion.

SickKids scored in the 67th percentile with 3.82 out of five. SickKids scored highest in infrastructure and environment, and research resources. The survey found that in both small and large institutions, researchers valued a productive yet fun and casual atmosphere to conduct their research.

“Collaboration was a recurring theme among this year’s top-ranked institutions,” said The Scientist editor Jef Akst in a news release. “It’s clear that scientists value the accessibility of fruitful partnerships to enhance their research.”

The Research & Learning Tower continues to climb on the corner of Bay and Elm streets and embodies the notion of collaboration. “The Tower will be a magnet to attract and retain the best researchers from around the world to make a difference in the health of children everywhere,” says Dr. Janet Rossant, Chief of Research at SickKids. “It should keep SickKids on the list of best places to work for a long time to come."

SickKids researchers take innovative approaches to tackle global paediatric health problems

Wed, 06 Jul 2011 24:00:00 EDT

Millions of infants die each year in developing regions of the world that lack advanced technologies commonly found in Canadian hospitals. Two research teams led by The Hospital for Sick Children (SickKids) have come up with innovative proposals to test the effectiveness of portable, low-cost technologies to improve maternal and infant survival in low-income countries.

Dr. Daniel Roth, Staff Physician in the Division of Paediatric Medicine at SickKids and Dr. Diego G. Bassani, Epidemiologist, in the Division of Paediatric Medicine and SickKids International are among 19 recent recipients of Canada’s Rising Stars in Global Health grants from Grand Challenges Canada, announced on June 29, 2011. The Rising Star awards are among the first grants given to Canadian researchers by Grand Challenges Canada, a non-profit organization funded from the Government of Canada’s foreign aid budget through the Development Innovation Fund.

Pulse oximetry, an everyday tool used in modern paediatric practice, has been called the fifth vital sign. The technology provides a precise measure of a patient’s blood-oxygen saturation and alerts health-care providers if a patient has a lack of adequate oxygen circulating in the blood. At any given moment, pulse oximetry is being used to assess and monitor children at SickKids.

“Initial signs of severe illness in newborns are often subtle and early recognition is critical to introducing life-saving therapy,” says Roth who is also Assistant Professor in the Department of Paediatrics at the University of Toronto. “Objective, standardized methods are needed to rapidly and accurately identify sick infants in resource-poor countries. When we think about technologies that are low-cost, portable, non-invasive and give an accurate answer within seconds, pulse oximetry is the obvious tool to consider.”

With partners from the Department of Pediatrics at the Aga Khan University in Pakistan, Roth will study the integration of pulse oximetry into the routine assessment of young infants presenting to primary health clinics in Karachi. Roth’s research will assess if implementation of routine pulse oximetry is feasible and has the potential to improve care delivery and health outcomes among young infants in resource-poor settings.

Bassani’s research will involve using a human-powered fetal heart monitor on pregnant women in Uganda. He will investigate whether the medical device could help reduce infant mortality.

The partnership between Canadian and African researchers will test the innovative, life-saving, low-cost monitor based on the idea that medical devices in developing countries must be rugged, reliable and not dependent on electricity. The crank-operated mechanism will be tested at two sites in Uganda. One minute of winding can power 10 minutes of monitoring.

“A baby’s heart rate is the most important signal of distress in labour. These monitors will come as a substitution to expensive and fragile devices that are largely unavailable in developing countries,” says Bassani who is also Assistant Professor at the Dalla Lana School of Public Health at the University of Toronto. “If successful, large-scale implementation of the fetal heart monitors could reduce infant deaths.”

Fetal heart monitoring has been identified as a top research priority to reduce deaths from birth asphyxia by 2015.

Both researchers say their projects involve the evaluation of simple measures that, if implemented appropriately in low-resource settings, have the potential to save lives and contribute towards reducing mortality in developing countries.

According to Grand Challenges Canada, the Canadian Rising Stars in Global Health program aims to support early career innovators in global health, recognizing the difficulties of early career innovators in securing research funding in global health. Grantees were each awarded $100,000 to pilot-test their ideas; those researchers who are successful in demonstrating proof-of-concept will be eligible to apply for scale-up grants of up to $1 million.

Reduced TV time and computer use alone have little impact on childhood obesity

Mon, 04 Jul 2011 24:00:00 EDT

The number of overweight and obese children is rising, not just in Canada but around the world. Perhaps it’s not surprising that the amount of screen time, or time spent in front of the television or computer, has also increased significantly among children. In Canada, children and youth are getting an average of six hours of screen time per day on weekdays, and seven on weekends. There has been considerable research suggesting that a reduction in screen time will impact outcomes in childhood obesity, but does it?

Up Up and Away! The Research & Learning Tower is on the Rise

Wed, 22 Jun 2011 24:00:00 EDT

On Saturday morning, builders on the SickKids Research & Learning Tower construction site raised one of the large Tower cranes on the site located at Bay and Elm streets. This is another phase in the building process to support The Research & Leaning Tower’s continued rise into the Toronto skyline.

The raising of the crane, also referred to as a crane jump, took eight workers roughly five hours to complete. The height of the crane from the underside of its counter jib, or counter weight, was approximately 29 metres above street level and following the jump, it now stands at 43 metres above street level. The crane will be raised a total of eight times during the construction of The Research & Learning Tower and, with its final elevation, is expected to reach 120 metres.

When the tower is complete, the crane will be dismantled by a derrick crane – a crane used for hoisting and swinging loads horizontally. Sitting on the roof of the tower, the crane will lower pieces down to street level.
For more information on the Tower check out our construction updates or visit our webcam.

For more information on the SickKids Research & Learning Tower or to donate, visit our Tower website.

Surfs Up With SickKidsWiFi!

Mon, 20 Jun 2011 24:00:00 EDT

Surfing the web at SickKids just got easier with today’s launch of a new wireless network. The free network, called SickKidsWiFi, provides Internet access for all patients, families and guests while at SickKids. Patients and visitors can connect to the network from their mobile devices and laptops, making it easy to connect with others.

SickKids announces new Board appointments

Fri, 17 Jun 2011 24:00:00 EDT

Toronto, ON – June 17, 2011 – The Board of Trustees of The Hospital for Sick Children (SickKids) is pleased to announce the appointment of Robert Harding as the Chair of the Board, effective June 16, 2011. Mr. Harding joined the Board of Trustees in 2005.

Daneman re-appointed Chair of Paediatrics, U of T, and Paediatrician-in-Chief at SickKids

Fri, 17 Jun 2011 24:00:00 EDT

We are pleased to announce the re-appointment of Dr. Denis Daneman for a second five-year term as Chair of the Department of Paediatrics in the Faculty of Medicine and Paediatrician-in-Chief at SickKids. This is a joint appointment, effective July 1, 2011. Daneman also holds the RS McLaughlin Foundation Chair in Paediatrics.

Sonia and Arthur Labatt receive honorary degrees from University of Toronto

Wed, 15 Jun 2011 24:00:00 EDT

SickKids and SickKids Foundation congratulate two of our most visionary donors on the receipt of their Doctor of Laws (honoris causa) degrees from the University of Toronto on June 13.
Mary Jo Haddad joined the academic procession and represented SickKids and the Foundation at U of T’s Convocation Hall to celebrate the philanthropic and public service achievements of Sonia and Arthur Labatt.

Long-time supporters of SickKids, the Labatts are generous funders of the Labatt Family Heart Centre and the Labatt Brain Tumour Research Centre - both centres of breakthroughs in care, research and education. The Labatts’ convocation address are posted at www.utoronto.ca/convocation-2011.htm.

Dr. Sonia Labatt, PhD, is an adjunct faculty member at the Centre for Environment at the University of Toronto, focusing on issues of corporate environmental management. Her volunteer activities include directorships at the National Ballet of Canada, the Wellesley Hospital Foundation, the Art Gallery of Ontario and World Wildlife Fund Canada. Dr. Labatt was also a member of the Board of Trustees at SickKids.

Dr. Arthur Labatt is co-founder of Trimark Financial Corporation and a past Chancellor of the University of Western Ontario. He was named an Officer of the Order of Canada in 1996 and has held directorships at SickKids Foundation, Parkinson Foundation of Canada, Canadian Opera Company, Young People’s Theatre, Toronto French School and the African Medical and Research Foundation. Dr. Labatt is also a SickKids kid.

Parents conflicted about use of feeding tubes in children with neurologic disabilities

Fri, 10 Jun 2011 24:00:00 EDT

Researchers provide recommendations to improve the parental decision-making process

For people of all ages, mealtime is an important part of every day. It is not only a basic nutritional need, but also represents a social need, with food customs varying across religions, cultures, ethnicities and classes. While eating can be viewed as an enjoyable and social activity, for children with complex chronic conditions eating can be a daily struggle. To ensure proper nourishment, gastrostomy tube insertion - also known as feeding tubes - is common and often recommended for these children.

In a review led by Dr. Sanjay Mahant, lead author of this study and Staff Paediatrician at The Hospital for Sick Children (SickKids), researchers acknowledge that the decision to replace feeding by mouth with feeding tubes can be a very difficult decision for parents and caregivers. They found that the primary conflict was based on the family’s values and their interpretation of feeding. Recognizing this decisional conflict, Mahant and his team developed a framework that aims to support and improve parental decision-making around gastrostomy-feeding tube insertion. The review was published in the June edition of Pediatrics.

“While gastrostomy-feeding has been shown to be effective in improving nutrition, administering medication and making feeding easier for parents of children with neurologic disabilities,” says Mahant, “for some caregivers it represents disability, loss of normality and a disruption of maternal nurturing.”

The goal of the review was to understand the decision-making experiences and perspective of the parents around gastrostomy-feeding tubes. The investigators hope to improve parents’ experience through information-sharing and education, more opportunities to gain knowledge from other families in similar situations, and support from health-care professionals.

The review showed that the decision-making process was one of stress, uncertainty and conflict for the parents. “We found that the significance of feeding was much more complicated than simply a means to provide nutrition and maintain an adequate weight,” says Mahant. “Understanding this internal conflict is important in improving the decision-making process for both parents and health-care providers.”

This research provides recommendations for clinicians when communicating about feeding tubes with families. It highlights the importance of explaining health benefits and potential complications, clarifying parental expectations and fears, and providing the appropriate time to discuss the situation.

DONNY & MARIE LIVE to support SickKids

Fri, 03 Jun 2011 24:00:00 EDT

Fans can look forward to a little bit country, and a little bit rock n' roll this summer as Donny and Marie Osmond hit the stage to perform for the first time together in Toronto. Dancap Productions Inc. is bringing the internationally-adored duo's interactive Las Vegas theatrical concert DONNY & MARIE LIVE to Toronto for a strictly limited engagement at the Four Seasons Centre for the Performing Arts this summer.

Akwaaba, SickKids!

Fri, 03 Jun 2011 24:00:00 EDT

SickKids International spoke with Patricia Malloy (Clinical Nurse Specialist/Nurse Practitioner, Infectious Diseases) and Karen Breen-Reid (Advanced Nursing Practice Educator, Paediatric Medicine, Respiratory Medicine and Infectious Diseases) days before they travelled 9,000 kilometres to help train paediatric nurses in Ghana. The SickKids Global Child Health Program - Paediatric Nursing Training Programme is a three-year joint initiative between SickKids International, the University of Ghana, Ghana Ministry of Health, and the Canadian International Development Agency (CIDA).

SickKids launches new Child and Family Relations service

Mon, 30 May 2011 24:00:00 EDT

Patients and families have another avenue to discuss their care experience at SickKids with the launch of the new Child and Family Relations service.

Ghana-SickKids Paediatric Nursing Training Programme: May 2011 Launch

Mon, 30 May 2011 24:00:00 EDT

On May 30, 2011, SickKids’ own Pat Malloy (Advanced Practice Nurse), Karen Breen-Reid (Advanced Nursing Practice Educator) and Dr. Isaac Odame (Staff Haematologist) celebrated the launch of the Ghana-SickKids Paediatric Nursing Training Programme with aspiring paediatric nurses, and healthcare and academic leaders in Ghana. “The first cohort of [nursing] students radiated pride as each speaker approached the podium challenging the nurses to increase the health of children in Ghana”, said Co-Lead Educator Pat Malloy (pictured below) as she experienced her first day in the classroom.

Mary Jo Haddad receives Order of Canada

Fri, 27 May 2011 24:00:00 EDT

Mary Jo Haddad, President and CEO of SickKids with His Excellency the Right Honourable David Johnston, Governor General of Canada - Photo credit: Sgt Serge Gouin, Rideau Hall

Mary Jo Haddad, President and CEO of SickKids, was formally welcomed as a Member of the Order of Canada on May 27. The investiture ceremony took place at Rideau Hall in Ottawa, the residence of the Governor General of Canada.

Governor General visits SickKids

Wed, 25 May 2011 24:00:00 EDT

His Excellency the Right Honourable David Johnston, Governor General of Canada, and Her Excellency Mrs. Sharon Johnston came to Toronto May 24 to recognize excellence in philanthropy and volunteerism. This included a visit to The Hospital for Sick Children.

Severity of cystic fibrosis may be determined by presence of newly-identified modifier genes

Sun, 22 May 2011 24:00:00 EDT

TORONTO – In an age where personalized medicine is within reach, a one-size-fits-all approach just won’t cut it. A group of North American researchers have identified two “modifier” genes in the genomes of cystic fibrosis patients that may be responsible for variation in severity between patients. This is the first study to show evidence that modifier genes affect lung disease severity in cystic fibrosis.

‘Toronto protocol’ improves survival rates in children at risk for cancer

Tue, 17 May 2011 24:00:00 EDT

Researchers develop new surveillance approach to detect malignant tumours early

Minister of Health celebrates Nursing Week with SickKids nurses

Tue, 10 May 2011 24:00:00 EDT

SickKids nurses: Unwavering dedication to providing the best care for children and families

Mon, 09 May 2011 24:00:00 EDT

This year’s theme for National Nursing Week— Nursing: The Health of our Nation— aligns in so many ways with the overall direction of the nursing profession and the continuing focus of nursing at SickKids. Increasingly, nursing is recognized as having a critical role to play in protecting and enhancing the health and well-being of individuals, families and communities. Likewise, nurses are actively engaged in the development and integration of new knowledge into existing health-care systems, contributing to the building of sustainable and inclusive health care for all Canadians.

At SickKids, nurses have been integral to many impressive achievements, whether in relation to enhancing the care experience of children and families, or through sharing their expertise beyond the walls of the hospital.

Provincially, SickKids nurses influence so many key areas of the profession, including health policy, practice standards, research, and the development of new technology and information systems. Our nurses, through their work with stakeholders, such as the Registered Nurses’ Association of Ontario, Ministry of Health and Long-Term Care task forces, special interest groups, and cross-appointments to colleges and universities, participate in work that impacts health care across the province.

At the national level, there are numerous SickKids nurses sharing their expertise with fellow nurses, as well as interprofessional groups, in the areas of research, technology, practice standards, specialized paediatric education programming, and health human resource strategy development. As the largest single health professional group in Canada, nurses have an immeasurable impact on the health of our nation.

Thank you nurses at SickKids for your unwavering dedication to providing the very best possible care for the children and families we serve, for your furthering of the nursing profession, and for your invaluable contribution to the health of our families, communities, and nation.

Happy National Nursing Week!

Researchers advance microarray technology to improve discovery of copy number variation

Mon, 09 May 2011 24:00:00 EDT

TORONTO - Exploring the vast landscape of the human genome has been crucial in the understanding of human diseases. An international research team led by scientists at The Hospital for Sick Children (SickKids) in Toronto and Uppsala University in Sweden has described new approaches to discovering copy number variation (CNV) of genes implicated in diseases. The study is published in the May 8 advance online edition of Nature Biotechnology.

The proof is in – science is fun

Mon, 09 May 2011 24:00:00 EDT

A jiggling jello brain, bacteria-themed arts and crafts, and a bean bag toss demonstrating how materials are sorted in a lab were some of the activities at this year’s SickKids Science Rendezvous event, a fun-filled afternoon of hands-on science for kids of all ages.

For the third year in a row, SickKids participated in Science Rendezvous, Ontario’s largest public science festival. Each year, the festival invites the public into hospital research institutes, universities and other science organizations to witness the many different functions of science in our world.

At this year’s event on May 7, more than 150 people stopped by SickKids and stayed for over an hour, taking time to participate in the 14 exhibits. Participants received a passport to science that they could stamp at each station. At the end, a filled-out passport meant that participants were “Honourary SickKids Scientists” and they received a SickKids Research Institute green pencil with that title on it.

Science Rendezvous is an opportunity to showcase some of the world-class science that takes place at SickKids on a daily basis. Trainees, scientists and other volunteers are passionate about science and have fun sharing their knowledge with kids of all ages who drop by to experience the diversity of SickKids research hands-on.

What a year! SickKids celebrates a “groundbreaking” anniversary

Wed, 04 May 2011 24:00:00 EDT

On May 4, 2010, The Hospital for Sick Children (SickKids) broke ground on its new Research & Learning Tower. Now, a year later, the Tower has reached ground level and continues to climb.

From surveying, to digging, to building a foundation strong enough to support our super structure, there have been many construction steps completed this past year. Here are some highlights:

Biebermania rocks SickKids

Wed, 04 May 2011 24:00:00 EDT

The stage was set. Patients at The Hospital for Sick Children (SickKids) put the finishing touches on their guitars, received their backstage passes, tied their tie-dyed bandanas and imprinted their footprints onto the walk of fame before making their way to the stage.

Christine Harrison to be honoured for her contributions to health-care ethics in Canada

Tue, 03 May 2011 24:00:00 EDT

Dr. Christine Harrison, former Director of Bioethics at SickKids, will be receiving the Canadian Bioethics Society’s 2011 Lifetime Achievement Award for her leadership in shaping the field of health-care ethics in Canada.

Harrison has a highly respected national and international profile in health-care ethics. While her achievements extend well beyond our borders, her major contributions have been in Canada, where she contributed immensely to the fabric and development of health-care ethics through her work with the Canadian Bioethics Society, SickKids and the University of Toronto.

Harrison began working as a bioethicist at SickKids in 1993, two years after the establishment of the department, and was director from 1996 to 2011. At UofT, she has made significant contributions to the Joint Centre for Bioethics and the Department of Paediatrics, playing a key role in the development and implementation of curriculum in the discipline of bioethics.

Her work has been recognized through invited talks and presentations, invitations to publish, collaborate and supervise, as well as election and appointment to leadership positions in health-care ethics. She has taught health-care ethics at the undergraduate, graduate, post-graduate and continuing education levels; her exemplary teaching recognized by four prestigious teaching awards.
Since joining SickKids, Harrison has completed 30 peer-reviewed paper presentations, 177 invited talks, lectures and workshops, 16 poster presentations and 152 talks, lectures and workshops at SickKids. These numbers represent how active and sought-after Harrison has been in the field of health-care ethics, says colleague Dr. Randi Zlotnik Shaul, Bioethicist, SickKids.

“Her knowledge base, respectful manner of interaction, insight, integrity and commitment to providing genuine assistance to others are features she brought to every one of her achievements in health-care ethics,” says Zlotnik Shaul. “Christine Harrison is an example that many working in health-care ethics strive to emulate and an inspiration for achievement that is possible in health-care ethics.”

The Lifetime Achievement Award presentation will take place on Thursday June 2 at the Canadian Bioethics Society’s Annual Conference in Saint John, New Brunswick.

Hey kids, get moving!: Report card gives Canadian kids an "F" in physical activity!

Thu, 28 Apr 2011 24:00:00 EDT

Not too long ago, after-school time was synonymous with outdoor activity, as kids spent hours riding bikes, playing in neighbourhood parks and participating in sports. Today, Canadian children and youth are rarely doing any of these things; instead, they spend the majority of their after-school time indoors, in front of the TV, computer or video games.

New findings, released today in Active Healthy Kids Canada’s 2011 Report Card on Physical Activity for Children and Youth, revealed that six- to 19-year-olds are spending only 14 minutes of the critical after-school period – approximately 3 to 6 p.m. –doing moderate- to vigorous-intensity physical activity. The Report Card urges parents, schools and policymakers to work together to ensure Canadian children and youth have opportunities to be physically active during this critical period.

This sedentary after-school behaviour is one of the reasons the Report Card assigned an “F” to physical activity levels for the fifth consecutive year. Children and youth devoted more than 40 hours per week – the equivalent of a full-time work week – to screen time.

“This is concerning because such a sedentary lifestyle can lead to a variety of negative outcomes, particularly obesity,” says Dr. Brian McCrindle, Staff Cardiologist at The Hospital for Sick Children (SickKids) and leader of the SickKids Childhood Obesity Research Team. “Obesity leads to high cholesterol, high blood pressure and diabetes, which in turn may lead to a higher likelihood of heart attack and stroke in adulthood.”

On the other hand, physical activity can have significant benefits that go beyond physical health: building self-confidence and reducing the likelihood of risky behaviours like drug and alcohol use.

“Making small lifestyle changes can result in, long-term benefits for the whole family,” says Dr. Catherine Birken, Staff Paediatrician and Project Investigator at SickKids and Assistant Professor of Paediatrics at the University of Toronto. “Limiting after-school screen time and supporting participation in physical activity with friends or family members can be steps toward a healthier lifestyle for children and families.”

Birken is a part of TARGet Kids!, a collaborative project between SickKids and St. Michael’s Hospital that brings together child health researchers and community practitioners with the goal of improving children’s health through effective and timely primary care. TARGet Kids! is studying physical activity in over 3,000 preschool-aged children in Toronto. Birken says the goal of this research is to “lead to effective early interventions to improve physical activity, growth, development, and health in the broadest definition.”

Commercialization: SickKids and MaRS Innovation launch OtoSim Inc.

Mon, 25 Apr 2011 24:00:00 EDT

MaRS Innovation and The Hospital for Sick Children announced today the launch of OtoSim Inc. to commercialize an otoscopy training system and process developed by two otolaryngologists at SickKids.

The new product, a program and training device, is the first in a series of training systems directed at improving the accuracy of ear examinations, and is part of a growing trend to use simulation-based training in medicine.

In otoscopy, a health-care professional uses a device called an otoscope to examine the ear and diagnose ear problems. With the new system, otoscopy training can take advantage of modern simulation technology. Improved training will lead to better diagnosis, which in turn will result in reduced use of antibiotics.

Early funding of the OtoSim unit came from the Women’s Auxiliary at SickKids, and funding for the clinical trial came from the University of Toronto UME Curriculum Renewal Fund. Commercialization funding and business support for the new OtoSim simulator training system was provided by MaRS Innovation and included funding the final commercial design and filing a patent application.

Dr. Vito Forte, MD, FRCSC, Chief of Otolaryngology-Head and Neck Surgery at SickKids, Professor in the Department of Otolaryngology-Head and Neck Surgery at the University of Toronto’s Faculty of Medicine, is one of the inventors and Chair of the Board of OtoSim Inc. “We developed OtoSim to fill a huge training need,” Dr. Forte says. “Ailments of the ear in both adults and children account for many visits to health-care providers. OtoSim will improve training and bring about better patient care.”

Dr. Paolo Campisi, MSc, MD, FRCSC, FAAP, an Otolaryngologist at Sick Kids, is an OtoSim co-inventor, and Associate Professor and Undergraduate Director, Department of Otolaryngology – Head and Neck Surgery, University of Toronto. He cites testing of a group of third-year medical students which showed that the addition of three hours of OtoSim training to the regular curriculum increased the diagnostic accuracy of students by 44 percent. “This represents an enormous improvement for a minimal additional training effort,” Dr. Campisi says.

“We are confident that this breakthrough technology will be bought by medical schools, teaching hospitals, paediatric hospitals and other institutions to improve teaching outcomes,” says Andrew Sinclair Ph.D, a Senior Director at MaRS Innovation and CEO of OtoSim. “The modest cost of the device makes for a compelling and low-risk way for instructors to assess the improvements in their student training. The method allows an institution to add units incrementally, moving from teaching one-on-one to a single instructor teaching more than a dozen students simultaneously.”

Says Rafi Hofstein, President and CEO of MaRS Innovation: “OtoSim epitomizes the enormous reservoir of discoveries suitable for commercialization that are being made by Toronto researchers and scientists. MaRS Innovation is proud to play a crucial role in bringing those discoveries to market, to creating new companies, new jobs and ultimately, new industries.”

The results of the study will be presented at the Triological Society at the Combined Otolaryngology Spring Meetings - COSM in Chicago on April 30, and will be subsequently posted on the OtoSim website.

The product launch will take place at the COSM in Chicago on April 29. It will also be exhibited at the Canadian Society of Otolaryngology (CSO) AGM in Victoria BC May 22-24, the American Academy of Otolaryngology (AAO)and OTO EXPO in San Francisco Sept. 11-14, and the Society for Ear, Nose and Throat Advances in Children (SENTAC) in Kansas City Dec. 1-4. OtoSim units will be available for purchase over the Internet in June 2011.

Promoting research for kids on Research4kids

Thu, 21 Apr 2011 24:00:00 EDT

The Research4kids clinical studies recruitment database is now open for business. After several months of planning and consultation, development and testing, the new database was launched publicly today, April 21, 2011. Clinical research was identified as an organizational strategic priority for 2010-11. The Research4kids database has been designed to showcase the excellent clinical research being conducted at SickKids and enhance the volunteer recruitment efforts of our researchers.

Hide-and-seek: Cholesterol masks molecules on cell surfaces

Mon, 18 Apr 2011 24:00:00 EDT

Although it may be better known for its negative artery-hardening properties, an international team of researchers led by The Hospital for Sick Children (SickKids) and the Max Planck Institute for Molecular Cell Biology and Genetics, have found that cholesterol also plays a vital role in hiding molecules on a cell’s surface.

“We knew that glycolipids, which are involved in signaling and cellular recognition, were intriguing molecules,” said Dr. Clifford Lingwood, a study author and Senior Scientist in SickKids’ Molecular Structure and Function Program and a professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto. “Now we know they can be affected by cholesterol, changing how molecules and cells communicate.” The study was published in the April 3 issue of Nature Chemical Biology.

Lingwood points out that cholesterol acts like a cloaking device for cells, and could potentially slow the spread of infectious disease by stopping molecules involved in diseases , such as cholera or E. coli from binding to cells. “If you can hide the cells by changing the cholesterol, then you can make those cells more resistant to pathogens,” says Lingwood. “It’s a very exciting and broad-ranging application of this work.” Other applications could include locating new targets on cells currently masked by cholesterol, for example cancer cells, for treatment of disease.

The team – including scientists from Canada, Finland, Denmark and Germany – began by identifying cholesterol as a key molecule in regulating the appearance of glycolipids on the surface of a cell. Testing showed that cholesterol could hide membrane molecules and reduce the “visibility” of those molecules to others in the system.

To test whether this would also work in a biological body, the team used red blood cells and verotoxin, a toxin created by E. coli. “When we removed cholesterol from the cell membrane, the verotoxin began to bind to the cell’s surface,” says Lingwood. “Clearly, the cholesterol had been masking the binding agent on the cell, hiding it from the verotoxin.”

Considering situations when cholesterol is naturally removed from cells brought the researchers to the idea of sperm maturation. As sperm travels through a woman’s reproductive system, it matures by loss of cholesterol and readies itself to bind to the egg for fertilization. “It’s the same concept, perfectly illustrated in the natural system,” says Lingwood. “When the cholesterol is removed from the sperm cell during the maturation process, it reveals the carbohydrate molecules located on the cell’s surface.”

By finding that a cellular recognition process may be regulated by a simple interaction between cholesterol and glycolipids on a cell’s surface, the team has found a way to control molecular communication at the nanoscale, says Lingwood. “It’s a powerful instrument to add to our cellular toolkit.”

Brain Awareness Month: SickKids improves care for critically ill children

Thu, 14 Apr 2011 24:00:00 EDT

Critically ill children admitted to the intensive care unit (ICU) often have multiple health issues that put them at risk for brain injury, which can have a significant long-term impact on their health. The brain is a vital organ that controls movement, thought and neurological functions which control blood pressure, heart rate, body temperature and organ function.

Thank you to all our volunteers for making a difference

Mon, 11 Apr 2011 24:00:00 EDT

National Volunteer Week, April 10 to 16, pays tribute to the millions of Canadian volunteers who graciously donate their time and energy. It is Canada’s largest celebration of volunteers, volunteerism, and civic participation. This week, we honour our SickKids volunteers, who make a difference in people’s lives through their compassion and generous contribution of time.

At SickKids, volunteers play an important role across all areas of the hospital: in a playroom, making crafts with a patient; in the Surgical Waiting Room, sitting with a worried parent; in the coffee line, so mom doesn’t have to leave her child’s bedside; in an advisory council meeting, providing a parent’s perspective on a new hospital initiative; in the Echo Lab, having an ultrasound to help researchers learn more about heart disease; in The 5 Fifty 5 Shop, raising money for special projects across the hospital; and, well, the list goes on and on and on!

Volunteers coming through the Volunteer Resources program have contributed over 70,000 hours of service in the past year. There are over 1,000 registered volunteers through Volunteer Resources, from students to adults to retirees. The Women’s Auxiliary of The Hospital for Sick Children contributed 44,000 hours of service this past year. While the WA is primarily a service organization, its members raise substantial funds through sales in The 5 Fifty 5 Shop, its Annual Bazaar, sales of holiday cards and CareWear.

Parents’ habits influence preschoolers’ TV time and computer use

Thu, 07 Apr 2011 24:00:00 EDT

TORONTO – It’s no secret that children learn many of their habits, both good and bad, from their parents. In a study from The Hospital for Sick Children (SickKids), researchers examined the parental factors that affect media use – also known as screen time – in preschool-age children. They found that young children who eat lunch and dinner in front of the television, whose mothers are employed and whose parents spend an above-average amount of time in front of a screen were more likely to have elevated screen time themselves. The study was published in the April 5 advance online edition of Public Health Nutrition.

Show me your teeth

Wed, 06 Apr 2011 24:00:00 EDT

TORONTO – April is Oral Health Month and dentists from The Hospital for Sick Children (SickKids) discuss topics including: the most common infectious disease, which begins in your mouth; the role of dentistry in a paediatric hospital setting and how the Department of Dentistry at SickKids became leaders in wait-time management.

Pain hurts but it can be managed, says SickKids expert

Mon, 04 Apr 2011 24:00:00 EDT

A child’s biggest complaint about being hospitalized is the pain. In a new Canadian study, researchers found that on average children in hospital experience six painful procedures a day and less than one third of these procedures had specific strategies documented to manage pain. The study was published in the April 4 advance online edition of the Canadian Medical Association Journal(CMAJ).

SickKids experts help develop new guidelines for juvenile arthritis treatment

Thu, 31 Mar 2011 24:00:00 EDT

Like many kindergarteners, Jean O’Hanley is an active, energetic and playful girl. One day in gym class, she fell down and hurt her knee. Jean’s sore knee quickly became debilitating, leaving her unable to walk. The O’Hanley family travelled from Northern Ontario to The Hospital for Sick Children (SickKids) where Jean was diagnosed juvenile idiopathic arthritis (JIA). After aggressive treatments on her swollen knee, three months later she is back to herself participating in gymnastics, swimming and biking.

SickKids expert offers wake-up call on childhood sleep disorders

Tue, 29 Mar 2011 24:00:00 EDT

TORONTO – They are often difficult to detect, may cause behavioural issues or affect a child’s performance in school, and if left untreated, could even cause long-term cardiovascular and metabolic problems. While it is sometimes the last thing a parent or doctor would expect, a sleep disorder could be at the root of all of these issues.

Understanding schizophrenia: researchers uncover new underlying mechanism

Mon, 28 Mar 2011 24:00:00 EDT

TORONTO – A new way of thinking about the fundamental pathobiology of schizophrenia could one day lead to improved therapeutic approaches to treating this disorder. Researchers at The Hospital for Sick Children (SickKids), the University of Toronto and Tufts University School of Medicine have linked proteins and genes that are implicated in schizophrenia in a novel way. The study is published in the March 27 advance online edition of Nature Medicine.

SickKids-led research projects top Genome Canada’s leader board

Mon, 28 Mar 2011 24:00:00 EDT

Two projects led by researchers from The Hospital for Sick Children (SickKids) were tied for the number one spot when Genome Canada awarded $60 million to the 16 winning projects of the Large-Scale Applied Research Project competition on March 25. This competition is part of Genome Canada’s mandate to fund a wide-range of large-scale genomics research projects through a competitive process.

Coming for surgery? New section prepares families for surgery at SickKids

Thu, 24 Mar 2011 24:00:00 EDT

SickKids has launched a new section for families with children coming to SickKids for surgery. Coming for Surgery, can be found under Visiting SickKids on our website. This section is part of an effort to educate families, and improve pre-operative preparation and efficiency.

SickKids celebrates Canada’s newest citizens

Tue, 22 Mar 2011 24:00:00 EDT

New Canadians take their citizenship oath

“I wish you peace, happiness, prosperity and a rewarding life in Canada.”

New multilingual kiosks make it easier to find your way around SickKids

Sun, 20 Mar 2011 24:00:00 EDT

Eight new multilingual kiosks have been installed on the main floor of SickKids, offering information on wayfinding and hospital services to families and visitors.

The Research & Learning Tower springs up from the ground

Fri, 18 Mar 2011 24:00:00 EDT

SickKids project managers Wayne Walker and Flemming Galberg celebrate in front of the Tower construction site.

Buds are starting to pop up on trees, flowers are beginning to peek out from the ground and this spring something else will be growing on the corner of Bay and Elm Streets. In anticipation of spring’s arrival, the SickKids Research & Learning Tower reached ground level this week. Tower construction will now begin movin’ on up for everyone to see.

Should children be shielded from media coverage of traumatic world events?

Wed, 16 Mar 2011 24:00:00 EDT

Many people are captivated by the news surrounding the devastation in Japan, but if children are also seeing this media coverage, how does it affect them?

Ontario providing additional cochlear implants for children and adults with severe hearing loss

Mon, 07 Mar 2011 24:00:00 EST

Braydy Abbott’s first year of life was more eventful than her parents, Danielle and Jamie, ever expected it to be. She developed pneumonia only 24 hours after birth, was soon diagnosed with heart problems, and a hearing test at two months confirmed what earlier tests had suggested: Braydy had severe to profound hearing impairment.

Giant strides in childhood disease research

Tue, 22 Feb 2011 24:00:00 EST

Two teams of Canadian researchers, including five from The Hospital for Sick Children (SickKids), were awarded with two grants of up to $2 million jointly from Genome Canada and the Canadian Institutes for Health Research (CIHR) for their work in genome sequencing of childhood diseases. Over the next several years, the teams will focus on translating next-generation sequencing technologies into improved therapies for high-risk, genetic, childhood diseases.

Researchers identify genetic mechanism involved in common urinary tract birth defect

Tue, 22 Feb 2011 24:00:00 EST

TORONTO – In Canada, the most common abnormality found during prenatal ultrasound testing is an enlarged urinary tract in the fetus, occurring in one in every 150 pregnancies. This abnormality is called hydronephrosis. In 20 to 30 per cent of cases it can become a serious medical problem and in extreme cases can lead to infant renal failure. Testing for this defect is often invasive and can be stressful for both the babies and their caregivers. Researchers at The Hospital for Sick Children (SickKids) have uncovered a mechanism that could be responsible for development of this defect. The study was published in the Feb.21 online edition of The Journal of Clinical Investigation.

Researchers focus on children with medical complexity to improve efficiencies in the health-care system

Mon, 21 Feb 2011 24:00:00 EST

TORONTO – In Ontario, children with complex chronic conditions represent only one per cent of the paediatric population, but their impact on the health-care system is substantial, accounting for over 23 per cent of all child health-care spending. Children with medical complexity are those who have many health problems, see several specialists, often need home care and are at risk of being continuously sick. Examples include, but are not limited to, children with complex cardiac disease, autism with severe behavioural concerns or cancer patients with ongoing challenges in multiple areas.

Let’s talk about L-O-V-E: encouraging healthy relationships

Mon, 14 Feb 2011 24:00:00 EST

Consider the term first love. It is somewhat misleading because in reality, a person’s first real understanding of love is the bond between parent and child. This bond, say experts at The Hospital for Sick Children (SickKids), can lead to and encourage healthy relationships that have a profound effect on a child’s development.

Is digital more patient-friendly than paper? New study says yes

Mon, 07 Feb 2011 24:00:00 EST

Electronic forms may help improve care for kids with chronic conditions

In 2011, it’s the norm to book a vacation, take a course and even order groceries online. The move to a digital “self-serve” model is transforming most industries, including health care, in an effort to be quicker and improve ease of use and accuracy.

SickKids celebrates 60th anniversary on University Avenue

Fri, 04 Feb 2011 24:00:00 EST

The Hospital for Sick Children was founded in 1875. In 1891, when the hospital was located at 67 College St., it was running out of space. Plans for a larger, up-to-date facility were taking shape in 1929 but slowed down due to the Great Depression and World War II.

Health information available in English, French and Chinese

Fri, 04 Feb 2011 24:00:00 EST

AboutKidsHealth.ca now provides current, trusted and evidence-based information about children’s health in French and simplified Chinese. And through a partnership with BC Children’s Hospital, Children’s Hospital of London Health Sciences Centre, IWK Health Centre in Halifax and SickKids, AboutKidsHealth.ca is building a coast-to-coast collaboration in child health information on a wide range of child health topics, from asthma to whooping cough. Spread the word!

It's World Cancer Day

Fri, 04 Feb 2011 24:00:00 EST

The World Health Organization (WHO) marks World Cancer Day each year on Feb. 4 – a perfect day to highlight the developments of the past year in the field of cancer at SickKids.

Helping to improve the lives of kids with chronic conditions in the Middle East

Tue, 01 Feb 2011 24:00:00 EST

Doha, Qatar - Twelve children who depend on a ventilator to breathe, including several who have never before been out of bed are now able to enjoy some of the simple pleasures in life, thanks to the hard work of health-care workers from The Hospital for Sick Children (SickKids), Holland Bloorview Kids Rehabilitation Hospital and the Hamad Medical Corporation.

Early eye removal in children with advanced eye cancer can be lifesaving option compared with chemotherapy

Mon, 31 Jan 2011 24:00:00 EST

TORONTO – Children with the most common paediatric eye cancer fare better when the eye with advanced disease is surgically removed quickly rather than when the tumour is treated with chemotherapy, according to new research. A new study out of The Hospital for Sick Children (SickKids), Princess Margaret Hospital (PMH) and Beijing Tongren Hospital shows children treated with chemotherapy before surgery had a higher risk of death because chemotherapy delayed removal of the eye with advanced disease and masked the spread of the disease into the brain. The research is published in the January 31 advance online edition of the Journal of Clinical Oncology.

Treatment of vomiting and diarrhea in emergency departments varies across the country

Fri, 28 Jan 2011 24:00:00 EST

In Canada, it is estimated that 239,000 children visit the emergency department every year with vomiting or diarrhea due to an intestinal infection commonly called gastroenteritis. If the vomiting or diarrhea is significant enough, children may develop dehydration. Although the vast majority of children develop only minimal dehydration, in severe cases they may require intravenous treatment and even hospitalization. A multicentre study led by The Hospital for Sick Children (SickKids) evaluated the treatment of paediatric gastroenteritis in Canadian emergency departments and found that clinical practices varied dramatically. While guidelines describe the need to use oral rehydration therapy in all but severe cases, intravenous rehydration is often employed to treat children with lesser degrees of dehydration. The study was published in an advance online edition of Pediatrics on Jan. 24, 2011.

In 2006, Dr. Stephen Freedman, lead author for this study and Physician in the SickKids Departments of Paediatric Emergency Medicine and Gastroenterology, Hepatology and Nutrition, released a study that showed the use of an anti-vomiting drug called ondansetron in addition to oral rehydration therapy reduces vomiting and the need for intravenous rehydration. Moreover, in October 2010 he found that the appropriate use of ondansetron to prevent the need for intravenous rehydration results in both clinical and economic benefits, annually saving Canadian society an average of $1.72 million. The next logical step was to assess what rehydration therapies are being used by health-care institutions, and to attempt to understand the overuse of intravenous rehydration by Canadian emergency physicians, explains Freedman who is also Associate Scientist at SickKids and Assistant Professor of Paediatrics at the University of Toronto.

This nationwide study focused on children aged three to 48 months in 11 emergency departments and found that 23 per cent of patients suffering from gastroenteritis received intravenous rehydration. More importantly, there was enormous variation between centres in the use of intravenous rehydration, with the most significant predictor of intravenous usage being the emergency department where care was provided. In addition, “patients who received intravenous rehydration at the initial emergency visit were twice as likely to revisit the hospital,” says Freedman who postulates that the use of intravenous rehydration “may have an effect on the caregiver, making the diagnosis seem more severe, and causing the caregiver to believe that another trip to the hospital is necessary.”

According to Freedman, there is a variation in treatment across the country because there is a gap between evidence-based guidelines and clinical practice. Knowledge translation is needed in order to close the gap and enhance rehydration practices.

“Evidence shows that oral rehydration therapy is both clinically and economically advantageous, and should be the standard of care for the vast majority of children with gastroenteritis,” says Freedman. He also explains that continued research into the association between intravenous rehydration and consequent health-care use is warranted.

SickKids cancer research: Top 10 in 2010

Thu, 27 Jan 2011 24:00:00 EST

The top 10 list is out! The Canadian Cancer Society top ten research stories list that is. And two SickKids researchers made the cut. This list highlights the most notable research funded in full or in part by the Canadian Cancer Society.

We’re only going up from here!

Thu, 27 Jan 2011 24:00:00 EST

This week marks the end of excavation at The Research & Learning Tower construction site. This means that all the digging is done and now construction can begin movin’ on up. SickKids broke ground on the construction site, at the corner of Bay and Elm streets, in May 2010 and since then approximately 39 000 CM (cubic metres) of dirt has been displaced. This amount of dirt could fill over 15 Olympic sized swimming pools!

A vision for paediatric surgery

Wed, 26 Jan 2011 24:00:00 EST

Dr. James Wright, SickKids Surgeon-in-Chief, is named head of national group

Dr. James Wright, Chief of Perioperative Services and Surgeon-in-Chief, was recently named head of Pediatric Surgical Chiefs of Canada.

SickKids scientists’ serve more than a refreshing pint at Duggan’s Brewery

Fri, 21 Jan 2011 24:00:00 EST

Personalized medicine was on the menu last night at Duggan’s Brewery where community members gathered to listen to SickKids and University of Toronto experts take part in SickKids Café Scientifique – Personalized Medicine: It’s all about the fit of the genes. By 6 p.m. it was standing room only as Gwen Burrows, director, Strategic Projects, Research Institute, SickKids, and president, Couchiching Institute of Public Affairs got the discussion underway.

Leafs bring smiles to SickKids

Mon, 17 Jan 2011 24:00:00 EST

Patients at SickKids were visited by a group of men in blue and white on Monday. The entire Toronto Maple Leafs team, including coaches and Carlton the Bear, made their annual visit bringing plenty of goodies for patients. The players gathered with media in Marnie’s Lounge before making their way around the hospital delivering gifts to patients.

Low-income children with IBD are more likely to undergo surgery than their wealthier counterparts

Thu, 13 Jan 2011 24:00:00 EST

TORONTO, January 13, 2010 – Approximately 2,000 Ontario children under the age of 18 suffer from Crohn's disease and ulcerative colitis, collectively known as Inflammatory Bowel Disease (IBD). New research conducted at the Institute for Clinical Evaluative Sciences (ICES) and The Hospital for Sick Children (SickKids) has found children with IBD from low-income neighbourhoods are 17 per cent more likely to be hospitalized and up to 80 per cent more likely to undergo surgery for Crohn’s than those from high-income neighbourhoods.

Going to all ends to prevent relapse of neural cancers

Thu, 13 Jan 2011 24:00:00 EST

New therapy may reduce risk of cancerous neural tumours returning

TORONTO – Blocking an enzyme that is involved in the regeneration of cancer stem cells may be the key to treating tumours in the brain and other parts of the nervous system, according to a study from The Hospital for Sick Children (SickKids). Paediatric neural tumours – such as brain tumours and neuroblastoma (one of the common cancers of infants and children) – are the leading cause of death in childhood cancer, accounting for up to 40 per cent of deaths. This is invariably due to the tumour’s ability to recur even after aggressive treatment when no visible trace of the tumour remains.

He scores! SickKids wins! Prime Minister gives young patients air hockey table

Sat, 18 Dec 2010 24:00:00 EST

SickKids patient Kaitlyn O'Brien plays air hockey against Prime Minister Stephen Harper

The crowd in Marnie's Lounge fell silent as the puck dropped. On one side of the table was Kaitlyn O'Brien, age 14. On the other – Prime Minister Stephen Harper.

Folate deficiency virtually nonexistent among Canadians

Mon, 13 Dec 2010 24:00:00 EST

A new Canadian study found that folate deficiency is virtually nonexistent in the Canadian population. Researchers at The Hospital for Sick Children (SickKids) and The Children’s Hospital of Eastern Ontario Research Institute are the first in over three decades to examine folate status on a national scale with a subset of women of childbearing age. The study is published in the December 13 advance online edition of the Canadian Medical Association Journal (CMAJ).

Santa’s elves and Maple Leafs join forces for Operation HO HO HO

Fri, 10 Dec 2010 24:00:00 EST

Taking a break from their final preparations for Christmas, Santa’s elves spent the afternoon at The Hospital for Sick Children (SickKids) spreading holiday joy to patients and their families.

Centre for Commercialization of Regenerative Medicine receives $15 million from federal government

Mon, 06 Dec 2010 24:00:00 EST

Regenerative medicine received an important boost today through a significant investment from the Government of Canada. A $15-million grant was awarded to the Centre for Commercialization of Regenerative Medicine (CCRM), a University of Toronto-hosted project for which The Hospital for Sick Children (SickKids) is a research partner.

Financial barriers may be increasing the number of visits to the emergency room for kids with asthma

Thu, 02 Dec 2010 24:00:00 EST

Canadian study is the first to identify how challenges related to medication costs affect asthma control in children

A new Canadian study reveals that financial barriers – in the form of sharing asthma medication costs between insurers and families, are contributing to poor asthma control in children.

NICU book of rhymes promotes family-centred care

Thu, 02 Dec 2010 24:00:00 EST

Dan Yashinsky never dreamed that he would spend the first weeks of his son’s life in the Neonatal Intensive Care Unit (NICU) at The Hospital for Sick Children (SickKids). He felt helpless as doctors and nurses cared for his fragile newborn. The thought that his son would experience the world for the first time through beeps from a machine was unimaginable, so he and his family began singing and telling stories in an attempt to normalize the situation. “We wanted our baby to hear our voices and not just the sounds of the monitors or the doctors discussing test results,” said Yashinsky, a professional storyteller.

Mary Jo Haddad recognized as one of Canada’s Most Powerful Women

Mon, 29 Nov 2010 24:00:00 EST

Mary Jo Haddad, President and CEO of The Hospital for Sick Children (SickKids), is a recipient of the 2010 Canada’s Most Powerful Women: Top 100 Awards, in the Public Sector Leaders category. This is the third time Haddad is receiving this honour. She was also recognized in 2007 and 2008.

New guidelines may help health-care providers minimize immunization pain in children

Fri, 26 Nov 2010 24:00:00 EST

A newly-released guideline for pain management during childhood immunization aims to help reduce pain, and ultimately, the fear of needles. A multidisciplinary panel of experts led by Dr. Anna Taddio, Adjunct Scientist and Pharmacist at The Hospital for Sick Children (SickKids) and Associate Professor in the Leslie Dan Faculty of Pharmacy at the University of Toronto, has developed a new evidence-based clinical practice guideline to help doctors, health-care providers and parents reduce the pain and distress of immunization in children. The guidelines are published in the November 22 issue of the Canadian Medical Association Journal.

Rutka new head of Department of Surgery at U of T

Wed, 24 Nov 2010 24:00:00 EST

Neurosurgeon Dr. James Rutka, co-founder and co-director of the Arthur and Sonia Labatt Brain Tumour Research Centre, has been appointed Chair of the Department of Surgery at the Faculty of Medicine for a five-year term, starting April 1, 2011.

Barrera honoured with a POGO Recognition Award

Wed, 24 Nov 2010 24:00:00 EST

By Charlene Fong

Dr. Maru Barrera, Psychologist, Haematology/Oncology Division, Senior Associate Scientist, Child Health Evaluative Sciences and Associate Professor at the University of Toronto, was recently awarded the 2010 Pediatric Oncology Group of Ontario (POGO) Companion Award. Barrera was presented with the honour at the annual Pediatric Oncology Group of Ontario Symposium dinner on Nov. 19, 2010.

David Foster visits SickKids

Fri, 19 Nov 2010 24:00:00 EST

This morning, SickKids transplant patients and their families enjoyed a rare opportunity to meet David Foster, world-renowned songwriter and producer. The music icon visited SickKids with board members from the David Foster Foundation, which provides financial support to help cover the non-medical expenses of hundreds of Canadian families in need of organ transplants.

Dietary changes may prevent autoimmunity that leads to type 1 diabetes in at-risk babies: NEJM study

Thu, 11 Nov 2010 24:00:00 EST

TORONTO – Changing the diets of babies with high genetic risk for type 1 diabetes protected them from developing the autoimmunity that destroys insulin-producing cells over the first ten years of life. This just-released research data comes from the world’s largest and longest-running type 1 diabetes prevention trial. The study, conducted by researchers at the University of Helsinki and The Hospital for Sick Children (SickKids), is published in today’s advance online edition of the New England Journal of Medicine.

SickKids Pilot Supported by AstraZeneca Award for Innovation

Thu, 11 Nov 2010 24:00:00 EST

SickKids Nurse Practitioners Krista Keilty and Cathy Daniels received the Nurse Practitioners Association of Ontario-AstraZeneca Award for Innovation in Chronic Disease Management, a $5,000 grant supporting a pilot to bring community care to vulnerable children living with asthma, a priority for local Community Health Centres.

SickKids named performance leader

Wed, 10 Nov 2010 24:00:00 EST

From left to right: Dr. Dave Norton (Founder and Director, Palladium Group, Inc.), Aaron Smith (Manager, Strategic Initiatives, SickKids), Irene Blais (Direction, Decision Support, SickKids), Mary Jo Haddad (President and CEO, SickKids), Jeff Mainland (Vice President, Corporate Strategy & Performance,SickKids), Dr. Robert Kaplan (Baker Foundation Professor, Harvard Business School, and Chairman of Professional Practice, Palladium Group, Inc.).

For many years, SickKids has made high performance a priority in the areas of clinical care, research, education and administration. “We pride ourselves in being recognized as one of the top children’s hospitals in the world, and we are pleased to be part of a broader health-care system in Ontario that is focused on performance and accountability,” says Mary Jo Haddad, President and CEO of SickKids.

SickKids Brand Campaign Emphasizes Strength in Unity

Mon, 08 Nov 2010 24:00:00 EST

“Together We Will”calls on community to join doctors, researchers and caregivers to help advance child health

Canadian icons, artists, philanthropists and children have come together to support a new brand campaign for The Hospital for Sick Children (SickKids). “Together We Will”, the campaign’s theme and tagline, aims to inspire the community to come together with SickKids doctors and researchers to help advance child health care through donations.

Research Institute Retreat 2010: Celebrating an exciting year in SickKids research

Thu, 04 Nov 2010 24:00:00 EDT

On November 1st, 2010 over 860 SickKids Research Institute staff and trainees gathered at the Metro Toronto Convention Centre for the 23rd Annual Research Institute Retreat. This was an exciting year for research at SickKids with the groundbreaking of The Research & Learning Tower and the completion of a successful five-year review of the leadership in the Institute.

SickKids recognized as a health information technology leader for clinical care system

Thu, 04 Nov 2010 24:00:00 EDT

The Hospital for Sick Children’s (SickKids) “big-bang implementation” of a new clinical information system has earned SickKids recognition as one of the most innovative organizations in health care today. SickKids has received an Allscripts 2010 Circle of Excellence Award for demonstrating exceptional outcomes that drive improved care for patients and better business performance.

Daneman receives prestigious award

Mon, 01 Nov 2010 24:00:00 EDT

Dr. Denis Daneman, Paediatrician-in-Chief, has received a prestigious international award from the International Society for Pediatric and Adolescent Diabetes – the ISPAD Prize for Achievement which recognizes outstanding contributions in the areas of science, education or advocacy which have had a major impact on childhood and adolescent diabetes.

SickKids celebrates Patient Safety Week, November 1 to 5

Mon, 01 Nov 2010 24:00:00 EDT

It’s Canadian Patient Safety Week, a national campaign led by the Canadian Patient Safety Institute to increase awareness of patient safety issues and share information about best practices in patient safety. As leaders in patient safety, SickKids has plenty to celebrate – and we are doing just that this week with several awareness events for staff, families and patients!

Transformational Gift to SickKids Cancer Care, Research, and Education

Mon, 25 Oct 2010 24:00:00 EDT

Believed to be single largest private gift to paediatric cancer in North America, gift will establish the Garron Family Cancer Centre

A transformational gift of $30 million, believed to be the single largest private gift to paediatric cancer in North America, was announced this morning by Mary Jo Haddad, President and CEO of The Hospital for Sick Children (SickKids). The gift will establish the Garron Family Cancer Centre and allow SickKids to help more children survive their cancer diagnosis.

Number of individuals with asthma in Ontario increases

Thu, 21 Oct 2010 24:00:00 EDT

A new study in the American Journal of Epidemiology, led by Sunnybrook Health Sciences Centre researcher and Respirologist, Dr. Andrea Gershon and The Hospital for Sick Children (SickKids) researcher, Dr. Teresa To, suggests that there has been a startling increase in the number of people living with asthma in Ontario since 1996.

Use of an anti-vomiting drug for stomach flu patients could save millions of dollars

Thu, 14 Oct 2010 24:00:00 EDT

TORONTO – Stomach flu or gastroenteritis, a common illness in children, can be unpleasant to say the least. Not only do patients experience diarrhea and vomiting, but in cases where children become very dehydrated, they could require intravenous treatment and even hospitalization, causing additional pain for patients and stress for parents. Recent studies suggest the use of an anti-vomiting drug called ondansetron reduces the frequency of vomiting, the need for intravenous rehydration and maybe even hospitalization. A study led by The Hospital for Sick Children (SickKids) published this month in PLoS Medicine shows that there is also a big economic benefit to using the drug.

Clinical research at its best: science helping patients, patients advancing science

Wed, 13 Oct 2010 24:00:00 EDT

SickKids opens new home for clinical research

TORONTO – At only three and a half years old, Jake Da Luz couldn’t walk, because he suffered from pain and limited joint movement. He was diagnosed with systemic juvenile idiopathic arthritis. The existing treatments weren’t working, so Jake was invited to participate in a drug trial at The Hospital for Sick Children (SickKids). Nearly two years later, Jake, who is now six, is not only walking, but playing hockey.

Synergy between U of T and SickKids lifts both institutions in the eyes of the world

Tue, 05 Oct 2010 24:00:00 EDT

U of T ranked among world’s top 20 universities

Scientists at the University of Toronto (U of T) and The Hospital for Sick Children (SickKids) have made a major scientific advancement in (insert area of study here).

If there’s a research breakthrough at SickKids those are likely the first words you’ll see or hear in media reports. When great minds get together, good things happen!

Toronto database for genomic medicine extends global reach

Thu, 30 Sep 2010 24:00:00 EDT

TORONTO – This week marks the launch of the Database of Genomic Variants archive (DGVa) – a public resource that will facilitate the translation of genetic information into new diagnostic, prognostic and therapeutic tools for improved human health. DGVa was created by the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) in collaboration with the University of Toronto’s McLaughlin Centre and The Centre for Applied Genomics (TCAG) at The Hospital for Sick Children (SickKids). The new database is announced in the latest online edition of Nature Genetics.

Toronto scientists discover novel laser technique that could lead to near-scarless surgery

Wed, 29 Sep 2010 24:00:00 EDT

TORONTO – Wounds heal after surgery, but often the size of the scar can impact a patient in a variety of ways long after the operation. Large scars not only result in cosmetic deformities, but they can also create discomfort and cause long-term psychological stress and unhappiness. Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto have found a novel laser technique that could significantly reduce scarring after surgery. The study appears in the September 28 online edition of PLoS ONE.

Oh Baby … Motherisk turns 25!

Tue, 21 Sep 2010 24:00:00 EDT

SickKids program celebrates a quarter-century of empowering pregnant women and protecting babies around the world

Link to autism in boys found in missing DNA

Wed, 15 Sep 2010 24:00:00 EDT

New research from the Centre for Addiction and Mental Health (CAMH) and The Hospital for Sick Children (SickKids), both in Toronto, Canada provides further clues as to why Autism Spectrum Disorder (ASD) affects four times more males than females. The scientists discovered that males who carry specific alterations of DNA on the sole X-chromosome they carry are at high risk of developing ASD. The research is published in the September 15 issue of Science Translational Medicine.

Cancer patients at SickKids remember Terry Fox’s inspiring story

Wed, 15 Sep 2010 24:00:00 EDT

Steve Nash’s Terry Fox documentary “Into the Wind” premiered at TIFF

Last August, cancer patients at The Hospital for Sick Children (SickKids) had the opportunity to meet NBA superstar Steve Nash, who visited SickKids while filming a documentary on the Canadian hero, Terry Fox. Patients and their families got to know Nash and his film crew as they read the Terry Fox story together, signed autographs and smiled for the camera. On September 12, 2010, just over a year later, the Terry Fox film Into the Wind premiered at the Toronto International Film Festival. Some of these SickKids moments were captured in the documentary.

Katie Armstrong – Be a role model!

Fri, 10 Sep 2010 24:00:00 EDT

Katie Armstrong, a SickKids Ambassador, is used to sharing her story with the local community, but now she is hoping to inspire tweens and teens across North America.

SickKids scientists find new types of brain cancer

Tue, 07 Sep 2010 24:00:00 EDT

Medulloblastoma is actually four different cancers – gender- and age- specific

TORONTO – A landmark international study led by scientists at The Hospital for Sick Children (SickKids), has added a new dimension to the understanding of medulloblastoma, the most common malignant type of childhood brain tumour.

SickKids researchers among Early Researcher Award recipients

Thu, 19 Aug 2010 24:00:00 EDT

At his first official event as Minister of Research and Innovation, Honourable Glen Murray recognized the researchers in downtown Toronto, including two from SickKids, benefitting from this year’s Ontario Research Fund and Early Researcher Award program.

“I am proud of the tremendous talent we have in Toronto – a research powerhouse in Ontario. Our government is helping researchers make discoveries that will ensure a better quality of life for Ontarians and people around the world,” said Murray

SickKids researchers Dr. Paul Nathan and Dr. Simon Sharpe are among 80 emerging researchers from across Ontario receiving more than $11 million through the Ministry of Research and Innovation’s Early Researcher Awards program. Researchers will receive up to $140,000 each through the program.

Nathan, an Associate Scientist in Child Health Evaluative Sciences and an Oncologist at SickKids is creating a comprehensive database of children and adolescents treated for cancer in Ontario over a 20-year period. This registry is expected to become an important resource for examining acute outcomes in children with cancer, and for understanding the long-term physical and psychological challenges faced by the growing population of childhood cancer survivors.

Sharpe, a Scientist in Molecular Structure & Function at SickKids, is researching the interaction between tetherin and the HIV-1 virus. The protein tetherin protects our bodies by preventing cells infected by certain viruses from releasing new virus particles into the rest of the body. Some viruses, however, can fight back. The HIV-1 virus, for instance, has a protein that can overcome tetherin’s protective effect. Sharpe’s research could lead to new antiviral therapies.

At the event, Dr. Michael Salter, Head and Senior Scientist, Neurosciences & Mental Health, thanked the government of Ontario and acknowledged the great research being done at SickKids, especially by Nathan and Sharpe.

“These two young researchers exemplify the breadth of research happening at SickKids from fundamental knowledge to applied research. Because of funding like this from the Ontario Government, we are able to achieve our main goal of using new knowledge to improve the health outcomes of children,” said Salter.

The Early Researcher Award (ERA) program helps promising, recently-appointed Ontario researchers build their research teams of undergraduates, graduate students, post-doctoral fellows, research assistants, associates, and technicians. The goal of the program is to improve Ontario’s ability to attract and retain the best and brightest research talent.

Accelerating the search for new cancer therapies: SickKids scientists find new twist on drug screening to treat common childhood cancer

Wed, 18 Aug 2010 24:00:00 EDT

TORONTO – A study led by scientists at The Hospital for Sick Children (SickKids) reveals a new method of identifying drugs to treat children suffering from fatal cancers for which an effective treatment has not been found. Rather than developing a new drug from scratch, which is a complicated and time-consuming process, they tried a different approach: in the lab, they tested existing drugs on cancer stem cells from young patients with neuroblastoma, one of the common cancers of infants and children. Cancer stem cells are the very cells that scientists suspect are responsible for relapses. The study is published in the August 18 advance online edition of EMBO Molecular Medicine.

The idea of repurposing existing medications is not new, but testing them on the cells isolated directly from children and that are thought to be responsible for the spread and regrowth of their tumours is novel. According to the study’s principal investigator, Dr. David Kaplan, there is an urgent need to develop new treatments for neuroblastoma. Less than 40 per cent of patients over the age of one survive this cancer, and the disease usually relapses, aggressively spreading or metastasizing to other parts of the body.

“We conducted our drug discovery by targeting the cells that we think are responsible for the cancer coming back,” says Kaplan, Senior Scientist at SickKids and Professor in the Department of Molecular Genetics at the University of Toronto. “This is a new way of developing drugs for kids, as we are taking the patients’ own cancer stem cells and testing them in the lab.”

The team, led by Dr. Kristen Smith, postdoctoral fellow in Kaplan’s laboratory, had two main goals in this project: to eliminate the cancer cells and to do this without harming healthy cells. Since cancer therapies like chemotherapy kill good cells along with the bad, striking this delicate balance – even in adult cancers – can be challenging. This risk of toxicity is amplified in children, whose growing bodies are particularly vulnerable to the side-effects of powerful treatments, which can result in developmental problems and a higher risk of developing cancers as adults. As a result, some drugs that are proven to effectively treat cancer in adults cannot be used in children, leaving few options for some young patients.

Neuroblastoma, a solid tumour found outside the brain in the nervous system, is the most frequent cause of disease-related death in children.

The research team identified two drugs, DECA-14, a version of an antibiotic that is found in some mouthwashes, and rapamycin, a drug that is used to prevent organ rejection in children who have received transplants. Both medications were found to be effective in treating mice with neuroblastoma and were non-toxic to the normal stem cells from children.

The researchers were able to begin a clinical trial much faster than if a new drug was being developed since one of the therapies, rapamycin, had already been proven to be safe in children, with established protocols that outline the quantity and frequency of treatment. On the basis of this study, a SickKids-led North American Phase I clinical trial is already underway in collaboration with CHU Sainte-Justine in Montreal, as well as two centres in the US. The trial will evaluate rapamycin in combination with the chemotherapy drug vinblastine, for paediatric solid tumours. This trial is led by Dr. Sylvain Baruchel, Staff Oncologist and Senior Associate Scientist at SickKids and Professor in the Department of Paediatrics at the University of Toronto, who was also a collaborator on this study.

If the clinical trial shows positive results, this could be the beginning of a personalized medicine approach, Kaplan says. “Our dream is that children will come to SickKids, we’ll isolate their cancer stem cells, screen them with libraries of drugs and find out whether Patient A will respond to Therapy B.”

This research was funded by the Stem Cell Network in partnership with the James Fund for Neuroblastoma Research, and Solving Kids’ Cancer. This study was also supported by the Canadian Institutes of Health Research, Canadian Cancer Society Research Institute, Lilah’s Fund, Shania's Sunflower of Hope, Sam's Day, the Ontario Institute for Cancer Research, the Terry Fox Research Institute, and the McLaughlin Centre and SickKids Foundation.

When the new SickKids Research & Learning Tower opens its doors, Kaplan’s lab will be relocated to the Cancer, Stem Cells & Regenerative Medicine neighbourhood. The shared resources and close proximity to colleagues in other scientific disciplines will encourage novel ideas and may result in collaborations between researchers who may not otherwise interact.

Slippery DNA holds clues to fighting diseases that progress with age: SickKids study

Sun, 15 Aug 2010 24:00:00 EDT

SickKids celebrates UN International Year of Youth

Thu, 12 Aug 2010 24:00:00 EDT

The United Nations (UN) has declared 2010 the International Year of Youth (IYY). The year-long celebration begins today. This year’s theme, Dialogue and mutual understanding, aims to encourage an exchange of thoughts and ideas across generations, while promoting ideals of peace, respect for human rights and freedoms and solidarity.

Web cam gives bird’s eye view of Tower construction

Wed, 11 Aug 2010 24:00:00 EDT

A newly-installed web cam is offering a bird’s eye view on the construction of SickKids’ new Research & Learning Tower at the corner of Bay and Elm streets. The camera produces an image that’s updated every two seconds.

SickKids shines in CIHR competition

Wed, 11 Aug 2010 24:00:00 EDT

In an era where research grants are increasingly difficult to get, SickKids continues to shine.

SickKids researchers were awarded 20 grants (out of 66 applications) in the latest Canadian Institutes of Health Research (CIHR) operating grants competition. That's a success rate of 30 per cent, compared to the 17 per cent national average. Most impressively however was that six of the SickKids grants were ranked number one by the committees who reviewed them.

Cystic fibrosis now seen as a disease affecting many ethnicities

Wed, 04 Aug 2010 24:00:00 EDT

SickKids-led study proves there is ethnic diversity among North American patients

Cystic fibrosis (CF) has long been thought of by most people as a disease affecting only Caucasians. While some experts asserted this was not the case, they did not have the data to correct this misconception. Now they do.

Brain work

Sun, 01 Aug 2010 24:00:00 EDT

SickKids' Centre for Brain & Behaviour has developed one of the world’s leading paediatric epilepsy surgery programs and set a gold standard for centres of excellence.

The Big Dig

Fri, 30 Jul 2010 24:00:00 EDT

Construction of SickKids’ new Research & Learning Tower is well under way at the corner of Bay and Elm streets. The groundbreaking ceremony took place May 4 at 11 a.m., and digging started just hours later. According to schedule, the new home for scientists and educators at SickKids will be ready for occupancy in August, 2013.

Teens at SickKids spend “A Night in Wonderland”

Tue, 13 Jul 2010 24:00:00 EDT

Two years ago, a teenage girl made a wish to attend prom. She had missed hers while undergoing treatment at The Hospital for Sick Children.

Doctors can influence when parents wean children from bottle study finds

Mon, 12 Jul 2010 24:00:00 EDT

Prolonged bottle-feeding is linked to tooth decay, obesity and iron deficiency, and once children turn two, they don’t want to give it up

TORONTO - Family doctors and paediatricians can influence when parents wean their children from the bottle, thereby helping to reduce tooth decay, obesity and iron deficiency, according to a new study by researchers at St. Michael’s Hospital and The Hospital for Sick Children (SickKids).

Impact of HPV infection of the airway measured for the first time

Wed, 07 Jul 2010 24:00:00 EDT

TORONTO – For the first time, the scope and devastating impact of the human papilloma virus (HPV) infection of the airway in children has been measured, according to a new population study from the University of Toronto and The Hospital for Sick Children (SickKids).

SickKids President & CEO Appointed to the Order of Canada

Wed, 30 Jun 2010 24:00:00 EDT

Toronto - The Board of Trustees and Senior Management Team at The Hospital for Sick Children (SickKids) in Toronto are delighted that Mary Jo Haddad, President & CEO of SickKids has been appointed a Member of the Order of Canada. The announcement was made earlier today by Her Excellency the Right Honourable Michaëlle Jean, Governor General of Canada.

Will I have to get a needle?

Mon, 28 Jun 2010 24:00:00 EDT

Parents taking their children to the doctor’s office can now arm themselves with a new tool to help make the visit less painful. Dr. Anna Taddio, Adjunct Scientist and Pharmacist at The Hospital for Sick Children (SickKids) and Associate Professor at the University of Toronto has teamed up with Dr. Vinita Dubey from Toronto Public Health to provide an easy-to-use tip sheet to help reduce children’s pain during immunizations.

Who has the ‘WOW’ Factor? SickKids’ IT team does

Fri, 18 Jun 2010 24:00:00 EDT

Since May, The Quest for Canada’s Smartest IT has been on the hunt for organizations with IT departments that go above and beyond the average call of technological duty – departments who are re-inventing the way their organization uses technology. The Hospital for Sick Children (SickKids) has one of those IT teams, and Tuesday night, at a special gala, SickKids' IT Department won a special award for using IT that sets them apart from the rest of the competition.

Rheumatology celebrates 25 years of excellence

Fri, 18 Jun 2010 24:00:00 EDT

Since its inception, The Hospital for Sick Children’s (SickKids) Rheumatology Division has had a lot to celebrate.

New Leadership in Medical and Academic Affairs

Wed, 16 Jun 2010 24:00:00 EDT

Dr. Stanley Zlotkin has been appointed Vice-President, Medical and Academic Affairs, effective July 27. As a member of SickKids’ Senior Management Team, reporting to the President & CEO, Mary Jo Haddad, Zlotkin will assume executive medical leadership for Quality, Medical and Academic Affairs, as well as executive support to the chiefs of Diagnostic Imaging, Laboratory Medicine and Psychiatry. He will chair the Quality Management Council, participate as a member of the Senior Management Committee and support the business and chair of the Medical Advisory Committee.

Zlotkin also a Senior Scientist, Child Health Evaluative Sciences at SickKids and Professor, Departments of Nutritional Sciences & Paediatrics at the University of Toronto, will represent SickKids as medical executive lead with the University of Toronto and as a member of the Toronto Academic Health Science Network.

Zlotkin’s research interests involve examining mineral requirements and metabolism in premature and full-term infants, especially iron; clinical trials to treat and prevent iron and vitamin A deficiency; and establishing evidence-based nutrition public policy. Zlotkin created Supplefer Sprinkles, an iron and vitamin supplement that can easily be added to food and drinks. It is an easy way for children and adults to improve their iron intake. The supplements are being administered to millions of children in Ghana, Sri Lanka and Pakistan in an ongoing program initiated and run by Zlotkin. In recognition of his leadership in child health and nutrition Zlotkin was appointed as a Member of the Order of Canada in 2006.

New Chief Financial Officer joining SickKids

Fri, 11 Jun 2010 24:00:00 EDT

Denise Arsenault will be joining SickKids as Chief Financial Officer and Vice-President, Finance, effective July 12, 2010. Arsenault will replace Angela Holtham, who is retiring after eight years at the Hospital.

New genetic findings expected to accelerate autism testing and development of treatments

Wed, 09 Jun 2010 24:00:00 EDT

Results of International Autism Genome Project - Phase 2 are unveiled

TORONTO – Canadian and international scientists have uncovered key changes in DNA in individuals with autism. The Phase 2 results of the multinational Autism Genome Project Consortium published in the June 9 advance online edition of Nature, substantiate the importance of genes as susceptibility factors in autism spectrum disorders.

Canada's highest nursing honour for Board Trustee

Wed, 09 Jun 2010 24:00:00 EDT

SickKids Board Trustee, Dr. Gail Donner, has received Canada's most prestigious nursing award, the Jeanne Mance Award, for her positive impact on the practice of nursing in Canada.

Camp Ooch’s leader named one of Canada’s Top 40 Under 40

Tue, 08 Jun 2010 24:00:00 EDT

Thanks to Rob Drynan, children with cancer at The Hospital for Sick Children (SickKids) do not need to worry about missing out on summer fun. Drynan brings excitement into the Hospital every day.

SickKids H1N1 study suggests ways to manage pain caused by vaccinations

Fri, 04 Jun 2010 24:00:00 EDT

Researchers hope findings will help increase future immunization rates

TORONTO – While Ontario’s H1N1 immunization program resulted in lower-than-expected immunization rates, a new study out of The Hospital for Sick Children (SickKids) and the University of Toronto finds several strategies were effective in minimizing pain caused by the H1N1 vaccine, and sheds light on why some people avoid vaccinations. The study is published in the June 4 advance online edition of Vaccine.

SickKids welcomes the First Lady of Mexico

Fri, 28 May 2010 24:00:00 EDT

Today, The Hospital for Sick Children (SickKids) received a very special visit from Licenciada Margarita Zavala, First Lady of Mexico. The First Lady was joined by Mrs. Hortensia Olivas de Barrio, wife of the Mexican Ambassador, and Lic. Isabel Aguilera de Sabines, wife of the Governor of the State of Chiapas.

First-ever congenital heart surgery trial identifies procedure that improves babies’ survival in first year

Thu, 27 May 2010 24:00:00 EDT

TORONTO – In the first and largest study of its kind, doctors compared two routine surgical procedures used to treat infants with a severe form of congenital heart disease. They found that one procedure resulted in higher survival rates than the other in the baby’s first year. The study is published in the May 26 advance online edition of the New England Journal of Medicine.

Caregivers can reduce pain in premature babies simply by choosing less-painful urine test

Wed, 19 May 2010 24:00:00 EDT

TORONTO – Premature babies in neonatal intensive care units (NICU) undergo many tests and procedures that sometimes cause significant pain. New research led by The Hospital for Sick Children (SickKids) shows that health-care providers can reduce pain by 40 per cent, simply by selecting one type of urine test over another. The less-painful procedure also had a higher success rate. The research is published in the May 17 advance online edition of Pediatrics.

Science at the Summit

Wed, 19 May 2010 24:00:00 EDT

TORONTO (May 19, 2010) – She has transformed the understanding of human biology and stem cell origins. His research has given scientists and clinicians new ways of thinking about the diagnosis and treatment of a range of cancers. Both are at the top of their fields and committed to translating the best research into clinical outcomes.

Watch the Science at the Summit Video

Remembering Dr. Robert Salter

Tue, 11 May 2010 24:00:00 EDT

Dr. Robert Bruce Salter, world-renowned orthopaedic surgeon, researcher, professor, humanitarian and “medical giant” whose pioneering work has impacted millions of people around the world, died May 10 at the age of 85. Dr. Salter was born in Stratford, Ontario on December 15, 1924.

Scherer to lead genomic medicine program

Mon, 10 May 2010 24:00:00 EDT

One of The Hospital for Sick Children’s (SickKids) renowned geneticists has just been announced as the new Director of the McLaughlin Centre (previously known as the McLaughlin Centre for Molecular Medicine). Dr. Steve Scherer, the Director of The Centre for Applied Genomics and a Senior Scientist in Genetics & Genome Biology at SickKids, will work with the McLaughlin Centre’s fellows to further genomic medicine through research and education.

Rutka named President of the American Association of Neurological Surgeons

Mon, 10 May 2010 24:00:00 EDT

At the recent Annual Meeting of American Association of Neurological Surgeons (AANS), The Hospital for Sick Children’s (SickKids) own Dr. James Rutka, a Neurosurgeon and Co-director & Principal Investigator at The Arthur and Sonia Labatt Brain Tumour Research Centre as well as a Senior Scientist in Cell Biology, was named President of the organization.

Sarkar Appointed Fellow of the Royal Society of Chemistry, U.K.

Mon, 10 May 2010 24:00:00 EDT

Dr. Bibudhendra (Amu) Sarkar, a Senior Scientist Emeritus of Molecular Structure & Function at The Hospital for Sick Children (SickKids), has been appointed Fellow of the Royal Society of Chemistry, U.K. The Royal Society of Chemistry is the oldest Society of Chemical Sciences in the world and dates back to 1841. He was recognized for his significant contributions in the Chemical Sciences field.

SickKids invited kids of all ages to a “Science Rendezvous”

Mon, 10 May 2010 24:00:00 EDT

Going through obstacle courses, tying intricate knots and checking out bugs – this may sound like a regular day at summer camp, but it was actually an interactive science fair, SickKids-style!

New Kid on the Block

Tue, 04 May 2010 24:00:00 EDT

SickKids announces the most ambitious capital redevelopment plan in its 135-year history

Toronto – The Hospital for Sick Children (SickKids) today announced the details of the $400 million, 21-storey, 750,000 square foot Research & Learning Tower to be built at the corner of Bay and Elm Streets; bringing together the 2,000 scientists and staff of SickKids Research Institute. The Tower is slated to be completed by 2013. Designed by Diamond and Schmitt Architects Inc. with HDR Inc., the world-class facility will achieve LEED® Gold Certification – setting the standard for energy efficiency and sustainable infrastructure in Toronto’s Discovery District. The construction contract to build the Tower was awarded to Ellis Don Corporation.

Paediatric Nurses Save Children’s Lives

Mon, 03 May 2010 24:00:00 EDT

Paediatric Nurses Save Children’s Lives

The SickKids Global Child Health Program will work with the Ministry of Health (MoH), Ghana Health Service (GHS), the Nurses and Midwives Council of Ghana (NMCG), the University of Ghana, and Korle Bu Teaching Hospital to develop a Paediatric Nursing Training Program. The MoH has identified a dire need for 1500 Paediatric Nurses over the next 10-15 years, where none exist to date. The complete absence of nurses trained in Paediatrics has hindered Ghana’s ability to improve child survival in addressing the Millennium Development Goal to reduce child mortality. Development of a Paediatric Nurse workforce is crucial to improving child survival in Ghana, where children continue to die from mainly avoidable causes such as malaria, respiratory infection, diarrheal disease and neonatal causes of death in institutional and community settings.

Autism research at SickKids receives a boost of more than $9 million

Thu, 29 Apr 2010 24:00:00 EDT

TORONTO – A research team co-led by Dr. Stephen Scherer, Senior Scientist at The Hospital for Sick Children (SickKids) was awarded an $8.9 million grant today from the Global Leadership Round in Genomics & Life Sciences (GL²), which is part of the Ontario Research Fund (ORF) by the Ministry of Research and Innovation (MRI).

Abdominal obesity in some teens may be linked to mom’s smoking while pregnant

Tue, 27 Apr 2010 24:00:00 EDT

TORONTO – Smoking during pregnancy is a known risk factor for a variety of health problems for the baby, including low birth weight, respiratory issues and even sudden infant death syndrome (SIDS). A new study suggests exposure to cigarette smoke in utero may also contribute to abdominal obesity in late adolescence. The research is published in the April 27 edition of Obesity.

Zlotkin receives prestigious award

Tue, 27 Apr 2010 24:00:00 EDT

One of Canada’s leading nutrition researchers and a long-time staff member at The Hospital for Sick Children (SickKids) has been awarded the 2010 Distinguished Nutrition Leadership Award by the Danone Institute. Dr. Stanley Zlotkin, Division Head and Medical Director of the Nutrition Support Program, Gastroenterology, Hepatology and Nutrition and a Senior Scientist in Child Health Evaluative Sciences received the award for his contribution to the field of nutrition within Canada.

SickKids celebrates Earth Day

Thu, 22 Apr 2010 24:00:00 EDT

It's easy being green. Just ask Rana Alhegagi, 9, a patient at The Hospital for Sick Children (SickKids). She was the lucky child chosen to take part in a tree-planting ceremony to commemorate Earth Day's 40th Anniversary earlier this afternoon. "Going green is fun," says Alhegagi. "I've never planted a tree before. I'm so excited."

Henkelman to receive 2010 Killam Prize in health sciences

Tue, 13 Apr 2010 24:00:00 EDT

By Lisa Nethercott

Dr. Mark Henkelman, a Senior Scientist in Physiology & Experimental Medicine and the Director of the Mouse Imaging Centre (MICe) at The Hospital for Sick Children (SickKids), is the recipient of the 2010 Killam Prize in health sciences. The announcement was made at a news conference earlier this morning at the Michener Institute for Applied Health Sciences.

SickKids study points to growing gap between paediatric and adult clinical trials

Fri, 09 Apr 2010 24:00:00 EDT

Health-care professionals rely on solid clinical trials to help them assess the benefits of treatment. Clinical trials are an integral part of evidence-based medicine and lead to improved outcomes for many conditions in children and adults. However, conducting studies with children can be more challenging than with adults, mainly due to logistical, financial and ethical factors. Scientists from The Hospital for Sick Children (SickKids) have found that there is a widening gap between the number of important paediatric and adult clinical trials. The study is published in the March issue of Archives of Pediatrics and Adolescent Medicine.

SickKids scientists use a common pet-store fish to reel in a deeper understanding of birth defects and genetic disorders

Wed, 07 Apr 2010 24:00:00 EDT

Zebrafish are known as common aquarium fish because they are small, abundant and easily grown. They are also transparent, so while you can’t watch a human baby grow inside its mother, this is actually possible in a zebrafish. These are just some of the reasons why these fish are popular with scientists, too.

deVeber to receive 2010 Sidney Carter Award

Mon, 05 Apr 2010 24:00:00 EDT

Dr. Gabrielle deVeber, a Staff Neurologist and Scientist in Child Health and Evaluative Studies at The Hospital for Sick Children (SickKids), is the recipient of the 2010 Sidney Carter Award in Child Neurology. The award, presented by the American Academy of Neurology (AAN), recognizes outstanding achievements in the field of child neurology.

Kaplan, Robinson Canada Research Chairs renewed

Mon, 05 Apr 2010 24:00:00 EDT

At an announcement on March 26 at the University of Ottawa, two members of The Hospital for Sick Children’s (SickKids) Research Institute received renewals for a portion of a $165.5 million investment from the Government of Canada Research Chairs Program. The pair are among 147 recipients at 44 universities across Canada.

Researchers make a connection between CNS nerve cells and why they don’t regenerate

Mon, 29 Mar 2010 24:00:00 EDT

TORONTO – Finding treatments for injuries and diseases involving the brain and spinal cord can make an already-difficult situation even more challenging, because once nerves from the central nervous system are damaged they don’t normally regenerate. Understanding why this occurs can shed light on possible ways to repair the injured brain or spinal cord.

SickKids exhibit gives voice to youth from Toronto’s at-risk neighbourhoods

Mon, 29 Mar 2010 24:00:00 EDT

My Dream project highlights students’ needs and aspirations

SickKids discovery changes the recommended standard of care for children with rare brain tumour

Mon, 22 Mar 2010 24:00:00 EDT

Choroid plexus carcinoma patients with a specific genetic mutation may now be able to avoid aggressive radiation therapy

TORONTO – For many patients, one of the most difficult aspects of cancer treatment is undergoing radiation therapy. New research led by The Hospital for Sick Children (SickKids) and funded in part by the Canadian Cancer Society, indicates that patients suffering from a rare form of paediatric brain cancer may now be spared from the debilitating effects of radiation.

3D model of cellular “pump” may hold clues to developing new treatments for diseases

Mon, 08 Mar 2010 24:00:00 EST

Researchers at The Hospital for Sick Children (SickKids) have developed a new three-dimensional model of the physical structure of Vacuolar-type ATPase (V-ATPase). V-ATPase is a molecular complex that uses energy from a chemical called ATP to control the acidity within parts of the cell. Understanding the structure of V-ATPase provides a better understanding of how it works in normal cells, and also provides insights into how it can be controlled in cells affected by disease. The study is published in the February 2010 issue of Proceedings of the National Academy of Sciences.

Paralympic torch comes to SickKids

Fri, 05 Mar 2010 24:00:00 EST

By Heather Irwin

With the opening ceremonies of the 2010 Vancouver Paralympic Games one week away, The Hospital for Sick Children (SickKids) had the privilege of hosting a pit stop of the Paralympic torch earlier this morning. The torch is in the city as part of the cross-country torch relay.

Worms may hold key to better cancer treatment, SickKids study finds

Thu, 04 Mar 2010 24:00:00 EST

Researchers discover gene that influences cellular response to radiation

Researchers at The Hospital for Sick Children (SickKids) have made a surprising discovery about how cells respond to radiation. New research on the kri-1 gene in worms indicates that radiation-induced cell death is not solely controlled within the affected cell, as previously thought. It appears that signals sent from neighbouring cells are required to instruct damaged cells to destroy themselves. The discovery is published in a recent issue of Current Biology.

SickKids researcher awarded $3.5 M from the Ministry of Research and Innovation to study chronic pain

Thu, 04 Mar 2010 24:00:00 EST

Funding will support research into development of more effective therapies

TORONTO – Dr. Michael Salter, a researcher at The Hospital for Sick Children (SickKids), has been awarded a Research Excellence Grant from the Ministry of Research and Innovation’s Ontario Research Fund (ORF) to study chronic pain. The grant, totalling $3.5 million over five years, will support lead investigator Salter and his team to study pain pathways and potentially develop innovative new drugs to prevent and treat chronic pain.

SickKids receives $10 million in funding to support medical research and the development of KidsArm

Mon, 01 Mar 2010 24:00:00 EST

Read the backgrounder.

International study finds novel SickKids-developed technique reduces the size of heart attacks by up to 50 per cent

Thu, 25 Feb 2010 24:00:00 EST

More SickKids Olympic news

Mon, 22 Feb 2010 24:00:00 EST

By Heather Irwin

Looking for something to do on Saturday, Feb. 27? Check out the men’s parallel giant slalom as Richard Evanoff, son of Kimberley Evanoff, Staff Nurse in Emergency Medicine at The Hospital for Sick Children (SickKids), carves his way down Cypress Mountain with the Olympic forerunning team.

SickKids scientists discover a genetic clue for Type 1 diabetes

Thu, 18 Feb 2010 24:00:00 EST

New genetic loci may provide insights into blood glucose control in people with diabetes

A new discovery is providing important insight into how genes may influence a patient’s ability to regulate blood glucose. Researchers at The Hospital for Sick Children (SickKids) have identified four regions in the human genome that correlate with glucose control in patients with Type 1 diabetes. This discovery is published in the February 2010 issue of Diabetes.

One in three Ontarians at risk of being diagnosed with asthma

Tue, 16 Feb 2010 24:00:00 EST

TORONTO, February 15, 2010 – New research from the Institute for Clinical Evaluative Sciences (ICES), The Hospital for Sick Children (SickKids), and Sunnybrook Heath Sciences Centre has found that one in three Ontarians are at risk of being diagnosed with asthma during their lifetimes.

Protect Your Child from Gas Fireplace Burns

Thu, 11 Feb 2010 24:00:00 EST

Gas fireplaces are perfect for keeping you and your family warm throughout the winter, but can pose a risk for severe burns to young children and infants.

SickKids signs historic partnership to develop state-of-the-art children’s hospital in Qatar

Sun, 07 Feb 2010 24:00:00 EST

TORONTO –The Hospital for Sick Children (SickKids) has partnered with Hamad Medical Corporation (HMC) in Qatar to advise on the creation of a brand new, state-of-the-art children’s hospital in the Middle East.

New SickKids program helps teens STOMP out obesity

Fri, 05 Feb 2010 24:00:00 EST

First program in Canada to offer weight-loss surgery to paediatric patients

TORONTO – Today, Stephanie Atwood, 18, is like most teens. She goes to school, holds down a part-time job, and enjoys aerobic dancing, going to the mall and spending time outdoors. But this wasn’t always the case.

For most of Stephanie’s life, she has struggled with obesity. Following surgery to remove a craniopharyngioma (a type of brain tumour) at age seven, Stephanie began to feel hungry all the time. Doctors had to remove a part of the hypothalamus, the part of the brain that controls appetite. Stephanie gained weight to the point that she had difficulty moving and walking. She felt isolated from her teenage peers.

Norman Rosenblum to receive Maureen Andrew Mentor Award

Tue, 02 Feb 2010 24:00:00 EST

Dr. Norman Rosenblum, Senior Scientist, Developmental & Stem Cell Biology, SickKids Research Institute, Staff Nephrologist, SickKids, and Professor, Associate Dean, Physician Scientist Training, departments of Paediatrics, Physiology and Laboratory Medicine & Pathobiology, is the recipient of the 2010 Maureen Andrew Mentor Award. The award acknowledges individuals who serve as exemplary mentors for trainees and junior faculty working in child health research.

AboutKidsHealth receives $4.5 million from the Government of Canada

Fri, 29 Jan 2010 24:00:00 EST

At a special ceremony earlier today, Health Minister Leona Aglukkaq announced the Government of Canada would contribute $4.5 million over three years to AboutKidsHealth.

SickKids scientist takes on television of Olympic proportions

Thu, 28 Jan 2010 24:00:00 EST

By Heather Irwin

A familiar face to some in the The Hospital for Sick Children (SickKids) community will soon be familiar to millions of viewers tuning in to the Winter Olympics beginning Feb. 12.

SickKids doctors to receive Ontario’s highest honour

Thu, 28 Jan 2010 24:00:00 EST

Two members of The Hospital for Sick Children (SickKids) will be appointed to the Order of Ontario at a special ceremony happening this afternoon at Queen’s Park. Dr. Helen Chan, Clinical Oncologist, Haematology/Oncology, and Dr. Kellie Leitch, Orthopaedic Surgeon, are among 29 people receiving the honour – Ontario’s highest. Joining them will be Paul Godfrey, Toronto businessman and civic leader and creator of the Herbie Fund.

Dr. Steven Schwartz appointed the inaugural holder of The Norine Rose Chair in Cardiovascular Sciences

Thu, 28 Jan 2010 24:00:00 EST

Dr. Steven Schwartz, Head of the Division of Cardiac Critical Care Medicine and Senior Associate Scientist, Physiology & Experimental Medicine, has been appointed the inaugural holder of The Norine Rose Chair in Cardiovascular Sciences. The formal announcement was made today at a special ceremony.

The Sweet Side of Pain Management

Fri, 22 Jan 2010 24:00:00 EST

Just a drop or two of sugar water (sucrose) really does go a long way in reducing pain in infants, who are exposed to pricks and pokes and more during their hospital stay. That’s according to researchers at The Hospital for Sick Children (SickKids). Using sucrose is the most frequently studied non-drug approach to managing pain in infants and now SickKids researchers have compiled the most comprehensive analysis of the data yet. The study is in published in The Cochrane Database of Systematic Reviews 2010, Issue 1.

Family-centred Sears Cancer Clinic offers SickKids patients and families a new place to call their own

Thu, 14 Jan 2010 24:00:00 EST

New clinic features vibrant spaces and allows for improved patient flow

TORONTO – Children dealing with cancer and serious blood diseases spend a great deal of their young lives visiting the hospital. Ten-year-old Tobin Haas knows this all too well. When he was only two years old he was diagnosed with a brain tumour. It was treated but then grew back; last summer a routine MRI revealed Tobin had relapsed again and the cancer had spread to Tobin’s spine. Tobin has endured surgeries, chemotherapy, radiation and countless hospital visits.

Leafs make time for SickKids

Mon, 11 Jan 2010 24:00:00 EST

Some very special guests popped by SickKids this afternoon: Toronto Maple Leafs players and coaching staff. Making their annual visit to the Hospital, the team spent time with young patients and their families, playing games and signing autographs. The visit from the Maple Leafs is a highlight for many patients and families at SickKids.

SickKids researchers find powerful predictor of bone cancer prognosis

Wed, 06 Jan 2010 24:00:00 EST

TORONTO – Scientists at The Hospital for Sick Children (SickKids) have discovered a powerful new tool that can help predict the prognosis for patients with bone cancer and help doctors more accurately determine how aggressively they need to treat specific patients. They found that the presence of a specific type of genetic mutation found in the tumours results in poorer outcomes for patients with osteosarcoma – the most common bone cancer in children and adolescents. The study is published in the current issue of Cancer Research.

Motherisk study reveals “non-alcoholic” or “low-alcohol drinks” may contain more alcohol than labels claim

Wed, 06 Jan 2010 24:00:00 EST

TORONTO – Pregnant women should be cautious when it comes to drinking non-alcoholic or low-alcoholic beverages, says a new study which warns alcohol content labels may be misleading.

Global Child Health Leadership Training: Ghana, Ethiopia, and Tanzania

Fri, 01 Jan 2010 24:00:00 EST

The SickKids Global Child Health Program is the collective strategy for global outreach and international development activities undertaken by The Hospital for Sick Children (SickKids), and seeks to make an active contribution towards achieving Millennium Development Goal # 4. As a part of the global solution to improve children’s health and strengthen health systems, the primary focus of the program is to develop innovative, sustainable and collaborative projects that meet the child health needs of our partnering organizations.

Santa’s elves touch down on SickKids heliport with toys and special guests

Thu, 17 Dec 2009 24:00:00 EST

Santa’s Workshop is a very busy place these days, but that didn’t stop a few of Santa’s elves from taking the afternoon off to bring some joy to patients at SickKids.

The Olympic torch ignites SickKids' Olympic spirit

Thu, 17 Dec 2009 24:00:00 EST

It's not every day you get to catch a glimpse of one of the world's most recognized symbols: the Olympic flame. So it's no surprise that hundreds of people packed the SickKids Atrium tonight to see the torch make a very special pit stop at the Hospital as part of the 2010 Olympic torch relay.

SickKids closes $200 million offering to fund construction of Research Tower

Thu, 17 Dec 2009 24:00:00 EST

TORONTO – The Hospital for Sick Children (SickKids) announced today that it has completed its previously announced offering of $200 million Series A Senior Unsecured Debentures. The 5.217% 40-year debentures will mature on December 16, 2049.

Wood chips or sand: Which makes for a safer playground landing?

Tue, 15 Dec 2009 24:00:00 EST

TORONTO – Researchers at The Hospital for Sick Children (SickKids) and York University have found that using granite sand as playground surfacing reduced the risk of arm fractures, compared to frequently-used wood-chip surfaces. The study is published this week in the open-access journal PLoS Medicine. Falls on a playground may go with the territory, but many children’s spills and tumbles off playground equipment can lead to emergency room visits and hospital stays. And just how badly a child is hurt not only depends on how far they fall, but also on the type of surface they land on.

SickKids receives a healthy dose of social networking just in time for the holidays

Wed, 09 Dec 2009 24:00:00 EST

Introducing Upopolis, Canada’s first secure online community connecting kids in hospital

Toronto, ON – Some kids in hospital can’t go home for the holidays, but they now have a new way to stay connected to family and friends.

Upopolis scores with Zachary Starkman, as SickKids becomes the largest centre in Canada to offer Upopolis to its patients

Wed, 09 Dec 2009 24:00:00 EST

“It’s a pretty good idea.”

SickKids-led international study identifies important piece of puzzling brain tumour

Tue, 08 Dec 2009 24:00:00 EST

An international team of scientists have made an important breakthrough in describing a rare type of brain tumour that currently delivers a grim prognosis to the young children stricken by it.

Women in Cell Biology honour Janet Rossant, SickKids Chief of Research

Tue, 08 Dec 2009 24:00:00 EST

Dr. Janet Rossant, Chief of Research at SickKids and Senior Scientist in the Developmental & Stem Cell Biology Program, SickKids Research Institute, is the recipient of the American Society for Cell Biology (ASCB), Women in Cell Biology Senior Career Recognition Award for 2009. The Senior Award is given to a woman or man in a later career stage (generally full professor or equivalent) whose outstanding scientific achievements are coupled with a long-standing record of support for women in science and by mentorship of both men and women in scientific careers.

SickKids launches offering to fund construction of Research Tower

Mon, 07 Dec 2009 24:00:00 EST

TORONTO – The Hospital for Sick Children (SickKids) announced today that it intends to issue approximately $200 million of Series A Senior Unsecured Debentures. The offering will be made by way of a private placement, pursuant to certain exemptions from the prospectus requirements of applicable securities laws of the provinces of Canada, and is expected to be completed prior to December 31, 2009.

World AIDS Day: SickKids quilt represents life and hope for children with HIV and their families

Thu, 03 Dec 2009 24:00:00 EST

Tuesday Dec. 1 is World AIDS Day. At SickKids, a giant quilt, each panel designed by children and parents with HIV, is on display just inside the Atrium main entrance, Elizabeth Street entrance. The quilt will be on display all week. All the children and parents who participated in making the quilt 12 years ago are alive and well due to advances in HIV treatment and medications. So while the bigger world 'AIDS Quilt' is comprised of sections honouring those who have died, ours represents life and hope for children with HIV and their families.

SickKids scientists scratch below the surface and identify a stem cell for the lower layer of the skin

Thu, 03 Dec 2009 24:00:00 EST

TORONTO – The skin is known for its ability to regenerate, because the cells in the skin are constantly turning over. This “healing property” has attracted much attention from scientists wanting to know what makes the skin repair itself. Researchers at The Hospital for Sick Children (SickKids) are now a step closer to understanding its regenerative power. The scientists are the first to identify a stem cell for the dermis or the second layer of the skin. The study is published in the December 4 issue of Cell Stem Cell.

Dr. Paul Babyn to hold Ontasian Chair in Paediatric Diagnostic Imaging

Wed, 02 Dec 2009 24:00:00 EST

Dr. Paul Babyn, Radiologist-in-Chief, SickKids, has been selected as the Inaugural Chair of the Ontasian Chair in Paediatric Diagnostic Imaging.

Dr. Babyn, who is also an associate professor with the Department of Medical Imaging at University of Toronto, has been on staff at SickKids since 1988. Dr. Babyn has published more than 150 publications to date and is involved in a variety of funded research projects. He has an active role in resident and fellow teaching and is a member of the Radiological Society of North America, Canadian Association of Radiology and the Society of Pediatric Radiology. Dr. Babyn’s main research interests lie in the areas of musculoskeletal radiology and cross-sectional imaging, and health-care informatics.

A chair is an academic honour bestowed on scientists and clinicians to recognize achievements in their field of study or potential to contribute to an area of study. The impressive number of chairs awarded to members of SickKids reflects the excellence and high caliber of the Research Institute’s scientists, clinicians and faculty.

Learn more about the many scientific and academic chairs at SickKids.

Research Institute Scientific Retreat 2009: Not retreating but moving forward in Research

Mon, 30 Nov 2009 24:00:00 EST

On November 27, 865 SickKids Research Institute staff and trainees gathered at the Metro Toronto Convention Centre for the Annual Research Institute Scientific Retreat. This year’s retreat featured 194 scientific posters by trainees and platform presentations by researchers that focused on three themes: personalized medicine, stem cells and regenerative medicine and development of new technologies to improve clinical care.

“These important areas are likely to have major impact on the health care system in the next few years and we are lucky to have scientists from SickKids who are at the forefront of advances and who can address the likely future impact,” said SickKids Chief of Research Dr. Janet Rossant.

The Aser Rothstein keynote speaker Dr. Michael Hayden, Killam Professor of Medical Genetics at the University of British Columbia, Canada Research Chair in Human Genetics and Molecular Medicine and Director of the Center for Molecular Medicine and Therapeutics in Vancouver, followed the flow of the day focusing on genetic research and personalized medicine.

In his presentation entitled Global Adventures in Genetics: from Genes to Therapy, Hayden discussed his work with patients suffering from rare disorders. In studying the genetics behind these disorders, he works to find therapies that could be of use to the greater population. He argued that while we have a long way to go before many applications of personalized therapeutics become an everyday reality, predictive testing is one example which is helping today in early detection and treatment.

Hayden applauded SickKids for its leadership in pharmacogenomics and distinguished the culture of collaboration between researchers and clinicians at SickKids and with their external colleagues as crucial to advancements in health outcomes.

Hayden concluded by speaking directly to research trainees and fellows, “Have the courage and self-confidence to immerse yourselves in questions that matter. Although many of you are separated by language and culture you are united in changing the lives of children and changing medicine for the population.”

The retreat is also a time to honour those who have excelled in the past year. The Citizenship Award recognizes an individual Research Institute staff member who consistently goes "above and beyond" expectations in carrying out their work in the Institute. This year’s honoree, Paul Taylor, is “one of those people who has quietly had a big impact on the Research Institute,” said Dr. John Rubinstein who presented the award. Taylor is a Senior Proteomics Specialist in Molecular Structure & Function and Manager of the Advanced Protein Technology Centre who has conducted seminars, started clubs and written journals to ensure the understanding of mass spectrometry across the board.

The Exceptional Trainee Awards were also presented. Each program acknowledges one trainee for extra efforts to improve research and/or the lives of their colleagues.

Cell Biology – Ian Watson
Child Health & Evaluative Sciences – Dr. Ivan Diamond
Development & Stem Cell Biology – Dr. Akitsu Hotta
Genetics & Genome Biology – Adam Durbin
Molecular Structure & Function – Dr. James Wasmuth
Neurosciences & Mental Health – Dr. Yin Chan
Physiology & Experimental Medicine – David Douda

Safe Kids Canada launches national charter on helmet safety for winter ski sports to help reduce devastating injuries

Fri, 20 Nov 2009 24:00:00 EST

VANCOUVER – Safe Kids Canada, the national injury prevention program of The Hospital for Sick Children, is asking Canadians to show their support for the use of helmets during winter ski sports by signing the Vancouver Charter on Skiing Safety. The charter, to be publicly launched this afternoon at Safe Kids Canada’s winter helmet safety forum in Vancouver, is designed to encourage the use of helmets during skiing and snowboarding activities. British Columbia is the first province that has officially endorsed the charter, created in the context of the 2010 Winter Olympic Games. Canadians can read the Vancouver Charter on Skiing Safety and show their support at www.safekidscanada.ca .

SickKids launches free legal service for patients and families

Fri, 20 Nov 2009 24:00:00 EST

By Beata Rydyger

Child health equity shared responsibility, says panel

Fri, 20 Nov 2009 24:00:00 EST

TORONTO – There’s “a coalition of wills and skills” to improve the development, health and well-being of children in Ontario, said Dr. Charles Pascal at a panel presentation at SickKids today. The presentation marked National Child Day and the 20th anniversary of Canada signing the UN Convention on the Rights of the Child.

$2.4 million for paediatric nurse training in Africa

Fri, 20 Nov 2009 24:00:00 EST

SickKids continues to stretch its wings internationally

The Canadian International Development Agency (CIDA) has announced funding of up to $2.4 million for a three-year, SickKids-led program to help train paediatric nurses in Ghana. The training will lead to an improved quality of healthcare for children in the African country. The three-year program, involving SickKids and SickKids Foundation, will also include specialized paediatric training for health care workers in two other African countries.

$2.4 million for paediatric nurse training in Africa

Fri, 20 Nov 2009 24:00:00 EST

SickKids continues to stretch its wings internationally

Premier’s Early Learning Advisor, Dr. Charles Pascal, addresses SickKids

Thu, 19 Nov 2009 24:00:00 EST

TORONTO –The right to health care (Article 24). The right to be protected from harm (Article 3). The right to freedom from discrimination (Article 2). The right to be heard (Article 12). The right to an education (Article 28).

Asthma found to play a significant role in children developing H1N1 complications

Thu, 19 Nov 2009 24:00:00 EST

TORONTO - If your child has asthma, a new study shows you should be extra vigilant in making sure they don’t get H1N1. Researchers from The Hospital for Sick Children (SickKids) found a higher percentage of asthmatic children were hospitalized due to H1N1 compared to the seasonal flu.

SickKids researchers play key role in largest gene study of childhood IBD

Tue, 17 Nov 2009 24:00:00 EST

By Beata Rydyger

SickKids scientists discover Hedgehogs could play a role in treating osteoarthritis

Mon, 16 Nov 2009 24:00:00 EST

TORONTO – Osteoarthritis, the most common form of arthritis, is a painful and debilitating disease affecting over 200 million people worldwide. It occurs when the cartilage in the joints wear down over time. Currently, there is no cure for it; drugs are used mainly to manage the pain. Researchers at The Hospital for Sick Children (SickKids) have found a pharmacological approach to treating the disease. The study is published in the November 15 advance online edition of Nature Medicine.

“If used in patients this could be the first example of a treatment to prevent the degeneration of joints,” says the study’s principal investigator Dr. Benjamin Alman, Head of Orthopaedic Surgery and Senior Scientist at SickKids, and Professor of Surgery at the University of Toronto. “It would be a true biological approach to attack the pathogenesis of osteoarthritis.”

Osteoarthritis is not a paediatric condition and SickKids researchers didn’t set out to find a solution to this disease. The scientists had actually been investigating the role that a family of proteins, called Hedgehog, plays in the development of cartilage tumours, when they stumbled upon an unexpected observation. They found that when Hedgehog proteins were activated in mice, the mice developed osteoarthritis.

SickKids and Pro Bono Law Ontario launch Canada’s first program to prescribe legal remedies in a hospital setting

Tue, 10 Nov 2009 24:00:00 EST

TORONTO - There are certain aspects of health that health-care workers can’t mend on their own. Studies have shown that families who live in poverty and those who have inadequate housing and nutrition are more likely to have poorer health outcomes. There are also parents or caregivers whose financial situations, immigration status and work conditions may impede their ability to focus on the health of their children. Helping these families sometimes requires lending a legal hand.

AboutKidsHealth partners with Canwest to provide trusted health information

Thu, 05 Nov 2009 24:00:00 EST

By Beata Rydyger

SickKids scientists recipients of Canadian Cancer Society Awards

Wed, 04 Nov 2009 24:00:00 EST

On Nov. 16, Dr. Lillian Sung, Scientist in Child Health Evaluative Sciences and Dr. Michael D. Taylor, Scientist in the Developmental & Stem Cell Biology Program, will both be awarded the Canadian Cancer Society Awards of Excellence in Cancer Research.

“My research is focused on supportive cancer treatment for children with cancer,” says Sung. “I am working on trying to better understand, prevent and treat invasive infections that children undergoing chemotherapy treatment often experience.”

Rossant leads Ontario Stem Cell research team thanks to $10 million boost from Ontario government

Mon, 02 Nov 2009 24:00:00 EST

Dr. Janet Rossant, Chief of Research and Senior Scientist in the Developmental & Stem Cell Biology program at SickKids and University Professor in the Departments of Molecular Genetics, Obstetrics and Gynaecology at the University of Toronto joined Ontario’s Minister of Research and Innovation, the Honourable John Milloy on October 28 as he announced $10 million in funding for the Ontario Initiative in Personalized Stem Cell Medicine. This initiative, led by Rossant, is a joint project involving 30 leading stem cell researchers and six institutes of research across Ontario.

Focused on the advancement of stem cell research and the generation of new innovations in the production of embryonic-like stem cells, the Ontario Initiative in Personalized Stem Cell Medicine is poised to lead in the development of personalized medicine and cutting-edge health care products.

Teaching children about railway crossing safety at an early age provides tools to protect them for a lifetime

Mon, 02 Nov 2009 24:00:00 EST

Safe Kids Canada, the national injury prevention program of The Hospital for Sick Children, and CN today launched Safe Crossing Week 2009, a national education campaign focused on keeping Canadian children safe at railway crossings and away from trains. From November 1 to 7, about 80,000 students in elementary schools across Canada will learn about safety at railway crossings in their classrooms with educational material developed by partners Safe Kids Canada and CN.

SickKids Exceptional Trainee becomes certified ABMM Diplomate

Tue, 27 Oct 2009 24:00:00 EDT

Dr. Kaede Ota has been certified as a Diplomate of the American Board of Medical Microbiology (ABMM). ABMM certification is the highest credential that a doctoral-level clinical microbiologist can earn in the United States and a rare accomplishment for a Canadian clinician.

Celebrating 40 years of kidney transplantation

Thu, 22 Oct 2009 24:00:00 EDT

“Every time I had to come back to SickKids, familiar faces and friends greeted me,” says Alison Agar, SickKids pharmacy technician and three-time kidney transplant recipient. “The atmosphere here is incomparable to anywhere else. I think that’s why there was no doubt in my mind I would work here.”

Prestigious international rheumatology awards for Laxer and Yeung

Mon, 19 Oct 2009 24:00:00 EDT

Dr. Ron Laxer and Dr. Rae Yeung have returned from the American College of Rheumatology Annual Scientific Meeting with two of the most prestigious awards in rheumatology, rarely awarded to paediatricians and rarely to Canadians.

SickKids President and CEO honoured by U of T

Fri, 16 Oct 2009 24:00:00 EDT

Last night, Oct. 15, Mary Jo Haddad, SickKids President and CEO, was awarded the 2009 Leadership Award at the Annual Recognition Dinner of the Society of Graduates of the Department of Health Policy, Management and Evaluation at the University of Toronto.

The Society called Haddad “a leader by example” who is “known for setting the bar high for excellence in performance, accountability and customer service. Through her work at SickKids and as chair of the Council of Academic Hospitals of Ontario and the Provincial Council for Maternal, Newborn, Child and Youth Health, Haddad has become one of Ontario’s top child health advocates.”

Booster seats laws are driving down number of fatal accidents

Thu, 15 Oct 2009 24:00:00 EDT

Booster seat laws have a real impact on saving lives. A recent study led by The Hospital for Sick Children and York University has shown that U.S. booster seat laws may have significantly reduced child fatalities in serious head-on motor vehicle accidents. The study appears in the October issue of Injury Prevention.

Fold up the genetic “roadmap”: SickKids researchers unveil “GPS” to navigate human genome

Wed, 07 Oct 2009 24:00:00 EDT

TORONTO – Exploring the vast landscape of the human genome has been crucial in the understanding of human diseases. Scientists at The Hospital for Sick Children (SickKids) and an international research team have made a major scientific advancement in the study of the genome. The researchers have developed the most comprehensive map yet of genetic variation. The study is published in the Oct. 7 advance online edition of Nature.

SickKids takes learning to a higher level with launch of Learning Institute

Tue, 06 Oct 2009 24:00:00 EDT

TORONTO – Medical science is evolving at an exponential rate, while clinicians are treating more and more patients with complex conditions that require the expertise and management of multiple health-care providers. Top professionals are constantly learning and refining their skills in order to stay abreast of the latest developments.

The SickKids Burn Prevention Outreach Team wants to help you keep the young ones in your care from being scalded

Mon, 05 Oct 2009 24:00:00 EDT

Children are curious, but not yet able to understand the dangers in their environment. This is especially true of children three years old and younger who are most likely to be scalded.

The SickKids Burn Prevention Outreach Team is launching an awareness campaign to protect children from being scalded. Burn prevention posters will be distributed to schools, daycare centres and medical offices across Toronto. The campaign will run from Oct. 4 to 31. Community events at Toronto Fire training towers will take place between Oct. 4 and 8.

The Burn Prevention campaign will highlight four simple tips you can do to protect children from serious injury:

Renovated Emergency Department offers patient-centred registration, improved patient flow and new patient areas; opens to the public on Sept. 2

Tue, 01 Sep 2009 24:00:00 EDT

Beginning at 9 a.m. on Wednesday Sept. 2, staff and volunteers at SickKids will be welcoming patients and their families through a new entrance and improved patient areas in the Emergency Department (ED).

With the completion of Phase 2 in a three-phase ED renovation, SickKids now offers the first patient-centred ED triage and registration process in Ontario. The renovation includes a new information system that helps with triage and patient tracking.

Ouch! That hurts!

Wed, 26 Aug 2009 24:00:00 EDT

Childhood vaccinations don’t have to be painful, say SickKids researchers

TORONTO – Most people associate childhood vaccinations with pain, but new Canadian research shows this doesn’t have to be the case.

SickKids researchers find popular painkiller may be life-threatening following a common childhood operation

Wed, 19 Aug 2009 24:00:00 EDT

TORONTO – Doctors from The Hospital for Sick Children (SickKids) warn that codeine given after an adenotonsillectomy can be life-threatening for some toddlers. A SickKids-led study published in the August 20 issue of the New England Journal of Medicine finds giving codeine after an adenotonsillectomy could have a fatal outcome in some young children.

Team SickKids aims to paint Australia’s Gold Coast Team Canada red

Tue, 11 Aug 2009 24:00:00 EDT

Young transplant recipients will compete in World Transplant Games

NBA superstar Steve Nash visits SickKids

Fri, 07 Aug 2009 24:00:00 EDT

NBA superstar Steve Nash scored a slam dunk with patients when he visited SickKids on Friday, August 7.

Posters promote campfire safety

Wed, 05 Aug 2009 24:00:00 EDT

Campfires can provide endless hours of warmth and fun, but they can also be dangerous. When the night is over, it’s vital to put out your fire and “cool your coals.”

SickKids scientists discover a potential treatment for a previously untreatable bone cancer

Mon, 03 Aug 2009 24:00:00 EDT

TORONTO – While recent advancements in cancer research have led to longer survival rates, there are still some cancers that are not responsive to existing treatments. Chondrosarcoma, a rare bone cancer that develops in the bone cartilage, is one of the cancers that is not effectively treated with chemotherapy. Scientists at The Hospital for Sick Children (SickKids), Mount Sinai Hospital and the University of Toronto have found a novel approach to treating this disease.

Battling the bulge?

Sun, 26 Jul 2009 24:00:00 EDT

SickKids scientists find the immune system weighs heavily in reducing the health risks of obesity and Type 2 diabetes

SickKids teens dance the night away with Canadian stars

Tue, 14 Jul 2009 24:00:00 EDT

While the rest of the hospital was winding down for the evening, teenage patients at The Hospital for Sick Children (SickKids) and their friends were celebrating an evening to remember. The teens enjoyed an “After Hours Exclusive Teen Event” at the hospital with So You Think You Can Dance Canada’s Tamina Pollack-Paris, cast members from Degrassi: The Next Generation and Toronto FC’s O’Brien White.

SickKids welcomes Their Majesties the Emperor and Empress of Japan

Thu, 09 Jul 2009 24:00:00 EDT

Canadian tour commemorates the 80-year relationship between Canada and Japan

SickKids scientist named to Order of Canada

Thu, 09 Jul 2009 24:00:00 EDT

Dr. Roderick McInnes, Senior Scientist at The Hospital for Sick Children (SickKids), a University Professor and Professor of Paediatrics and of Molecular Genetics at the University of Toronto, was named to the Order of Canada, Canada’s highest civilian order.

Do you want to spit for science?

Wed, 08 Jul 2009 24:00:00 EDT

SickKids researchers invite kids to be part of a massive science project – by spitting in a tube at the Ontario Science Centre

Baby Lily gets a new heart

Thu, 25 Jun 2009 24:00:00 EDT

PEI infant undergoes successful transplant at SickKids

SickKids part of $6.4 million research grant

Wed, 24 Jun 2009 24:00:00 EDT

SickKids researcher, Dr. Philip Sherman, is part of a major $6.4 million grant from Ontario Research Fund announced June 23 by the Ministry of Research and Innovation.

Sherman, SickKids Senior Scientist, Cell Biology, at the Research Institute and Staff Gastroenterologist, is part of a collaborative project that aims to treat debilitating diseases such as inflammatory bowel disease (IBD) by developing new biological materials that can repair and regenerate damaged tissues. Sherman is also a Professor of Paediatrics, Microbiology and Dentistry at the University of Toronto, a Canada Research Chair in Gastrointestinal Disease and a Scientific Director with the Institute of Nutrition, Metabolism and Diabetes at CIHR.

The project, led by Dr. Michael Sefton of the University of Toronto, Institute of Biomaterials and Biomedical Engineering, is titled Therapeutic biomaterials for regenerative medicine. The total SickKids’ budget for this project is $2.9 million.

The research, a partnership with Toronto-based company Rimon Therapeutics Ltd., is based on using “therapeutic polymers” called Theramers™ which have biological activity and can be used to repair and regenerate diseased tissues without the use of cells, drugs or soluble factors. Such materials, regulated as devices, have potentially a shorter time to market than devices with cells or drugs.

The grant is part of the provincial government’s investment of $42 million to support the work of 15 Toronto-based research projects and more than 100 researchers. It is part of the government’s $94 million province-wide investment to support 31 world-class research projects and more than 300 researchers in seven communities across Ontario.

The research grant from Ontario Research Fund also supports SickKids’ researchers working with the Ontario Pre-Clinical Imaging Consortium project led by Sunnybrook Health Sciences Centre. The collaborators for this project are Dr. Mark Henkelman, Director, Mouse Imaging Centre, and Senior Scientist, Physiology & Experimental Medicine with the Toronto Centre for Phenogenomics (TCP), and also Professor, Medical Biophysics and Medical Imaging at University of Toronto; and Dr. John Sled, Scientist, Physiology & Experimental Medicine at the Research Institute, and Assistant Professor, Medical Biophysics at the University of Toronto. The total SickKids’ budget for this project is $1.5 million.

To read more about the announcement please visit the Ministry of Research and Innovation website.

SickKids doctors to address the UN this week

Fri, 19 Jun 2009 24:00:00 EDT

Doctors coordinate an international network to reduce the adverse effects of Sickle Cell Disease around the world

The United Nations has declared this Friday, June 19, 2009 the first-ever Sickle Cell Anaemia Awareness Day, and two leading physicians from The Hospital for Sick Children (SickKids) will mark the occasion by speaking to international leaders about recent initiatives to reduce the effects of sickle cell disease (also known as sickle cell anaemia) around the world.

SickKids receives over $6.4 million dollars in CFI funding to support leading researchers

Thu, 18 Jun 2009 24:00:00 EDT

TORONTO – Dr. Janet Rossant, Chief of Research at The Hospital for Sick Children (SickKids) and Professor of Molecular Genetics at the University of Toronto, welcomed the $6,476,707 investment announced today by the Canada Foundation for Innovation (CFI). This funding will advance two innovative projects led by SickKids scientists.

Programme for Global Paediatric Research (PGPR) coordinates global research on developing world diseases

Fri, 12 Jun 2009 24:00:00 EDT

Motherisk broadens international scope and delivers safety messages to more pregnant moms worldwide

Thu, 11 Jun 2009 24:00:00 EDT

The Motherisk Program’s mission is simple: to safely treat the mother without hurting the baby. Based at The Hospital for Sick Children (SickKids), the program is widely recognized as the pre-eminent international centre for the study of the safety or risk of medications during pregancy and breastfeeding. The program also offers a call centre for parents to obtain advice and address any concerns related to these exposures.

International research team identifies autoinflammatory syndrome

Mon, 08 Jun 2009 24:00:00 EDT

A team of international researchers, including doctors at The Hospital for Sick Children (SickKids), has identified an autoinflammatory disorder of the bone and skin. Autoinflammatory diseases are made up of a group of genetic disorders that can cause recurrent and persistent inflammation lesions that can affect the skin, joints, bones, eyes, the GI tract and the nervous system, including hearing.

Minister of Health visits Sickkids

Fri, 05 Jun 2009 24:00:00 EDT

On June 5, the Honourable Leona Aglukkaq made her first visit to SickKids since she was appointed the Federal Minister of Health in October 2008.

Cancer stem cell studies could open the door to personalized, targeted treatments for brain cancers

Thu, 04 Jun 2009 24:00:00 EDT

Researchers develop new technique that maintains cancer stem cell “purity,” provide insight into targeting cells for future therapies

(Toronto) – Scientists in Toronto and in the United Kingdom have developed a new technique to efficiently grow cancer stem cells in the lab. This finding not only provides insight into how malignant brain tumours are formed, it is also a significant step forward in the quest to develop individualized therapy for patients with brain cancer. The research will be published in the June 4th advance online edition of the journal Cell Stem Cell.

SickKids president elected chair of Council of Academic Hospitals of Ontario

Mon, 01 Jun 2009 24:00:00 EDT

Mary Jo Haddad, President and CEO, SickKids, has been elected chair of the Council of Academic Hospitals of Ontario (CAHO). Haddad will lead CAHO for a two-year term, effective immediately. The announcement was made at the CAHO annual meeting on May 29.

HOT TOPIC - Researchers find children under five living in poor neighbourhoods have the greatest chance of being killed in a homicide

Thu, 28 May 2009 24:00:00 EDT

Children under five living in Canada’s poorest urban neighbourhoods have the highest risk of death by homicide, according to a new study. A team of researchers from The Hospital for Sick Children (SickKids), Bloorview Kids Rehab and Statistics Canada investigated the relationship between homicides and socioeconomic status in children under the age of 15. The study, published in the journal Pediatrics, found that children in poorer neighbourhoods have three times the risk of homicide as children in high-income neighbourhoods, with children under five at the highest risk.

Lee appointed to steering committee of Chinese research centre

Thu, 28 May 2009 24:00:00 EDT

Dr. Shoo Lee, Head, Division of Neonatology, Women's Auxiliary Chair in Neonatology, has been appointed to the steering committee of a major Chinese research centre, a position that will see him advise the institution on its future direction and strategy.

"Junk" drives tumour growth

Tue, 26 May 2009 24:00:00 EDT

Novel cancer gene accelerates or stops tumour growth depending on amount of "junk" in cell

(Toronto) - Researchers at The Hospital for Sick Children (SickKids) have found a gene that plays a crucial role in the development of rhabdomyosarcoma – the most common childhood sarcoma (soft tissue cancer). The gene is called integrin-linked kinase (ILK) and is unique in that it can act as both a tumour suppressor and a tumour promoter. The study is published in the June issue of The Journal of Clinical Investigation.

First in Canada: baby has heart procedure while inside her mother’s womb and is now doing fine

Fri, 08 May 2009 24:00:00 EDT

(Toronto) – In a Canadian first, doctors at The Hospital for Sick Children (SickKids) and Mount Sinai Hospital successfully performed a lifesaving heart intervention on a baby in utero. A team of doctors, including Dr. Edgar Jaeggi, Head of the Fetal Cardiac Program at SickKids, Dr. Greg Ryan, Head of the Fetal Medicine Unit at Mount Sinai and Dr. Lee Benson, Director of the Cardiac Diagnostic and Interventional Unit at SickKids, expanded the baby’s aortic valve using a balloon catheter inserted through the mother’s abdomen while the baby was still in her womb to reverse the baby’s heart failure before birth. This allowed the baby to remain safely in utero for a crucial extra month.

Michael Taylor one of Canada's top 40 under 40

Wed, 06 May 2009 24:00:00 EDT

SickKids' Dr. Michael Taylor, Neurosurgeon, Neurosurgery; Principal Investigator, Brain Tumour Research Centre; and Scientist, Developmental & Stem Cell Biology, has been named one of Canada's Top 40 Under 40.

Simple change means less pain associated with vaccination

Tue, 05 May 2009 24:00:00 EDT

Since vaccine injections are the most common painful medical procedure for children, researchers at The Hospital for Sick Children (SickKids) looked for ways to manage the discomfort of vaccinations and found that giving scheduled vaccinations in a particular order can help manage the discomfort. This result is easily incorporated into clinical practice -- good news for infants who might receive more than one innoculation during one visit to the doctor.

Canadian kids don't get enough Vitamin D

Mon, 04 May 2009 24:00:00 EDT

SickKids study finds one third of urban Canadian toddlers have deficiency

Stem cells are going green to study autism

Mon, 27 Apr 2009 24:00:00 EDT

Scientists have developed a new technique to quickly identify stem cells with the goal of fast-tracking medical advancements

SickKids receives $9.2 million in federal funding for immigrant support network

Fri, 24 Apr 2009 24:00:00 EDT

Newcomer families will have improved access to health-care services at SickKids as they settle and integrate into Canada, Citizenship, Immigration and Multiculturalism Minister Jason Kenney announced today during a press conference at SickKids.

His Royal Highness The Duke of York visits SickKids

Fri, 24 Apr 2009 24:00:00 EDT

His Royal Highness The Duke of York, Royal Patron of SickKids Foundation, visited SickKids today, ahead of his appearance at tomorrow evening’s Brazilian Carnival Ball in support of SickKids Foundation.

Morning sickness may lead to brighter kids

Thu, 23 Apr 2009 24:00:00 EDT

(Toronto) - For many expectant mothers, that queasy feeling is one of the hardest parts of pregnancy. But new research reveals that mom’s nausea and vomiting of pregnancy (NVP), commonly known as morning sickness, may actually result in a smarter baby.

SickKids scientists muscle in on cause of muscular dystrophy

Thu, 16 Apr 2009 24:00:00 EDT

An international group of researchers led by scientists at The Hospital for Sick Children (SickKids) Research Institute has found the gene that causes a form of muscular dystrophy. The study is published in the April 17 issue of Cell.

SickKids patient-positive hospital, shows OHA website

Thu, 16 Apr 2009 24:00:00 EDT

Staff continue to make SickKids one of the province's best when it comes to how satisfied patients are with the care they receive. On a new website called myhospitalcare.ca, launched April 16 by the Ontario Hospital Association, SickKids scored above average on patient satisfaction indicators and even earned a top rating as a 'high performing' hospital for satisfaction among acute care patients.

SickKids’ Corporate Ventures office licenses peptide discovered by Research Institute scientists to treat chronic pain

Fri, 03 Apr 2009 24:00:00 EDT

A new pharmaceutical technology licensed in February by the Corporate Ventures office at The Hospital for Sick Children (SickKids) may help treat neuropathic and inflammatory pain in children and adults, but without the serious side effects that can accompany currently available treatments.

SickKids Corporate Ventures office licenses new compound that may treat lysosomal storage and neurological disorders

Tue, 31 Mar 2009 24:00:00 EDT

The Hospital for Sick Children (SickKids) has licensed its rights to a new compound to Neuraltus Pharmaceuticals in order to further research and development, and move the technology into clinical trials. The compound, which was developed in collaboration with Neuraltus, may be useful in treating certain lysosomal storage disorders and neurological disorders.

Pregnant women shouldn’t fear taking antidepressant drugs

Tue, 31 Mar 2009 24:00:00 EDT

Researchers have found taking antidepressants during pregnancy does not increase the chance of birth defects

(Toronto) – Taking an antidepressant during pregnancy has become a difficult and complicated process, mostly because of the conflicting information regarding safety. Researchers at The Hospital for Sick Children’s (SickKids) Motherisk Program studied the link between antidepressants and birth defects. The research will be published in the April edition of The Canadian Journal of Psychiatry.

Scientists uncover a new one-two punch combination that knocks out infection

Mon, 30 Mar 2009 24:00:00 EDT

Researchers find a new role oxidants play in fighting bacteria

TORONTO – For many years, we have heard about the harmful effects of oxidants (compounds that are highly reactive). They have been labelled as “bad” molecules because they are often associated with radiation exposure and the damage of cellular parts such as DNA and proteins. But not all oxidants are “bad”.

SickKids switches off for Earth Hour

Wed, 25 Mar 2009 24:00:00 EDT

The Hospital for Sick Children (SickKids) is shrinking its carbon footprint down to baby size. On March 28, from 8:30 to 9:30 p.m., SickKids will be joining more than 1,600 cities and towns across 80 countries in turning off its lights to raise awareness about climate change.

Sick stuffies saved at Child Life pet clinic

Wed, 18 Mar 2009 24:00:00 EDT

A sudden increase in stuffed-animal injuries and illness caused some concern over March Break, but fortunately patients at The Hospital for Sick Children (SickKids) were able to step in and “treat” their ailing bedside companions.

SickKids scientists selectively erase fear memories and gain insight into how the memory works

Thu, 12 Mar 2009 24:00:00 EDT

TORONTO – It may sound like something out of a science fiction movie – but bad memories can be erased in mice and this finding sheds light into how memories are normally encoded and stored in the brain. In a study published in the March 13 issue of the journal Science, researchers at The Hospital for Sick Children (SickKids) have established a link between specific neurons and a given memory.

Genetic research narrows in on cause of childhood brain cancer

Sun, 08 Mar 2009 24:00:00 EST

Researchers hope the discovery of multiple genetic mutations leads to improved cancer treatments

TORONTO – Scientists at The Hospital for Sick Children (SickKids) have discovered a family of eight genes that are mutated in patients with medulloblastoma – the most common childhood brain cancer. The research is published in the March 8 online edition of Nature Genetics.

HOT TOPIC - Heavy drinking during pregnancy could lead to Fetal Alcohol Spectrum Disorder

Wed, 04 Mar 2009 24:00:00 EST

Mothers who drink heavily during pregnancy put their children at risk of Fetal Alcohol Spectrum Disorder (FASD), a cognitive and developmental disorder with long-term effects. New research started at The Hospital for Sick Children (SickKids) documents the lifetime costs to Canada of the estimated 4,000 children born with FASD every year. The study is the first to estimate the cost of FASD to the Canadian economy.

Electronic Child Health Network celebrates 10th birthday at SickKids

Tue, 03 Mar 2009 24:00:00 EST

On March 2, The Hospital for Sick Children (SickKids) hosted a unique birthday party in recognition of the electronic Child Health Network (eCHN). David Caplan, Ontario Minister of Health and Long-Term Care, joined in the celebration of the 10th birthday of Canada’s first province-wide integrated electronic patient record system.

Sugar water: The sweet solution for pain relief in babies that lasts

Mon, 02 Mar 2009 24:00:00 EST

TORONTO – Something as simple as a diaper change after a blood test can be painful for infants. But according to a new study, an ingredient found in your kitchen cupboard –ordinary sugar – could be the answer.

New insight into MS – Researchers shed light on an underlying cause of damage to the nerve coating

Thu, 26 Feb 2009 24:00:00 EST

A team of scientists has found changes in the amount, or charge, of a protein may cause the breakdown of myelin – the protective casing that surrounds nerve fibres – in MS patients. The study is published in the advance online edition of Proceedings of the National Academy of Sciences of the United States of America.

Researchers at SickKids identify a protein critical for memory and learning

Tue, 24 Feb 2009 24:00:00 EST

TORONTO – Researchers from The Hospital for Sick Children (SickKids) have made a breakthrough discovery that may eventually change the way physicians approach treatment of learning and memory defects in children and adults. Their findings are published in the current issue of PLoS Biology.

Paediatric world first - SickKids team performs lifesaving lung procedure

Tue, 17 Feb 2009 24:00:00 EST

16-year-old patient back in action at school and soccer field

Toronto – In a world first, doctors at The Hospital for Sick Children (SickKids) performed an innovative operation using an external artificial lung to keep a paediatric patient alive until new donor lungs were available.

Lunatic and Manic Proteins Sweeten Immune Cells

Thu, 12 Feb 2009 24:00:00 EST

SickKids researchers have discovered a molecular interaction that controls the development of immune cells in the spleen

Toronto - The spleen is a little talked about organ that has a big job. It helps clear away bacteria and other infections that get into the blood. All the blood is filtered through the spleen, where there are special immune cells called Marginal Zone (MZ) B cells. These MZ B cells help get rid of bacteria. Dr. Cynthia Guidos, SickKids Senior Scientist and Professor in Immunology at the University of Toronto and Dr. Sean Egan, Senior Scientist and Associate Professor in Medical Genetics and Microbiology at the University of Toronto, found an important molecular interaction that controls the development of the MZ B cells. Their findings are published today in the on-line edition of Immunity and will be published in the Feb 20 print issue.

SickKids researchers solve a universal lab test mystery

Mon, 09 Feb 2009 24:00:00 EST

It is a phenomenon that has boggled molecular scientists for decades … the protein size puzzle. It has to do with a lab test called SDS-PAGE, arguably the world’s most commonly used biochemical lab method. The procedure is used to identify and study proteins. But while it is widely used, it often doesn’t give correct readings for certain types of proteins and scientists have been at a loss to explain why.

Unusually High Rates of Antibiotic-Resistant Gonorrhea

Mon, 02 Feb 2009 24:00:00 EST

The magnitude of the rate of resistance to quinolone antibiotics in Ontario is unusually high by any threshold reported in North America.

Repatriated Canadian scientist leads an international study on the discovery of the first gene linked to the most common form of epilepsy

Thu, 29 Jan 2009 24:00:00 EST

Lisa Strug a Scientist at The Hospital for Sick Children (SickKids) and Assistant Professor, Public Health Sciences, University of Toronto, was the lead author of a paper
published today in the online issue of the European Journal of Human Genetics, in advance of the print edition.

Appointment of the Director of the Centre for Patient Safety

Wed, 14 Jan 2009 24:00:00 EST

The President and CEO of The Hospital for Sick Children (SickKids), Mary Jo Haddad, the President and CEO of Sunnybrook Health Sciences Centre, Barry McLellan, and the Dean of Medicine, Catharine Whiteside, are very pleased to announce that Dr. Kaveh Shojania has been appointed as the inaugural Director of the new University of Toronto Centre for Patient Safety.

Researchers identify potential new weapon in battle against HIV infection

Mon, 12 Jan 2009 24:00:00 EST

(Toronto) - Researchers have discovered a potentially important new resistance factor in the battle against HIV: blood types. An international team of researchers from Canadian Blood Services, The Hospital for Sick Children (SickKids) and Lund University in Sweden have discovered that certain blood types are more predisposed to contracting HIV, while others are more effective at fending it off.

SickKids scientist Dr. Teresa To receives Eminent Scientist of the Year Award

Thu, 18 Dec 2008 24:00:00 EST

(Toronto) - Dr. Teresa To, Senior Scientist and Head of the Child Health Evaluative Sciences program at SickKids Research Institute, has been selected to receive the Eminent Scientist of the Year Award 2008 in the field of Pediatrics and Community Health Research, by the International Research Promotion Council (IRPC). Her award is announced in the December issue of Recent Advances and Research Updates , a journal published by IRPC.

SickKids’ health information website, AboutKidsHealth.ca becomes a national source for child health information

Tue, 02 Dec 2008 24:00:00 EST

TORONTO – AboutKidsHealth.ca, a child health information website created by The Hospital for Sick Children (SickKids), is providing resources to centres across Canada to ensure that Canadian parents have easy access to reliable child health information. Through partnerships with Sympatico / MSN, IWK Health Centre and other hospitals, child health news from AboutKidsHealth.ca will reach more Canadian families than ever before.

SickKids researchers discover the effectiveness of aerobic exercise in children with Fibromyalgia

Mon, 01 Dec 2008 24:00:00 EST

Toronto – Bring on the winter sports and get children active this season because a new study proves once again the benefits of physical activity for children. According to a team of researchers from The Hospital for Sick Children (SickKids) and Bloorview Kids Rehab, moderate-intensity exercise can significantly improve the health and quality of life of children with Fibromyalgia (FM). This research is reported in the October issue of Arthritis & Rheumatism.

SickKids led study of mutant gene in fruit flies provides insight into learning and memory deficits

Mon, 01 Dec 2008 24:00:00 EST

TORONTO – Learning and memory are key attributes of higher organisms. While many genes have already been linked to these functions, the precise molecular and cellular mechanisms underlying these processes have not always been understood. A recent international study led by Dr. Gabrielle Boulianne, Senior Scientist in the Developmental & Stem Cell Biology program at The Hospital for Sick Children (SickKids), professor of Molecular Genetics at the University of Toronto and Canada Research Chair in Molecular and Developmental Neurobiology, examines a Drosophila (fruit fly) gene that impacts extended memory and also plays a critical role in disrupting associative learning.

Researchers discover a novel therapy for chronic pain by blocking an intracellular protein interaction in the central nervous system

Sun, 16 Nov 2008 24:00:00 EST

TORONTO – Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto have developed a novel peptide for treating pain by blocking an intracellular protein interaction in the central nervous system. This research is reported online on November 16 in the journal Nature Medicine.

Wong receives chair in vision neuroscience

Thu, 06 Nov 2008 24:00:00 EST

Funds provided by SickKids Board of Trustees member

Researchers determine that longer surgical wait times negatively affect infants with inguinal hernias

Mon, 03 Nov 2008 24:00:00 EST

Longer wait times for infant inguinal hernia surgery is associated with more Emergency Department visits and higher complication rates, according to a team of researchers at The Hospital for Sick Children (SickKids). This research is reported in the November 3 issue of the Canadian Medical Association Journal (CMAJ).

SickKids hosts joint symposium with Shanghai Institute of Biochemistry and Cell Biology

Mon, 27 Oct 2008 24:00:00 EDT

Toronto – Advancing its partnership with the Shanghai Institute of Biochemistry and Cell Biology (SIBCB), one of China 's leading life science research institutes, SickKids hosted the first in a series of international symposia. On October 20 th TheToronto-Shanghai Joint Symposium on Stem Cell and Systems Biology , organized in collaboration with the Department of Molecular Genetics and the Terrence Donnelly Center for Cellular & Biomolecular Research at the University of Toronto, featured presentations by six SIBCB scientists including Dr. Naihe Jing, Acting Director of SIBCB, and six Toronto researchers including Dr. Freda Miller and Dr. Steve Scherer from SickKids.

McInnes to head The American Society of Human Genetics

Thu, 23 Oct 2008 24:00:00 EDT

Toronto – SickKids scientist Dr. Roderick McInnes has been elected president of the American Society of Human Genetics (ASHG). A Senior Scientist in the Developmental & Stem Cell Biology program at SickKids and a University Professor and Professor of Molecular Genetics and Paediatrics at the University of Toronto , Dr. McInnes has served on the ASHG Board of Directors from 2005-2007. He will begin his term January 1, 2010 after serving as president-elect in 2009.

Sherman appointed CIHR Scientific Director

Mon, 20 Oct 2008 24:00:00 EDT

Toronto – SickKids Senior Scientist and Staff Grastroenterologist Dr. Philip Sherman has been appointed incoming Scientific Director of the Canadian Institute's of Health Research (CIHR) Institute of Nutrition, Metabolism and Diabetes (CIHR-INMD) . The appointment announced today by CIHR President Dr. Alain Beaudet and CIHR Governing Council is effective January 1, 2009.

Scientists develop cost effective strategy to address safe drinking water in Bangladesh

Tue, 07 Oct 2008 24:00:00 EDT

(Toronto) – The drinking water of Bangladesh , known to be contaminated with toxic agents can be addressed, according to an international team of volunteer researchers, led by a scientist at The Hospital for Sick Children (SickKids). Following years of study of the contaminants in the water, the team has d eveloped a practical strategy to ensure its safety. Their findings are published online ahead of print in the journal Environmental Health Perspectives .

New understanding of the aging brain

Wed, 10 Sep 2008 24:00:00 EDT

Variations of the gene that protects the brain as it ages may also indicate a susceptibility for Alzheimer's.

A team of researchers led by scientists at The Hospital for Sick Children (SickKids) has discovered that the mammalian gene, p73 is essential for protecting the brain through the normal aging process. The findings suggest that reduced levels of p73 may increase a person's likelihood of developing Alzheimer's or another neurodegenerative disorder. Their findings are published in the September 2008 issue of Neuron .

Seeing eye to eye with…the fly? SickKids scientists confirm common ancestry of the eyes in humans and flies

Mon, 08 Sep 2008 24:00:00 EDT

Toronto - Scientists at The Hospital for Sick Children (SickKids) have established that despite our many differences, the genes that control the development of eyes in humans and flies are remarkably similar. This research, published in the September 9, 2008 issue of the journal Current Biology, suggests that the eyes of invertebrates (such as fruit flies) and vertebrates (such as humans) have a common ancestry.

Henkelman receives NCIC's cancer research award

Fri, 05 Sep 2008 24:00:00 EDT

Dr. Mark Henkelman has been awarded a National Cancer Institute of Canada (NCIC) Award of Excellence in Cancer Research. He is the 2008 recipient of the Robert L. Nobel prize in recognition of his achievements in cancer research

SickKids scientists confirm Ontario’s bike helmet law saves lives

Tue, 02 Sep 2008 24:00:00 EDT

Toronto – Using data spanning 12 years, researchers at The Hospital for Sick Children (SickKids) have established that the bicycle helmet law introduced in Ontario in 1995, has helped to make our children safer on the roads. According to research published this week in the journal Pediatrics by Dr. Patricia Parkin, SickKids Senior Associate Scientist, Director of the Paediatric Outcomes Research Team and Fellowship Program in Paediatric Medicine and Associate Professor, Department of Paediatrics, Health Policy, Management and Evaluation, and the Institute for Medical Sciences at the University of Toronto, the average number of bicycle-related deaths for children one to 15 years of age decreased 52 per cent – from 13 to six deaths annually.

ERA supports SickKids safety scientist

Tue, 02 Sep 2008 24:00:00 EDT

A demanding schedule may be part of the job for health-care professionals, yet the number of hours on duty can affect performance and become a factor in the delivery of care.

SickKids scientist confirms the risks of codeine use and breastfeeding

Wed, 20 Aug 2008 24:00:00 EDT

Toronto – Using pain treatments which contain codeine may be risky for some breastfeeding mothers, according to research published this week by researchers at The Hospital for Sick Children (SickKids). Dr. Gideon Koren, Senior Scientist in the Child Health Evaluative Sciences program at SickKids Research Institute, Director of Motherisk, Professor of Paediatrics at the University of Toronto, and Richard and Jean Ivey Chair in Molecular Toxicology in the Schulich School of Medicine & Dentistry at The University of Western Ontario, published research in the journal, Clinical Pharmacology & Therapeutics which suggests that the codeine used in some pain relief drugs can actually have harmful and even fatal results for infants when ingested by some breastfeeding mothers.

SickKids receives over $91 million in CFI funding to support research infrastructure

Wed, 20 Aug 2008 24:00:00 EDT

TORONTO – The Hospital for Sick Children (SickKids) will receive $91,119,176 in funding for research infrastructure under the Canada Foundation for Innovation's (CFI) Large-Scale Institutional Endeavours (LSIE) component of the Research Hospital Fund (RHF) , announced today by Dr. Eliot Phillipson, President and CEO, CFI, and Dr. Colin Carrie, Parliamentary Secretary to the Minister of Industry.
“CFI's investment is a testament to the government's commitment to science and technology innovation at SickKids,” says Mary Jo Haddad, President and CEO, SickKids. “This investment will allow our researchers to work together at one location where their combined expertise will lead to discoveries and innovative treatments that will improve not only the health of children but will have a real impact on the health of adults and future generations to come.”

SickKids scientists uncover the key to controlling how stem cells develop

Wed, 06 Aug 2008 24:00:00 EDT

Toronto – Canadian researchers are one step closer to controlling human embryonic stem cell differentiation thanks to the work of scientists Dr. Cheryle Séguin and Dr. Janet Rossant of the Developmental and Stem Cell Biology program at The Hospital for Sick Children (SickKids).

SickKids scientists demonstrate link between DNA copy number changes and cancer risk

Mon, 04 Aug 2008 24:00:00 EDT

Discovery may lead to the early identification of individuals who are predisposed to developing cancer

Next generation of scientists in training at SickKids

Wed, 23 Jul 2008 24:00:00 EDT

Last year, third-year science student Stephanie Taillefer's summer job was filing medical records in a dark, windowless basement in Barrie . “It was mind-numbing work,” she says, “and it gave me paper cuts.”

Barwick recipient of $4.4 million CIHR grant to improve the mental health of Canadians

Fri, 18 Jul 2008 24:00:00 EDT

Toronto – Dr. Melanie Barwick, psychologist, Community Health Systems Resource Group, and associate scientist in the Child Health Evaluative Sciences program at The Hospital for Sick Children (SickKids), is one of three recipients of a $4.4 million grant from the Canadian Institutes of Health Research (CIHR), announced today in Winnipeg by Steven Fletcher, Parliamentary Secretary for Health, on behalf of Tony Clement, Minister of Health.

Malkin to receive Men of Distinction award

Thu, 17 Jul 2008 24:00:00 EDT

Toronto – Dr. David Malkin, associate chief of research (clinical), senior staff oncologist, senior scientist, and co-director of the Cancer Genetics Program at The Hospital for Sick Children (SickKids) and professor of paediatrics at the University of Toronto has been selected as a recipient of the 2008 Men of Distinction Award from the Israel Cancer Research Fund (ICRF). This annual award is given in recognition of excellence and outstanding humanitarian achievement. Recipients are selected by a tribute committee based on their ongoing commitments to the wellbeing of the community.

From Telethon to a "Night of Miracles," Saturday's Behind-the-Scenes Look at SickKids is also a Fundraising Success!

Thu, 03 Jul 2008 24:00:00 EDT

Toronto-The Hospital for Sick Children Foundation's special broadcast, "Night of Miracles" on Saturday, May 31st - was a behind-the-scenes look at what SickKids is doing for children. This year's telecast brought in 500 new monthly donors over the two hours. Last year's telethon brought in a total of 166 monthly donors over the entire 24-hour period. This represents an increase of almost 70 percent in less than 10 percent of the time and with significantly fewer overhead costs.

A spoonful of sugar makes the ‘pain go away’

Mon, 30 Jun 2008 24:00:00 EDT

SickKids researchers confirm sugar as an effective painkiller for newborns

SickKids Scientist Dr. Lisa Robinson nationally recognized as a mentor of tomorrow’s researchers

Tue, 24 Jun 2008 24:00:00 EDT

Toronto – SickKids Scientist and Staff Physician Dr. Lisa Robinson received today the Canadian Institutes of Health Research's Synapse Award. This award recognizes her outreach and guidance to youth and her contribution to the next generation of health scientists.

The Synapse award, worth $5000, is all the more special because the awardees are selected by the CIHR Youth Outreach Advisory Board – the very youth that have been inspired by the actions of these scientists. Robinson was nominated for her ongoing efforts to mentor youth through the Kids Science program that she founded and runs at The Hospital for Sick Children. The Kids Science program is designed to reach out to ‘at risk' youth and those who might not have exposure to science and technology opportunities in their communities. Through school visits from researchers, lab visits at SickKids, an annual event at SickKids - the Science Extravaganza - and youth mentoring, Robinson and her team provide youth with an opportunity to learn, experience research first-hand and consider the many academic opportunities and career options that are available in the world of science.

"When it comes to mentorship, Lisa Robinson is a leader for all of us here at SickKids," says Dr. Janet Rossant, Chief of Research. "Through the Kids Science program, Lisa inspires young people to consider a brighter future that is full of career possibilities in science and health research. And she reminds all researchers that, while it is important to succeed in our respective career paths, it is equally important to help young people follow in our footsteps."

The CIHR Synapse initiative is a program designed to bring together health researchers and young students across Canada. Synapse is a popular program in the science community with more than 4,000 CIHR-funded health researchers already signed up to become CIHR Synapse mentors. The program works to connect high school students with these mentors, to give them hands-on training experience that will help create the next generation of Canadian health researchers.

New research warrants caution when applying common therapy to children with severe, traumatic brain injury

Wed, 04 Jun 2008 24:00:00 EDT

( Toronto ) – An international team of researchers from 17 centres led by a scientist at The Hospital for Sick Children (SickKids) has discovered that the common practice of cooling paediatric patients after traumatic brain injury does not improve the neurological outcome of patients and may actually increase mortality. Their research is reported in the June issue of The New England Journal of Medicine .

SickKids names Judith John, Vice-President, Communications and Public Affairs

Wed, 28 May 2008 24:00:00 EDT

Toronto – Mary Jo Haddad, President and CEO of The Hospital for Sick Children (SickKids), has announced that Judith John has been appointed as Vice-President of Communications and Public Affairs, effective June 2.

Breakthrough at SickKids: How cancer stem cells ‘hide’ in tumours

Fri, 23 May 2008 24:00:00 EDT

Toronto - A group of investigators at The Hospital for Sick Children (SickKids) published a paper in the May 2008 issue of the journal, Stem Cells, which documents the role of hypoxia –low oxygen content – on the growth of cancer cells. Dr. Bikul Das, a research fellow in the Division of Pathology at SickKids under the primary supervision of Dr. Herman Yeger, and co-supervision of Dr. Ernest Cutz, at SickKids in collaboration with Drs. David Malkin, Gideon Koren, Sylvain Baruchel also of SickKids and, and Dr. Rika Tsuchida, a former SickKids research fellow, who is now at University of Tokyo, have demonstrated that cancer stem cells appear to hide in the low oxygen areas of the tumour and in effect, avoid the lethal effects of drug and radiation therapies. This discovery explains in part why cancers may at times recur, even after having initially responded to treatment.

SickKids Researchers celebrated at Innovation Awards Dinner

Wed, 14 May 2008 24:00:00 EDT

Toronto – Three SickKids researchers were presented with Ontario Research Commercialization Program (ORCP) BioDiscovery Toronto awards at a dinner held at MaRS Discovery District on May 14. Drs. Jayne Danska, Deborah O'Connor, and Walid Farhat were each awarded $50,000 to pursue commercial development and prototyping of their intellectual property.

SickKids researchers provide new information to improve treatment of complications of pneumonia in children

Wed, 14 May 2008 24:00:00 EDT

Toronto – Drs. Eyal Cohen, Michael Weinstein of the Department of Paediatrics and the Paediatric Outcomes Research Team at The Hospital for Sick Children (SickKids), and Dr. David N. Fisman a scientist in the Child Health Evaluative Sciences program at SickKids Research Institute published this month in the prestigious journal Pediatrics , a compelling analysis of the various treatment strategies for paediatric empyema, a complication of pneumonia where pus is collected in the airways. This condition is increasing in incidence throughout the developed world.

SickKids Chief of Research elected to the U.S. National Academy of Sciences

Wed, 30 Apr 2008 24:00:00 EDT

SickKids Chief of Research, and Senior Scientist, Dr. Janet Rossant has been elected to the U.S. National Academy of Sciences (NAS) (http://www.national-academies.org/ ). Announced in an April 29 th media release from the NAS, Rossant was among 72 new members and one of only 18 foreign associates elected to the Academy this year.

SickKids scientist receives Ontario Premier’s Summit Award

Wed, 30 Apr 2008 24:00:00 EDT

Toronto – Stephen Scherer, senior scientist at SickKids Research Institute and director of The Centre for Applied Genomics, received the highly coveted Premier's Summit Award last evening at an awards gala hosted by Premier Dalton McGuinty. SickKids President and CEO Mary Jo Haddad had the honour of presenting the prestigious award to Dr. Scherer. The award was created by the Government of Ontario to provide support to outstanding medical research leaders in Ontario .

Scientists develops new model for determining optimal antibiotic use for treatment of community acquired pneumonia

Fri, 11 Apr 2008 24:00:00 EDT

A group of Toronto scientists including Dr. David N Fisman, a scientist in the Child Health Evaluative Sciences program at The Hospital for Sick Children (SickKids), have developed a theoretical model to guide the best use of antibiotics for treating infectious diseases. This model estimates the risk of a bad outcome (such as death), based on the use of antibiotics to which resistance may be emerging. The model can also take into account various risk probabilities of the infectious agent as well as the age and health of patients. Fisman and team tested this model using the best available data on pneumonia and antibiotic resistance in Canada , the US and Europe . The model was built because current guidelines for antibiotic use do not consider the size of changes in risk for patients when certain antibiotics are used despite the presence of resistance in bacteria. This research is published online and in the April 15 th issue of the journal Clinical Infectious Diseases.

Use of antidepressant drug paroxetine in early pregnancy does not increase risk of cardiovascular birth defects

Wed, 02 Apr 2008 24:00:00 EDT

TORONTO – No association has been found between the use of the antidepressant paroxetine in the first trimester of pregnancy and an increased risk of heart defects in exposed infants according to a study conducted by researchers at The Motherisk Program of The Hospital for Sick Children (SickKids), and the University of Toronto. Their findings are published online today in the American Journal of Psychiatry.

Researchers determine traditional treatment for simple bone cysts to be superior to newly adopted method

Tue, 01 Apr 2008 24:00:00 EDT

An international team of researchers, led by Dr. James Wright of The Hospital for Sick Children (Sick Kids), has found that the traditional treatment of steroid injections provides superior healing for children with simple bone cysts compared with injections of bone marrow, a more recent method of treatment adopted by the orthopaedic community. This research is reported in the April 1 issue of The Journal of Bone and Joint Surgery.

International partnership to produce “gold standard” gene copy reference of the human genome

Thu, 13 Mar 2008 24:00:00 EDT

Wellcome Trust grant expands the Toronto Database

Infectious disease risk increases as a result of climate change

Mon, 10 Mar 2008 24:00:00 EDT

SickKids researchers anticipate increases in infectious disease in Canada

SickKids Scientists discover potential therapeutic agent for cancer

Fri, 22 Feb 2008 24:00:00 EST

Scientists at The Hospital for Sick Children (Sickkids) have made an important research discovery which may influence the way that chemotherapy is delivered in certain types of cancer. The discovery is highlighted in a research paper, entitled “ Inhibition of Multidrug Resistance 1 (MDR1) by AdamantylGb3, a globotriaosylceramide analog ”, published in today's issue of the Journal of Biological Chemistry (JBC).

Scientists discover a genetic combination that may worsen pulmonary disease in paediatric CF patients; Finding could pave the way for future clinical trials and genetic tests

Thu, 21 Feb 2008 24:00:00 EST

TORONTO – Scientists at The Hospital for Sick Children (SickKids), the University of British Columbia (UBC), the University of Toronto (UofT) and Université de Montréal (UdeM) have identified key genetic factors influencing the severity of lung disease in paediatric cystic fibrosis (CF) patients. Their research is reported this month in The Journal of Clinical Investigation .

Cancer Research Excellence at SickKids

Tue, 05 Feb 2008 24:00:00 EST

Toronto – With a capacity crowd gathered in the SickKids Main Auditorium, the National Cancer Institute of Canada (NCIC) honoured SickKids researchers Dr. Peter Dirks and Dr. Mark Greenberg for excellence in cancer research. Dr. Mr. Michael Wosnik, Executive Director of NCIC and Mr. Peter Goodhand, CEO of the Canadian Cancer Society Ontario Division awarded Greenberg with the Dr. O. Harold Warwick Prize, sponsored by the Canadian Cancer Society . Named for the pioneering researcher, the prize is given annually to a scientist whose research has had a major impact on cancer control in Canada . Greenberg's efforts have led to remarkable improvements in survival and long-term outcomes for childhood leukemia, brain tumours and solid tumour cancer care delivery. He has made many contributions to public health policy in this area. Greenberg is senior staff oncologist and professor of Paediatrics and Surgery at the University of Toronto.

Prime Minister presents awards to nurses

Fri, 01 Feb 2008 24:00:00 EST

Prime Minister Stephen Harper and Health Minister Tony Clement recognized 14 nurse leaders from across Canada on Friday February 1 at a Canadian Nurses Association (CNA) centennial signature event, held at SickKids.

Commentary on Cystic Fibrosis research finding emphasizes the need for complimentary scientific approaches to solve complex disease problems

Fri, 25 Jan 2008 24:00:00 EST

Toronto – Scientists at The Hospital for Sick Children (SickKids) have provided an important commentary on a research finding published in the January 25th edition of the scientific journal Chemistry and Biology . The commentary by Dr. Charles Deber, a Senior Scientist in the SickKid Research Institute's Molecular Structure & Function program, provides perspective and reflections on the results of a research study by Pissarra et al., focusing on the cystic fibrosis transmembrane conductance regulator (CFTR). The commentary is co-authored by Dr. Joanne Cheung and Dr. Arianna Rath, both post-doctoral research fellows in Dr. Deber's laboratory.

Substance use and pregnancy: Fact or fiction?

Fri, 18 Jan 2008 24:00:00 EST

New Health Canada-sponsored resource helps healthcare professionals advise mothers

Canadian scientists find frequent structural changes of chromosomes in autism

Thu, 17 Jan 2008 24:00:00 EST

Copy number alterations of genes contribute to autism in seven per cent of cases

Cell biologists find clues to chronic bacterial infection

Wed, 16 Jan 2008 24:00:00 EST

TORONTO – The January 17, 2008 issue of the prestigious journal, Nature, includes an article by researchers at The Hospital for Sick Children (SickKids), University of Toronto and Harvard Medical School that documents new knowledge about one chronic bacterial infection and suggests a pattern for others.

SickKids scientists discover new method to track an important lipid in the cell

Thu, 10 Jan 2008 24:00:00 EST

Toronto - An important cellular membrane lipid, phosphatidylserine (PS), through its negative charge, is responsible for regulating the surface charge of cellular membranes, a biophysical entity that can impact the function of many signaling proteins in the cell. Up until now, the distribution of this lipid within the cell was poorly understood, due to the lack of available experimental tools. By creating a novel biosensor that can recognize this lipid specifically, the precise localization of PS in the cell has been revealed. This discovery, published tomorrow in the journal Science , opens new paths in the study of this lipid in the cell.

SickKids scientists discover one of the genetic variations responsible for kidney failure in diabetics

Wed, 02 Jan 2008 24:00:00 EST

Toronto - Following a two-year genetic association study, scientists at The Hospital for Sick Children (SickKids) have discovered that variations in the gene SOD1 are linked to the development and progression of diabetic nephropathy (kidney failure). This research is reported in the January issue of the journal Diabetes.

Human Genetic Variation” named breakthrough of the year by the journal Science

Wed, 02 Jan 2008 24:00:00 EST

On December 21, the international journal Science announced the breakthrough of the year - the important steps taken by researchers in 2007 to see how genomes differ among individuals and the implications of this variation for deciphering the genetics of complex diseases and personal traits. One of the leading research stories in this area was the publication of the first individual genome sequence of an individual, Dr. J. Craig Venter, decoded by the Craig Venter Institute, along with collaborators at SickKids and the University of California, San Diego related article. »»

SafeKids Canada applauds the Federal Government’s new action plan to make children’s products safer

Mon, 17 Dec 2007 24:00:00 EST

TORONTO – Safe Kids Canada supports the new action plan released today by Prime Minister Stephen Harper aimed at making children's products sold in Canada safer for children. Survey results show that the vast majority of Canadians believe that if a toy or product is available on the market it is safe. While the public may assume that products for sale have been tested or inspected for safety, this has not necessarily been the case in Canada .

Latest Round of Canada Research Chairs announced

Mon, 03 Dec 2007 24:00:00 EST

Strategic investments in research promote innovation

Researchers find that quick injections for babies are less painful

Thu, 29 Nov 2007 24:00:00 EST

TORONTO – Infants cry less when they receive immunization shots quickly than they do if the shots are administered slowly, a study by researchers at The Hospital for Sick Children (SickKids) shows. The research team recommends that the fast injection technique be used for routine intramuscular immunizations from now on. This research is reported in the December issue of the Archives of Childhood Diseases.

SickKids researchers find link between iron-deficiency anemia and stroke in young children

Mon, 05 Nov 2007 24:00:00 EST

TORONTO – Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have found that previously healthy toddlers who have a stroke are 10 times more likely to have iron-deficiency anemia than otherwise healthy children of this age group. The study also showed that children with iron-deficiency anemia accounted for more than half of all stroke cases in children without an underlying medical illness, which indicates that iron-deficiency anemia is a significant risk factor for stroke in otherwise healthy toddlers. This research is reported in the November issue of the journal Pediatrics.

A New Understanding of the Role of Proteins in Accurate Cell Division

Mon, 05 Nov 2007 24:00:00 EST

Researchers at SickKids have discovered the role that the mammalian protein Sept 2 plays in cell division, an important breakthrough since failures in the process can lead to cancer. These findings are published in the November 2007 issue of Developmental Cell.

New Territory Mapped in Stem Cell Transplantation

Sun, 04 Nov 2007 24:00:00 EDT

TORONTO – Transplant research has taken another step forward at The Hospital for Sick Children (SickKids) where scientists have discovered a gene with properties that allow for the successful engraftment of stem cells from human bone marrow into mice. Researchers hope further studies will lead to the development of a therapy so more children with blood diseases can receive bone marrow transplantation.

New study to test oral insulin in the prevention of diabetes

Tue, 16 Oct 2007 24:00:00 EDT

TORONTO – Researchers at The Hospital for Sick Children (SickKids) are leading the Canadian component of a multinational clinical study aimed at preventing or delaying type 1 diabetes. The Type 1 Diabetes TrialNet study will examine whether taking insulin orally can prevent or delay diabetes in people who are at risk for the disease.

Canada’s first hospital-based solar thermal energy site to be installed at SickKids

Thu, 20 Sep 2007 24:00:00 EDT

TORONTO – In an effort to reduce energy costs and greenhouse gas emissions, The Hospital for Sick Children (SickKids) is installing a new solar panel system on the hospital's Atrium roof. The solar energy system will supplement SickKids' hot water system, an environmentally friendly method to reduce energy costs and increase savings for the hospital.

Researchers use skin-derived stem cells to repair spinal cord injuries

Wed, 05 Sep 2007 24:00:00 EDT

TORONTO – Researchers at The Hospital for Sick Children (SickKids) and the University of British Columbia (UBC) have used skin-derived stem cells to repair spinal cord injuries in rats. This research was made possible with the support of a $1.5-million NeuroScience Canada Brain Repair ProgramTM team grant that enabled scientists from across Canada to work together and fast track their research. This research is reported in the September 5, 2007 issue of the Journal of Neuroscience.

Researchers find that despite evidence of efficacy, topical anesthetics are not commonly used for routine immunization

Tue, 04 Sep 2007 24:00:00 EDT

( TORONTO ) – Researchers at The Hospital for Sick Children (SickKids) have found that even though topical anesthetics have been shown to reduce pain during routine immunizations, they are not widely used by paediatricians. This research is reported in the September 4 issue of the journal Pediatrics.

Childhood immunizations are traumatic for children, their families, health care workers, and society at large. Beyond the acute injection and post-injection pain, repeated immunizations lead to pre-procedural anxiety and hypersensitivity to future painful procedures. In its most extreme form it can lead to avoidance of medical care because of “blood-injection-injury phobia.” The stress upon parents is also profound, leading some parents to become noncompliant with vaccine administration, which in turn contributes to the risk of resurgence of vaccine-preventable disease.

The trauma of having a painful needle experience can last a lifetime. Studies have shown that most needle phobias develop between the age of 4 and 6 and about 10 per cent of the population is needle phobic. More than 50 per cent of school aged children are afraid of needles

Topical anesthetics such EMLA cream (lidocaine-prilocaine) and Ametop gel (amethocaine) have been proven to be highly effective at reducing injection pain, however SickKids researchers found in a survey of physicians and parents that they were rarely used as part of their vaccination pain management strategy. Oral analgesics such as Tylenol (acetaminophen) and Advil (ibuprofen), however, were used more commonly to manage pain.

The researchers found these results surprising, because scientific evidence consistently supports topical local anesthetics for injection pain but such evidence is equivocal for the use of oral analgesics, which were used more frequently to manage injection and post-injection pain.

“Topical anesthetics do not prevent all pain, but they do reduce it, by about half” said Dr. Anna Taddio, the study's lead author and principal investigator, an adjunct scientist in Child Health Evaluative Sciences at the SickKids Research Institute and pharmacist, and an associate professor of Pharmacy at the Leslie Dan Faculty of Pharmacy at the University of Toronto. "There is an expectation that topical anesthetics make injections pain free. Since they do not, people have not adopted their use.”

Taddio noted that topical anesthetics take about 30-60 minutes to become effective which some paediatricians sited time as a barrier to use. Parents, on the other hand, reported that they were unfamiliar with topical local anesthetics, but had been informed about oral analgesics.

“The good news is that if doctors endorse the use of topical anesthetics, like they endorse the use of oral analgesics, patients would be more inclined to use them,” added Taddio.

Other researchers involved in this study were Jennifer Manley, Leah Potash and Moshe Ipp from SickKids, Michael Sgro of St. Michael's Hospital and Vibhuti Shah of Mt. Sinai Hospital.

This research was funded by the Canadian Pain Society, the Canadian Institutes of Health Research and SickKids Foundation.

The Hospital for Sick Children (SickKids), affiliated with the University of Toronto, is Canada's most research-intensive hospital and the largest centre dedicated to improving children's health in the country. As innovators in child health, SickKids improves the health of children by integrating care, research and teaching. Our mission is to provide the best in complex and specialized care by creating scientific and clinical advancements, sharing our knowledge and expertise and championing the development of an accessible, comprehensive and sustainable child health system. For more information, please visit www.sickkids.ca. SickKids is committed to healthier children for a better world.

First individual human diploid human genome published by international research group

Tue, 04 Sep 2007 24:00:00 EDT

( TORONTO ) - Researchers at the J. Craig Venter Institute (JCVI), along with collaborators at The Hospital for Sick Children (SickKids) in Toronto and the University of California, San Diego (UCSD), have published a genome sequence of an individual, J. Craig Venter, PhD, that covers both of his chromosome pairs (or diploid genome), one set being inherited from each of his parents.

Two other versions of the human genome currently exist—one published in 2001 by Dr. Venter and colleagues at privately-funded Celera Genomics, and another at the same time by a consortium of government and foundation-funded researchers. These genomes were not of any single individual, but rather were a mosaic of DNA sequences from various donors. In the case of Celera it was a consensus assembly from five individuals, while the publicly-funded version was based on patching together sequences from over 100 anonymous human sources. Both versions greatly underestimated human genetic diversity.

This new genome represents the first time a true diploid genome from one individual—Dr. Venter, has been published. The research is available in September issue of the open assess public journal, PLoS Biology.

Researchers at the JCVI have been sequencing this version of Dr. Venter's genome since 2003. Building on reanalyzed data from Dr. Venter's genome that constituted 60 per cent of the previously published Celera genome, the team had the goal of constructing a definitive reference human genome based on one individual.

The Toronto group, led by Stephen Scherer, PhD, senior scientist in Genetics & Genome Biology at SickKids and professor of Molecular and Medical Genetics at the University of Toronto , assisted in decoding the genetic variants found in Dr. Venter's DNA sequence, as well as in the clinical genetic studies. In particular, they catalogued the copy number variation (CNV) regions, a new form of genetic variation that Scherer's team co-discovered with Charles Lee, PhD at Brigham and Women's Hospital, Harvard Medical School , in 2004.

From the combined data of more than 20 billion base pairs of DNA, the international team assembled the majority of Dr. Venter's genetic blueprint. Since this genome assembly uniquely catalogues the contributions of each of the parental chromosomes, for the first time the total amount of variation existing between the two could be determined. Surprisingly, a higher than expected amount of genetic variation was found.

“Each time we peer deeper into the human genome we uncover more valuable insight into our intricate biology,” said Dr. Venter. “With this publication we have shown that human to human variation is more than five fold greater than earlier estimates proving that we are in fact more unique at the individual genetic level than we knew about before.” He added, “It is clear however that we are still at the earliest stages of discovery about ourselves and only with continued sequencing of more individual genomes will we be able to garner a full understanding of how our genes influence our lives.”

Within the human genome there are several different kinds of DNA variants. The most studied type is single nucleotide polymorphisms or SNPs and some 3.2 million were found in Dr. Venter's genome. This is a typical number expected to be found in any other human genome but at least 1.2 million of these SNPs had not been described before.

The team also found an abundance of other important variants. In fact, hundreds of thousands of CNV or smaller CNV-like variants were discovered. While the SNP events outnumbered the non-SNP variants, the latter class involved a larger portion (74 per cent) of the variable component of Dr. Venter's genome. The combined data suggests that human-to-human variation is much greater than the 0.1 per cent difference found in earlier genome sequencing experiments. The new estimate reveals that genomes between individuals have at least 0.5 per cent total genetic variation (or are 99.5 per cent similar).

According to Samuel Levy, PhD, lead author and senior scientist at JCVI, “The ability to use unbiased, high throughput, sequencing methods coupled with advanced computational analytic methods, enables us to characterize more comprehensively the wide variety of individual genetic variation. This offers us an unprecedented opportunity to study the prevalence and impact of these DNA variants on traits and diseases in human populations.”

Another important feature that is made possible by having an individual, diploid genome is the ability to generate more informed haplotype assemblies. Haplotypes are groups of linked variations along the chromosomes. Other studies have generated many common haplotypes, however, these are based on averages of large ethnogeographic populations rather than individuals. Individual haplotypes enable scientists to study rare or 'private' variants that might explain and help predict traits and diseases in that particular person—allowing an individualized approach in genomic applications.

“In the future it will be possible to know the parental origin of DNA that contributes, either alone or in combination, to various traits or disease,” said Dr. Scherer. “This landmark study discovered that in an individual genome upwards of 44 per cent of genes were variable in sequence, a number that geneticists have wondered about for 50 years.”

“With this type of knowledge now in hand, the stage is set for an era of personalized medicine where genome sequence information becomes a critical reference to assist with health-related decisions.” concluded Scherer.

This research was funded by J. Craig Venter Institute, Genome Canada/Ontario Genomics Institute, the McLaughlin Centre for Molecular Medicine, the Canada Foundation for Innovation, Canadian Institutes of Health Research, the Canadian Institute for Advance Research and SickKids Foundation.

The Hospital for Sick Children (SickKids), affiliated with the University of Toronto, is Canada's most research-intensive hospital and the largest centre dedicated to improving children's health in the country. As innovators in child health, SickKids improves the health of children by integrating care, research and teaching. Our mission is to provide the best in complex and specialized care by creating scientific and clinical advancements, sharing our knowledge and expertise and championing the development of an accessible, comprehensive and sustainable child health system. For more information, please visit www.sickkids.ca. SickKids is committed to healthier children for a better world.

National team of SickKids heart transplant patients to participate in the World Transplant Games in Bangkok

Fri, 10 Aug 2007 24:00:00 EDT

TORONTO – The Hospital for Sick Children (SickKids) is proud to announce that an official hospital team of heart transplant patients will be travelling to Bangkok to participate in the 16th World Transplant Games, held from August 25 to September 3, 2007.

Researchers find that lithium can promote better bone healing

Tue, 31 Jul 2007 24:00:00 EDT

TORONTO – Researchers at The Hospital for Sick Children (SickKids) have found a molecular pathway that plays a critical role in bone healing and have found that the drug lithium can improve the healing process. This research is reported in the July 31 issue of PLoS Medicine.

Researchers find gene associated with ulcerative colitis

Thu, 05 Jul 2007 24:00:00 EDT

TORONTO – Researchers at The Hospital for Sick Children (SickKids), Mount Sinai Hospital and the University of Pittsburgh have identified a previously unsuspected gene found to be associated with ulcerative colitis. This research is reported in the July 5 issue of Current Biology.

Brace provides more efficient and effective treatment for low-risk ankle fractures

Thu, 05 Jul 2007 24:00:00 EDT

Children with low-risk ankle fractures recover faster when treated with a removable brace rather than the traditional cast. A study at The Hospital for Sick Children (SickKids), published in the June issue of the journal Pediatrics, challenging the current practice of routine casting and the necessity for orthopedic care, has found the brace provides earlier recovery of physical function. Additionally, the brace is associated with greater patient and family satisfaction and is also less costly.

Study finds corticosteroids offer effective treatment for "Strawberry Marks"

Thu, 28 Jun 2007 24:00:00 EDT

Researchers at The Hospital for Sick Children (SickKids) have found that corticosteroids administered orally can effectively stop the growth and even reduce the size of congenital benign skin lesions in infants. These lesions—dense, usually elevated masses of dilated blood vessels called hemangiomas—are the most common benign tumours of infancy, occurring in about ten per cent of children by one year of age. Sometimes called “Strawberry Marks,” they are seen more frequently in girls, premature infants and twins.

New Ashoka fellow, Dr. Stan Zlotkin

Tue, 26 Jun 2007 24:00:00 EDT

(June 26) Dr. Stanley Zlotkin, head of the Division of Gastroenterology, Hepatology and Nutrition, and senior scientist at the Research Institute, was recently elected an international fellow of Ashoka, a global association that identifies and supports the world’s leading social entrepreneurs. Three others were elected as well: Dr. Gilles Julien, a pediatrician from Quebec, Sidney Ribaux of Montreal and Jessica Clogg of British Columbia. The four were honoured at a special ceremony on June 6 for their innovative solutions to social problems.

SickKids spin-off will seek new treatments for diabetes

Tue, 26 Jun 2007 24:00:00 EDT

Approach anything but complacent

Canada Foundation for Innovation recognizes leading researchers at SickKids

Fri, 15 Jun 2007 24:00:00 EDT

Public Affairs
The Hospital for Sick Children

Ciruna appointed Canada Research Chair

Fri, 25 May 2007 24:00:00 EDT

The May 23rd national announcement of new Canada Research Chairs puts the spotlight on SickKids Scientist Brian Ciruna, who was appointed Canada Research Chair in Developmental Genetics and Cell Biology. Dr. Ciruna's research is furthering our understanding of the mechanisms of early development. His research team uses zebrafish--a fish that children might use to neutralize their aquariums--to gain insight into how aberrations in cell signaling contribute to congenital malformations and diseases such as Spina Bifida.

Rossant awarded 2007 March of Dimes Prize in Developmental Biology

Mon, 07 May 2007 24:00:00 EDT

Dr. Jennifer L. Howse (March of Dimes President), Dr. Anne McLaren, Dr. Janet Rossant and Elizabeth Roosevelt Johnston (March of Dimes board member)

Dr. Janet Rossant, Chief of Research at The Hospital for Sick Children was presented with 2007 March of Dimes Prize in Developmental Biology along with Dr. Anne McLaren of Cambridge University on Monday, May 7, 2007. This award was given to them by the US-based March of Dimes Foundation during the 2007 Annual Meeting of the Pediatric Academic Societies, which was held in Toronto for the first time. This was also the first time the March of Dimes Prize was shared by two women, and brings to the total number of women who have received this honour to four.

Safe Kids Canada reminds parents and caregivers to protect children from window and balcony falls

Wed, 02 May 2007 24:00:00 EDT

(TORONTO) – With warm weather quickly approaching, many families will keep their windows and balcony doors open, putting their children at risk of falling and causing serious injuries. Since children can easily fall because they are curious, top heavy and don’t understand the risks of falling from heights, Safe Kids Canada urges parents and caregivers to install window safety devices to prevent serious injuries.

SickKids opens state-of-the-art cardiac diagnostic and interventional unit specially designed for children

Mon, 30 Apr 2007 24:00:00 EDT

TORONTO – The opening today of The Mitchell Goldhar Cardiac Diagnostic & Interventional Unit at The Hospital for Sick Children (SickKids) will enable Canada's largest paediatric interventional catheterization program to develop new innovations in minimally invasive alternatives to open-heart surgery.

Ontario announces over $11 million provincial match for innovative SickKids centres

Tue, 24 Apr 2007 24:00:00 EDT

Two new centres at The Hospital for Sick Children will receive more than $11 million in support from the Ontario Research Fund (ORF) Research Infrastructure Program, announced today by Deputy Premier George Smitherman, on behalf of Premier and Minister of Research and Innovation Dalton McGuinty. A key component of the province's Research and Commercialization Strategy, the fund aims to keep Ontario's researchers at the leading-edge in priority economic sectors. The Research Infrastructure Program supports new infrastructure through matching funds towards projects that have been awarded grants from the Canada Foundation for Innovation (CFI). Together with federal funding, the centres have received more than $22 million in government support.

Scientists find that neural stem cell formation may be a factor in abnormal brain development

Thu, 19 Apr 2007 24:00:00 EDT

TORONTO – Taking an innovative approach to the investigation of genetic syndromes causing learning disabilities and mental retardation, researchers at The Hospital for Sick Children (SickKids) and Harvard Medical School have found that neural stem cell development during embryogenesis may have a direct effect on abnormal brain development. This research is reported in the April 19 issue of Neuron.

Researchers find that neurons compete to become part of memory networks in the brain

Thu, 19 Apr 2007 24:00:00 EDT

TORONTO – Researchers at The Hospital for Sick Children (SickKids), Columbia University, UCLA, Harvard Medical School and University of California, Irvine have found that there is competition between brain cells during memory formation and that the expression of a particular protein is involved in the success of a brain cell becoming part of a given memory. This research is reported in the April 20 issue of Science.

Researchers find paediatric clinical trials published in general medical journals less frequently

Wed, 11 Apr 2007 24:00:00 EDT

Clinical researchers at SickKids have found that there is a dramatic lack of peer-reviewed publications on paediatric clinical trials. This research is published in the February issue of the Journal of Clinical Epidemiology.

Babies can be exposed to "crystal meth" while in the womb

Wed, 11 Apr 2007 24:00:00 EDT

A study led by Dr. Gideon Koren, director of the Motherisk Program and Senior Scientist at The Hospital for Sick Children’s Research Institute, finds that analysis of hair samples can reveal exposure to methamphetamine before birth. This finding demonstrates that the drug is able to cross the placenta directly to the developing fetus. The study by the hospital’s Motherisk Laboratory will be published Monday October 30, in the Archives of Disease in Childhood, Fetal and Neonatal edition.

Chemicals that regulate neurotransmitter signaling in neurons can also prevent neural stem cell proliferation

Wed, 11 Apr 2007 24:00:00 EDT

Using drugs as probes to interrogate the mechanisms of neural stem cell growth, researchers at The Hospital for Sick Children and Mt. Sinai Hospital have found some surprising facts about how these cells are wired that have important implications for understanding human brain diseases, drug action in the human brain and brain cancer. A number of neuromodulator drugs currently in clinical use for brain disorders have been thought to mainly regulate mature nerve cell circuits in the brain. But chemical screens reveal that these also play a role in regulating the regenerative capabilities of neural stem cells--a potentially important therapeutic target for neurological diseases--and they also show activity against brain tumour stem cells in culture.

Researchers develop new mouse model to better understand neuroblastoma metastasis

Wed, 11 Apr 2007 24:00:00 EDT

Researchers at SickKids have found that expression of the chemokine receptor CXCR4 makes neuroblastoma more aggressive and more metastatic in a mouse model. This link between tumour metastasis and the expression of chemokine receptors, like CXCR4, will allow researchers to develop new treatments for neuroblastoma. This research is reported in the January issue of the journal Neoplasia.

50,000 Ontarians are poisoned each year, according to the Ontario Poison Centre

Thu, 15 Mar 2007 24:00:00 EDT

TORONTO – Every year, more than 50,000 people in Ontario are poisoned. An estimated 95 per cent of these poisonings occur in the home, resulting from the improper use and storage of such common household items as cleaners, car products, medications, vitamins, cosmetics, perfumes, plants and even toothpaste. During this year's Poison Prevention Week (March 18 - 24), the Ontario Poison Centre will work to educate Ontarians about poison prevention at home.

SickKids notifies study participants of stolen laptop

Thu, 01 Mar 2007 24:00:00 EST

TORONTO - The Hospital for Sick Children (SickKids) is notifying patients that have participated in 10 different research studies about a stolen laptop that contained their personal health information. The laptop was stolen on January 4, 2007 from the car of a physician who was doing data analysis.

SickKids researchers find prenatal multivitamins reduces risk of childhood cancers

Wed, 21 Feb 2007 24:00:00 EST

TORONTO – Researchers at The Hospital for Sick Children (SickKids) have found that taking prenatal multivitamins fortified with folic acid can reduce the risk of three common childhood cancers: leukemia, brain tumours and neuroblastoma. This research was published online on February 21, 2007, in the journal Clinical Pharmacology & Therapeutics.

Canadian team launches second phase of international autism genome project

Sun, 18 Feb 2007 24:00:00 EST

TORONTO – Fresh from their latest discovery and supported by $26.7 million CAD in public and private funding, Canadian and international scientists today launched the second phase of a global scientific effort to map the genes responsible for causing autism.

Canadian scientists lead international autism genome discoveries

Sun, 18 Feb 2007 24:00:00 EST

Autism-causing genes linked to a special group of neurons

SickKids researchers discover predictive marker for early onset cancer in some cancer-prone families

Thu, 15 Feb 2007 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have found that the rate of shortening of the ends of chromosomes in the white blood cells in people with Li-Fraumeni syndrome can predict the time of the onset of tumour development. This research is reported in the February 15 issue of the journal Cancer Research.

SickKids sets a new Canadian record for heart transplants in 2006

Tue, 16 Jan 2007 24:00:00 EST

TORONTO – The Hospital for Sick Children (SickKids) performed 20 heart transplants on children from across the country in 2006, setting a record for the number of heart transplants performed in a year by a Canadian paediatric transplant centre.

One step closer to understanding the cause of cystic fibrosis

Tue, 09 Jan 2007 24:00:00 EST

Researchers at SickKids have discovered some of the underlying causes of cystic fibrosis at the molecular level. Deletion of a single amino acid, the most common cause of cystic fibrosis, results in the defect of the cystic fibrosis protein maturation and manifests in cystic fibrosis. These findings are reported in the January issue of Nature Structural & Molecular Biology.

Discovery of a critical role for sensory nerves in diabetes opens door to new treatment strategies

Thu, 14 Dec 2006 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids), the University of Calgary and The Jackson Laboratory, Bar Harbor, Maine have found that diabetes is controlled by abnormalities in the sensory nociceptor (pain-related) nerve endings in the pancreatic islet cells that produce insulin. This discovery, a breakthrough that has long been the elusive goal of diabetes research, has led to new treatment strategies for diabetes, achieving reversal of the disease without severe, toxic immunosuppression. This research is reported in the December 15 issue of the journal Cell.

SickKids scientists named Howard Hughes Medical Institute International Research Scholars

Thu, 14 Dec 2006 24:00:00 EST

SickKids scientists Dr. Freda Miller and Dr. Michael Salter have been named international research scholars by the Howard Hughes Medical Institute (HHMI) and will receive five-year awards totaling nearly $500,000.

Holiday safety tips from Safe Kids Canada

Wed, 06 Dec 2006 24:00:00 EST

TORONTO (December 6, 2006) – With the holiday season upon us, Safe Kids Canada, the national injury prevention program of The Hospital for Sick Children (SickKids), reminds parents and caregivers about a few simple precautions you can take to help keep children safe over the holidays:

SickKids receives over $11 million in CFI Funding

Mon, 27 Nov 2006 24:00:00 EST

Researchers at The Hospital for Sick Children (SickKids) will receive over $11 million in funding for infrastructure through the Canada Foundation for Innovations’ (CFI) inaugural New Initiatives Fund (NIF) and Leading Edge Fund (LEF) programs, announced today. Funding for these projects is part of a major $422,343,180 investment by the CFI to support 86 projects at 35 institutions across the country.

Researchers redefine understanding of variation in the human genome

Wed, 22 Nov 2006 24:00:00 EST

TORONTO - A consortium of scientists led by The Hospital for Sick Children (SickKids), the Wellcome Trust Sanger Institute (WTSI), Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS), Affymetrix Corporation, and the University of Tokyo has created the first map of DNA and gene copy number variation in the human genome. This new resource, which provides critical information for understanding human evolution and disease, was published as a compendium of four scientific manuscripts released November 23 in Nature, Nature Genetics and Genome Research.

Researchers determine that a balance of amino acids determines whether a protein will become elastomeric or amyloid; may have implications for treatment of tissue-degenerative diseases

Wed, 15 Nov 2006 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children have found that specific combinations of the amino acids proline and glycine are responsible for proteins developing into either elastomeric or amyloid fibrils. This research is reported today in the November 15 issue of the journal Structure.

SickKids launches innovative online referral system

Thu, 26 Oct 2006 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) is launching an automated, Web-based referral system – the first of its kind in Canada - to support more timely and efficient management of referrals to its outpatient clinics.

The Ambulatory Referral Management (ARM) system will electronically route patient referrals for review, triage and booking. It will then provide physicians and other health-care professionals with automated faxed responses to let them know the status of their referrals: when a referral has been received, whether it has been redirected and to whom, and when the patient has been booked for an appointment.

“In addition to streamlining the referral process and improving communications, this unique system will help us measure and manage wait times in each clinic – specifically, the time between when a referral is received to when a patient is seen by a specialist,” said Dr. Daune MacGregor, associate paediatrician-in-chief.

Currently, there is no other system in Canada that measures this wait time.

Health alert from the Ontario Regional Poison Information Centre: Warning against consuming wild mushrooms

Sat, 30 Sep 2006 24:00:00 EDT

(TORONTO) – The Ontario Regional Poison Information Centre, located at The Hospital for Sick Children (SickKids), is warning the public of the serious health risks associated with eating wild mushrooms, after several adults and children from across Ontario were hospitalized earlier this week with life-threatening symptoms. Eating a small part of any wild mushroom can cause serious illness and can be fatal. Some may confuse wild mushrooms with similar-looking non-toxic mushrooms found in China and other parts of the world.

SickKids celebrates 20 years of liver transplantation

Thu, 14 Sep 2006 24:00:00 EDT

TORONTO – Staff and patient families from across the country today celebrated 20 years of clinical and research advances in liver transplantation at The Hospital for Sick Children (SickKids). Since 1986, the Liver Transplant Program at SickKids has performed over 275 transplants in children from across the country, establishing it as the largest paediatric liver transplant program in Canada.

SickKids researchers show that stem cells found in adult skin can be transplanted and function in mouse models of disease

Tue, 13 Jun 2006 24:00:00 EDT

TORONTO — Researchers at The Hospital for Sick Children (SickKids) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted into and function in mouse models of disease. This research is reported in the June 14, 2006 issue of The Journal of Neuroscience.

Researchers identify potential prognostic marker for preeclampsia

Sun, 04 Jun 2006 24:00:00 EDT

TORONTO — Researchers at Harvard Medical School and The Hospital for Sick Children (SickKids) have found a protein that contributes to the pathogenesis of preeclampsia, a common problem during pregnancy. This research was reported in the June 4, 2006 online advance issue of the journal Nature Medicine.

Multi-centre clinical trial finds two vastly different surgical procedures produce same results in infants with intestinal disorder

Wed, 24 May 2006 24:00:00 EDT

TORONTO – A minimally-invasive technique pioneered at The Hospital for Sick Children (SickKids) has proven to be as effective as surgery for treating premature infants with a severe intestinal disease, necrotizing enterocolitis, according to a study published in the May 25 issue of The New England Journal of Medicine.

Researchers determine that the prognosis for some paediatric brain tumours is correlated with expression of the protein telomerase

Tue, 18 Apr 2006 24:00:00 EDT

A team of researchers from SickKids has identified a new prognostic marker for two types of paediatric brain tumours related to the expression of the protein telomerase. This research was reported in the February issue of the journal Neoplasia and the April issue of the Journal of Clinical Oncology.

SickKids appoints Dr. Denis Daneman as Paediatrician-in-Chief

Mon, 03 Apr 2006 24:00:00 EDT

TORONTO - Denis Daneman, MB, BCh, FRCP(C) has been appointed the next Paediatrician-in-Chief at The Hospital for Sick Children (SickKids) and Chair, Department of Paediatrics at the University of Toronto (U of T) effective July 1, 2006.

SickKids researchers determine humidity is an ineffective therapy for moderate to severe cases of croup

Tue, 14 Mar 2006 24:00:00 EST

TORONTO -- Researchers at The Hospital for Sick Children (SickKids) have determined that humidity is an ineffective therapy for the common childhood ailment croup. This research is reported in the March 15, 2006 issue of The Journal of the American Medical Association.

Researchers calculate the costs of Fetal Alcohol Spectrum Disorder to Canadians to be upwards of $344 million annually

Tue, 28 Feb 2006 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) and St. Michael’s Hospital have calculated that the annual cost of Fetal Alcohol Spectrum Disorder to Canadians is upwards of $344 million a year. This research is reported in the February 28, 2006 issue of the Journal of FAS International.

Researchers describe novel inhibitor of HIV infection

Tue, 28 Feb 2006 24:00:00 EST

Researchers at SickKids and Canadian Blood Services have found a novel molecule which may prevent many types of HIV from infecting different kinds of cells. This research is reported in the February 20 issue of AIDS.

SickKids receives renewed Genome Canada funding for The Centre for Applied Genomics

Thu, 16 Feb 2006 24:00:00 EST

The Centre for Applied Genomics (TCAG) has secured additional funding – in excess of $5 million – from Genome Canada through the Ontario Genomics Institute (OGI), to maintain and enhance its operations through 2008.

SickKids researchers find morphine and topical anaesthesia effective in treating procedural pain in newborn infants

Tue, 14 Feb 2006 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have found that intravenous morphine used alone or with a topical anaesthetic (tetracaine) effectively reduced levels of pain in newborn infants undergoing insertion of central venous catheters (central lines). This research is reported in the February 15, 2006 issue of the journal JAMA.

About 10 to 15 per cent of newborns require prolonged hospitalization for conditions such as preterm birth, congenital defects and sepsis (a blood stream infection). As part of their medical care, these infants are often exposed to multiple invasive procedures that may be painful.

“It was not so long ago that infants routinely underwent painful procedures without the benefits of analgesia. Our previous studies showed that infants do feel extreme pain, that they remember this pain and that it affects their future pain responses,” said Dr. Anna Taddio, the study's lead author and principal investigator, a SickKids scientist and pharmacist, and an assistant professor of Pharmacy at the University of Toronto.

“Within the last decade, the pendulum started to swing in the other direction, and pain relievers began to be used more liberally in infants. However, more information was needed about the benefits and risks of the different treatment options. We undertook this study to determine the most effective way to manage pain in infants undergoing central line placements and to delineate the side effects associated with their use,” said Dr. Taddio.

The research team studied the relative efficacy and safety of a topical anaesthesia (tetracaine) and intravenous opioid analgesia (morphine), used alone or in combination, for management of pain in newborns undergoing insertion of a central venous catheter. Many hospitalized newborns require central lines for the administration of medication and nutrition. The randomized, double-blind, controlled trial included 132 ventilated newborns in the neonatal intensive care units at SickKids and Mount Sinai Hospital , both located in Toronto, Canada , between June 2000 and July 2005.

The amount of pain was determined by measuring the proportion of time the newborns displayed facial grimacing (brow bulge) during different phases of the central line insertion (skin preparation, needle puncture and recovery).

“We found that morphine, or a combination of morphine and tetracaine, to be the most effective in treating the infants' pain during central line placement. Topical anaesthesia (tetracaine) alone was found to be a weak analgesic. This data can be used to support evidence-based protocols for the management of pain during central line placements in infants,” said Dr. Taddio. “We believe morphine was more effective because it reduced the sensory input derived from the multiple phases of the procedure, while tetracaine decreased sensation from the needle puncture site alone."

Both medications were associated with side effects: morphine caused mild respiratory depression and tetracaine caused erythema (abnormal redness of skin).

Other members of the research team included Amelia Yip and Dr. Patrick McNamara from SickKids, Charlene Lee and Dr. Vibhuti Shah from Mount Sinai Hospital , and Dr. Boriana Parvez from Maria Fareri Children's Hospital, Valhalla , New York .

This research was supported by the Canadian Society of Hospital Pharmacists, a Canadian Institutes of Health Research New Investigator Award to Dr. Taddio, an Ontario Student Opportunity Trust Fund – SickKids Foundation Student Scholarship to Ms. Lee, and SickKids Foundation.

SickKids Foundation is the largest non-governmental granting agency in child health in Canada . Established in 1972, the Foundation has granted over $500 million to The Hospital for Sick Children and over $65 million to researchers across the country. The mission of the Foundation is to inspire our communities to invest in health and scientific advances to improve the lives of children and their families across Canada and around the world.

The Hospital for Sick Children (SickKids), affiliated with the University of Toronto, is Canada's most research-intensive hospital and the largest centre dedicated to improving children's health in the country. Its mission is to provide the best in family-centred, compassionate care, to lead in scientific and clinical advancement, and to prepare the next generation of leaders in child health. For more information, please visit http://www.sickkids.ca/.

New SickKids atlas for pediatrics health-care professionals

Mon, 02 Jan 2006 24:00:00 EST

TORONTO - Students, physicians and other pediatric health-care practitioners looking for more information on how to diagnose and treat pediatric conditions now have a new resource to consult, The Hospital for Sick Children Atlas of Pediatrics. The recently published atlas provides a comprehensive overview of the important disorders affecting newborns, children and adolescents and includes contributions from more than 60 pediatric and surgical specialists at The Hospital for Sick Children.

Clinical trials needed for paediatric stroke

Thu, 29 Dec 2005 24:00:00 EST

TORONTO (December 29, 2005) — Researchers at The Hospital for Sick Children (SickKids), Stollery Children's Hospital and Chedoke McMaster have advised that randomized clinical trials are urgently needed to equip diagnosing physicians with the most effective treatment options for paediatric stroke. This research is published in the January 2006 issue of the journal Stroke.

Holiday safety tips from Safe Kids Canada

Thu, 15 Dec 2005 24:00:00 EST

TORONTO - With the holidays fast approaching, Safe Kids Canada, the national injury prevention program of The Hospital for Sick Children (SickKids), wants to remind parents and caregivers about some of the dangers at home for children during the holiday season. Here are a few simple precautions you can take to help keep children safe over the holidays:

Researchers identify key protein involved in neuropathic pain

Wed, 14 Dec 2005 24:00:00 EST

TORONTO - A team of researchers led by Université Laval and The Hospital for Sick Children (SickKids) has discovered a protein that plays a major role in neuropathic pain. This discovery, published in the December 16 issue of Nature, paves the way for the development of new diagnostics and treatments for chronic pain.

Dr. Janet Rossant, SickKids’ Chief of Research, receives 2005 Michael Smith Prize in Health Research

Wed, 23 Nov 2005 24:00:00 EST

TORONTO - Dr. Janet Rossant, Chief of Research at The Hospital for Sick Children (SickKids), has received the 2005 Michael Smith Prize in Health Research, Canada's most prestigious health research award. The award was presented at the fourth annual Canadian Health Research Awards held yesterday in Ottawa.

SickKids is the first hospital in North America to replace a pulmonary valve without performing open-heart surgery

Wed, 09 Nov 2005 24:00:00 EST

TORONTO – SickKids is the first hospital in North America to use a catheter to replace a pulmonary valve, eliminating the need for open-heart surgery in patients with heart valve disease. This innovative procedure is a significant step for SickKids in reducing multiple open-heart surgeries, prolonged hospital stays and long recovery periods for children with congenital heart defects.

Researchers discover a protein responsible for shaping the nervous system

Mon, 07 Nov 2005 24:00:00 EST

TORONTO - A team of researchers led by The Hospital for Sick Children (SickKids), the University of Toronto (U of T) and Cold Spring Harbor Laboratory have discovered a protein that is responsible for shaping the nervous system. This research was made possible with the support of a $1.5-million NeuroScience Canada Brain Repair Program team grant that enabled scientists from across Canada to work together and fast track their research. This research is reported in the December 8, 2005 issue of the journal Neuron.

Flipped genetic sequences illuminate human evolution and disease

Fri, 28 Oct 2005 24:00:00 EDT

TORONTO - By comparing the human genome with that of the chimpanzee, man's closest living relative, researchers at The Hospital for Sick Children (SickKids) have discovered that chunks of similar DNA that have been flipped in orientation and reinserted into chromosomes are hundreds of times more common in primates than previously thought. These large structural changes in the genome, called inversions, may account for much of the evolutionary difference between the two species. They may also shed light on genetic changes that lead to human diseases. This research was published in the October 28, 2005 issue of the open-access journal Public Library of Science Genetics ( PLoS Genetics ).

Researchers discover gene involved in heart arrhythmia

Wed, 26 Oct 2005 24:00:00 EDT

TORONTO - An international team of researchers led by The Hospital for Sick Children (SickKids) and the University of Toronto has discovered that the cardiac expression of a gene called Irx5 controls the heart's electrical pattern. Alterations in the electrical pattern of the heart lead to electrical disturbances in the heart, a life-threatening condition called cardiac arrhythmias. This research is reported in the October 2005 issue of Cell .

SickKids hosts information day on managing pain in children

Thu, 13 Oct 2005 24:00:00 EDT

TORONTO - From the sharp agony of a sudden headache to the relentless throb of a sore back, everyone is familiar with what pain feels like, but watching your child experience pain can be especially difficult. To help, The Hospital for Sick Children (SickKids) is hosting an interactive educational fair for parents and health-care professionals on relieving pain in children, this year’s theme for Global Day Against Pain on October 17, 2005.
The interactive exhibit will show how SickKids clinicians and researchers are working together to understand how to lessen and eliminate the pain experienced by children, from identifying the nature of pain in children to how it is diagnosed and treated. Parents and health-care professionals will learn how to assess pain in children, have an opportunity to examine the tools used by SickKids to diagnose pain in children, learn strategies on how to treat a child’s pain at home, for acute, chronic and cancer pain, and find out about some of the leading-edge research done by SickKids researchers into the nature of pain and the development of new pain management techniques.

Study proves genetic variations influence severity of cystic fibrosis

Wed, 05 Oct 2005 24:00:00 EDT

TORONTO - Subtle differences in genes other than the defective CFTR (cystic fibrosis transmembrane conductance regulator) gene known to cause the disease cystic fibrosis (CF), can significantly modify the severity of CF, a large new multi-centre international study has concluded. A report on the findings appears in the October 6 issue of The New England Journal of Medicine.

International study provides physicians with guidelines for the treatment of juvenile idiopathic arthritis and highlights need for individualized patient care

Tue, 04 Oct 2005 24:00:00 EDT

TORONTO — A study published by the Cleveland Clinic and The Hospital for Sick Children (SickKids) provides the medical community for the first time with specific guidelines for treating juvenile idiopathic arthritis (JIA), previously known as juvenile rheumatoid arthritis (JRA), a condition that affects approximately one in every 1,000 children. This study is publishing in the October 4 edition of the Journal of the American Medical Association (JAMA).

Researchers find use of multiple sclerosis drug during pregnancy connected to miscarriage and low birth weight

Mon, 26 Sep 2005 24:00:00 EDT

TORONTO) - Researchers at The Hospital for Sick Children (SickKids) have determined that women being treated for multiple sclerosis (MS) with beta interferon therapy have increased risks of miscarriage or low infant-birth weight . This research was reported in the September issue of the journal Neurology.
Beta interferon therapy is the most commonly used therapy for treating relapsing-remitting MS. Based on a protein found naturally in the body that helps to regulate the immune system, it is known to help decrease the formation of lesions, reduce the frequency of relapses and help affect the course of the disease.

Scientists identify two key genes linked to aggressive breast cancers

Thu, 15 Sep 2005 24:00:00 EDT

Drugs already in development to target the genetic pathway.

SickKids study finds that the Internet can be an effective tool for the distribution of Emergency Department test results

Wed, 31 Aug 2005 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have found that the Internet can be effectively used by parents to check test results after discharge from the SickKids Emergency Department. This research was reported in the August issue of The Journal of Pediatrics.

Researchers discover multiple fates for damaged DNA

Tue, 23 Aug 2005 24:00:00 EDT

Researchers at The Hospital for Sick Children (SickKids) have discovered that unusual DNA structures; slippery-DNA can completely escape being repaired or even undergo error-prone repair and these process may lead to disease-causing mutations. This research was reported in the August edition Nature: Structural & Molecular Biology.

Researchers discover mechanism of tumour cell survival

Mon, 15 Aug 2005 24:00:00 EDT

Researchers at The Hospital for Sick Children (SickKids) have discovered a mechanism of tumour cell survival in a hypoxic environment, which may lead to new treatment options for patients with neuroblastoma. This research was reported in the August 15 edition of Cancer Research.

Bruce Richmond appointed chair of the SickKids Board of Trustees

Mon, 25 Jul 2005 24:00:00 EDT

TORONTO - The Board of Trustees of The Hospital for Sick Children (Sick Kids) is pleased to announce the appointment of Bruce Richmond as the chair of the board, effective July 1, 2005.

SickKids celebrates twins’ first birthday and return to Zimbabwe

Mon, 18 Jul 2005 24:00:00 EDT

TORONTO - Eight months after arriving at The Hospital for Sick Children (Sick Kids) for life-saving separation surgery, Sick Kids staff and friends who made the separation possible will say goodbye to twins Tinashe and Tinotenda Mufuka on July 19.

SickKids Foundation receives $3.5 million gift from FirstPro Shopping Centres

Thu, 14 Jul 2005 24:00:00 EDT

Toronto, Ontario - Sick Kids Foundation today announced a $3.5 million gift from Mitchell Goldhar, owner of FirstPro Shopping Centres. This generous and timely gift in support of The Hospital for Sick Children (Sick Kids) will help it maintain its position as Canada’s most research-intensive hospital and the largest centre dedicated to improving children’s health in the country.

SickKids to receive $23 million to create cardiac diagnostic and interventional unit

Wed, 13 Jul 2005 24:00:00 EDT

TORONTO - The Sick Kids Heart Centre will receive $23 million in funding from the Ministry of Health and Long-Term Care and from a committed group of donors to Sick Kids Foundation for the creation of the Cardiac Diagnostic and Interventional Unit (CDIU). The state-of-the-art unit will be used to diagnose and treat children with congenital heart disease. Minimally invasive procedures that will be performed in this unit can eliminate the need for open-heart surgery among cardiac patients.

SickKids researchers find new topical pain cream reduces pain and improves effectiveness of procedures in paediatric emergency department

Mon, 20 Jun 2005 24:00:00 EDT

TORONTO — Researchers at The Hospital for Sick Children (Sick Kids) have found that a new topical anaesthetic (liposomal lidocaine 4% cream, brand name Maxilene) effectively reduced pain for children having IVs inserted (cannulation) in the emergency department and improved procedural success rates. This research is reported in the June 21, 2005 issue of the Canadian Medical Association Journal (CMAJ).

Flat Stanley joins SickKids Research Institute as summer student

Thu, 16 Jun 2005 24:00:00 EDT

TORONTO — World traveler Flat Stanley is coming to the Sick Kids Research Institute to accept a position as a summer student in the lab of Dr. Stephen Scherer, a Sick Kids senior scientist, and an associate professor in the Department of Molecular and Medical Genetics at the University of Toronto .

Sixteen-year-old girl travels 3000 miles to SickKids to fulfill her greatest wish

Wed, 08 Jun 2005 24:00:00 EDT

Toronto, Ontario - A sixteen-year-old Make-A-Wish® recipient has traveled from London, England to Toronto, Canada, to fulfill her greatest wish, to meet the doctor who identified two genes for the illness she suffers from – Lafora disease, which is a severe form of adolescent-onset epilepsy.

SickKids study shows injury rates decreased at Toronto District School Board playgrounds due to safer equipment

Mon, 23 May 2005 24:00:00 EDT

TORONTO – Research at The Hospital for Sick Children (Sick Kids) shows that playground injuries among children were significantly reduced after the Toronto District School Board (TDSB) removed hazardous equipment from school playgrounds in 2000 and replaced it with safer equipment. This research is reported in the May 24, 2005 issue of the Canadian Medical Association Journal.

Cavalia to perform at The Hospital for Sick Children - Final Toronto Performances to benefit SickKids

Wed, 18 May 2005 24:00:00 EDT

Toronto (Ontario) - To thank the City of Toronto for a successful run, Cavalia has extended their performance for one last time. From Monday, May 23-29 $5 dollars from each ticket sold will be donated to support Sick Kids.

SickKids Foundation celebrates the 15th year of the Humanitarian Awards

Tue, 17 May 2005 24:00:00 EDT

TORONTO - Sick Kids Foundation is celebrating the 15th year of the Humanitarian Awards Program. A ceremony honouring nominees and recipients will be held on Wednesday May 18, 2005 in the Atrium Terrace from 5 to 7 p.m.

SickKids to launch telehealth link with Trinidad and Tobago

Fri, 13 May 2005 24:00:00 EDT

TORONTO - On Monday, May 16, SickKids expands its global reach with the launch of a formal telehealth partnership with Trinidad and Tobago. Using videoconferencing technology, SickKids will conduct real-time patient consultations with physicians in Trinidad and collaborate with health-care providers at the University of the West Indies in order to strengthen health-care services for children.

SickKids celebrates 500th cochlear implant during Speech and Hearing Awareness Month

Mon, 02 May 2005 24:00:00 EDT

TORONTO - To mark May as Speech and Hearing Awareness Month, the Cochlear Implant Program at The Hospital for Sick Children (Sick Kids) is celebrating on Tuesday, May 3, the gift of sound for patients who have received cochlear implants. Since the Sick Kids Cochlear Implant Program began in 1990, over 500 children have received implants at the hospital, establishing Sick Kids as the largest paediatric centre for cochlear implantation in North America.

Janet Rossant, PhD, named next Chief of Research at SickKids

Fri, 29 Apr 2005 24:00:00 EDT

TORONTO - Janet Rossant, PhD, has been appointed Chief of Research at The Hospital for Sick Children (Sick Kids), effective July 1, 2005. Dr. Rossant is an internationally recognized expert in developmental biology and one of Canada’s top stem cell researchers.

Is your child a picky eater? Learn helpful tips at SickKids’ lecture on May 16

Wed, 27 Apr 2005 24:00:00 EDT

TORONTO - Is your child a picky eater? Learn how to be more successful at the dinner table by attending the Sick Kids Specialty Food Shop’s lecture, The Feeding Relationship: Feeding Behaviour of Children by Ellyn Satter, a nationally recognized children’s nutrition specialist, at The Hospital for Sick Children (Sick Kids) on Monday May 16 from 7 to 9 p.m. The evening lecture will provide valuable and practical information for parents who dread mealtimes with finicky eaters in the household.

Meagan's Walk 2005 Launch, Tuesday April 26th, 1 p.m. at SickKids

Mon, 25 Apr 2005 24:00:00 EDT

TORONTO – A Japanese Crane Ceremony will launch Meagan's Walk 2005 on the front lawn of Sick Kids on April 26 th at 1pm .

Researchers determine two arthritis medications are safe and effective for children

Wed, 20 Apr 2005 24:00:00 EDT

TORONTO - An international team of researchers, led by Dr. Earl Silverman of The Hospital for Sick Children (Sick Kids), has found that two arthritis medications (methotrexate and leflunomide) commonly used in adults are safe and effective in children. This research is reported in the April 21, 2005 issue of The New England Journal of Medicine .

“Have a Heart for SickKids” Radiothon raises a world record-setting $3.2 million

Mon, 18 Apr 2005 24:00:00 EDT

TORONTO – The community showed its overwhelming support for Sick Kids by donating a record amount of $3,218,656 during the “Have a Heart for Sick Kids Radiothon” broadcast on sister stations Newstalk 1010 CFRB, 97.3 EZ Rock and Mix 99.9 of Standard Radio, presented by Foresters.

SickKids celebrates 15 years of heart transplantation

Wed, 13 Apr 2005 24:00:00 EDT

TORONTO (April 13, 2005) – Staff and patients are celebrating 15 years of clinical and research advances in heart transplantation at The Hospital for Sick Children (Sick Kids) on Thursday April 14. Since the Sick Kids Cardiac Transplant Program began in 1990, over 155 heart transplants have been performed at the hospital, establishing Sick Kids as one of the largest paediatric heart transplant centres in North America.

The Hospital for Sick Children hosts largest radiothon in Canada

Tue, 12 Apr 2005 24:00:00 EDT

Toronto - The Hospital for Sick Children hosts the largest radiothon in Canada on Wednesday, Thursday and Friday (April 13 to 15). Sick Kids and Standard Radio are asking radio listeners across the GTA to open their hearts and make a gift to the hospital. Presented by Foresters, the money raised through this three-day event will be used for the highest priority needs of the hospital.

Install window safety devices to protect children from injury, urges Safe Kids Canada

Wed, 06 Apr 2005 24:00:00 EDT

TORONTO - Before opening a window to enjoy the warm weather, Safe Kids Canada is urging parents to install safety devices to prevent young children from falling out of windows in their homes. In past summers, and as recent as an incident that took place in Toronto earlier this week, Canadian children have been seriously injured and have sometimes died falling from as low as a second-storey bedroom window. Many of these children were reported to be two to three years old, a common age for this kind of fall.

Conjoined twins to be discharged from SickKids

Mon, 04 Apr 2005 24:00:00 EDT

TORONTO – Conjoined twins, Tinashe and Tinotenda, will be discharged from hospital today, a month after Sick Kids surgeons separated the eight-month-old Zimbabwean boys. The twins will continue to receive treatment at Sick Kids as outpatients and will undergo additional procedures to correct their cleft lip and palate before returning home.

SickKids researchers determine most effective treatment for broken thighbones

Tue, 29 Mar 2005 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (Sick Kids) have conducted the world’s first multi-centre randomized clinical trial to evaluate the effectiveness of two standard treatments for treating fractures of the femur (thighbone) in children. This research is reported in the March 26, 2005 issue of the medical journal The Lancet.

Condition update for Inara Amarsi

Mon, 14 Mar 2005 24:00:00 EST

TORONTO - Five-year-old Inara Amarsi is awake and breathing on her own this morning. She continues to recover from chest and abdominal injuries in the Critical Care Unit at The Hospital for Sick Children (Sick Kids) and is listed in critical but stable condition.

Condition update for conjoined twins at SickKids

Sun, 13 Mar 2005 24:00:00 EST

TORONTO - Conjoined twins, Tinashe and Tinotenda, have been upgraded to serious condition, following separation surgery that took place six days ago at The Hospital for Sick Children (Sick Kids). Tinashe was moved out of the Critical Care Unit on Friday March 11 and Tinotenda, the smaller twin, was moved out of the Critical Care Unit on Sunday March 13.

Ontario hospitals launch Fetal Alert Network

Tue, 08 Mar 2005 24:00:00 EST

TORONTO — Hospitals in Hamilton, Kingston, London, Ottawa and Toronto today announced the creation of the Fetal Alert Network, a new provincial program designed to improve health care for pregnant women and their unborn babies with birth defects.

Condition update for Inara Amarsi

Tue, 08 Mar 2005 24:00:00 EST

TORONTO - Five-year-old Inara Amarsi remains in critical condition after being admitted to The Hospital for Sick Children’s Critical Care Unit on Sunday, March 6 with chest and abdominal injuries. She is not alert and has not undergone surgery. Inara remains unconscious and is breathing with the assistance of a ventilator.

Separation surgery underway for conjoined twins at SickKids

Mon, 07 Mar 2005 24:00:00 EST

TORONTO - Seven-month-old Zimbabwean conjoined twins, Tinashe and Tinotenda, were taken to the Sick Kids’ operating room at 7:30 a.m. on Monday March 7, to undergo separation surgery.

Condition update for conjoined twins at SickKids

Wed, 23 Feb 2005 24:00:00 EST

TORONTO - Seven-month-old Zimbabwean conjoined twins, Tinashe and Tinotenda, were taken to the Sick Kids’ operating room at 7:30 a.m. on Monday March 7, to undergo separation surgery.

Protect children from gas fireplace burns during the holiday season, urges Safe Kids Canada

Mon, 20 Dec 2004 24:00:00 EST

TORONTO – With cold winter temperatures fast approaching, Safe Kids Canada is reminding parents to protect young children from gas fireplaces, a dangerous source of heat that can cause severe burns.

SickKids Research Institute celebrates 50th birthday

Fri, 17 Dec 2004 24:00:00 EST

TORONTO - Pablum, the gene that causes cystic fibrosis, a brain tumour stem cell, the first biological proof that second-hand smoke can affect a fetus. What do all of these discoveries have in common? They were generated from The Hospital for Sick Children (SickKids) Research Institute. A celebration was held today to mark the 50 th anniversary of the establishment of the SickKids Research Institute.

Research Milestones at The Hospital for Sick Children

Fri, 17 Dec 2004 24:00:00 EST

Research at SickKids began in 1918 when the Nutritional Research Laboratory was set up to tackle the most pressing child health issue of that time – infant malnutrition. In 1930, Pablum, a precooked baby cereal, was invented in this laboratory, and royalties from the sale of Pablum were used to formally establish The Hospital for Sick Children Research Institute in 1954.

SickKids Research Institute 50th birthday party – Patients, staff and government officials to celebrate landmark event

Tue, 14 Dec 2004 24:00:00 EST

From the invention of Pablum to the discovery of the cystic fibrosis gene, The Hospital for Sick Children (SickKids) has been improving the health of children through its research for over 50 years. Representatives from the federal and provincial governments, as well as a former SickKids patient, will speak of the impact of research at SickKids. A science fair for patients and families will showcase current SickKids research in a fun and interactive way.

SickKids evaluates conjoined twins for separation surgery

Tue, 14 Dec 2004 24:00:00 EST

TORONTO - A team of physicians at The Hospital for Sick Children (SickKids) is currently assessing four-month-old conjoined twins for separation surgery. The twin boys, who are joined at the abdomen, arrived at SickKids on December 2 from Zimbabwe.

SickKids takes part in the Santa Claus Parade

Fri, 19 Nov 2004 24:00:00 EST

TORONTO (November 19, 2004) - On Sunday November 21, 2004, SickKids patients, families and staff will celebrate the 100th anniversary of the Santa Claus Parade on the hospital's front lawn. Commemorative toques, stickers and the 100th anniversary DVD will be for sale at the hospital, with a portion of the proceeds coming to SickKids Foundation. Three SickKids patients will also take part in the fun on top of Quest for the Gold, one of the official floats sponsored by RBC Financial Group.

The Hospital for Sick Children appoints new President and CEO

Thu, 18 Nov 2004 24:00:00 EST

TORONTO - The Board of Trustees of The Hospital for Sick Children (SickKids) announced today that Mary Jo Haddad has been appointed President and CEO. Ms Haddad has been Interim President and CEO at SickKids since July 2004.

SickKids researchers confirm that cancer stem cells initiate and grow brain tumours

Wed, 17 Nov 2004 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have confirmed that childhood and adult brain tumours originate from cancer stem cells and that these stem cells fuel and maintain tumour growth. This discovery has led to development of a mouse model for human brain tumours and opens the door for new therapeutic targets for the treatment of brain tumours. This research is reported in the November 18, 2004 issue of the scientific journal Nature.

Research team discovers possible genetic mechanism behind congenital heart defects

Wed, 03 Nov 2004 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) and Mount Sinai Hospital (MSH) have discovered a possible genetic mechanism behind congenital heart defects. This finding has implications for understanding how congenital heart defects occur, and may lead to genetic tests for certain defects, such as proteins that determine how genes are expressed. This also opens new insights into how general chromosome properties can relate to specific disease processes. This research is reported in the November 4, 2004 issue of the scientific journal Nature.

Research team discovers possible genetic mechanism behind congenital heart defects

Wed, 03 Nov 2004 24:00:00 EST

SickKids researchers unmask the potential of stem cells found in adult skin

Sun, 31 Oct 2004 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have shown that stem cells found in adult skin retain their embryonic capability of making many types of cells. This discovery affirms the potential that stem cells derived from this non-controversial source possess for the development of possible therapies for spinal cord injury and nervous system disorders. This research is reported in the November issue of the scientific journal Nature Cell Biology.

SickKids researchers explain why incompatible blood type heart transplants are possible in infants

Sun, 24 Oct 2004 24:00:00 EDT

TORONTO — Researchers at The Hospital for Sick Children (SickKids) have illustrated the mechanisms that allow for successful infant heart transplants with major blood type (ABO) incompatibility. This discovery opens the door for the development of a means to induce incompatible transplantation tolerance in older patients. This research is reported in the November 2004 issue of the scientific journal Nature Medicine (available online October 24, 2004).

Djamshid Popal to be discharged from The Hospital for Sick Children

Wed, 13 Oct 2004 24:00:00 EDT

TORONTO (October 13, 2004) – Nine year-old Djamshid Popal is being discharged from The Hospital for Sick Children (SickKids) today after recovering from heart valve surgery. Djamshid underwent surgery to replace two of his heart valves and repair a third on October 1, 2004. Djamshid will continue to be treated at SickKids as an outpatient and will have regular appointments with the cardiac team, where they will continue to monitor his heart function until he is able to go back to Afghanistan.

Maternal occupational exposure to solvents associated with poorer neurocognitive function in offspring

Mon, 04 Oct 2004 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have linked maternal exposure to organic solvents in the workplace with poorer performance on measures of neurocognitive function, language, and behaviour in offspring. This research is reported in the October 2004 issue of the journal Archives of Pediatrics and Adolescent Medicine.

Clown Nose Day at SickKids on Tuesday October 5

Mon, 04 Oct 2004 24:00:00 EDT

TORONTO - The Therapeutic Clown Program kicks off over 10 years of bringing healing play to young patients and their families at The Hospital for Sick Children (SickKids) with Clown Nose Day on Tuesday, October 5th, 2004. Clown Nose Day is a special day that gives the community an opportunity to have fun and support the Therapeutic Clown Program at SickKids.

Update on Djamshid Popal's condition

Fri, 01 Oct 2004 24:00:00 EDT

TORONTO - Djamshid Popal, a nine-year-old boy from Afghanistan, is listed in critical condition after undergoing heart valve surgery earlier today at The Hospital for Sick Children (SickKids).Djamshid went into the operating room today at 9:30 a.m. The operation lasted over six hours and went as expected. Two of Djamshid's four heart valves were replaced and one was repaired.

Djamshid is currently in the Cardiac Critical Care Unit on life support, as is common practice for children who undergo complex cardiac procedures. He will remain in the Cardiac Critical Care Unit for at least several days, where his heart and lung function will be closely monitored.

Djamshid was transferred to SickKids on August 4, 2004. Over the last two months, the cardiac team has been working on improving his heart function and helping him to gain weight in order to prepare him for surgery.

Interviews with the cardiac team will not be available.

Opening of Vivre Encore, a photo exhibit from France capturing daily life of children with cancer

Mon, 27 Sep 2004 24:00:00 EDT

Vivre Encore (To live on) is a photographic exhibition by renowned French photographer Jean-Louis Courtinat. In 1989, Courtinat began accompanying children with cancer as they were being treated in the paediatric ward of the Curie Institute. The result of this two-year project was the Vivre Encore photo exhibit and book.

Surprising discovery reveals gains or losses of large segments of DNA in healthy people

Sun, 01 Aug 2004 24:00:00 EDT

TORONTO - Scientists at The Hospital for Sick Children (SickKids), Brigham and Women’s Hospital (BWH) and Harvard Medical School (HMS) have made the unexpected discovery that significant differences can exist in the overall content of DNA and genes contained in individual genomes. These findings, which point to possible new explanations for individual uniqueness as well as why disease develops, are published in the September 2004 issue of the scientific journal Nature Genetics (available online August 1, 2004).

Alan Gayer announces resignation from SickKids

Mon, 19 Jul 2004 24:00:00 EDT

Toronto - The Hospital for Sick Children (SickKids) announced today that Alan J. Gayer has resigned as President and CEO of The Hospital for Sick Children to pursue other business interests. Mr. Gayer was appointed to his position two years ago and came to SickKids from Atlanta where he was a management consultant at McKinsey and Company and CEO of a leading children’s hospital.

SickKids Foundation announces gift from CanWest Global Communications Corp. establishing endowment for innovative health promotion at The Hospital for Sick Children

Thu, 24 Jun 2004 24:00:00 EDT

Toronto -The Hospital for Sick Children Foundation, also known as SickKids Foundation, announced a $500,000 gift from CanWest Global Communications Corp. establishing the CanWest Endowment for Innovative Health Promotion at The Hospital for Sick Children. The fund will generate income to support the AboutKidsHealth Family Resource Centre and Web site, www.AboutKidsHealth.ca, two SickKids initiatives developed to ensure families in Toronto, across Canada and around the world have access to advice from the world-renowned health care professionals at The Hospital for Sick Children.

SickKids launches new Website and resource centre, thanks to a $5 million gift from TD Securities

Mon, 21 Jun 2004 24:00:00 EDT

TORONTO – Starting tomorrow, parents looking for reliable information about their child’s health can turn to a new SickKids’ website, AboutKidsHealth.ca, and those with children in the hospital can visit the on-site resource centre, thanks to a $5 million gift from the project’s founding sponsor, TD Securities.

New study to explore risk factors for type 1 diabetes

Mon, 07 Jun 2004 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids) are recruiting patients for a new natural history study (Type 1 Diabetes TrialNet) that will probe the risk factors and biological events leading to type 1 diabetes. SickKids is the only Canadian centre participating in this National Institutes of Health study that involves 18 centres in the United States, Europe, and Australia.

Information line extended to Monday, May 31

Tue, 25 May 2004 24:00:00 EDT

The Hospital for Sick Children’s information line will be open until Monday May 31 at 8 p.m. for patient families concerned about the arrest of Scott Faichnie, a former nurse in the inpatient oncology unit on 8A. The information line has received over 100 calls and continues to support patient families through this difficult time. The information line will operate tonight, Tuesday May 25, until 10 p.m. and from Wednesday May 26 to Monday May 31 from 8 a.m. to 8 p.m. The phone number is 416-813-6500.

Statement from The Hospital for Sick Children regarding police investigation

Mon, 24 May 2004 24:00:00 EDT

The Hospital for Sick Children (SickKids) is cooperating with Toronto Police Services in an investigation of child pornography possession by a nurse in the inpatient oncology unit on 8A.

SickKids Foundation hosts 2004 Humanitarian Awards Ceremony

Tue, 18 May 2004 24:00:00 EDT

TORONTO – On Wednesday May 19 from 5 to 7 p.m., The Hospital for Sick Children Foundation will honour the staff and volunteer winners of its 2004 Humanitarian Awards Program during a special ceremony held in the hospital’s Atrium Terrace. The Humanitarian Awards Program has been offered by the Foundation for the past 13 years and celebrates staff, students and volunteers at the hospital who exemplify the qualities of compassion and humanitarianism. Every year, the Foundation hosts the awards ceremony to recognize both award winners and nominees.

Scientists shed light on how the immune system recognizes bacterial invasion

Wed, 12 May 2004 24:00:00 EDT

Scientists at The Hospital for Sick Children (Sick Kids) and the University of Toronto (U of T) have provided further insight on how the immune system recognizes and reacts to bacterial invasion. This research is reported in the May 4, 2004 issue of the journal Current Biology.

Toronto's one-of-a-kind Mother's Day event: A hug for SickKids to raise hope, awareness and funds to support paediatric brain tumour research Third Annual Meagan's Walk: Creating a Circle of Hope

Thu, 06 May 2004 24:00:00 EDT

WHAT: Held on Mother’s Day May 9, Meagan’s Walk is a 5 km walk kicking off at Ontario Place and ending at The Hospital for Sick Children with participants forming what is believed to be a world first – hundreds of participants embracing a building. This human hug sends a powerful message of hope to the children and families within. Funds raised through Meagan’s Walk support paediatric brain tumour research at SickKids.

Scientists uncover how the brain retrieves and stores older memories

Thu, 06 May 2004 24:00:00 EDT

TORONTO - Scientists at The Hospital for Sick Children (SickKids) and UCLA have pinpointed for the first time a region of the brain responsible for storing and retrieving distant memories. This research is reported in the May 7, 2004 issue of the journal Science.

Ontario study first population-wide look at childhood asthma in Canada 35% increase in the number of children with asthma

Tue, 04 May 2004 24:00:00 EDT

TORONTO – A new ICES report released for World Asthma Day (May 4) marks the first population-based study in Canada to look at the impact of asthma on children.

Researchers with ICES and The Hospital for Sick Children (SickKids) tracked Ontario children from 0 to 9 years of age between 1995 and 1999. Within this group they examined the incidence (new cases) and prevalence (existing cases) of childhood asthma, the death rate of children with asthma, differences in physician visits and hospitalizations among children with asthma and the general pediatric population, and seasonal and geographic variations of health care use by children with asthma.

Scientists correct cystic fibrosis defect in mice with turmeric extract

Thu, 22 Apr 2004 24:00:00 EDT

TORONTO - Scientists at The Hospital for Sick Children (SickKids) and Yale University School of Medicine have found that a compound in the spice turmeric corrects the cystic fibrosis defect in mice. This research is reported in the April 23, 2004 issue of the journal Science.

SickKids researchers look at viral triggers for multiple sclerosis in children

Tue, 20 Apr 2004 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have shown an association between paediatric multiple sclerosis (MS) and the Epstein-Barr virus (EBV), indicating that exposure to the virus at a certain time in childhood may be an important environmental trigger for the development of MS. This research is reported in the April 21, 2004 issue of JAMA (The Journal of the American Medical Association).

Researchers identify a new form of disease gene associated with Rett syndrome

Mon, 22 Mar 2004 24:00:00 EST

TORONTO - Scientists at The Hospital for Sick Children (SickKids), the Centre for Addiction and Mental Health (CAMH) and the University of Toronto (U of T) have identified an alternate form of the disease gene and protein for the neurodevelopmental condition Rett syndrome. This discovery is being incorporated into a new molecular test that will aid not only in the diagnosis of Rett syndrome, but also for other developmental disabilities. This research is reported in the April issue of the scientific journal Nature Genetics (available online March 21, 2004).

Put poison in its place: poison prevention week at SickKids, March 21-27

Fri, 19 Mar 2004 24:00:00 EST

TORONTO – Last year the Ontario Regional Poison Centre located at SickKids received over 44,000 calls about unintentional poisonings that occurred in both children and adults. Did you know that these accidents often happen because of exposure to items that are left lying around the house and not properly stored?

Researchers model embryo implantation and tumour metastasis in fruit flies

Thu, 11 Mar 2004 24:00:00 EST

TORONTO - A research team at The Hospital for Sick Children (SickKids) led by Dr. Howard Lipshitz has discovered that a protein previously linked to mammalian embryo implantation, as well as tumour metastasis, plays similar roles in fruit fly development. This research is reported in the featured article in the March 9, 2004 issue of the scientific journal Current Biology.

SickKids researcher awarded prestigious scientific prize for contributions to medical genomics

Thu, 26 Feb 2004 24:00:00 EST

TORONTO - Dr. Stephen Scherer of The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) was awarded today the 2003 Steacie Prize in the Natural Sciences for outstanding scientific research carried out in Canada. The prize is one of Canada's most prestigious science awards encompassing a wide range of disciplines including mathematics, engineering, chemistry, physics, and biology.

SickKids scientist to receive prestigious award

Wed, 25 Feb 2004 24:00:00 EST

TORONTO —Dr. Stephen Scherer of The Hospital for Sick Children (SickKids) and the University of Toronto will be awarded the 2003 Steacie Prize in the Natural Sciences for outstanding scientific research carried out in Canada. The prize is one of Canada’s most prestigious awards that recognizes a wide range of disciplines including mathematics, engineering, chemistry, physics, and biology.

When: Thursday, February 26, 2004
10 a.m.

SickKids offers tips for treating fever in children

Wed, 18 Feb 2004 24:00:00 EST

TORONTO – A child with a fever is one of the most common reasons for a trip to the Emergency Department. Parents are worried about their sick child and are unsure of what to do to lower their child's temperature. Parents' fears about fever can often lead to improper use of fever medications and in some cases, unnecessary trips to the doctor's office or local hospital. Emergency Department physicians at The Hospital for Sick Children (SickKids) want to help parents in these situations by offering tips on how to treat children with fever.

The Hospital for Sick Children breaks North American record

Fri, 13 Feb 2004 24:00:00 EST

"Have a Heart for SickKids" Radiothon raises close to $2.3 million in three days

SickKids researchers find obesity not linked to asthma in children

Thu, 12 Feb 2004 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have shown that there is no association between obesity and asthma in Canadian children age four to 11 years. Other risk factors for asthma in this age group were identified, including a maternal history of the disease. This research is reported in the February 2004 issue of The Journal of Pediatrics .

Have a Heart for SickKids Radiothon to broadcast live from the hospital atrium on February 11, 12 and 13

Tue, 10 Feb 2004 24:00:00 EST

Former SickKids Patient will attempt to break the Guinness World Record 24-hour treadmill distance run – a distance of three back-to-back marathons

Monday February 9 - More than 100 patients, staff and families will share stories about their experiences at The Hospital for Sick Children during the Have a Heart for SickKids Radiothon broadcast live from the Atrium of the hospital on February 11, 12, and 13 from 5 a.m. to 6 p.m.

SickKids announces achievements in children's heart program

Tue, 10 Feb 2004 24:00:00 EST

TORONTO - During Heart Month, The Hospital for Sick Children is celebrating a number of exciting developments in its cardiac program – one of the top three in the world, with unsurpassed survival rates.

Protect children from gas fireplaces and other burn hazards this winter, urges Safe Kids Canada

Fri, 09 Jan 2004 24:00:00 EST

TORONTO – With frigid temperatures taking place across most of the country this week, Safe Kids Canada is reminding parents to protect young children from dangerous sources of heat that can cause severe burns. In the past two weeks, four children were treated at The Hospital for Sick Children (SickKIds) for gas fireplace burns.

SickKids researchers determine the protein Gli2 is a key regulator controlling cell proliferation in the epidermis

Wed, 31 Dec 2003 24:00:00 EST

Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have determined that the protein Gli2 is a key regulator controlling cell proliferation in the epidermis (the outer layer of skin). This supports the group’s past findings that Gli2 can function abnormally as a cancer-inducing gene in the adult skin. The researchers have also determined that Gli2 plays a pivotal role in hair development. This research is reported in the January 15 issue of the scientific journal Genes & Development.

SickKids researchers develop vector for potential cystic fibrosis gene therapy

Tue, 23 Dec 2003 24:00:00 EST

TORONTO - A research team at The Hospital for Sick Children (SickKids) led by Dr. Jim Hu has developed a new gene therapy method that might be used for treating infections related to cystic fibrosis (CF). This research is reported in the December 23 issue of the scientific journal Proceedings of the National Academy of Sciences (PNAS).

How to keep your children safe during the Holidays: Advice from The Hospital for Sick Children

Thu, 11 Dec 2003 24:00:00 EST

TORONTO – The Emergency Room is the last place where parents and children want to be during the holidays. Unfortunately, with routines disrupted and adults distracted with holiday preparations, injuries in the home involving children are more likely to happen during this time of year, often requiring a trip to the local hospital. It only takes a few minutes for unsupervised children to get into mischief!

SickKids team deciphers kids’ terms for private body parts and functions

Tue, 09 Dec 2003 24:00:00 EST

Poombinga, bechos, boli bushushek and kalinirehem may look like gibberish to some people, but to children trying to explain themselves, they represent important things.

The Reading Room at SickKids celebrates eighth birthday with children's author Robert Munsch

Mon, 17 Nov 2003 24:00:00 EST

TORONTO – Patients at The Hospital for Sick Children will be joined by children's celebrities to mark the eighth anniversary of The Reading Room, the “storefront” for the literacy initiative supported by SickKids, The Toronto Public Library, and the Toronto District School Board.

Cujo donates $280,000 to SickKids to help in pain management

Thu, 30 Oct 2003 24:00:00 EST

The Hospital for Sick Children Foundation announced a $280,000 contribution from hockey star Curtis Joseph to a long-term pain management initiative at the hospital. On behalf of Cujo's Kids Charitable Foundation, Cujo has supported SickKids with close to $1 million since 1999.

SickKids launches an online teaching aid for clinicians

Thu, 09 Oct 2003 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) launched today a new online teaching aid which illustrates child physiology, to assist physicians when explaining to parents the cause of their child's illness. The site can be found at http://www.aboutkidshealth.ca/HowTheBodyWorks/default.aspx

SickKids partners with Air Canada Kids Horizons Air Transportation Program

Wed, 01 Oct 2003 24:00:00 EDT

Toronto - The Hospital for Sick Children announced today that more children from across the country have access to hospital services through the new Kids Horizons Air Transportation Program, through a new partnership with Air Canada.

SickKids researchers link maternal folic acid intake to decrease in deadly childhood cancer

Thu, 25 Sep 2003 24:00:00 EDT

TORONTO - A research team at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) has shown that folic acid food fortification has resulted in a 60 per cent reduction in the incidence of neuroblastoma, a deadly childhood cancer. This research is reported in the September 2003 issue of the journal Clinical Pharmacology & Therapeutics.

SickKids researchers identify cancer stem cell for brain tumours

Tue, 16 Sep 2003 24:00:00 EDT

TORONTO - A research team at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T), led by Dr. Peter Dirks, has identified for the first time a cancer stem cell in both malignant and benign brain tumours. This discovery may change how brain tumours are studied and how this deadly condition is treated in the future. This research is reported in the September 15, 2003 issue of the scientific journal Cancer Research.

The Hospital for Sick Children receives $2 million gift to establish Mira Godard Chair in Vision Research

Tue, 09 Sep 2003 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) announced today a $2-million gift from Mira Godard, establishing in perpetuity, the Mira Godard Chair in Vision Research. This is the first private donation to a vision research chair in Canada. The chair, held jointly with the University of Toronto, will provide vital resources to ensure that advances continue to be made in the research and treatment of eye disorders leading to blindness.

SickKids scientists identify gene for most severe form of adolescent epilepsy

Sun, 07 Sep 2003 24:00:00 EDT

TORONTO - An international research team led by Drs. Berge Minassian and Stephen Scherer of The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) has identified a gene responsible for the most severe form of teenage-onset epilepsy, known as Lafora disease (LD). The discovery is reported in the September issue of the scientific journal Nature Genetics.

The Hospital for Sick Children resumes all outpatient clinic appointments and elective surgery on Monday, August 18

Sun, 17 Aug 2003 24:00:00 EDT

TORONTO - Outpatient clinic appointments and elective
surgery at The Hospital for Sick Children (SickKids) will take place as scheduled
on Monday, August 18. SickKids' Emergency Department is open and inpatient care
continues to be provided as usual. For regular updates, parents should call
the SickKids Family Information Line at (416) 813-7700.
All hospital staff are asked to report for their regularly scheduled
shift. For staff updates, staff should call the Staff Information Line at
(416) 813-8999.

The Hospital for Sick Children cancels all out-patient clinic appointments and elective surgery for Friday, August 15

Thu, 14 Aug 2003 24:00:00 EDT

TORONTO - The Hospital for Sick Children has cancelled all out patient clinic appointments and elective surgery scheduled for Friday, August 15. SickKids Emergency Department remains open only for emergencies and in-patient care continues to be provided. If your child needs immediate assistance, please go to your local hospital. For regular updates, parents should call the SickKids Family Information Line at (416) 813-7700. Only hospital staff who are directly involved with patients should report to the hospital as usual. Other staff should call their managers before coming to the hospital. For staff updates, please call the Staff Information Line at (416) 813-8999.

Researchers identify a new molecular player in chronic pain

Wed, 13 Aug 2003 24:00:00 EDT

TORONTO (August 13, 2003) — Researchers at The Hospital for Sick Children (HSC) and the National Institute of Health Sciences in Japan have identified a molecule that causes neuropathic pain, a sharp and chronic pain associated with nerve injury and diseases affecting the nervous system. This finding may lead to a new and previously unknown way of treating chronic pain. This research is reported in the August 14 issue of the scientific journal Nature.

Heart transplant recipient Robbie Thompson goes home to Courtenay B.C.

Tue, 29 Jul 2003 24:00:00 EDT

Toronto - Five-year old Robbie Thompson, who underwent a second heart transplant at The Hospital for Sick Children in May, is returning home to Courtenay, B.C. with his family on Thursday July 31.

SickKids uses new cardiac therapy to treat children with abnormal heart rhythms

Thu, 10 Jul 2003 24:00:00 EDT

TORONTO - Physicians at The Hospital for Sick Children (SickKids) are using a new minimally invasive procedure to correct abnormally fast heartbeats (arrhythmia) in children who previously faced a high risk of heart block with other curative procedures.

West Nile virus in children

Thu, 12 Jun 2003 24:00:00 EDT

TORONTO - As the warmer weather approaches, many parents are concerned about their children catching West Nile virus while spending time outdoors this summer. According to The Hospital for Sick Children, recognizable illness in children due to West Nile virus is uncommon, suggesting that if an infection does occur, it seems to be much milder than in adults and may not cause any symptoms at all.

Executive Vice-President and Chief Operating Officer appointed at The Hospital for Sick Children

Wed, 11 Jun 2003 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) is pleased to announce the appointment of Mary Jo Haddad as Executive Vice-President and Chief Operating Officer, effective immediately. In this new position, she will oversee the day-to-day operations of the hospital.

SickKids researchers provide insight into the creation of malformed kidneys

Fri, 06 Jun 2003 24:00:00 EDT

Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have provided novel insights into the role that crucial development signaling pathways may play during the creation of malformed renal tissue elements. This research is reported in the June 15 issue of the scientific journal, Development.

SickKids researchers identify possible SARS diagnostic test

Sun, 01 Jun 2003 24:00:00 EDT

Researchers in Toronto, Vancouver and Winnipeg, including the laboratory of SickKids' Dr. Raymond Tellier, published a landmark study on severe acute respiratory syndrome (SARS) in Canada in The New England Journal of Medicine on Monday night. The full article was published online in early release.

"Night of Miracles" Broadcast Offers Viewers A Behind the Scenes Look at SickKids

Fri, 30 May 2003 24:00:00 EDT

Toronto - The Hospital for Sick Children invites you to watch a "Night of Miracles" - Making the Impossible Possible, a two-hour fundraising and awareness event which will be broadcast Saturday May 31, 7 p.m. to 9 p.m. on CFTO and MCTV in Northern Ontario.

Nurses from SickKids discharged on all criminal charges

Fri, 16 May 2003 24:00:00 EDT

Two nurses from The Hospital for Sick Children were discharged on all criminal charges arising from the death of Lisa Shore, which occurred at the hospital in 1998.

The Hospital for Sick Children Foundation hosts 2003 Humanitarian Awards ceremony

Wed, 14 May 2003 24:00:00 EDT

TORONTO - On Thursday May 15th from 5 to 7 p.m., The Hospital for Sick Children Foundation honours the staff and volunteer winners of its 2003 Humanitarian Awards Program during a special ceremony held at Ryerson's Oakham House. The Humanitarian Awards Program has been offered by the Foundation for the past 12 years and celebrates staff, students and volunteers at the hospital who exemplify the qualities of compassion and humanitarianism. Every year, the Foundation hosts the awards ceremony to recognize both award winners and nominees.

Wal-Mart Supports SickKids by Hosting "Wear Your Bear" Sales

Thu, 08 May 2003 24:00:00 EDT

Wal-Mart Canada is supporting The Hospital for Sick Children (SickKids) by selling merchandise from the hospital's Wear Your Bear clothing line. Four Wal-Mart stores across the Greater Toronto Area will participate in the promotion, May 10 - 11.

The Hospital for Sick Children cancels all elective surgery and outpatient clinic appointments until Monday, April 21

Fri, 11 Apr 2003 24:00:00 EDT

TORONTO - Due to the SARS outbreak in the Greater Toronto Area, The Hospital for Sick Children (SickKids) has cancelled all elective surgery and outpatient clinic appointments until Monday, April 21. Parents will be contacted if their child should come into the hospital for an urgent appointment. SickKids' Emergency Department remains open and inpatient care and emergency surgery continue to be provided. The hospital continues to allow only one parent or guardian at a time to visit a patient. For regular updates, parents should call the SickKids Family Information Line at (416) 813-7700.

DNA sequence of chromosome 7 decoded - Canadian-led project generates database with medical annotation available to the public

Thu, 10 Apr 2003 24:00:00 EDT

TORONTO - Scientists at The Hospital for Sick Children (SickKids) have compiled the complete DNA sequence of human chromosome 7 and decoded nearly all of the genes on this medically important portion of the human genome. The research, which involved an international collaboration of 90 scientists from 10 countries, publishes in the online version of the scientific journal Science on April 10, 2003.

The Hospital for Sick Children limits access during SARS outbreak

Mon, 31 Mar 2003 24:00:00 EST

TORONTO - The Hospital for Sick Children (SickKids) has cancelled all elective surgery and outpatient clinic appointments until Monday, April 14. Parents will be contacted if their child should come into the hospital for an urgent appointment. SickKids' Emergency Department remains open and inpatient care and emergency surgery continue to be provided. For regular updates, parents should call the SickKids Family Information Line at (416) 813-7700.

The Hospital for Sick Children cancels all elective surgery and outpatient clinic appointments for Monday, March 31 and Tuesday, April 1

Fri, 28 Mar 2003 24:00:00 EST

TORONTO - The Hospital for Sick Children (SickKids) has cancelled all elective surgery and outpatient clinic appointments scheduled for Monday, March 31 and Tuesday, April 1. Parents will be advised if they should come to the hospital. SickKid's Emergency department remains open and inpatient care and emergency surgery continue to be provided. For regular updates, parents should call the SickKids family information line at (416) 813-7700.

The Hospital for Sick Children only open for emergencies and inpatients

Thu, 27 Mar 2003 24:00:00 EST

TORONTO - As instructed by the Commissioner of Public Health, The Hospital for Sick Children (SickKids) is taking all necessary precautions to prevent transmission of SARS among staff and patients. To date, there have been no confirmed cases of SARS at SickKids. The hospital's Emergency Department remains open and inpatient care and emergency surgery continue to be provided. All non-urgent outpatient clinic appointments have been cancelled until further notice.

SickKids requests that anyone coming to the hospital follow these guidelines:

The Hospital for Sick Children continues to treat patients during SARS outbreak

Wed, 26 Mar 2003 24:00:00 EST

TORONTO - The Hospital for Sick Children would like to reassure families that inpatient care and outpatient appointments continue to take place as usual during the Severe Acute Respiratory Syndrome (SARS) outbreak in the Greater Toronto Area. The Emergency Department remains open and clinic appointments and surgeries are taking place as scheduled.

How to talk to your children about war: Advice from The Hospital for Sick Children

Thu, 20 Mar 2003 24:00:00 EST

TORONTO - With the intense media coverage that accompanies traumatic events such as war, it's almost impossible not to be aware of current events, regardless of age. Even very young children hear and see more than you think so it's important to question them about what they know and how they are feeling. Dr. Arlette Lefebvre, staff psychiatrist at The Hospital for Sick Children, suggests parents follow some general guidelines when talking to children about war, suited to their age and maturity level:

Poison Prevention Week at SickKids focuses on the danger of over-the-counter products and medications

Thu, 13 Mar 2003 24:00:00 EST

TORONTO - Many parents are unaware of the toxic effects of over-the-counter products and tend to leave containers lying around on counters or in cupboards that are easily accessible to a curious child. Contrary to popular belief, over-the-counter preparations can be just as harmful to children if not stored properly as prescription drugs, according to the Ontario Regional Poison Information Centre located at The Hospital for Sick Children.

The Hospital for Sick Children Foundation receives $1 million donation to fund Clinical Scholar in Paediatric Nerve Injury

Fri, 07 Mar 2003 24:00:00 EST

The Hospital for Sick Children Foundation today announced it has received a $1 million donation to fund a Clinical Scholar in Paediatric Nerve Injury. The donation represents the first gift to the precedent-setting SickKids Clinical Scholar Program designed to provide research funding to recruit and retain the world's best paediatric physicians and surgeons.

Exposure to antidepressants trazodone and nefazodone does not increase risk of birth defects

Sat, 01 Mar 2003 24:00:00 EST

A Motherisk study, published in the March issue of the scientific journal The Canadian Journal of Psychiatry, demonstrates that the use of trazodone and nefazodone does not increase the rates of major malformations, above the expected baseline rate of one to three per cent.

Radio trio hosts largest radiothon in North America and raises a record-breaking $1,772,120 for SickKids

Tue, 18 Feb 2003 24:00:00 EST

Toronto - Last week, The Hospital for Sick Children hosted the largest radiothon in North America from February 12th to 14th and announced a total of $1,744,120. However, the phones kept ringing and online donations continued to flood in over the weekend - and we're pleased to announce a NEW TOTAL of $1,772,120!

SickKids researchers identify genetic events leading to leukemia in Down syndrome children

Thu, 13 Feb 2003 24:00:00 EST

A research team at Sick Kids has identified important clues as to the genetic origins of acute megakaryoblastic leukemia in children with Down syndrome. The research team included Dr. Hans Hitzler, a staff physician in Haematology/Oncology and scientist-track investigator in Developmental Biology, Dr. Alvin Zipursky, former head of the Division of Haematology/Oncology, and Dr. Stephen Scherer, director of The Centre for Applied Genomics and a senior scientist in Genetics and Genomic Biology. This research was published online in the scientific journal Blood on February 13.

The Hospital for Sick Children hosts largest radiothon in Canada

Wed, 12 Feb 2003 24:00:00 EST

Toronto - The Hospital for Sick Children hosts the largest radiothon in Canada on Wednesday, Thursday and Friday (February 12 to 14). SickKids and Standard Radio are asking radio listeners across the GTA to open their hearts and make a gift to the hospital. Presented by Foresters, the money raised through this 3-day event will be used to buy important equipment for the hospital's Cardiology department.

Researchers identify gene for rare disease found primarily in Quebec

Tue, 04 Feb 2003 24:00:00 EST

An international team of researchers in Quebec, Boston, and at SickKids has identified the gene for Leigh syndrome French Canadian variant (LSFC), a genetic disease found primarily in the Saguenay-Lac St. Jean region in Quebec. This research is reported in the January 14 issue of the scientific journal Proceedings of the National Academy of Sciences.

EZ Rock's Mike and Christine's Get Reading Tour makes a stop at SickKids

Fri, 31 Jan 2003 24:00:00 EST

On Monday February 3 at 11 a.m., EZ Rock's Morning Show Hosts Mike Cooper and Christine Cardoso will put down their microphones and pick up some books as they read to some younger listeners at The Hospital for Sick Children's (SickKids) Reading Room.

The Hospital for Sick Children Foundation announces President's departure

Wed, 29 Jan 2003 24:00:00 EST

Toronto - The Board of Directors at The Hospital for Sick Children Foundation announces the departure of President Dianne Lister, LL.B, CFRE, effective June 30, 2003.

SickKids 'Bears' it all with Jeanne Beker

Mon, 27 Jan 2003 24:00:00 EST

TORONTO -- This Wednesday, January 29th at 10:30 a.m., The Hospital for Sick Children Foundation will launch an all-new Wear Your Bear 2003 merchandise line. This line, features an array of t-shirts, sweatshirts, golf shirts, tote bags, blankets and bears that raise funds for the hospital.

SickKids researchers create novel mouse model for leukemia

Tue, 21 Jan 2003 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have created a mouse model relevant to the study of lymphoma and acute lymphoblastic leukemia (ALL). The mouse model will allow for further research into the genetic causes of leukemia and help define genetic markers that will improve prediction of the risk for spread of leukemia into the brain. This research is reported in the January 21 issue of the scientific journal Cancer Cell.

SickKids researchers pinpoint link between diabetes and nervous system autoimmunity, resulting in new therapeutic and diagnostic targets

Mon, 20 Jan 2003 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have extended their earlier discovery of an unsuspected link between Type 1 diabetes and nervous system autoimmunity, such as that found in multiple sclerosis (MS). This research has identified new therapeutic targets for diabetes prevention, and a strategy for diagnostic tests for early detection of diabetes risk. The research is described in the February issue of the scientific journal Nature Medicine, available online on January 21, 2003.

Distinguished Spinal Cord Researcher receives Barbara Turnball Award - $50,000

Fri, 17 Jan 2003 24:00:00 EST

SickKids' David Kaplan leading way for Canada-based researchers

Dr. David Kaplan, one of Canada's outstanding neuroscientists based at Toronto's Hospital for Sick Children, has been named the 2002 recipient of the Barbara Turnbull Award.

Gas fireplaces cause serious burns, warns The Hospital for Sick Children

Thu, 16 Jan 2003 24:00:00 EST

TORONTO - During the Christmas holidays, the Burn Unit at The Hospital for Sick Children (SickKids) treated four children for gas fireplace burns. With 20 similar cases seen at the hospital in the last three years, staff at SickKids is concerned that contact burns from gas fireplaces are becoming a regular danger for children.

New Genome Research Centre in Hong Kong to Collaborate with Leading Canadian Genomics Centre

Mon, 13 Jan 2003 24:00:00 EST

The newly established University of Hong Kong Genome Research Centre will be collaborating with one of the world's leading centres for genomics research. A memorandum of understanding on collaborative initiatives in genomics research and development was signed today by representatives of The University of Hong Kong (HKU) and The Hospital for Sick Children (SickKids) of Toronto, Canada.

Researchers find chemotherapy is an effective alternative to bone marrow transplant in acute myeloid leukemia patients with good prognosis

Fri, 03 Jan 2003 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids), Mount Sinai Hospital, Princess Margaret Hospital (PMH), and Sunnybrook & Women's College Health Science Centre and the University of Toronto have found that chemotherapy is an effective alternative treatment to bone marrow transplant for adult patients with acute myeloid leukemia (AML) with good prognosis. The research will be reported in the January 15 issue of the scientific journal Cancer.

SickKids researchers identify gene for Shwachman-Diamond syndrome

Mon, 23 Dec 2002 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SICKKIDS) and the University of Toronto (U of T) have identified the gene that is altered in Shwachman-Diamond syndrome. The researchers studied 250 Shwachman-Diamond syndrome families from around the world and identified two major disease-causing mutations in a gene on chromosome 7. This research is reported in the January issue of the scientific journal Nature Genetics.

SickKids offers advice for families dealing with vomiting and diarrhea

Thu, 12 Dec 2002 24:00:00 EST

TORONTO - With the spread of vomiting and diarrhea in the community due to the Norwalkvirus, The Hospital for Sick Children is taking preventative measures in order to minimize risk to its patients. Many parents are unsure of where to go for medical advice and are bringing children to the Emergency Department with these symptoms, even if the child is only minimally unwell. The hospital is concerned that viruses associated with these symptoms will be passed on to those waiting to be treated for other illnesses. In order to prevent the spread among patients, staff in the Emergency Department are asking parents to follow these suggestions:

The Hospital for Sick Children Foundation launches

Thu, 21 Nov 2002 24:00:00 EST

TORONTO - Tomorrow, The Hospital for Sick Children Foundation will launch the first full-length direct response television program produced for national broadcast on behalf of a children's hospital.

November 20 is National Child Day and the launch of Show Kids You Care at The Hospital for Sick Children

Tue, 19 Nov 2002 24:00:00 EST

The Hospital for Sick Children is celebrating National Child Day on Wednesday, November 20, with the launch of Show Kids You Care (SKYC), a national campaign whose mission is to encourage adults to show that they care about children - and to act on that caring more often.

Joint Statement

Tue, 12 Nov 2002 24:00:00 EST

Dr. Nancy Olivieri, The Hospital for Sick Children and the University of Toronto are pleased to announce a resolution of all outstanding disputes arising from the clinical drug trials conducted by Dr. Olivieri at The Hospital for Sick Children which were terminated by Apotex in 1996. Dr. Olivieri wishes to thank the many individuals and organizations that supported her and in particular, her colleagues Dr. John Dick, Dr. Brenda Gallie, Dr. Helen Chan, Dr. Peter Durie, the University of Toronto Faculty Association (UTFA) and the Canadian Association of University Teachers (CAUT).

SickKids study shows bicycle helmet legislation leads to fewer bicycle-related head injuries in children

Mon, 04 Nov 2002 24:00:00 EST

TORONTO - Research at The Hospital for Sick Children (SICKKIDS) and the University of Toronto (U of T) has shown that provinces which have adopted mandatory bicycle helmet legislation have had a significant reduction in the number of bicycle-related head injuries in children. This research is reported in the November issue of the scientific journal Pediatrics.

New Drug Stops Stroke Damage to Brain Injection has potential to prevent brain damage in majority of human stroke patients

Thu, 24 Oct 2002 24:00:00 EDT

A team of researchers have developed a promising new drug that, when given to animals, immediately stops brain damage caused by stroke. Encouraged by this discovery, researchers at Toronto Western Hospital, The Hospital for Sick Children, University of Toronto and University of British Columbia are hopeful that with further investigation, this same drug will serve as an effective treatment for people who experience a stroke.

SickKids' award-winning play for patients celebrates its 10th year-run

Tue, 08 Oct 2002 24:00:00 EDT

Toronto - On Thursday, October 10, 2002, Tails, one of the longest running live musicals in Toronto celebrates its 10th anniversary with a special performance to salute its volunteer cast and crew.

Researchers identify candidate vaccine for Sjögren syndrome

Thu, 03 Oct 2002 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids), Toronto Western Hospital and the University of Toronto (U of T) have identified the protein that triggers the autoimmune response in Sjögren syndrome, a prevalent autoimmune disease, as well as a candidate vaccine to treat this condition. This research is reported in the October 5 issue of the scientific journal The Lancet.

High concentrations of toxic metals in Bangladesh's drinking water identified by team led by SickKids researcher

Mon, 23 Sep 2002 24:00:00 EDT

TORONTO - Leading an international team of volunteer scientists, Dr. Bibudhendra Sarkar , a senior scientist at The Hospital for Sick Children (SickKids), has identified high concentrations of toxic metals in Bangladesh's drinking water. This research has been published online in September in Articles Online First, for the scientific journal Environmental Health Perspectives.

Rectal acetaminophen an effective alternative treatment for fever in young children

Tue, 17 Sep 2002 24:00:00 EDT

TORONTO - Researchers in the Emergency Department at The Hospital for Sick Children (SickKids), have found that many parents do not know that rectal acetaminophen is available to treat children with fever. This research is reported in the September issue of the journal, Canadian Family Physician.

Kimberley Seldon, Home Depot and Pottery Barn transform three parent rooms in the Critical Care Unit

Mon, 26 Aug 2002 24:00:00 EDT

TORONTO - This Wednesday, August 28 at 2:00 p.m., The Hospital for Sick Children will unveil three newly decorated parent sleep rooms in the Critical Care Unit thanks to a generous donation from the Kimberley Seldon Media Group, Home Depot and the Pottery Barn.

Researchers pinpoint pain responses in newborns

Tue, 20 Aug 2002 24:00:00 EDT

TORONTO - Dr. Anna Taddio, a researcher at The Hospital for Sick Children (SickKids), has found that newborns who experience repeated painful procedures in the first days of life experience more intense pain and learn to anticipate it. This research is reported in the August 21 issue of The Journal of the American Medical Association.

The Hospital for Sick Children Foundation funds national training program

Thu, 01 Aug 2002 24:00:00 EDT

TORONTO - The Hospital for Sick Children Foundation's National Grants Program is contributing $1.8 million to establish a new national training program that will improve children's health by bridging the gap between scientific research and clinical care in Canada.

SickKids attracts new head of Cancer Research and leading stem cell researcher

Wed, 31 Jul 2002 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) has attracted two prominent scientists to its Research Institute - Dr. David Kaplan and Dr. Freda Miller. The husband and wife team recently arrived in Toronto from the Montreal Neurological Institute and McGill University.

Researchers identify gene for most common paediatric malignant brain tumour

Mon, 17 Jun 2002 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids), the University Health Network (UHN), and the University of Toronto (U of T) have identified a novel gene that when mutated results in medulloblastoma, the most common malignant brain tumour found in children. This research is reported in the July issue of the scientific journal Nature Genetics.

Minister McLellan launched largest pediatric clinical trial in Canada

Mon, 10 Jun 2002 24:00:00 EDT

Canada to provide $ 10 million to prevent the development of Type 1 Diabetes in its earliest beginnings

Donors across Canada contribute more than $6 million during Sick Kids Miracle Weekend

Mon, 03 Jun 2002 24:00:00 EDT

TORONTO - Thanks to the generous support of donors from across Canada, The Hospital for Sick Children Foundation raised a record $6,002,341 during the SickKids Miracle Weekend, its annual television fundraiser. It's the highest amount ever raised in the hospital's 18 years of TV fundraising. Last year's program raised $5.6 million.

Sick Kids Miracle Weekend brings stories of hope to CTV

Thu, 23 May 2002 24:00:00 EDT

TORONTO - Eleven incredible stories of courage, commitment and hope will be highlighted during the SickKids Miracle Weekend, The Hospital for Sick Children's annual 24-hour television program to be broadcast Saturday, June 1 and Sunday, June 2 on CTV affiliates CFTO and MCTV.

The Hospital for Sick Children Foundation hosts Humanitarian Awards ceremony

Thu, 09 May 2002 24:00:00 EDT

TORONTO -- This Tuesday, May 14 from 5 to 7 p.m., The Hospital for Sick Children Foundation will honour the staff and volunteer winners of its 2002 Humanitarian Awards Program during a special ceremony at SickKids.

Cystic Fibrosis Foundation explores new research avenue with proteomics at The Hospital for Sick Children, Toronto

Mon, 06 May 2002 24:00:00 EDT

Cystic Fibrosis Foundation Therapeutics, Inc. (CFFTI), the drug discovery and development arm of the Cystic Fibrosis Foundation today announced that it has awarded $1,115,000 US to scientists at The Hospital for Sick Children and Affinium™ Pharmaceuticals, in Toronto, to harness the power of proteomics in the search for new cystic fibrosis (CF) therapies.

Researchers find that pregnant women with untreated epilepsy are not at an increased risk of having an infant born with a birth defect

Mon, 06 May 2002 24:00:00 EDT

Researchers at Toronto's Hospital for Sick Children (SickKids) have concluded that there is no evidence of an increased chance of major birth defects occurring in the offspring of women with epilepsy who do not take anti-epileptic medications during pregnancy.

Exposure during pregnancy to the antidepressant drug paroxetine is associated with a high rate of neonatal complications

Mon, 06 May 2002 24:00:00 EDT

Researchers at Toronto's Hospital for Sick Children (SickKids) have concluded that exposure during pregnancy to paroxetine (Paxil), a drug commonly used to treat depression, panic, and obsessive-compulsive disorders, is associated with a high rate of neonatal complications when used near term.

Bravery Beads launched at The Hospital for Sick Children

Mon, 29 Apr 2002 24:00:00 EDT

TORONTO -- This Wednesday, May 1 at 10 a.m., a new initiative will be launched at The Hospital for Sick Children to recognize and record the challenging personal journey of children undergoing difficult treatments for cancer, blood disorders and related diseases.

Organ donor families honoured at The Hospital for Sick Children

Tue, 23 Apr 2002 24:00:00 EDT

The Hospital for Sick Children will host a special organ donation recognition ceremony to honour the children and families who have given the gift of life through organ and tissue donation, and to raise awareness of the critical need for more. The Hon. Tony Clement, Minister of Health and Long Term Care will attend the event to recognize 37 donor families and living donors who will be presented 'Gift of Life' medals by transplant recipients.
Speakers will include: The Hon. Tony Clement, Minister of Health and Long Term Care, Paul Henderson, hockey legend and Dr. Sam Shemie, Director of the Organ Donation Program, SickKids. Sharon, Lois & Bram will provide musical entertainment. WHEN: Wednesday, April 24, 2002 at 11:00 a.m.
WHERE: The Hospital for Sick Children Garden Terrace 170 Elizabeth Street
SickKids is Canada's major paediatric transplant centre, performing more than 60 organ transplants each year. Since its first transplant operation in 1969, SickKids has performed more than 900 transplants of the kidney, liver, heart and lungs. The hospital is a leader in advocating for organ donation and has instituted a model to promote organ donation at SickKids and beyond.

TB investigation at Sick Kids continues

Tue, 23 Apr 2002 24:00:00 EDT

An investigation into the possible exposure of TB in the Neonatal Intensive Care Unit (NICU) at The Hospital for Sick Children (SickKids) has shown no new cases of TB in the babies that have been tested to date.

Scientists identify DNA flanking region as trigger for genetic instability in family of neurological disorders

Sun, 21 Apr 2002 24:00:00 EDT

TORONTO - Scientists at The Hospital for Sick Children and the University of Toronto have shown that the DNA flanking region in a family of neurological disorders is triggering the genetic mutation that underlies these diseases. This research is reported in the May issue of the scientific journal Nature Genetics.

Tuberculosis cases identified at The Hospital for Sick Children

Fri, 19 Apr 2002 24:00:00 EDT

The Hospital for Sick Children (SickKids), in conjunction with the Chief Medical Officer of Health for the Province of Ontario, is investigating the possibility of an exposure to tuberculosis (TB) at the hospital's Neonatal Intensive Care Unit (NICU) that may have occurred during a seven-week period from December 15, 2001 to February 5, 2002. Two cases of TB have been identified in the NICU.

Dr. Victor Blanchette appointed chair holder of the Women's Auxiliary Millenium Chair in Haematology/Oncology at The Hospital for Sick Children

Fri, 22 Feb 2002 24:00:00 EST

The Hospital for Sick Children is pleased to announce the appointment of Dr. Victor Blanchette as chair holder of The Women's Auxiliary Millenium Chair in Haematology/Oncology.

Biochemical tests show relationship between environmental tobacco smoke and the risk of SIDS

Thu, 21 Feb 2002 24:00:00 EST

Researchers at The Hospital for Sick Children, the University of Toronto and the University of Maryland have shown the relationship between environmental tobacco smoke and the risk of sudden infant death syndrome (SIDS) using biochemical tests. Higher concentrations of nicotine were found in the lungs of SIDS victims compared with infants whose deaths were not attributed to SIDS, regardless of whether smoking was reported by the parents or not. This research is reported in the February issue of The Journal of Pediatrics.

Researchers uncover potential chemotherapy for common bone tumour

Wed, 20 Feb 2002 24:00:00 EST

Researchers at The Hospital for Sick Children, Mount Sinai Hospital and the University of Toronto have identified the genetic pathway that causes enchondromas, a common form of bone tumour. This finding may lead to a potential chemotherapy for these tumours, where one currently does not exist. This research is reported in the March issue of the scientific journal Nature Genetics.

Have a Heart for SickKids broadcast raises more than $1 million and breaks Canadian record

Thu, 14 Feb 2002 24:00:00 EST

The 12th annual CFRB Have a Heart for SickKids broadcast, presented by The Independent Order of Foresters, has raised a record $1,002,153.10 for The Hospital for Sick Children. It's the largest amount ever raised by a Canadian radiothon, and is almost double the amount raised during last year's broadcast. The unprecedented total includes $75,000 from Foresters and $185,000 raised through the Change Bandit program at Loblaws, sponsored by President's Choice Financial. All proceeds will be used to buy much-needed equipment, including an MRI machine, for the hospital's cardiology department.

Researchers find gene involved in pain relief

Thu, 10 Jan 2002 24:00:00 EST

Researchers at the University of Toronto, The Hospital for Sick Children and the Amgen Institute have discovered a genetic mechanism involved in pain modulation that could lead to an entirely new approach to pain control. The results of their research are published in the Jan. 11 issue of the journal Cell.

SickKids research chief available to comment on federal budget

Mon, 10 Dec 2001 24:00:00 EST

Manuel Buchwald, OC, PhD, FRSC, Chief of Research at The Hospital for Sick Children, will be available for media interviews in response to the federal budget being released this afternoon.

SickKids welcomes research funding in budget

Mon, 10 Dec 2001 24:00:00 EST

Today's budget announcement that the federal government will increase health research funding and plans to expand the funding formula to recognize the indirect costs of research is a welcome boost to the Canadian health research community.

Researchers find a cluster of risk factors in pregnant Ecstasy users

Thu, 06 Dec 2001 24:00:00 EST

Researchers at The Hospital for Sick Children have found that pregnant women who use the drug Ecstasy have a clustering of risk factors that may compromise pregnancy and the unborn fetus.

SickKids appoints new President and CEO, effective April 1, 2002

Tue, 27 Nov 2001 24:00:00 EST

TORONTO, Ontario - Alexander R. Aird, Chairman of the Board of Trustees, The Hospital for Sick Children (SickKids), announces that Alan J. Gayer has been appointed President and Chief Executive Officer of SickKids effective April 1, 2002.

Heinz supports research into innovative new food supplement

Tue, 06 Nov 2001 24:00:00 EST

On Thursday, November 8 at The Hospital for Sick Children, The H.J. Heinz Company will announce significant financial support into the research of an innovative supplement that may reduce childhood anemia around the world.

Four-year old boy returns to Vietnam after successful treatment at SickKids for rare cancer of the eye

Wed, 31 Oct 2001 24:00:00 EST

Four-year old Khuong To, (affectionately known as "Baby To") came to The Hospital for Sick Children three years ago for treatment for advanced retinoblastoma --a rare cancer of the eye that causes blindness or death. On November 1, SickKids staff will say goodbye to Khuong To, who will return home to Vietnam next week.

Superstar Jackie Chan visits children at SickKids

Wed, 31 Oct 2001 24:00:00 EST

Martial arts film star Jackie Chan takes time from his busy filming schedule in Toronto to visit patients at The Hospital for Sick Children. Jackie Chan, a humanitarian who believes in giving back to the community, will spend time signing autographs and meeting patients at SickKids.

Scientists identify new genetic mechanism for disease

Mon, 29 Oct 2001 24:00:00 EST

Scientists at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have identified a previously unknown genetic basis for Williams syndrome. This finding also points to a new genetic mechanism for disease. This research is published in the cover article of the November issue of the scientific journal Nature Genetics.

The Hospital for Sick Children Foundation hosts paediatric home care forum

Thu, 18 Oct 2001 24:00:00 EDT

On Monday, October 22 and Tuesday, October 23, dozens of paediatric home care practitioners and researchers will gather for the second Child and Youth Home Care Forum, funded by The Hospital for Sick Children Foundation. The forum will be held at the Ontario Heritage Centre, 8 Adelaide St. E., in downtown Toronto.

SickKids asks federal government to maintain health research funding and recognize full costs of research

Tue, 16 Oct 2001 24:00:00 EDT

At the hearings of the House of Commons' Standing Committee on Finance today, The Hospital for Sick Children (SickKids) and The Hospital for Sick Children Foundation called on the federal government to maintain its commitment to health research funding and to expand the funding formula to recognize the full costs of research.

Exposure during pregnancy to the antidepressant drug venlafaxine does not increase the risk of birth defects

Wed, 10 Oct 2001 24:00:00 EDT

Researchers at The Hospital for Sick Children have concluded that exposure during pregnancy to venlafaxine, a relatively new and increasingly popular antidepressant drug, does not increase the chances of major birth defects.

Researchers create mouse model for human congenital heart disease

Thu, 20 Sep 2001 24:00:00 EDT

Researchers at The Hospital for Sick Children, Harvard Medical School and the Clinical Research Institute of Montreal have created the first mouse model relevant to the study of congenital heart disease in humans. The mouse model will allow for further research into the genetic causes of congenital heart disease, as well as providing a living model to test possible new treatments. This research is reported in the cover article of the September 21 issue of the scientific journal Cell.

Researchers link exposure to organic solvents during pregnancy to an increased risk of visual impairment in exposed children

Mon, 10 Sep 2001 24:00:00 EDT

Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto have linked exposure to organic solvents during pregnancy to an increased risk of visual defects in exposed offspring. Organic solvents are chemicals found in paints, adhesives, lacquers and cleaning agents, and are used in industries such as dry cleaning, printing, and plastics manufacturing. This research was published in the September issue of the journal Teratology.

SickKids scientists identify mechanism for white blood cell development

Thu, 23 Aug 2001 24:00:00 EDT

Scientists at The Hospital for Sick Children (SickKids) have identified an important mechanism that determines how white blood cells develop. This discovery, reported in the August 22 issue of the scientific journal Immunity, provides important information on how the immune system develops, both in normal and disease states.

Province announces $48-million agreement for quality patient care and related teaching and research

Mon, 20 Aug 2001 24:00:00 EDT

TORONTO, Aug. 20 /CNW/ - Associate Minister of Health and Long-Term Care, Helen Johns, today announced a $48 million agreement to ensure continued access to quality patient care and support related teaching and research activities at the Hospital for Sick Children in Toronto.

SickKids study leads to better understanding of stroke in children

Wed, 08 Aug 2001 24:00:00 EDT

A team of Canadian researchers led by scientists at The Hospital for Sick Children (SickKids) has completed the first large-scale, multi-centre study to determine the incidence and characteristics of sinovenous thrombosis, a type of stroke that occurs in children due to blood clots blocking the brain's venous flow. The research is published in the August 9 issue of The New England Journal of Medicine.

SickKids researchers link activity of cancer-causing genes to normal wound healing process using a fruit fly model

Mon, 23 Jul 2001 24:00:00 EDT

Scientists at The Hospital for Sick Children (SickKids) have linked known cancer-causing genes to normal developmental processes as well as wound healing using a fruit fly model. This research in reported in the cover article of the July 24 issue of the scientific journal Current Biology.

SickKids researchers identify function of protein for a form of Fanconi Anemia

Wed, 04 Jul 2001 24:00:00 EDT

Scientists at The Hospital for Sick Children (SickKids) and the University of Toronto have discovered the function of the protein for a form of Fanconi Anemia. This discovery provides a clue for the development of treatments for this disease and explains a cellular mechanism that was not previously known. This research is published in the July issue of the scientific journal Nature Medicine.

Researchers identify gene for rare form of leukemia that strikes infants

Fri, 29 Jun 2001 24:00:00 EDT

A team of researchers at Toronto’s Hospital for Sick Children (SickKids) and St. Jude Children’s Research Hospital in Tennessee has identified the genetic cause of rare form of leukemia that strikes infants, as well as the corresponding diagnostic test. This research is reported in the July issue of the scientific journal Nature Genetics.

SickKids researchers uncover protein defect that causes a milder form of cystic fibrosis

Tue, 26 Jun 2001 24:00:00 EDT

Scientists at The Hospital for Sick Children have uncovered a protein defect that underlies a milder form of cystic fibrosis. This research is reported in the July issue of the scientific journal Nature Structural Biology.

Donors contribute a record $5.6 million during SickKids Miracle Weekend

Sun, 03 Jun 2001 24:00:00 EDT

Thanks to the generous, ongoing support of organizations and individuals across Canada, The Hospital for Sick Children Foundation raised a record $5,615,606 during its 17^th annual TV fundraiser. It’s the highest amount ever raised in the history of the broadcast, bringing the 17-year total to more than $51.6 million.

Eleven-month old cord-blood transplant recipient, Jesse Farquharson, leaves SickKids

Tue, 22 May 2001 24:00:00 EDT

Eleven-month old Jesse Farquharson, the first patient at The Hospital for Sick Children to receive a bone marrow transplant on April 19, 2001, using his own cord-blood stem cells that were stored at the time of his birth, has made a speedy recovery and was discharged from the hospital on Friday, May 19.

SickKids scientists discover ‘off-switch’ for cancerous cell growth

Tue, 01 May 2001 24:00:00 EDT

Scientists at The Hospital for Sick Children (SickKids) have identified an ‘off-switch’ for cancerous cell growth, opening the door for new targets in the development of anti-cancer drugs. This research is reported in the May 1 issue of the European Molecular Biology Organization Journal (EMBO).

The Hospital for Sick Children advances auditory development

Mon, 23 Apr 2001 24:00:00 EDT

May is Speech and Hearing Month

Update on Samiha Hoque review of care

Wed, 04 Apr 2001 24:00:00 EDT

The Hospital for Sick Children has completed a preliminary review of the care provided to Samiha Hoque, an 11-year-old girl who died in the hospital at 7:10 p.m. on Monday, April 2, 2001.

Medical Information Line at SickKids to close April 1

Mon, 26 Mar 2001 24:00:00 EST

With the advent of the Ontario government’s new Telehealth telephone service, The Hospital for Sick Children (SickKids) will close its Medical Information Centre on April 1, 2001 after 23 years of operation.

Researchers determine that multiple sclerosis and diabetes are closely linked diseases

Tue, 20 Mar 2001 24:00:00 EST

A team of researchers led by Hospital for Sick Children (SickKids) senior scientist Michael Dosch has determined that multiple sclerosis and type I (juvenile) diabetes mellitus are far more closely linked than previously thought, including the role cow milk protein plays as a risk factor in the development of both diseases for people who are genetically susceptible. This research is published in recent issues of The Journal of Immunology (April 1 and February 15, 2001).

SickKids study offers new hope for infants awaiting heart transplantation

Wed, 14 Mar 2001 24:00:00 EST

Researchers at The Hospital for Sick Children have discovered that infant heart transplants can be performed safely and successfully despite major blood type incompatibility between the donor and recipient. The study, published in the March 15 issue of The New England Journal of Medicine, challenges current clinical thinking about the human immune system and offers new hope for infants waiting for heart transplantation.

Researchers Take a Close Look at Health Services for Children

Tue, 06 Mar 2001 24:00:00 EST

Two studies looking at the inpatient and outpatient services provided to Ontario’s children are being released today by the Institute for Clinical Evaluative Sciences (ICES). The authors are researchers associated with ICES and The Hospital for Sick Children in Toronto. These reports are part of the ICES Atlas Report series that profile the health and health care services available to Ontarians.

The Hospital for Sick Children hosts ceremony to honour organ donor families

Fri, 23 Feb 2001 24:00:00 EST

Tuesday at 11 a.m., The Hospital for Sick Children will host a special organ donation recognition ceremony to honour the children and families who have given the gift of life through organ and tissue donation, and to raise awareness of the critical need for more.

Human Genome Sequencing

Fri, 16 Feb 2001 24:00:00 EST

Scientists around the world celebrate in Washington, DC today on the occasion of the publication of two historical papers on the Human Genome Project in the scientific journals Nature and Science. The papers summarize the monumental work of the International Human Genome Sequencing Consortium and that of Celera Genomics Corporation.

11th Annual Have a Heart for SickKids Radiothon Raises a Record $560,866.15

Thu, 15 Feb 2001 24:00:00 EST

Thanks to the generosity and commitment of thousands of CFRB listeners, the 11th Annual Have a Heart for Sick Kids radiothon has raised a record $560,866.15 for The Hospital for Sick Children -- the largest amount ever raised by a Canadian radiothon. The unprecedented total was raised during a three-day campaign which included 32 hours of live broadcasting. The largest corporate donation was a $50,000 contribution from President’s Choice Finanacial Services, and the largest individual donation was made by a grandfather of 10 who is contributing $1010 a month in his grandchildren’s honour. Proceeds from this year’s radiothon will be used to buy equipment for the hospital's cardiology department.

Exposure during pregnancy to DM, a main ingredient in cough syrup, does not increase the risk of birth defects

Thu, 15 Feb 2001 24:00:00 EST

Researchers at The Hospital for Sick Children have concluded that exposure during pregnancy to Dextromethorphan (DM), an active ingredient present in a variety of cough and cold remedies does not increase the chances of major birth defects. Recently, data generated from a study in chick embryos suggested that pregnant women should not use this drug because of the risk of birth defects.

Alan L. Goldbloom, MD, FRCPC appointed Executive Vice-President and Chief Operating Officer

Wed, 07 Feb 2001 24:00:00 EST

Alan L. Goldbloom, MD, has been appointed Executive Vice-President and Chief Operating Officer at The Hospital for Sick Children. Dr. Goldbloom will have overall day-to-day operational responsibility for the hospital.

Benefits outweigh risks for antidepressant use during pregnancy and breastfeeding

Fri, 02 Feb 2001 24:00:00 EST

Researchers in the Motherisk Program at The Hospital for Sick Children have found that the benefits outweigh any potential risks for pregnant or breastfeeding women taking medications for depression. This study was published in the recent issue of the Journal of Psychiatry and Neuroscience.

Inherited prostate cancer gene identified

Tue, 30 Jan 2001 24:00:00 EST

An international team of scientists has identified a gene that leads to inherited prostate cancer. The study, conducted by 43 scientists in the United States and Canada, is published in the February issue of the scientific journal Nature Genetics.

SickKids CEO announces his departure

Fri, 26 Jan 2001 24:00:00 EST

Toronto, January 26, 2001-The Board of Trustees at The Hospital for Sick Children has learned that President & CEO, Michael Strofolino will leave the hospital when his contracts ends in July 2002.

SickKids’ researchers discover different types of stem cells

Thu, 28 Dec 2000 24:00:00 EST

A team of researchers at The Hospital for Sick Children (SickKids), led by geneticist John Dick, has discovered that distinct types of stem cells exist within the blood system that differ in the length of time that they can sustain a stem cell transplant. They have been termed short-term repopulating and long-term repopulating stem cells. The discovery of distinct types of stem cells with different functions has important clinical implications. This research is reported in the January issue of the scientific journal Nature Immunology.

The Hospital for Sick Children receives $5 million gift to help fight childhood cancer

Thu, 21 Dec 2000 24:00:00 EST

A $5 million gift received today from The Roy C. Hill Charitable Foundation will help transform cancer research, training, and care for seriously ill patients at The Hospital for Sick Children (SickKids) and around the world.

The Hospital for Sick Children launches direct response television ads

Wed, 13 Dec 2000 24:00:00 EST

Starting December 18, The Hospital for Sick Children Foundation will be testing direct response television as a new fundraising initiative. The Foundation will be launching two two-minute television commercials encouraging potential donors to join the monthly giving program called The Miracle Club.

SickKids scientist appointed inaugural scientific director of CIHR’s Institute of Genetics

Thu, 07 Dec 2000 24:00:00 EST

Dr. Roderick McInnes, a Hospital for Sick Children (SickKids) senior scientist, has been appointment the inaugural scientific director of the Genetics Institute of the Canadian Institutes of Health Research (CIHR).

The Hospital for Sick Children established Canada's first national registry to track Multiple Sclerosis in children

Mon, 04 Dec 2000 24:00:00 EST

North America’s first paediatric MS clinic continues commitment to understanding
disease

SickKids signs first Canadian deal with Celera Genomics to advance genetics research

Tue, 21 Nov 2000 24:00:00 EST

The Hospital for Sick Children (SickKids) and Celera Genomics announced today that SickKids is the first Canadian institution to gain access to Celera’s genomic database. Celera made headlines earlier this year when it announced the first assembly DNA sequence of the human genome.

Hospital completes investigation into unexpected death of a 17-year-old girl

Thu, 09 Nov 2000 24:00:00 EST

The Hospital for Sick Children (SickKids) has completed an internal investigation into the death a 17 year-old patient who died following an elective surgical procedure on September 14, 2000.

Inhaled steroids safe and effective for children with asthma

Thu, 12 Oct 2000 24:00:00 EDT

Inhaled corticosteroids are safe and effective for the long-term treatment of children with mild to moderate asthma, according the Childhood Asthma Management Program (CAMP), a five-year, eight-centre study funded by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health in the United States. The study appears in the October 12, 2000 New England Journal of Medicine.

Innovative fund raising program targets Canadian companies seeking public market financing

Tue, 10 Oct 2000 24:00:00 EDT

The Hospital for Sick Children Foundation is launching an innovative fund raising program aimed at Canadian companies at the time of their initial public offering (IPO).

Frequently Asked Questions: The Options Campaign

Tue, 10 Oct 2000 24:00:00 EDT

1. What is The Options Campaign?

Partnership between The Hospital for Sick Children and the Canadian Cystic Fibrosis Foundation has led to major advancements in CF research

Tue, 12 Sep 2000 24:00:00 EDT

Forty years ago, a group of parents who had children with cystic fibrosis (CF) got together at The Hospital for Sick Children (SickKids) to discuss forming a foundation dedicated to improving treatments for this incurable disease. Since the Canadian Cystic Fibrosis Foundation (CCFF) was established by this group of parents in 1960, the median age of survival of affected individuals has increased from age four to more than 30 years – thanks to advances in treatment made possible through research.

The Reading Room at The Hospital for Sick Children celebrates its 5th anniversary

Mon, 11 Sep 2000 24:00:00 EDT

Patients and staff at The Hospital for Sick Children (SickKids) were joined by children's celebrities today to mark the fifth anniversary of The Reading Room, the "storefront" for the literacy initiative supported by SickKids, The Toronto Public Library, and the Toronto District School Board.

Gene discovery leads to diagnostic test for kidney disease

Wed, 30 Aug 2000 24:00:00 EDT

An international team of researchers, including scientists from The Hospital for Sick Children (SickKids) and the University of Toronto, have identified the gene responsible for a form of kidney disease, and the corresponding diagnostic test. This research is published in the September issue of the scientific journal Nature Genetics.

Baby at Sick Kids is youngest patient to receive Cochlear implant

Fri, 21 Jul 2000 24:00:00 EDT

A seven-month old baby is the youngest patient in North America to receive a Cochlear implant today at The Hospital for Sick Children (SickKids).

Santa Moose comes to SickKids

Mon, 17 Jul 2000 24:00:00 EDT

Santa Moose, an extension of the Moose in the City exhibit, will be unveiled at The Hospital for Sick Children (SickKids) on Tuesday, July 18, at 1:00 p.m. at the University St. entrance of The Hospital for Sick Children.

New scientific theory may change how treatments for inherited neurodegenerative diseases are developed

Wed, 12 Jul 2000 24:00:00 EDT

A team of researchers led by The Hospital for Sick Children (SickKids) and the University of Toronto has shown that what scientists thought caused neurons to die in inherited neurodegenerative diseases such as Huntington’s and Parkinson’s is in fact not the case. The scientists propose a new model for neuronal cell death in the July 13 issue of the journal Nature, which will lead to new research into treatments for these types of diseases.

SickKids’ Women’s Auxiliary announces funding of second research chair in five years

Mon, 05 Jun 2000 24:00:00 EDT

In a ceremony with the Lieutenant Governor of Ontario, the Honourable Hilary M. Weston, The Hospital for Sick Children’s Women’s Auxiliary (WA) announced today a pledge to fund a second chair for the hospital. The Women’s Auxiliary Millennium Chair in Haematology/Oncology follows the WA’s unprecedented success in funding their first chair in Neonatology, which they started funding in 1995. An initial pledge of $1.5 million over ten years increased to $2-million and was raised in half the time, exceeding everyone’s expectations.

SickKids’ researchers reverse fatal pulmonary hypertension

Mon, 29 May 2000 24:00:00 EDT

Research conducted at The Hospital for Sick Children (SickKids) has opened up the possibility for a new treatment for pulmonary hypertension that may also be applicable to all types of blood vessel obstruction. This research is reported in the June issue of the scientific journal Nature Medicine.

The Hospital for Sick Children advances MS treatment and research

Wed, 17 May 2000 24:00:00 EDT

Collaboration leads to advancement in MS research

Tue, 16 May 2000 24:00:00 EDT

May is designated as Multiple Sclerosis month – a time to create awareness about this debilitating disease that affects nearly 50,000 Canadians. Canada has one of the highest rates of Multiple Sclerosis (MS) in the world, and it is the most common disease of the central nervous system affecting young adults in this country. Collaboration between basic science researchers at The Hospital for Sick Children (SickKids), through funding from the Multiple Sclerosis Society of Canada, and clinicians at St. Michael’s Hospital, has led to promising clinical trials to treat MS.

Dr. Bonnie Stevens named inaugural holder of first paediatric nursing research chair in Canada

Tue, 09 May 2000 24:00:00 EDT

The Hospital for Sick Children (SickKids) announced another first today, with the appointment of Bonnie Stevens, RN, PhD, as inaugural holder of The Signy Hildur Eaton Chair in Paediatric Nursing Research. This is the first chair of its kind in Canada, where the focus is on nursing research and the focus group is made up of infants and children.

Fundraising for The Hospital for Sick Children Foundation

Thu, 20 Apr 2000 24:00:00 EDT

In celebrating The Hospital for Sick Children’s 125^th birthday and the Toronto Cathay Lions Club’s 25^th year of serving the community, the Toronto Cathay Lions Club announced today a $100,000 contribution to the The Hospital for Sick Children Foundation.

Ontario invests $75 million in genomics research

Wed, 05 Apr 2000 24:00:00 EDT

The government through the Ontario Research and Development Challenge Fund will invest up to $75 million over five years to boost the province’s capability in genomics research, Energy, Science and Technology Minister Jim Wilson announced today.

Ontario government to announce investment in genomics research

Tue, 04 Apr 2000 24:00:00 EDT

This Wednesday morning, a major new genomics initiative will be announced at The Hospital for Sick Children (SickKids), made possible by the Ontario Research and Development Challenge Fund.

SickKids celebrates its 125th Birthday

Mon, 03 Apr 2000 24:00:00 EDT

Patients at The Hospital for Sick Children (SickKids) and their families joined together today with staff and a special guest, the Honourable Hilary M. Weston, Lieutenant Governor of Ontario, to celebrate the hospital’s 125^th birthday.

The Hospital for Sick Children’s Summary of Success

Mon, 03 Apr 2000 24:00:00 EDT

The Hospital for Sick Children (SickKids) has made landmark contributions to the health and well-being of children around the world. Just a few of the highlights include:

Prestigious scientific award for two Hospital for Sick Children researchers

Wed, 29 Mar 2000 24:00:00 EST

Scientists at The Hospital for Sick Children (SickKids) have received two out of three of Canada’s most prestigious scientific award for biomedical research.

Researchers discover retinal stem cells in adult mammals

Thu, 16 Mar 2000 24:00:00 EST

When it comes to stem cells, it appears the eyes have it. Researchers at the University of Toronto and The Hospital for Sick Children (SickKids) have identified retinal stem cells in the adult mammalian eye, opening the door for retinal regeneration as a possible cure for damaged or diseased eyes.

SickKids and Toronto CCAC to study new way of delivering patient care at home

Tue, 14 Mar 2000 24:00:00 EST

A new telecommunications-based monitoring program launched today at The Hospital for Sick Children (SickKids) in collaboration with the Toronto Community Care Access Centre allows patients with semi-acute illness to continue their care at home.

Tele-HomeCare Project

Tue, 14 Mar 2000 24:00:00 EST

What is the Tele-HomeCare Project (THC)?

Ministry of Health approves retinoblastoma genetic testing at The Hospital for Sick Children

Wed, 08 Mar 2000 24:00:00 EST

The Ministry of Health and Long Term Care has confirmed that retinoblastoma gene mutation analysis testing will be added to the list of molecular diagnostic tests offered to Ontario residents at The Hospital for Sick Children (SickKids).

SickKids and nurses report to College of Nurses of Ontario

Mon, 06 Mar 2000 24:00:00 EST

Two registered nurses involved in the care of Lisa Shore, a child who died at The Hospital for Sick Children (SickKids), Ruth Doerkson, RN, and Anagaile Soriano, RN, self-reported to the College of Nurses of Ontario on Friday, March 3, 2000. The Hospital for Sick Children also formally reported the two nurses to the College and asked for a review of the nursing care provided. Two nursing leaders, Chief of Nursing Dr. Jean Reeder and Nurse Educator Mary Douglas, self-reported to the College on Friday as well.

The Different Faces of Sick Kids, A Hospital on the Move

Sat, 04 Mar 2000 24:00:00 EST

A historical photo exhibit to commemorate the hospital’s history: The Different Faces of Sick Kids –A Hospital on the Move is open to the public from April 3 to 7. It’s located in the Hospital’s Rotunda (the entrance at 555 University Avenue).

Changes implemented to date by The Hospital for Sick Children as a result of Lisa Shore's death

Thu, 24 Feb 2000 24:00:00 EST

The hospital will thoroughly review the jury’s recommendations. Since Lisa Shore’s death, the hospital has proactively and thoroughly investigated the issues that led to Lisa’s death and has already addressed many of the issues involved in the jury’s recommendations. Some of the changes implemented by the hospital to date include:

Oracle Canada donated $1.2 Million in software, services to The Hospital for Sick Children

Wed, 23 Feb 2000 24:00:00 EST

Gift to Provide Critical Foundation to Human Genome Research Project

Double-lung transplant recipient Sabrina Gotman has died at SickKids

Mon, 17 Jan 2000 24:00:00 EST

Double-lung transplant recipient, Sabrina Gotman died peacefully today at 2:15 p.m. at The Hospital for Sick Children (SickKids) of chronic rejection and severe infections. She was 14.

Power restored at The Hospital for Sick Children

Mon, 10 Jan 2000 24:00:00 EST

TORONTO - Power was fully restored to the Elm, Gerrard and Black Family Wings at The Hospital for Sick Children (SickKids) as of 4:00 p.m. today. All clinic and diagnostic appointments scheduled for January 11 will take place.

Fire breaks out at The Hospital for Sick Children

Sun, 09 Jan 2000 24:00:00 EST

TORONTO - A fire broke out at The Hospital for Sick Children (SickKids) this evening after a series of explosions occurred in a generator vault under the receiving area of the hospital’s Elm Wing at 6:03 p.m. By 7:47 p.m., the fire was extinguished. No patients, staff or families were injured from the fire.

Update on fire at The Hospital for Sick Children

Sun, 09 Jan 2000 24:00:00 EST

TORONTO - All clinic and diagnostic imaging appointments located in the Elm, Gerrard and Black Family Wings at The Hospital for Sick Children (SickKids) have been cancelled for Monday, January 10 because of the fire that broke out in the Annex (the old part of the hospital) on Sunday at approximately 6:00 p.m. All surgeries will proceed as scheduled. An information line listing the clinics that will be closed has been set up for families. The number is (416) 813-8999. The information line will be updated when new information becomes available.

Koren Hearing Adjourned

Tue, 04 Jan 2000 24:00:00 EST

The disciplinary hearing held by The Hospital for Sick Children (SickKids) and the University of Toronto concerning Dr. Gideon Koren has been adjourned. The hearing will be reconvened later in January. In the mean time, Dr. Koren will remain suspended from all duties.

A private hearing between Dr. Gideon Koren and senior officials of The Hospital for Sick Children and the University of Toronto

Tue, 04 Jan 2000 24:00:00 EST

A private hearing between Dr. Gideon Koren and senior officials of The Hospital for Sick Children (SickKids) and the University of Toronto takes place today in the hospital. Media are not invited to attend.

No photo opportunities at The Hospital for Sick Children on Christmas and Boxing Days

Wed, 22 Dec 1999 24:00:00 EST

Attention: Assignment & Photo desks

Approximately 240 children will spend Christmas at The Hospital for Sick Children (SickKids). They are too sick to leave the hospital, even for the day. Most will be joined by their parents and families.

There will be no photo opportunities offered at the hospital this year. Patients who remain in hospital at Christmas are very sick, and it’s important they spend the day with their families. Many staff and community volunteers donate their time to make this a special day for the children — other staff volunteer to work. Everyone working at SickKids on Christmas and Boxing Day wants to dedicate all of their time and energy attending to the needs of their patients and making the holidays extra special.

The Hospital for Sick Children Tele-HomeCare Project March 14, 2000

Wed, 24 Nov 1999 24:00:00 EST

What is the Tele-HomeCare Project (THC)?

The Tele-HomeCare Project is a research study looking at a new way of caring for children at home.

The Tele-HomeCare Project services are delivered jointly by The Hospital for Sick Children (SickKids) and the Community Care Access Centres (CCAC). The CCAC will provide the community health, personal support and case management services to the patients as well as a link to SickKids.

Does this mean that the patient will leave the hospital sooner?

Not necessarily. The doctors and other members of the child’s medical team will decide when the patient is ready to go home.

How will children be chosen for the project?

Children who may be candidates will be identified by their clinical team from the following services: Cardiology and Cardiovascular Surgery, Respiratory Medicine, General Paediatrics, Otolaryngology (ears nose and throat) and the Critical Care Unit.

Children will be carefully chosen based on the type of care they require and how often they need to be checked. Children who need to be checked more than every 4 hours will not be chosen. Doctors and other members of the child’s medical team will decide what type of care best suits each child’s needs. Those chosen will be on Tele-HomeCare for up to 6 weeks.

How does Tele-HomeCare work?

A video camera lets the family, the patient, and specially trained nurses at the SickKids Bell Home Tele-Monitoring Centre see, hear and talk with each other. A special monitor lets doctors and nurses check the child’s vital signs, such as heart rate, blood pressure and breathing. This information is sent to the centre through a phone line.

The nurses at the centre, the patient’s doctors, other members of the patient’s medical team, and the nurses who visit the patient home, will all work together to care for the child.

What will parents have to do?

Before the child leaves the hospital, a nurse will teach the child’s parents how to use the monitor and phone equipment. Someone from the hospital will visit the patient’s home to set the equipment up.

When the patient and family arrive home, a nurse at the SickKids Bell Home Tele-Monitoring Centre will call to check in on the patient. It will be the parents job to hook the child up to the monitor and to tell the nurse how the child is doing.

Parents can call a nurse at the centre at any time - day or night.

What will be studied in the pilot project?

The project will help to evaluate the impact of the technology on the patient and family, their quality of life and the quality of care. In addition, it will assess the impact on health care providers in the hospital and the community and cost effectiveness. If there are differences between children and families who receive Tele-HomeCare and those who solely receive visits from nurses in the community.

How may Tele-HomeCare help patients and their families?

Some of the things we want to find out are:

Bronze statues returned to SickKids sculpture

Wed, 20 Oct 1999 24:00:00 EDT

The two larger than life bronze statues reported stolen on October 6 by The Hospital for Sick Children (SickKids) were returned at 2:15 p.m. today, and reinstalled in their place on the sculpture, "The Endless Bench."

"The Endless Bench," a 12-foot outdoor sculpture that depicts the bond between mothers and children was installed on July 7, 1984 on the front lawn of University Avenue entrance to the hospital.

Hospital officials issued a no-questions-asked public plea on October 14 for the return of the statues. Within the first hour the story became public an anonymous caller revealed the location of the statues and arrangements were made to have them returned to SickKids.

"We’d like to thank the public and the media for their assistance with the search and for the safe return of the statues," said Chris Carew, director, support services. "We’ve taken added measures to secure them." No charges will be laid, and all information that led to the return of the statues will remain confidential.

Two bronze statues stolen from SickKids landmark sculpture on University Avenue

Thu, 14 Oct 1999 24:00:00 EDT

Two larger than life bronze statues of a pregnant mother and a nursing mother seated on a circular bench outside the University Avenue entrance of The Hospital for Sick Children (SickKids) have been stolen.

"The Endless Bench," a 12-foot outdoor sculpture that depicts the bond between mothers and children has graced the front lawn of the University Avenue entrance to the hospital since its installation on July 7, 1984 –15 years ago. The sculpture which is six feet in height, and weighing more than 3,000 pounds has been a centrepiece to hundreds of hospital events and a familiar landmark of SickKids.

The crime was reported to Toronto police on Wednesday, October 6. "We believed at first that the statues were taken as a prank, and that they would soon be returned," says Chris Carew, director, support services. A hospital surveillance tape shows seven people at the site; three are seen moving the more than 300 lb. statues into a van on Sunday, October 3, at approximately 9:00 p.m. "We are asking these individuals to please contact the hospital at 813-4985, and we’ll make arrangements to have the statues picked up," says Carew. All calls will be kept confidential.

"The Endless Bench" was donated by Kleinburg artist Lea Vivot in remembrance of her son Morris who died in 1979, and installed by the hospital in honour of the sesquicentennial of the City of Toronto and the bicentennial of the Province of Ontario.

The bench itself has inscribed on the surface 470 names and messages from people known throughout the world including Mother Theresa, Menachem Begin, Indira Ghandi, Dr. Christian Barnard, Katherine Hepburn, Pierre Trudeau, a number of Canadian politicial and government leaders, and members of the hospital staff and the community.

Anyone with information about the missing statues is asked to call
416- 813-4985.

Long weekend could mean busy Emergency department at The Hospital for Sick Children

Fri, 08 Oct 1999 24:00:00 EDT

TORONTO — With asthma season in full force and an earlier than usual flu season, the Emergency department at The Hospital for Sick Children (SickKids) has been busy. And with a long weekend fast approaching, children who are not seriously ill could experience long waiting times.

Many problems such as ear aches, flu, colds and low-grade fever (less than 39° or 102° F) do not require a response from a hospital-based emergency team, and can be looked after by a family physician, community paediatrician or staff in a community health care clinic.

To avoid long waiting times, staff in the Emergency Department offer the following suggestions:

Researchers solve vision mystery

Fri, 01 Oct 1999 24:00:00 EDT

TORONTO – Researchers at McMaster University, The Hospital for Sick Children (SickKids) and University of Toronto have unravelled the mystery of what causes the vision of human babies to improve so rapidly after birth. Vision scientists were previously unclear as to whether the five-fold visual improvement that babies experience within the first six months of life was built into the developing brain or depended on the babies actually using their eyes. The research is reported in the October 1 issue of the journal Science.

"By studying a group of infants with dense cataracts, we were able to determine that it’s visual stimulation, not intrinsic brain development, that is responsible for the rapid improvement in vision," explains one of the study’s authors Dr. Terri Lewis, a professor of Psychology at McMaster University, a vision scientist in Ophthalmology at The Hospital for Sick Children, and an adjunct professor of Ophthalmology with the University of Toronto.

"In our study, we assessed the vision of 28 babies at The Hospital for Sick Children, which has the largest program in North America for the treatment of cataracts in children," explains McMaster University vision scientist Dr. Daphne Maurer. "All of the babies, who ranged in age from 1 week to nine months old, had dense cataracts (in one or both eyes) that were surgically removed. The babies were then fitted with contact lenses. Immediately following contact lens fitting, the babies’ vision was measured using a special eye chart."

The researchers discovered that once the cataracts were removed and the contact lenses were in place, the babies’ vision was still like that of newborns but the brain was ready to learn to see. The babies began to develop the ability to see more clearly after only one hour of using their eyes. Over the next month, their vision continued to improve more rapidly than normal, so that the size of their visual impairment was reduced.

"Cataracts are a loss of transparency that develops in the natural lens of the eye," explains SickKids staff ophthalmologist Dr. Alex Levin, assistant professor of Paediatrics, Genetics and Ophthalmology at the University of Toronto and co-director of the SickKids Eye Genetics team, who performed the surgery on the babies. "When the cataracts are dense it’s like looking through waxed paper, or worse: light can be perceived but not definite shapes. To remove the cataract, we must remove the entire lens of the eye which leaves the eye with no means to focus the light that can now enter. The contact lenses, which are very strong, take the place of the natural lens."

The treatment implications of this study are critically important for the approximately one in 1,000 to 4,000 babies born with cataracts. If surgery is done too late then the brain may not learn to use the vision in that eye. With successful early intervention, even in the first week of life if possible, some children can develop vision as good as 20/20 and go on to lead relatively normal lives.

SickKids reverses brain drain with new Head of General Surgery

Wed, 01 Sep 1999 24:00:00 EDT

TORONTO — The Hospital for Sick Children (SickKids) has lured Dr. Jacob (Jack) Langer, a Toronto native, back from the United States to be the hospital’s new Head of General Surgery.

Dr. Langer came to The Hospital for Sick Children from St. Louis, Missouri where he was a surgeon at St. Louis Children’s Hospital and an associate staff member of the Department of Surgery at Barnes-Jewish Hospital, St. Louis. He was also an associate professor with tenure in the Department of Surgery and an associate professor in the Department of Pediatrics at Washington University School of Medicine in St. Louis.

"SickKids offers a unique environment where support for research activities is an important component of the hospital’s mission. There are many world-class people in this institution. SickKids’s alternate payment plan, where physicians and surgeons are not paid on a fee-per-service basis, also encourages clinical and scientific innovation," said Dr. Langer.

"It is very different from what I experienced in the United States where hospitals routinely compete for patients. Even the money, which is what draws a lot of people south of the border, is declining in the US. The wage gap between Canada and the United States is narrowing," he added.

Dr. Langer is also the inaugural holder of the Robert M. Filler Chair in Paediatric Surgery at The Hospital for Sick Children. This endowed academic chair, named in honour of SickKids’s former Head of General Surgery and Surgeon-in-Chief who came to Sick Kids from the US 22 years ago, ensures stable funding for research and academic activity in the field of paediatric surgery.

Dr. Langer received his medical training at the University of Toronto and did a portion of his residency at Sick Kids. He returned to SickKids from 1985 to 1987 as a clinical fellow in paediatric surgery, and spent three years on faculty at McMaster University, before moving to the United States.

"Jack Langer’s decision to come to Sick Kids is yet another example where we are able to reverse the brain drain and compete with American hospitals," said Michael Strofolino, president and CEO of The Hospital for Sick Children. "We just have to ensure that we are able to fund an environment of excellence where the best and the brightest want to work."

Dr. Langer brings special expertise in the area of fetal diagnosis and treatment to SickKids, and is well-known for his advancement of the field of minimally invasive (laparoscopic) surgery in children. Minimally invasive surgery decreases pain and scarring, as well as the amount of time a patient must stay in hospital.

"The Hospital for Sick Children is one of the best paediatric hospitals in the world, and the opportunity to become the Head of General Surgery and a clinician-scientist here was wonderful. My family is here in Toronto. It’s great to come back home," Dr. Langer said.

A photo of Dr. Langer is available upon request.

Condition update on Robbie Thompson from The Hospital for Sick Children

Fri, 30 Jul 1999 24:00:00 EDT

TORONTO, July 30, 1999 — Robbie Thompson , the 18-month-old from Courtenay, B.C., has been upgraded to good condition following a heart transplant operation at The Hospital for Sick Children (SickKids) on Wednesday, July 21.

"Robbie is doing remarkably well. He is off all monitors and just has an intravenous line to receive antibiotics to prevent infection," said his cardiologist, Dr. Anne Dipchand.

Robbie needed a heart transplant because he suffered from cardiomyopathy, a condition that enlarges the heart, impairing normal function. He had been waiting in Toronto for a donor heart since September 1998.

"We are a very lucky family," said Ron Thompson, Robbie’s father. "There are a lot of children and adults who will die waiting for transplants. We really need improvements to this country’s organ donation system."

The Thompsons plan on spending a quiet weekend as a family and will not be available for media interviews this weekend.

Condition update on Robbie Thompson from The Hospital for Sick Children

Mon, 26 Jul 1999 24:00:00 EDT

Robbie Thompson, the 18 month-old baby from Courtenay, B.C., who received a heart transplant on Wednesday, July 21 at The Hospital for Sick Children (SickKids), is doing remarkably well, according to his cardiologist Anne Dipchand.

He was taken off the ventilator on Friday and is now breathing on his own. For the first time in months, he ate baby food and drank apple juice. Robbie is sitting up and watching his favourite videos; Teletubbies and Wee Sing Train.

"Although Robbie is doing extremely well, the next few weeks will be critical as this is the timeframe that he is most at risk for organ rejection and for developing infection because of his immune suppressed state,'' says Dr. Dipchand.

Robbie required a heart transplant because he suffered from cardiomyopathy, a condition that enlarges the heart, impairing normal function. He was listed for a transplant in September, 1998.

His parents, Ron and Sue shared their story with the media in an effort to educate the public and government about the critical need for organ donors and for an integrated, national organ transplant program.

"We are thankful that Robbie was given a second chance at life. But he aited a very long time and nearly died while waiting for a donor heart,'' says Ron. "Sue and I will continue to do whatever we can to help improve the system so that no other child, or adult, in need of a life-saying transplant should wait as long as Robbie did, or die waiting.''

The Thompsons are grateful for the interest and support shown by the Toronto and B.C. communities, but request that the public please respect their need for privacy and rest during the next few weeks.

Robbie Thompson receives heart transplant

Thu, 22 Jul 1999 24:00:00 EDT

A news conference will be held today at The Hospital for Sick Children (SickKids). Robbie’s parents, Ron and Sue Thompson, will be present, as will Robbie’s physician, cardiologist Anne Dipchand.

Robbie is recovering well in the Intensive Care Unit at the hospital.

When: Thursday, July 22, 1999 11 a.m.

Where: Rotunda, First Floor, University Avenue entrance of
The Hospital for Sick Children

Robbie Thompson's condition

Wed, 21 Jul 1999 24:00:00 EDT

TORONTO - Robbie Thompson, an 18-month-old from Courtenay, BC, is currently undergoing a heart transplant operation at The Hospital for Sick Children (SickKids). The operation began at 5:30 p.m.

Robbie, who suffers from a rare heart condition, has been waiting at SickKids for a suitable donor heart since last September.

Robbie’s parents, Ron and Sue Thompson, will be available for interviews at a media conference tomorrow, July 22. Notification of the time and location for the media conference will be sent over Canada NewsWire.

Update on Lauren Poduch's condition

Fri, 16 Jul 1999 24:00:00 EDT

TORONTO — Lauren Poduch, the 9-year-old Waterloo girl injured when two personal watercraft collided on Six Mile Lake in the Muskoka region last Sunday, has died at The Hospital for Sick Children (SickKids).

Lauren succumbed to her injuries on Friday, July 16 at 7:30 a.m.

Lauren’s family wishes to thank the community for their support, but asks that their privacy be respected. We regret that the Poduch family and hospital medical staff will not be available for interviews.

The Hospital for Sick Children to host worldwide genome database on IBM Supercomputer

Thu, 08 Jul 1999 24:00:00 EDT

IBM Technology to Speed Pace of Research 100x

The Hospital for Sick Children (SickKids) today announced that it will use sophisticated technology developed by IBM to host and manage the worldwide Genome Database (GDB), the foremost public database for human genome information.

The new computer equipment and software, donated under IBM’s Shared University Research program, is expected to speed the pace of the hospital’s genetic research by 100 times.

Research institutions, such as SickKids, are making significant contributions to the various global initiatives working to isolate disease-causing genes. An established player in this field, scientists at SickKids have identified many disease-causing genes, including the gene for cystic fibrosis in 1989.

The GDB will run on an IBM RS/6000 SP, using IBM’s DB2 Universal Database. The hospital also plans to use powerful bioinformatics software, developed by researchers at IBM, for advanced analysis of DNA and protein sequence identification. Bioinformatics is the application of information systems and strategies to science.

The hospital recently took over management of the GDB, which supports the Human Genome Project, the global scientific effort to map and sequence man’s complete genetic material. The GDB is accessed by thousands of researchers around the world. Founded in 1989, the GDB previously was managed by Johns Hopkins University.

"As an international leader in genetic research, SickKids has a very personal stake in taking over the management of GDB," said Jamie Cuticchia, PhD, head of SickKids’ bioinformatics program. "SickKids will work aggressively to learn from and grow GDB’s rich content. With IBM technology, we expect to take genomics research to new levels."

The decision to use the IBM RS/6000 SP, a highly scaleable supercomputer, was based on its unique ability to manage complex information as well as IBM’s expertise in the emerging field of "deep computing." The deep computing tools developed by IBM will be essential in helping the hospital solve complex problems and analyze the vast amounts of data in the GDB.

"Today’s announcement demonstrates IBM’s growing commitment to the massively complicated area of genomics," said Sharon Nunes, PhD, director of the IBM Computational Biology Center at the Thomas J. Watson Research Center in New York. "Technology is advancing medical research by combining incredible processing power with application-specific software. In this case, IBM will help SickKids to accelerate its work in identifying the genetic causes of disease."

Since it began, the GDB has doubled in size annually as the world’s scientists submit data daily. These data include information about the location of disease genes, genetic markers, gene differences, as well as all known human gene mutations, which play a critical role in diagnostics.

Affiliated with the University of Toronto, The Hospital for Sick Children is the largest paediatric centre in North America and a world class referral centre in the forefront of paediatric medicine, research and teaching.

The Hospital for Sick Children to host Genome Database on "Deep Maple'' IBM supercomputer

Wed, 07 Jul 1999 24:00:00 EDT

The Hospital for Sick Children (SickKids) will tomorrow that it will use IBM's ``deep computing'' technology and bioinformatics software to host and help manage the Genome Database (GDB), the repository for all data generated by the international Human Genome Project.

SickKids has taken over the GDB management from Johns Hopkins University after funding cuts in the U.S. threatened the ongoing viability of the GDB. The GDB will reside on ``Deep Maple'', the nickname given by SickKids information scientists to its new IBM RS/6000 SP system, donated by IBM through its Shared University Research Program.

Media announcement:
Thursday, July 8, 1999
1 p.m.
Rotunda, 1st Floor, University Wing
The Hospital for Sick Children
555 University Avenue

Scheduled speakers:
Jamie Cuticchia, PhD
(pronounced Koo-TEE-shaw)
Director, Bioinformatics
The Hospital for Sick Children, Toronto

Sharon Nunes, PhD
(pronounced Noons)
Director, IBM computational Biology Center
Thomas J. Watson Research Center,
New York

Following the announcement there will be opportunities to obtain photos and video footage of the IBM RS/6000 SP system.

Scientists use bacterial toxin to kill brain tumours

Tue, 29 Jun 1999 24:00:00 EDT

TORONTO –-Researchers at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have used a toxin produced by the same bacteria that cause hamburger disease to completely eliminate malignant human brain tumours grown in mice. The research is published in the June issue of the scientific journal Oncology Research.

"E. coli is a common gastrointestinal bacterium," explains Dr. Cliff Lingwood, a senior scientist at HSC and a Professor of Laboratory Medicine and Pathobiology at the U of T. "Some E. coli strains produce a toxin known as verotoxin. Our earlier research has shown that, in the test tube, verotoxin kills certain brain tumour cells very efficiently. We wanted to determine if this was also the case in a living animal."

As part of her doctoral studies in Dr. Lingwood’s laboratory, Dr. Sara Arab (now a clinical fellow in Medical Genetics at SickKids) injected verotoxin directly into human astrocytoma brain tumours that had been grown in mice. After a single injection, the tumours had shrunk by half within 48 hours. Within seven to 15 days the tumours had completely disappeared and had not reappeared by the end of the experiment (60 days). Both the tumours and their blood vessels were killed by the toxin.

"We are very excited by this observation because astrocytoma is the most common type of malignant brain tumour and the prognosis is poor for patients with this diagnosis," explains SickKids neurosurgeon James Rutka, a collaborator in the research and head of the Arthur and Sonia Labatt Brain Tumour Research Centre. Approximately 20,000 people are diagnosed with brain tumours each year in Canada and the United States. "This discovery could be very promising because the verotoxin makes a two-pronged attack on the tumour: it destroys tumour cells and shuts down the tumour’s blood supply."

While earlier SickKids research has demonstrated that verotoxin-producing E. coli can cause kidney failure, primarily in very young children, the scientists suggest that a window of opportunity exists for verotoxin treatment in older patients.

Plans are already underway for the next phase of the research: preliminary clinical trials in older children and adults. In that trial, verotoxin will be injected into residual glioblastoma cells following surgical removal of the majority of the tumour. Glioblastoma is the most malignant form of astrocytoma.

This research was supported by the Medical Research Council of Canada and The Hospital for Sick Children Foundation. Select Therapeutics Inc. holds an exclusive licensing agreement with The Hospital for Sick Children to bring the benefits of this research to market.

Magnetic field exposure associated with childhood leukemia

Tue, 15 Jun 1999 24:00:00 EDT

TORONTO -- Researchers at the University of Toronto and The Hospital for Sick Children (SickKids) have found an association between magnetic field exposures in residences and the risk of developing childhood leukemia.

The study, reported in two separate papers in the current issues of the International Journal of Cancer (IJC) and the journal Cancer Causes and Control (CCC), shows that children with higher exposures to magnetic fields in residences are two to four times more likely to develop leukemia compared to children who are less exposed. The study comprehensively measured magnetic field exposures inside and outside the children’s homes. Wire code was also assigned to each residence. For some children, EMF exposures were measured by a personal monitor.

The authors report in IJC that overall, wire code -- a surrogate indicator of magnetic field exposure based on the physical characteristics of the line and proximity of the residence to power lines -- was not associated with an increased risk of developing leukemia. However, measured magnetic field exposure was associated with an elevated incidence of leukemia in children under age six who were exposed in residences occupied during the first two years of life.

A subset of the total study population wore a personal monitoring device which measured EMF during usual activities in the home over 48 hours. As reported in CCC, exposure to magnetic fields was associated with a two-fold increase in risk of developing leukemia.

When other factors such as residential mobility, power consumption, child’s medical history and other environmental exposures were taken into account, children exposed to higher levels of magnetic fields were 4.5 times more likely to develop leukemia compared to less exposed children. Risks were higher for children diagnosed at less than six years of age and for those with acute lymphoblastic leukemia -- the most common type of leukemia in children.

"As the methods of assessing exposure were refined, we found that the association between magnetic fields and the risk of developing childhood leukemia became stronger, particularly in children diagnosed at a younger age," says lead author Dr. Lois Green, epidemiologist in the department of public health sciences at U of T and at Ontario Power Generation. "But this study does not establish that magnetic fields cause cancer. To date, laboratory research has not shown a plausible biologic mechanism supporting a cause and effect relationship."

Researchers compared 201 children living in the Greater Toronto Area (GTA) who were diagnosed with leukemia at 0 to 14 years of age between 1985 and 1993 at The Hospital for Sick Children with 406 control children.

Where possible, magnetic field exposures were measured at all the GTA residences occupied by the child during the period of inquiry -- the only study to date to consider several different exposure time periods. A detailed questionnaire was also administered to gather information about other factors such as family history, which might be related to leukemia risk.

"Acute lymphoblastic leukemia is most commonly seen in children two to six years of age. The association we saw with this age group is interesting because the range of exposures to possible risk factors is smaller and shorter," says Dr. Mark Greenberg, professor of pediatrics at U of T and pediatric oncologist at The Hospital for Sick Children. "We don't know what it means however, because there is no good biologic explanation for how such exposure might work."

Another consideration, Green adds, is the possibility that lifetime exposures to magnetic fields may have been measured more accurately for younger children because the interval between diagnosis and measurement was short, thus reducing possible misclassification of exposure.

Funding was provided in part by the Ontario Hydro Services Company (formerly part of Ontario Hydro) and the Canadian Electrical Association.

Clinic appointments cancelled at SickKids due to power outage

Wed, 02 Jun 1999 24:00:00 EDT

All appointments located in clinics in the Gerrard and University wings of The Hospital for Sick Children (SickKids) have been cancelled for the balance of the day due to a power outage.

The power went out in the Gerrard and the University wings this morning at approximately 10:30 a.m. The cause of the outage is unknown, but Toronto Hydro and the hospital are working to restore power as soon as possible.

Clinics and services located in the main patient care and surgical areas, the Atrium, are not affected by the power outage.

The Emergency Department will remain open and all major surgical procedures will proceed. Regional hospitals are prepared to see children.

The following Clinics are closed:

Update on power outage at SickKids

Wed, 02 Jun 1999 24:00:00 EDT

Power has been restored to one of the two wings affected by a power outage today at The Hospital for Sick Children (SickKids). The University wing will be operational on Thursday June 3.

Efforts to fully restore power to the Gerrard wing will continue overnight. As a precaution, patients and families with appointments in clinics located in the Gerrard wing have been notified of appointment changes.

The power went out in the Gerrard and the University wings this morning at approximately 10:30 a.m.

The cause of the outage is unknown. Toronto Hydro and the hospital are continuing to work on restoring power to the Gerrard wing. Clinics and services located in the main patient care and surgical areas, the Atrium, are not affected by the power outage.

The Emergency Department will remain open and all major surgical procedures will proceed. Regional hospitals are also prepared to see children.

All staff working in the Gerrard wing are expected to report to work on Thursday.

Gene found for rare metabolic disorder

Tue, 01 Jun 1999 24:00:00 EDT

TORONTO -- Scientists at The Hospital for Sick Children (SickKids), University of Toronto (U of T), and colleagues in Japan have identified a gene which causes a metabolic disorder affecting the liver. The adult-onset version of the disorder, called type II citrullinemia, is caused by an amino acid deficiency and can lead to severe liver damage and even death. The research is published in the June issue of the journal Nature Genetics.

"Working with our Japanese collaborators we were able to identify more than 100 families with a history of citrullinemia and establish that the disease-causing gene was located on human chromosome 7," explains SickKids scientist Dr. Steve Scherer, who is an assistant professor of Molecular and Medical Genetics at the U of T. "We then used the technique of positional cloning, pioneered at SickKids by study co-author Dr. Lap-Chee Tsui, to identify the defective gene which causes citrullinemia."

Most patients with type II citrullinemia suffer neurological symptoms such as disorientation, tremor and coma, and a majority of patients die within a few years after onset of the symptoms. Until the present study, the late onset form of the disease was not even established as a well-defined clinical entity, which complicated accurate diagnosis.

"Since liver transplantation can apparently lead to complete recovery from both the metabolic and neurological effects of citrullinemia, an early and proper diagnosis based on biochemical and genetic data is essential," says Dr. Scherer. "Ultimately, it is hoped that the discovery of the disease gene will lead to a simpler and less intrusive method of treatment which might include protein or gene replacement."

Type II citrullinemia is most common in Japan, where one person in 100,000 has the disorder. Cases have also been found in Europe, the USA, China, and Canada. The disease is inherited in an autosomal recessive manner (both parents must carry the defective gene and pass it on to their offspring for the child to be affected).

Dr. Scherer and Dr. Tsui led the SickKids research team, which included David Sinasac, Dr. Andrew Boright, Michael Crackower, and Jeff Lee. Drs. Keiko Kobayashi and Takeyori Saheki of Kagoshima University headed the Japanese effort. The current study arises from the SickKids group’s human chromosome 7 research, which is part of the international Human Genome Project (HGP). The HGP aims to decipher and understand all of the genes in human DNA. The work was carried out in the Centre for Applied Genomics at SickKids, which conducts research focused on DNA sequencing and chromosome mapping, disease gene discovery, functional genomics, and bioinformatics.

This research was supported by the Medical Research Council of Canada, The Hospital for Sick Children Foundation, the Ministry of Education, Science and Culture in Japan and the Kodama Foundation for Research in Medical Science.

Researchers pinpoint region for cystic fibrosis modifier gene

Tue, 01 Jun 1999 24:00:00 EDT

TORONTO – An international team of researchers, led by Dr. Lap-Chee Tsui of The Hospital for Sick Children (SickKids) and the University of Toronto, has identified a region on chromosome 19 that contains a gene which modifies the severity of cystic fibrosis (CF). While such a modifier gene has been found in mice with cystic fibrosis, this is the first time a similar gene has been shown to exist in humans. Their research is published in the June issue of the scientific journal Nature Genetics.

"The data generated by previous SickKids research in mice led directly to this most recent discovery because there are corresponding regions in mice and humans that contain the same genes," explains Dr. Julian Zielenski, the paper’s lead author. "As a result, we knew exactly where to look in the human genome for one or more similar modifier genes."

The cystic fibrosis gene, identified in 1989 by Dr. Tsui and colleagues at SickKids and the University of Michigan, has more than 800 different mutations, all causing variations in the disease. However, not all clinical variations in cystic fibrosis can be attributed to mutations in the gene. As a result, scientists have suspected that other factors are involved, such as the activity of other genes which have a modifying effect on the disease or various environmental conditions. However, modifier genes have never been found in humans.

"The area we have pinpointed contains a gene that is involved in modifying the severity of a common intestinal obstruction in patients with cystic fibrosis," explains Dr. Zielenski. "Up to 20 percent of CF patients have this obstruction, called meconium ileus, but we’ve never been able to find a connection between a mutation in the CF gene and the development of the obstruction. Now we know that the obstruction is not caused by a specific mutation in the CF gene itself, but by the activity of a modifying gene."

Cystic fibrosis is the most common single gene disorder in the world, affecting one in every 2,000 children. In patients with CF, the secreting glands fail to function properly. Many body organs are affected, including the lungs, pancreas, liver, sweat and salivary glands, gastrointestinal tract and the male reproductive tract. The most serious symptom is a thick, dry mucus which clogs the airways and lungs and leaves the patient susceptible to chronic lung infections. Many CF patients also suffer from pancreatic malfunction, which leads to poor digestion and prevents the absorption of sufficient dietary fat. The majority of patients with CF succumb to severe lung infections before age 30.

The identification of modifier genes in CF will allow doctors to gain a better understanding of the different clinical presentations of the disease. It’s anticipated that this knowledge will lead to insights into prognosis and management of cystic fibrosis, as well as development of novel therapies.

The research was funded by the National Institutes of Health, the Canadian Genetic Diseases Network, the National Centre for Research, and The Hospital for Sick Children Foundation.

Researchers develop simple test for detection of deadly cancer

Tue, 04 May 1999 24:00:00 EDT

Toronto– A team of Toronto researchers has developed a simple test that promises to significantly reduce mortality rates for a deadly form of cancer. The research is published in the May issue of the Journal of the National Cancer Institute, the leading journal in the cancer research field.

Researchers at The Hospital for Sick Children (SickKids), Mount Sinai Hospital, Toronto Hospital, the University of Toronto and the Rouge Valley Health system’s Centenary Site, have completed a clinical trial of a new strategy for the detection of nasopharyngeal cancer (NPC), a tumour that grows deep behind the nose.

NPC is the major cause of death from cancer in Hong Kong, southern China and several Pacific and Mediterranean rim countries. Most North American patients who develop this cancer are of Asian, Mediterranean or African descent. In Canada, Chinese immigrants, Jews and Inuit belong to high-risk groups.

"Usually this type of cancer is detected only very late in its progress because of its obscure location in the body and he lack of signs and symptoms," says Dr. Jeremy Freeman, Temmy Latner/Dynacare Chair in Head and Neck Oncology and an Otolaryngologist at Mount Sinai Hospital, and a professor of Otolaryngology at the University of Toronto. "Currently, prognosis for patients is often late. However, the diagnostic test we have developed can be administered by an ear-nose and throat (ENT) or general physician on a routine basis and represents a true breakthrough because it detects the cancer at an early stage and allows us to act more proactively."

"In this cancer, every single tumour cell carries Epstein-Barr virus and we believe that the virus plays a direct role in tumour development," says principle investigator Dr. Michael Dosch, a senior scientist at The Hospital for Sick Children and a Professor of Paediatrics at U of T. "We have now learned to use this relationship to detect the tumour by tracing the virus."

The Toronto team developed an ambulatory testing technique using a sheathed brush reminiscent of a pap smear brush. Cells are gently retrieved from the back of the nose where the tumour develops. The cells are then analyzed for Epstein-Barr virus with a gene-based test. The test has an accuracy rate of over 90 percent. The presence of the virus gene is a strong predictor of the cancer.

The seven-year study evaluated subjects from the Toronto area that had either established or suspected NPC (21 patients), while 96 other patients had minor otolaryngological complaints, and 53 had head and neck cancers other than NPC. Thirty-two addition patients had been treated for NPC. Eighty-six percent of NPC patients were of Asian descent.

"The next stage in this exciting development will be to conduct a large population-based screening test in some of the high risk groups such as Chinese immigrants in Toronto," explains Dr. Raymond Ng, an otolaryngologist at the Centenary site of the Rouge Valley Health System. "This early screening test will help us identify patients with no overt clinical symptoms. The benefits of treating the disease early and the long-term cost savings for the Canadian health care system will be substantial."

In addition to Drs. Dosch, Freeman and Ng, the research team included Cathryn Tune, Per-Gunnar Liavaag and Roy Cheung of The Hospital for Sick Children; Michael van den Brekel, Thomas Shpitzer and Jeroen Kerrebijn of Mount Sinai Hospital; Dr. John Irish of the Toronto Hospital; and Dr. David Payne of Princess Margaret Hospital.

The research was supported by funds from the Medical Research Council of Canada, Temmy Latner/Dynacare, The Saul A. Silverman Family Foundation, the Tauba and Solomon Spiro Family Foundation as an Isabel Silverman Canada-International Scientific Exchange Program Project, and The Hospital for Sick Children Foundation.

Help Make SickKids Better Campaign Surpasses $82-Million Goal

Tue, 27 Apr 1999 24:00:00 EDT

Record-breaking $85.8 million campaign assures SickKids' place as world leader in paediatric research and patient care

Toronto, Ont – The goal of raising $82 million for research may have seemed daunting on September 15, 1997 when The Hospital for Sick Children (SickKids) launched the most ambitious fundraising campaign in its 123-year history. But today, with the campaign successfully completed, it's just one more reminder that SickKids is truly a world leader, and that research is an integral part of improving patient care.

“The Help Make SickKids Better campaign owes its outstanding success to those who rallied around it,” says Al Flood, campaign chair and chairman and chief executive officer of the Canadian Imperial Bank of Commerce. “I would like to thank everyone – from my fellow members of the campaign cabinet to the canvassers, staff and donors – who gave of their time and resources to ensure the health of children around the world will continue to be improved through the important research and education that takes place at SickKids.”

The investments in education and research made possible by the $85.8 million raised will benefit people worldwide for years to come. Nineteen endowed academic chairs have been funded since the campaign's inception. The establishment of endowed chairs is a fundamental way of securing funding in perpetuity for key areas of research, including both basic science and clinical research in such areas as genetics, nursing, psychiatry, immunology, and neonatology. Prior to the campaign, there were no endowed chairs at SickKids.

Funds raised during the campaign also enabled the opening of The Arthur and Sonia Labatt Brain Tumour Research Centre, a collaborative, state-of-the-art research laboratory that links the research of the University of Toronto and Toronto Western Hospital with SickKids.

A Research Training Centre was also established as a result of the campaign, increasing the number of graduate students and post-doctoral fellows the hospital can fund. There has been an increase in the number of disciplines and specialties in which researchers can receive funding, so that basic science and medical research continue to be supported, along with research from other health care professions, such as social work and nursing.

The Hospital for Sick Children marked the conclusion of the overwhelmingly successful campaign with a day-long celebration involving staff, volunteers, patients and their families. Al Flood presided over the campaign finale festivities, where he was made an honorary SickKids scientist and officially opened the “Main Street Science Fair”, which highlighted some of the research done at SickKids. With the help of a few young patients, he then undertook his first genetic scientific experiment. Mr Flood will also host a reception for the campaign volunteers and donors on the 56 th Floor of the CIBC this evening.

Sabrina Gotman has double lung transplant at The Hospital for Sick Children

Fri, 09 Apr 1999 24:00:00 EDT

TORONTO - Sabrina Gotman, 13, is listed in critical condition after undergoing a double lung transplant last night at The Hospital for Sick Children (SickKids). Sabrina went into surgery at midnight and the last operation lasted just under six hours.

The Gotman family is relieved that the transplant is complete but has asked for privacy today so that they can be with their daughter.

The first 72 hours are critical for transplant recipients. During that time, Sabrina will be gradually weaned from the mechanical ventilator that is breathing for her now to determine how her new lungs are functioning.

Exposure to organic solvents during pregnancy causes birth defects

Wed, 24 Mar 1999 24:00:00 EST

TORONTO — Researchers at The Hospital for Sick Children (SickKids) have concluded that occupational exposure during pregnancy to organic solvents increases the chances of major birth defects. While solvents had previously been shown to cause birth defects in laboratory animals, it is the first proof that humans can be affected as well.

The study, published in the March 24 issue of The Journal of the American Medical Association, demonstrates that pregnant women exposed in their jobs to organic solvents have a 13-times greater risk of major malformations in their babies as well as increased risk for miscarriages than women not exposed to solvents.

"Previous studies, in which women were asked after giving birth about their exposure to solvents during pregnancy, showed conflicting results regarding the link between solvent exposure and birth defects," says lead author Dr. Sohail Khattak, staff physician in the Division of Clinical Pharmacology and Toxicology and department of Emergency Medicine. "This study is important because it is the first in which women were assessed after exposure to solvents and before giving birth."

Organic solvents to which women reported being exposed to included vinyl chloride, acetone, phenols and aromatic hydrocarbons. Exposure to such solvents occurs either by absorption through the skin or by inhalation. Risk is decreased if adequate safety guidelines are followed, i.e. use of gloves and fume hoods. Although organic solvents are used in household products, the low levels of exposure associated with home use are not considered dangerous.

The study, led by researchers at the Hospital’s Motherisk program, involved 250 pregnant women, half of whom had been exposed in the workplace to organic solvents. The women in the study were counselled by the Motherisk program between 1987 and 1996. Each mother who reported occupational exposure to organic solvents was paired in the study with a woman who was exposed to an agent known to not cause birth defects. Factors such as smoking, alcohol intake, age, and stage of pregnancy were taken into consideration. All exposed women worked for at least the first trimester with organic solvents.

Among those women who reported being exposed during pregnancy to solvents, the risk of having a baby with birth defects was highest among those who also reported symptoms associated with solvent exposure, such as eye irritation, respiratory irritation, headaches, and difficulty breathing.

The mothers were followed up between six and nine months after the expected delivery date. All reports of birth defects were corroborated by a written report from the physician caring for the child. Birth defects were defined as any anomaly that has an adverse effect on either the functioning or the social acceptability of the child, and included spina bifida and other neural tube defects, heart malformations, and deafness. The rate of such malformations in the normal population is between one and three per cent.

The most common occupations dominated by females with potential exposures to solvents are health care and the clothing and textile industries. The most common occupations of the women who participated in the study were factory worker, laboratory technician, professional artist/graphic designer and printing industry worker.

"Given the results of this study, I think it’s important that women who are exposed occupationally to organic solvents take appropriate safety measures to reduce their risk," says Dr. Gideon Koren, the study’s principal investigator and head of SickKids’ division of Clinical Pharmacology and Toxicology and Motherisk program, and a Professor of Paediatrics, Pharmacology, and Medicine at the U of T. "Proper ventilation and protective clothing should be worn."

This research was funded by Physician Services Inc. and The Hospital for Sick Children Foundation.|

The Hospital for Sick Children is a health care, teaching and research centre dedicated exclusively to children; affiliated with the University of Toronto.

SickKids Physicians present to health committee on pediatric organ Donation

Tue, 16 Mar 1999 24:00:00 EST

Ottawa, Ontario - March 16, 1999 - Two physicians from The Hospital for Sick Children (SickKids) appeared before the House of Commons’ Standing Committee on Health. They urged Government to create a nationally-coordinated program, specifically for paediatric organ donation.

The two physicians are members of SickKids’ Paediatric Academic Multi-Organ Transplant program (PAMOT): Dr. Diane Hebert, Clinical Director of PAMOT, SickKids, and Assistant Professor, Paediatrics, Division of Nephrology, University of Toronto; and Dr. Sam Shemie, Education Director, Department of Critical Care Medicine, and Director of Paediatric Organ Donation, SickKids, and Assistant Professor of Paediatrics and Anaesthesia, University of Toronto.

SickKids made four recommendations to the committee and volunteered to work with Government to implement them:

Canada’s most powerful supercomputer now at SickKids

Tue, 16 Mar 1999 24:00:00 EST

TORONTO - The Hospital for Sick Children (SickKids) today unveiled a state-of-the-art supercomputer that will allow scientists to dramatically accelerate research into diseases that affect children. The hospital’s new Silicon Graphics Origin 2000 is the most powerful supercomputer of its type in Canada and the largest in the world devoted exclusively to health and biological research in the public sector.

"The Origin 2000 supercomputer will be an extremely powerful tool for researchers not only at SickKids but across the country," says Dr. Jamie Cuticchia, head of the Bioinformatics program at SickKids. "It has also become a necessity, considering the vast amounts of information being generated by research programs such as the Human Genome Project, the international scientific effort to decode the complete genetic material of humans."

Dr. Cuticchia estimates that in this year alone, the world’s researchers will produce more scientific data in the life sciences than has been previously generated in all of human history. The emerging science of bioinformatics - the use of information technology to answer complex biological questions — will help turn these large quantities of data into knowledge that can be used to improve diagnosis and treatment of childhood diseases.

A job that would take the fastest PC currently on the market three months to complete will take just a few minutes on the Origin 2000.

"We will use the Origin 2000 initially for research in two key areas: searching for similarities in gene sequences and developing three-dimensional models of human proteins, the products of genes," explains Dr. Cuticchia. "These two areas of research will generate fundamentally important information. Understanding the structure of a human protein can help us design more effective drugs. The ability to rapidly compare gene sequences can be applied in areas as diverse as gene discovery and diagnostics."

The Origin 2000 has 64 MIPS R10000 processors, 16 gigabytes of memory and close to a terabyte (one trillion bytes) of disk space. The Origin 2000 takes up 28 square feet in its own climate-controlled room. As it generates 125,000 BTUs of heat, a 10-ton air conditioning unit (the average house has a 1-ton unit) is used to maintain a constant room temperature. Its independent power supply is backed up by two UPS units that weigh 800 pounds each.

The $4.2 million supercomputer arrived at the hospital in January and took six weeks to install. It is now ready to begin its work.

"The acquisition of this amazing technology is made possible by an anonymous donor and an investment of approximately $1.4 million by Silicon Graphics Canada," says Michael Strofolino, the Hospital’s President and CEO. "I am confident that our partnership with them will lead to extraordinary advances not only at Sick Kids but at the many other centres who will be able to access this incredible resource."

"Almost overnight the volume and complexity of biological information has grown exponentially,"explains David Wharry, President of Silicon Graphics Canada. "At the same time, the ability to organize and distribute information for a diverse worldwide scientific community using a broad range of computer environments has become essential to gaining insight and new discoveries. To help meet these challenges, Silicon Graphics is advancing its commitment to bring the fastest, most expandable, most flexible computing systems to the world’s bioinformatics teams. On behalf of the employees of Silicon Graphics Canada, and in recognition of world leadership at The Hospital for Sick Children, it is our privilege to work in partnership with this discovery bound team and co-invest in support of their future success."

Dentistry Clinic at Sick Kids first in North America to achieve ISO 9002 registration Dentistry Clinic at Sick Kids first in North America to achieve ISO 9002 registration

Tue, 09 Feb 1999 24:00:00 EST

TORONTO...The Dentistry Clinic at The Hospital for Sick Children (SickKids) is the first, dental clinic in North America to achieve the ISO 9002 standard ÿan internationally recognized service industry standard identifying the clinic as a leader in providing health care.

Representatives from the Ontario Dental Association, The University of Toronto, the Royal College of Dental Surgeons of Ontario and SCG International Certification Services Inc., will be at SickKids for a formal presentation of the registration certificate on Thursday, February 11 at 4 p.m. in the Dental Clinic.

The Department of Dentistry at SickKids treats more than 20,000 children annually. The clinic provides 24-hour dental emergency service as well as ambulatory clinic treatment for patients referred by dentists and dental specialists throughout Canada. As a University of Toronto affiliated teaching and research centre, the department is a clinical training site for the specialties of paediatric dentistry , orthodontics, oral and maxillofacial surgery and endodontics. The size and diversity of the department requires systems to maintain consistency and provide quality service and education.

"We undertook the development of ISO 9002 standards to ensure consistency in a very large service, teaching and research unit with an ever-changing complement of personnel," says Dr. David Kenny, director of dental research and graduate studies, at SickKids and professor of dentistry, University of Toronto. "ISO 9002 registration is a sign to our patients, the hospital's administration, the Ministry of Health, the University of Toronto and private insurance carriers that the systems supporting our dental service and teaching program are both appropriate and consistently maintained."

Practice standards for the SickKids clinic and dentistry come from a wide variety of legal, government and regulatory agencies. In addition, dental staff of teaching and research hospitals must satisfy regulations of the Commission on Dental Accreditation of Canada, and the hospital's Research Ethics Board for the review and approval of research projects.

The concept of external review, such as ISO 9002 is new to dentistry. However, the Royal College of Dental Surgeons of Ontario is preparing to introduce a program for random reviews of dentists in their primary workplace. For the first time dentists, whether in a group dental practice, a hospital clinic, or public health or university clinic, will be reviewed. Salaried dentists (full or part-time) and associate dentists now have an increased stake in ensuring that their workplace meets the standards of infection control and radiation protection and that their personal dental records meet the standards of their regulatory body.

Once the decision was made by the dentistry clinic to apply for ISO 9002 registration, consultants from ISODOC, a service company with consultants experienced in preparing health care facilities for ISO registration, was retained. Dr. Robin Conway, whose own dental practice is ISO 9002 registered, and ISODOC consultants took 10 months to review and adapt ISO standards to the clinic's existing practice. All procedures from booking appointments, purchasing supplies, sterilizing equipment, infection control, radiation protection and staff training were reviewed and standardize.

The centerpiece of the process is a controlled document, the ISO Manual, that contains documentation on policy, procedures and process. ISODOC consultants met monthly with staff during production of the Manual and will continue to monitor the evolution of the practice.

The study called "Development of ISO 9002 quality management standards for Canadian dental practices" was published in the February issue of The Journal of the Canadian Dental Association. The study describes the process undertaken by the dental clinic at SickKids to acquire ISO 9002 registration. It was co-authored by David J. Kenny, BSc. DDS. PhD, Director of Dental Research and Graduate Studies, The Hospital for Sick Children and Professor of Dentistry, University of Toronto; Robin M Conway, BDS, President of ISODOC; Douglas H. Johnston, DDS. MSc, Dentist-in-Chief, The Hospital for Sick Children and Associate Professor of Dentistry, University of Toronto.

Scientists use bioengineering to buy time for ailing hearts

Tue, 02 Feb 1999 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have successfully used biological engineering to prevent the closing of a key passage between the two large blood vessels leading out of the heart to the body and lungs. The passage, called the ductus arteriosis, normally closes shortly after birth, but the survival of newborns with severe heart defects depends on the ductus remaining open, at least until corrective surgery can be carried out. The research is reported in the February issue of the scientific journal Nature Medicine.

Dr. Marlene Rabinovitch, SickKids' head of Cardiovascular Research, holder of the Heart and Stroke Foundation of Ontario Chair at SickKids, and a professor of Paediatrics at the University of Toronto, used a gene transfer process in her animal research to deliver a "decoy gene" that tricks cells into thinking they don't have to make a substance critical to the ductus closing process.

In normal heart development, the ductus closes within hours of birth and the lungs take over the task of oxygenating the blood. The ductus is sealed by cushions that grow together from each side of the passage. This seal prevents the back flow of blood into the heart, which can cause congestion and heart failure. But infants who are born with severe heart defects, such as blocked valves, rely on an open ductus to ensure that blood gets to the body.

"Keeping the ductus open ensures that the blood keeps flowing throughout the body, buying the baby time until surgery can be carried out to repair the heart defect," explains Dr. Rabinovitch.

The cushions that seal the ductus are made of muscle cells that migrate to the ductus along a slippery substance called fibronectin. In her research, Dr. Rabinovitch used a "decoy" gene to trick the cells into thinking they don't have to make fibronectin. Without it, muscle cells can't travel to the site of the ductus.

"Basically, we pulled the rug out from under the muscle cells as they were on their way to block off the ductus," explains Dr. Rabinovitch.

Almost one in 100 infants are born with a heart defect requiring open-heart surgery. Defects are often identified before birth through the use of fetal ultrasound. Usually the infants are treated with a hormone called prostaglandin, which helps keep the ductus open. However, prostaglandins need to be given continuously by intravenous and are associated with serious side effects such as low blood pressure and irregular heartbeats. The development of a bioengineering approach to keep the ductus open could lead to a more effective and safe way to help infants with serious heart problems survive.

"The next step in the research will be to develop a method for delivering our 'decoy gene' directly into the necessary cells before the baby is born," explains Dr. Rabinovitch. "We also anticipate that successful biological engineering of the ductus can be applied to other heart problems, such as preventing the reclosing of arteries after angioplasty."

This research was funded by the Medical Research Council of Canada and SickKids.

Joint Release: The Hospital for Sick Children and Dr. Nancy Olivieri

Tue, 26 Jan 1999 24:00:00 EST

TORONTO - The Hospital for Sick Children (SickKids) and Dr. Nancy Olivieri are pleased to release the following joint statement:

"The Hospital for Sick Children and Dr. Nancy Olivieri are pleased to announce that they have reached a comprehensive resolution of recent controversies between them. The resolution will strengthen both clinical care for haemoglobinopathy patients and clinically-based research on Thalassemia, Sickle Cell and related diseases.

Under the settlement, Dr. Olivieri will continue to lead the clinical and research programs on haemoglobinopathy at The Toronto Hospital and SickKids. Through reorganization of the program at SickKids, all parties are confident that the new arrangements will strengthen clinical care and research.

New centre to lead Canadian brain tumour research

Wed, 20 Jan 1999 24:00:00 EST

TORONTO - Canada's first basic science brain tumour research centre is set to open this week at The Hospital for Sick Children (SickKids). The Arthur and Sonia Labatt Brain Tumour Research Centre brings together clinicians and scientists from The Hospital for Sick Children (SickKids), The Toronto Hospital and the University of Toronto to form a leading-edge collaborative laboratory.

The Hospital for Sick Children open only for emergencies and inpatients

Thu, 14 Jan 1999 24:00:00 EST

ATTENTION - STORM ALERT DESKS, NEWS ASSIGNMENT EDITORS, HEALTH REPORTERS

Re: Photo opportunities at The Hospital for Sick Children on Christmas and Boxing Days

Thu, 24 Dec 1998 24:00:00 EST

TORONTO - Approximately 240 children will spend Christmas at The Hospital for Sick Children. They are too sick to leave the Hospital, even for the day. Most will be joined by their parents and families.

SickKids Emergency Department gets ready for another busy holiday season

Fri, 18 Dec 1998 24:00:00 EST

TORONTO - December is historically the busiest month in the Emergency Department at The Hospital for Sick Children particularly on Boxing Day. Surveys show that approximately 30 per cent of the children brought to Emergency don't need to come; many had problems such as ear aches, low-grade fever, flu and colds. They did not require a response from a hospital-based emergency team, and should have been looked after by the family physician, general practitioner, paediatrician or staff in a community health care clinic.

Keep children safe over the Holidays: Advice from The Poison Information Centre at Sick Kids

Thu, 17 Dec 1998 24:00:00 EST

TORONTO - Accidents in the home are most likely to happen when routines are disrupted and adults distracted -- and that makes the upcoming holiday season a time to take extra safety precautions, say staff of The Hospital for Sick Children.

Researchers discover new treatment for deadly heart virus

Tue, 01 Dec 1998 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids), the Toronto Hospital and the University of Toronto (U of T) have carried out studies which could lead to a new way to treat viral myocarditis, an inflammation of the heart leading to heart failure and, ultimately, the need for a transplant. Their research is reported in the December issue of the scientific journal Nature Medicine.

SickKids reviewer selects prominent associate panelists

Thu, 12 Nov 1998 24:00:00 EST

TORONTO - Dr. Arnold Naimark, the reviewer selected by The Hospital for Sick Children's Board of Trustees, has selected two prominent Canadians as associate panelists from a list of eminent and qualified individuals prepared by Dr. Henry Friesen, President, Medical Research Council of Canada. The two panelists are Dr. Frederick H. Lowy, Rector and Vice-Chancellor of Concordia University, and Dr. Bartha Maria Knoppers, a Professor at the Université de Montréal and a lawyer.

SicKKids improves access to global genome database

Thu, 05 Nov 1998 24:00:00 EST

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have improved access to an important resource for genetics researchers around the world: a genome database that provides the latest data from human gene mapping activities. SickKids information scientists have launched Canada's only mirror site of the Genome Database (GDB), currently located at the Johns Hopkins School of Medicine.

Statement by Jim Pitblado, chairman, SickKids Board of Trustees

Wed, 04 Nov 1998 24:00:00 EST

TORONTO - The Board of Trustees, The Hospital of Sick Children, deeply regrets that efforts to implement the participation process for the L-1 clinical trials review, as agreed upon by the parties, have failed in spite of the best efforts of Dr. Henry Friesen, President, Medical Research Council of Canada.

SickKids researchers embark on diabetes prevention study

Mon, 02 Nov 1998 24:00:00 EST

TORONTO - Diabetes researchers at The Hospital for Sick Children (SickKids) are hoping that thousands of Canadians will volunteer to be screened as part of a study aimed at preventing type 1 diabetes, also known as juvenile diabetes.

Statement from Jim Pitblado, chairman, Board of Trustees, The Hospital for Sick Children

Tue, 20 Oct 1998 24:00:00 EDT

TORONTO - The Board of Trustees, The Hospital for Sick Children, in consultation with Dr. Arnold Naimark, the Reviewer for Phase One, has taken steps to address the concerns expressed by internal and external constituencies as they relate to the L-1 clinical trials review process.

Scientists find gene for severe form of epilepsy

Wed, 30 Sep 1998 24:00:00 EDT

TORONTO - An international research team led by Dr. Steve Scherer, of The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) has identified a gene responsible for one of the most severe forms of epilepsy, known as Lafora disease (LD). The discovery is reported in the October issue of the prestigious scientific journal Nature Genetics.

Statement from James B. Pitblado, Chairman, Board of Trustees, The Hospital for Sick Children

Wed, 09 Sep 1998 24:00:00 EDT

TORONTO - On behalf of the Board of Trustees of The Hospital for Sick Children, James B. Pitblado, Chairman today said:

Discovery of new stem cell leads to better understanding of blood system, and raises questions about current methods used for human stem cell transplants

Mon, 31 Aug 1998 24:00:00 EDT

TORONTO - A team of researchers, led by SickKids geneticist John Dick, PhD, at The Hospital for Sick Children, has discovered a new stem cell in human blood providing researchers with further insight into the working of the blood system. The discovery also questions whether current methods for human stem cell transplants used in the treatment of some blood diseases need to be modified. This discovery will enable the development of new treatments, including gene therapy for blood diseases such as leukemia, thalassemia and sickle cell anemia. The work is published in the August 31 issue of Nature Medicine.

SickKids launches external review

Thu, 20 Aug 1998 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) has commissioned an external review of policies and procedures surrounding clinical trials and third party funding to ensure that everything possible is being done to protect both the safety of patients and scientific integrity of its research studies.

On the Tip of the Toes: Expedition for nine children with cancer, heads to Nunavik

Mon, 27 Jul 1998 24:00:00 EDT

TORONTO - On August 1, nine teens with cancer are taking a break from their battle with the disease to join in an eight-day, cross-cultural hiking expedition in Nunavik, northern Quebec.

The Hospital for Sick Children opens Centre for Applied Genomics

Wed, 22 Jul 1998 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) has created a research facility that will help ensure Canada maintains its prominent international role in genetic research. The Hospital's new Centre for Applied Genomics builds on more than 40 years of experience in genetics and focuses on activities that will allow Canada to benefit from the biological information being generated by the Human Genome Project, the worldwide scientific effort to decode the human genome.

SickKids invests in tomorrow's health researchers

Wed, 15 Jul 1998 24:00:00 EDT

TORONTO - A $10-million investment by SickKids Foundation will help provide financial assistance to University of Toronto (U of T) graduate students who are in training at The Hospital for Sick Children (SickKids). The Foundation's investment is matched equally by the University of Toronto and the provincial government's Ontario Student Opportunity Trust Fund program to create the $30-million Hospital for Sick Children Foundation Studentships program at the U of T.

Ulcer drug linked to birth defects

Thu, 25 Jun 1998 24:00:00 EDT

TORONTO - Researchers at Toronto's Hospital for Sick Children (SickKids) and several hospitals in Brazil have determined that a drug commonly used for the treatment and prevention of ulcers causes a significant birth defect if taken during pregnancy. The drug, misoprostol, joins an international list of approximately 24 medications proven to cause birth defects. The research is reported in today's issue of the New England Journal of Medicine.

SickKids establishes flagship chair

Tue, 23 Jun 1998 24:00:00 EDT

TORONTO - With the establishment of its flagship chair in paediatrics today, The Hospital for Sick Children took a landmark step towards ensuring the future of children everywhere. The R.S. McLaughlin Foundation Chair in Paediatrics at The Hospital for Sick Children, established with a $2-million gift from the R.S. McLaughlin Foundation, will help SickKids expand its role as an advocate for children's health. The chair will focus on helping to shape child health policy at the local, provincial, national, and international levels.

Research uncovers a key to aging and lifespan determination

Tue, 02 Jun 1998 24:00:00 EDT

TORONTO - A research team led by Dr. Gabrielle Boulianne of The Hospital for Sick Children (SickKids) and the University of Toronto ( U of T) and Drs. John Phillips and Arthur Hilliker of the University of Guelph has identified a critical weakness in the defence against aging. Using the fruit fly as a model biological system, the researchers discovered that a specific cell type - the motor neuron - is the major target for oxidative damage, known for several years to be a key factor affecting aging and lifespan. The researchers were able to boost the flies' defences by inserting a human gene which is known to protect against oxidative damage. As a result, the average lifespan of the flies (usually about 80 days) was increased by 40 per cent. Their research is reported in the June issue of the scientific journal Nature Genetics.

The H.E. Sellers Chair in Cystic Fibrosis established at The Hospital for Sick Children

Wed, 13 May 1998 24:00:00 EDT

TORONTO - In recognition of the Sellers' family long-term commitment to cystic fibrosis research, SickKids tomorrow announces the establishment of the H.E. Sellers Chair in Cystic Fibrosis at The Hospital for Sick Children. Named for family patriarch Henry Eugene Sellers, the Chair provides a stable base from which to consolidate the Hospital's role at the forefront of cystic fibrosis research, and ensures resources are available in perpetuity.

Scientists take another step forward in CF research

Tue, 10 Mar 1998 24:00:00 EST

TORONTO - Scientists at The Hospital for Sick Children (SickKids) and the University of Toronto (U of T) have provided the first structural evidence that the defective cystic fibrosis (CF) gene leads to a malformation of the protein that carries out the gene's biochemical orders. The discovery has important implications for developing new therapies for CF and other diseases caused by protein malformation. The research is reported in the March issue of Nature Structural Biology.

"New generation" of antidepressants found safe in pregnancy

Wed, 25 Feb 1998 24:00:00 EST

TORONTO - The first study of antidepressants dubbed the "next generation after Prozac" has shown that they are safe to take during pregnancy and do not increase the risk of birth defects, miscarriage, stillbirth or prematurity. The study assessed the effects of three new selective serotonin reuptake inhibitors (SSRI), a class of anti-depressant used by millions of people worldwide. The report is published in the February 25 issue of the Journal of the American Medical Association.

New service offers help to pregnant women suffering from nausea and vomiting

Wed, 11 Feb 1998 24:00:00 EST

TORONTO - A new toll-free phone counseling service is now available in Canada and the U.S. to assist and counsel women suffering from severe nausea and vomiting during pregnancy (NVP).

Lombard Insurance Chair in Paediatric Research established at The Hospital for Sick Children

Tue, 27 Jan 1998 24:00:00 EST

TORONTO - The hospital for Sick Children (SickKids) today announced a $2-million gift from Lombard Insurance, the largest in the company's history. The gift will endow, in perpetuity, the Lombard Insurance Chair in Paediatric Research at The Hospital for Sick Children. The chair, held jointly with the University of Toronto, will provide vital resources to ensure that advances continue to be made in the research and treatment of children's illnesses and diseases.

Dr. Manuel Buchwald, chief of Research at The Hospital for Sick Children, is the inaugural Chair holder. His responsibilities include leading all of the Hospital's research work; recruiting and retaining outstanding investigators who, together, will form one of the world's most effective teams in paediatric health research; and working with members of the Hospital's executive team to provide leadership to the entire institution.

The Chair is a linchpin in the $82-million Help Make Sick Kids Better campaign's efforts to establish stable research funding at SickKids. One of Dr. Buchwald's most challenging tasks as the inaugural chair holder is ensuring that philanthropists, policy makers, and other hospital leaders understand the importance of research.

"This chair will help promote the value of research," Dr. Buchwald explained. "It provides a platform to communicate the importance of long-term research funding to those who work outside the laboratory."

Byron Messier, Chairman and CEO of the company, explained Lombard Insurance's decision to endow the chair.
"The Hospital for Sick Children is a world-renowned, first class children's hospital and research institution. Lombard Insurance is delighted to be able to make this gift to help ensure ongoing research that has an impact on children's health," he said. "Any significant progress, whether in medical research or the insurance business, requires a substantial up front investment in the people and technology that can make it happen. The results aren't always immediately apparent, but if we don't try, we can't move forward."

Lombard Insurance is a Canadian-owned property and casualty insurance company that has been providing protection and peace of mind to individuals and businesses for almost 200 years. Its subsidiary, Zenith Insurance Company, specializes in automobile and homeowners coverage for Canadians over the age of 50 through its Privilege 50 Program.

SickKids scientists overcome gene therapy hurdle

Tue, 23 Dec 1997 24:00:00 EST

TORONTO - A research advance by scientists at The Hospital for Sick Children (SickKids) has the potential to overcome two key obstacles preventing successful and safe gene therapy in patients with cystic fibrosis and lung cancer. The advance enables the therapeutic gene to work only in the desired location in the lung and uses only human genetic material to make the gene work.

Dr. John Dick wins MRC's Michael Smith Award

Wed, 17 Dec 1997 24:00:00 EST

TORONTO - John Dick, senior scientist, Genetics, and professor of Molecular and Medical Genetics at the University of Toronto, has been named the 1997 recipient of the prestigious Michael Smith Award for Excellence.

New service from The Hospital for Sick Children provides confidential counseling about the risk of infection and HIV treatment during pregnancy

Mon, 01 Dec 1997 24:00:00 EST

TORONTO - A new service to provide Canadian women with free, confidential counseling about the risk of HIV infection and HIV treatment during pregnancy is now available through The Hospital for Sick Children Motherisk Program.

The Hospital for Sick Children conducts research at Bay & Adelaide

Tue, 25 Nov 1997 24:00:00 EST

TORONTO - In a celebration of Canadian research achievements, Sick Kids wants everyone to look for genes. That's the idea behind its new mural located at Bay & Adelaide streets, on the largest outdoor advertising face in Canada.

A disruption in postal service could cost The Hospital for Sick Children up to $1.6-million

Thu, 20 Nov 1997 24:00:00 EST

TORONTO - The hospital's annual direct-mail fund raising appeal is scheduled to be mailed next week to 230,000 households in Ontario. Hospital officials are concerned that the appeal won't reach the households, and that donations will be prevented from reaching the hospital.

Researchers find gene causing vision loss

Fri, 14 Nov 1997 24:00:00 EST

TORONTO - An international team of researchers, led by Dr. Roderick McInnes of The Hospital for Sick Children (SickKids), has identified a gene in which mutations cause inherited retinal degeneration. The work was done in collaboration with Drs. Shomi Bhattacharya of University College, London, Constance Cepko of Harvard Medical School, and Samuel Jacobson of the University of Pennsylvania. The research is published in today's issue of the scientific journal Cell.

Independent Order of Foresters donates $250,000 to SickKids' child abuse prevention program

Tue, 21 Oct 1997 24:00:00 EDT

TORONTO - To help prevent child abuse and improve the quality of life of child abuse victims, The Independent Order of Foresters (IOF) has donated $250,000 to The Hospital for Sick Children's (SickKids) Suspected Child Abuse and Neglect (SCAN) Program.

SickKids announces largest personal gift in its 123-year history

Mon, 22 Sep 1997 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) today announced a $5 million gift made by Arthur and Sonia Labatt towards the Help Make SickKids Better campaign. This gift, the largest ever made by a family to SickKids, sets a new standard for health care philanthropy in Canada.

SickKids launches $82 million campaign and Garth Drabinsky gift

Mon, 15 Sep 1997 24:00:00 EDT

TORONTO - The Hospital for Sick Children (SickKids) today announced a $5 million gift made by Arthur and Sonia Labatt towards the Help Make SickKids Better campaign. This gift, the largest ever made by a family to SickKids, sets a new standard for health care philanthropy in Canada.

The Hospital for Sick Children goes global; three international Telehealth partner sites announced

Fri, 25 Jul 1997 24:00:00 EDT

TORONTO --The Hospital for Sick Children (SickKids) bridged the geographical distance between Canada, Israel and Argentina within a matter of minutes today through a new international Telehealth Clinic.

Severe morning sickness forcing some women to terminate planned and wanted pregnancies

Mon, 23 Jun 1997 24:00:00 EDT

TORONTO - A recent study by researchers at The Hospital for Sick Children (SickKids) has revealed that severe morning sickness is forcing some Canadian women to terminate an otherwise planned and wanted pregnancy. The survey also indicates that most of the affected women did not receive appropriate medication for the condition, even though an approved drug is available in Canada. The survey results are published in the June issue of Canadian Family Physician.

First national study released on families living with HIV/AIDS

Mon, 28 Apr 1997 24:00:00 EDT

TORONTO -The findings of the first national study on how families cope with HIV/AIDS entitled: Children Born to Mothers with HIV: Psychosocial Issues for Families in Canada Living with HIV/AIDS will be presented tomorrow:

Providing pain control for circumcision necessary, safe, and effective

Wed, 23 Apr 1997 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids) and Women's College Hospital (WCH) are hoping the results of their study published in the April 24 issue of the New England Journal of Medicine will influence a change in the practice of circumcising male infants without analgesia. The research group has demonstrated that the use of an anaesthetic cream prior to the procedure is a safe way to effectively reduce circumcision pain.

Organ donor awareness event at The Hospital for Sick Children; a celebration of life

Tue, 22 Apr 1997 24:00:00 EDT

TORONTO - A reception to promote organ donor awareness week will take place at The Hospital for Sick Children (SickKids) in the Garden Patio (cafeteria, Elizabeth St. entrance) on April 23 from noon to 1 p.m. Children who have been transplanted at SickKids and those currently waiting for organ transplants have been invited to attend the event entitled Lives Are In Your Hands.

SickKids researchers identify new human immune disorder; bone marrow transplant may be a possible cure

Thu, 17 Apr 1997 24:00:00 EDT

TORONTO - Researchers at The Hospital for Sick Children (SickKids) have identified a genetic basis for a previously unidentified human immune disorder that causes severe inflammation of the gastrointestinal system and lungs. The discovery, announced this month in the Proceedings of the National Academy of Science USA, indicates that autoimmune disorders can result from abnormal development of the immune system.

Study shows that infants feel and remember circumcision pain

Fri, 28 Feb 1997 24:00:00 EST

TORONTO - A study led by Hospital for Sick Children (SickKids) researchers has demonstrated that not only do male infants feel pain during circumcision, they remember that pain six months later when they receive their routine vaccination. The results of the study, led by Anna Taddio, a graduate student supervised by Dr. Gideon Koren, head of Clinical Pharmacology & Toxicology at SickKids and a Professor of Paediatrics, Pharmacology, and Medicine at the University of Toronto, are reported in the March 1 issue of the British medical journal Lancet.

SickKids Liver Transplant Program celebrates 10 years

Fri, 28 Feb 1997 24:00:00 EST

TORONTO - Eight months ago a team of surgeons at The Hospital for Sick Children (SickKids) transplanted a two-year-old girl with a portion of her father's liver which was surgically removed by a team of surgeons at Toronto Hospital. The procedure was a first for the two hospitals and a major milestone for the liver transplant program at SickKids.

Eight-hour surgery on boy from the Philippines a success

Tue, 18 Feb 1997 24:00:00 EST

TORONTO - Surgeons at The Hospital for Sick Children (SickKids) today removed a grapefruit-sized tumour from the nose and forehead of a five-year-old boy from the Philippines. The procedure, which took nearly eight hours, was performed by neurosurgeon Harold Hoffman and craniofacial plastic surgeon John Phillips."The surgery went well," said Dr. Phillips.

Surgeons at The Hospital for Sick Children will remove facial tumour on Filipino boy

Mon, 17 Feb 1997 24:00:00 EST

TORONTO - A five-year old boy from the Philippines is scheduled for surgery (tomorrow) on February 18 at The Hospital for Sick Children (SickKids) to remove a tumour from his forehead and nose. His condition, a birth defect predominately seen in South East Asia, is known as frontalnasal encephalocele (pron. frontal nasal en-so-fa-lo-seal).

Common antidepressant drugs safe in pregnancy; infant neurodevelopment not affected

Wed, 22 Jan 1997 24:00:00 EST

TORONTO - Women who require antidepressant medication while pregnant, but are worried about the risk to their unborn babies, may be relieved at the results of a study to be published in the January 23 issue of the New England Journal of Medicine.

Early blood cell pinpointed; may hold key to successful gene therapy

Tue, 03 Dec 1996 24:00:00 EST

TORONTO - An international team of researchers, led by Hospital for Sick Children geneticist John Dick, has identified a human blood cell which regrows the entire blood system. While scientists have known for years that such a bone marrow cell (called a stem cell) exists, it is not until now that they have been able to pinpoint it by examining its blood-producing activity.

The Hospital for Sick Children Hepatitis C notification project continues; 1,000 additional letters are sent

Mon, 18 Nov 1996 24:00:00 EST

TORONTO - Children identified through The Hospital for Sick Children hepatitis C notification program make up one of the largest groups of children infected with the virus now being studied.

More than 6,000 notification letters were sent in August 1995 to patients or their parents informing them that they may have been exposed to the virus after receiving a blood transfusion or blood products at the hospital between January 1986 and May 1990. A second mailing of 1,000 letters was sent on Friday November 15, to patients not reached in the first round.

"Of the 4,500 patients we reached through the August 1995 mailing, we know that at least 135 have been infected with this virus," says Dr. Susan King, director of the Hepatitis C Information Project at The Hospital for Sick Children and Associate Professor of Paediatrics, Division of Infectious Diseases.

Letters sent November 15 advise patients of the risk of hepatitis C infection and suggest that they be tested. If testing determines that a child is infected with hepatitis C, his parents are encouraged to call the Transfusion

Information Line at The Hospital for Sick Children to arrange an appointment with a hepatologist (a specialist in diseases of the liver). The number is (416) 813-6264.

By registering in the program, children with hepatitis C can derive the greatest benefit from early intervention - like lifestyle counseling,- to better manage the disease and their health.

In addition, physicians and nurses will be able to collect information about how this infection is affecting children. "By registering, families will also be able to help us learn more about this infection," says Dr. King.

Background

Hepatitis C is a viral infection of the liver caused by the hepatitis C virus. A blood test to detect the virus was developed in 1990. Approximately one in 1,500 blood donors in Canada carry the hepatitis C virus. Before donors were tested for the virus, the risk from a single unit of blood was about one in 1,000 (or 0.1) percent. But since May 1990, when screening for donors for hepatitis C started, the risk has been dramatically reduced.

Little is known about the progress of hepatitis C in children. Children may have an active infection yet not exhibit symptoms for many years. These may include jaundice, nausea and fatigue. About 20 percent of adults with hepatitis C develop cirrhosis (scarring); severe cirrhosis is associated with liver cancer.

SickKids and Hyal Pharmaceutical to collaborate on research for vascular disease and cancer

Thu, 31 Oct 1996 24:00:00 EST

TORONTO - The Hospital for Sick Children and Hyal Pharmaceutical Corporation (TSE: HPC, NASDAQ: HYALF) announced today a collaborative research agreement designed to link the findings of basic laboratory research with the delivery of potential treatments for vascular disease and cancerous tumours.

SickKids scientists find the gene for Cyclops

Thu, 31 Oct 1996 24:00:00 EST

TORONTO - When the Greek poet Homer wrote The Odyssey, was he describing the one-eyed Cyclops from personal observation? His description may have been accurate, given a recent discovery by scientists at The Hospital for Sick Children (SickKids) and The Children's Hospital of Philadelphia.

A literacy success - The Reading Room at The Hospital for Sick Children celebrates one year anniversary

Mon, 09 Sep 1996 24:00:00 EDT

TORONTO - Patients and staff at The Hospital for Sick Children will be joined by children's celebrities Monday, September 9 at 2 p.m. to celebrate the first anniversary of the Reading Room, the "storefront" for the literacy initiative supported by SickKids, The Toronto Public Library, and the Toronto Board of Education.

Researchers find gene involved in colon cancer; learn why some cells become malignant

Fri, 23 Aug 1996 24:00:00 EDT

TORONTO - A husband and wife research team at The Hospital for Sick Children has discovered a gene implicated in the development of colon cancer - a disease from which approximately 6,000 Canadians will die this year.

Drs. Liliana Attisano and Jeff Wrana's discovery has brought cancer researchers a step closer in understanding what causes cells to multiply uncontrollably - an activity which leads to the development of malignancies. Their research is reported in the August 23 issue of Cell.

The gene, called MADR2, is located on chromosome 18 in a section that is also involved in the development of other human malignancies, such as pancreatic cancer. MADR2 produces a protein important for conducting signals that govern cell growth. When MADR2 is functioning normally it acts as a tumor suppressor. However, a defective MADR2 gene prevents cells from receiving the growth regulating signal.

"A key step in the development of malignancies is the cell's loss of sensitivity to a molecule called Transforming Growth Factor b (TGFb)," explains Dr. Attisano, an assistant professor of Anatomy and Cell Biology at the University of Toronto and a member of the Division of Gastroenterology and Nutrition in the Research Institute at The Hospital for Sick Children. "TGFb negatively regulates cell growth. A mutated MADR2 gene prevents the cell from receiving the TGFb signal, so it keeps growing. This can lead to the development of tumors."
Gaining an understanding of the events which cause a loss of sensitivity to TGFb could provide important insights into the general mechanisms underlying the causes of malignancies.

"With this new discovery of MADR2 in the TGFb signal pathway, work can begin on developing possible methods of gene therapy to replace the defective gene," explains Dr. Wrana, an assistant professor of Anatomy and Cell Biology at the University of Toronto and a member of the Division of Gastroenterology and Nutrition in the Research Institute of The Hospital for Sick Children. "It's possible that a new class of drugs could be created which would mimic the function of the protein, overcoming the defective gene."

The Canadian Cancer Society estimates that 16,300 Canadians will be diagnosed with colon cancer this year. Of those, 8,800 will be men and 7,500 will be women. The Society also estimates that 6,200 Canadians will die from the disease this year.

Collaborators in this work include researchers Drs. Lap-Chee Tsui and Stephen W. Scherer at The Hospital for Sick Children; Steven Gallinger and Irene L. Andrulis at The Samuel Lunenfeld Research Institute at Mount Sinai Hospital; Gerald H. Thomsen at the Institute for Cell and Developmental Biology at the State University of New York and the University of Toronto.

This research was supported by the Medical Research Council of Canada, The National Cancer Institute of Canada, the Canadian Breast Cancer Research initiative, the Canadian Genetic Diseases Network, the Howard Hughes International Fellowship, the U.S. National Science Foundation and the American Heart Association.

Infrastructure costs of the Research Institute are supported by The Hospital for Sick Children Foundation.

Molecular diagnosis of genetic disease could lead to huge health care savings

Thu, 01 Aug 1996 24:00:00 EDT

TORONTO - Costs for screening children at risk of developing cancer of the retina would be reduced by as much as 70 percent if molecular screening methods were used, say researchers at The Hospital for Sick Children, The Toronto Hospital and the University of Toronto.

The Hospital for Sick Children opens a Shoppers Drug Mart Prescription Centre

Mon, 15 Jul 1996 24:00:00 EDT

TORONTO - The need to provide strong financial support to research, education and health care initiatives not funded by the provincial government is behind an innovative partnership that links one of Canada's most respected hospitals with one of the country's most successful retailers.

Toronto's renowned Hospital for Sick Children has opened a Shoppers Drug Mart Prescription Centre within its facilities today that is both owned and operated by the hospital. As far as the hospital and Shoppers Drug Mart know, this is the first such arrangement of its kind in Canada.

Doctors at The Hospital for Sick Children and The Toronto Hospital perform their first joint living-related donor liver transplant

Fri, 21 Jun 1996 24:00:00 EDT

TORONTO - A 35-year-old Toronto father gave a priceless gift on June 18 when surgeons at The Toronto Hospital and The Hospital for Sick Children removed a portion of his liver and transplant it into his 19-month old daughter. Both father and daughter are doing well.

Nine-day-old conjoined twins separated yesterday at The Hospital for Sick Children

Thu, 02 May 1996 24:00:00 EDT

TORONTO - Twin boys joined at the abdomen and chest were separated at The Hospital for Sick Children on Wednesday
May 1.

Manuel Buchwald, O.C., PhD, named Director of The Hospital for Sick Children Research Institute

Tue, 23 Apr 1996 24:00:00 EDT

TORONTO - Manuel Buchwald, O.C., PhD, has been appointed Director of The Hospital for Sick Children Research Institute, effective immediately. Since last July he has served as Acting Director of the Institute, a position he also held for 15 months in 1986-87.

Researchers find major gene for eye development

Mon, 01 Apr 1996 24:00:00 EST

TORONTO - A team of researchers led by Dr. Roderick McInnes of the departments of Genetics and Paediatrics at The Hospital for Sick Children, Dr. Margit Burmeister at the University of Michigan, and Dr. Mark Hankin at the Medical College of Ohio, has identified a major regulatory gene -called Chx10 - that is a critical control of retina and eye development in mammals. The work was done in collaboration with Ben Taylor and Tom Roderick at the Jackson Laboratories in Bar Harbor, Maine. Their research is reported in the April issue of Nature Genetics.

Fanconi Anemia research advanced by development of new animal model

Mon, 01 Apr 1996 24:00:00 EST

TORONTO - A team of scientists, led by Manuel Buchwald, O.C., PhD., of The Hospital for Sick Children, has successfully reproduced characteristics of Fanconi Anemia in mice, giving them a living model in which to test novel treatments - including gene therapy - for this rare but devastating inherited blood disorder. Their research is published in the April 1, 1996 issue of Nature Genetics.

New liver disease caused by excess zinc, copper, SickKids study shows

Sat, 30 Mar 1996 24:00:00 EST

TORONTO - A new liver disease caused by excessive amounts of zinc and copper has been identifed by pathologist James Phillips and colleagues at The Hospital for Sick Children, it was announced in today's issue of the British scientific publication Lancet.

Novel treatment concept blocks signals that control growth of leukemia cells

Wed, 14 Feb 1996 24:00:00 EST

TORONTO - Researchers at Toronto's Hospital for Sick Children (SickKids) have developed a novel concept for anti-cancer treatment of recurrent acute lymphoblastic leukemia, the most common form of childhood cancer. Their approach is to selectively block an intracellular transmitter of signals which control the growth of leukemia cells.

Treatment proven effective for severe form of rare disease

Wed, 03 Jan 1996 24:00:00 EST

TORONTO - Sometimes you have to wait 30 years to learn if your discovery is really making a difference in a patient's life. The waiting is finally over for Dr. Bibudhendra (Amu) Sarkar of The Hospital for Sick Children (SickKids), as confirmed by a report in the January issue of Nature Genetics.

The Hospital for Sick Children opens Telemedicine Clinic for children in Northern Ontario communities

TORONTO -Telemedicine is welcome relief for Lisa Holdt and her eight-year-old son Michael. Starting in February, they'll be able to visit paediatric medical specialists at The Hospital for Sick Children (SickKids) without leaving Thunder Bay.

Unique Centre for Image-Guided Therapy opens at SickKids

The new Centre for Image-Guided Therapy (IGT), which offers a combined approach to diagnosis and treatment using minimally invasive procedures and state-of-the-art interventional radiology equipment, opens today at The Hospital for Sick Children (SickKids).

SickKids’ Motherisk Program celebrates 20th anniversary

TORONTO - The Motherisk Program at The Hospital for Sick Children (Sick Kids) is celebrating 20 years of counselling and research about the safety or risk to the developing baby of maternal exposure to drugs, chemicals, diseases, radiation and environmental agents. Since it was created in 1985, Motherisk has counselled more than 250,000 women. It is the only program of its kind in Canada and one of the most comprehensive in the world.

SickKids establishes telehealth partnership with Trinidad and Tobago

TORONTO - The Hospital for Sick Children (Sick Kids) expands its global reach with the establishment of a telehealth site in Trinidad and Tobago

Viagra may help children with fatal lung disorder

TORONTO – Physicians at The Hospital for Sick Children (Sick Kids) have found that the drug sildenafil, also known as Viagra, may help children suffering from pulmonary arterial hypertension. This research is reported in the June 14, 2005 issue of Circulation: Journal of the American Heart Association .