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Publications

Highlighted Publications

Adeli K, Higgins V, Trajcevski K, Palmert MR. Important considerations for interpreting biochemical tests in children. bmj. 2018 May;361. doi; 0.1136/bmj.k1950. View abstract

Adeli K, Higgins V, Trajcevski K, White-Al Habeeb N. The Canadian laboratory initiative on pediatric reference intervals: a CALIPER white paper. Crit Rev Clin Lab Sci. 2017 Sep;54(6):358-413. doi: 10.1080/10408363.2017.1379945. Epub 2017 Oct 11. Review.View abstract


Transference Studies and CALIPER SUB-STUDIES | Review Articles and Gap Analyses

Reference Interval Publications

  1. Higgins V, Asgari S, Chan MK, Adeli K. Pediatric reference intervals for calculated LDL cholesterol, non-HDL cholesterol, and remnant cholesterol in the healthy CALIPER cohort. Clinica Chimica Acta. 2018 Jul 17;486:129-134. Epub ahead of print doi: 10.1016/j.cca.2018.07.028. View abstract
  2. Higgins V, Truong D, White-Al Habeeb NMA, Fung AWS, Hoffman B, Adeli K. Pediatric reference intervals for 1,25-dihydroxyvitamin D using the DiaSorin LIAISON XL assay in the healthy CALIPER cohort. Clin Chem Lab Med. 2018 May 24;56(6):964-972. doi: 10.1515/cclm-2017-0767. View abstract
  3. Higgins V, Fung AWS, Chan MK, Macri J, Adeli K. Pediatric reference intervals for 29 Ortho VITROS 5600 immunoassays using the CALIPER cohort of healthy children and adolescents. Clin Chem Lab Med. 2018 Jan 26;56(2):327-340. doi: 10.1515/cclm-2017-0349.View abstract
  4. Daly CH, Higgins V, Adeli K, Grey VL, Hamid JS. Reference interval estimation: methodological comparison using extensive simulations and empirical data. Clin Biochem. 2017 Dec;50(18):1145-1158. doi: 10.1016/j.clinbiochem.2017.07.005. View abstract
  5. Adeli K, Higgins V, Seccombe D, Collier CP, Balion CM, Cembrowski G, Venner AA, Shaw J National survey of adult and pediatric reference intervals in clinical laboratories across Canada: a report of the CSCC Working Group on reference interval harmonization. CSCC Reference Interval Harmonization (hRI) Working Group. Clin Biochem. 2017 Nov;50(16-17):925-935. doi: 10.1016/j.clinbiochem.2017.06.006. View abstract
  6. Parkin PC, Hamid J, Borkhoff CM, Abdullah K, Atenafu EG, Birken CS, Maguire JL, Azad A, Higgins V, Adeli K. Laboratory reference intervals in the assessment of iron status in young children. BMJ Paediatr Open. 2017 Aug 31;1(1):e000074. doi: 10.1136/bmjpo-2017-000074. View abstract
  7. Cagman Z, Bingol Ozakpinar O, Cirakli Z, Gedikbasi A, Ay P, Colantonio D, Uras AR, Adeli K, Uras F. Reference intervals for growth arrest-specific 6 protein in adults. Scand J Clin Lab Invest. 2017 Apr;77(2):109-114. doi: 10.1080/00365513.2016.1275768. View abstract
  8. Higgins V, Chan MK, Adeli K. Pediatric reference intervals for transferrin saturation in the CALIPER cohort of healthy children and adolescents. EJIFCC. 2017 Mar 8;28(1):77-84. eCollection 2017 Mar. View abstract
  9. Kelishadi R, Marateb HR, Mansourian M, Ardalan G, Heshmat R, Adeli K. Pediatric-specific reference intervals in a nationally representative sample of Iranian children and adolescents: the CASPIAN-III study. World J Pediatr. 2016 Aug;12(3):335-342. doi: 10.1007/s12519-015-0065-8. View abstract
  10. Karbasy K, Lin DC, Stoianov A, Chan MK, Bevilacqua V, Chen Y, Adeli K. Pediatric reference value distributions and covariate-stratified reference intervals for 29 endocrine and special chemistry biomarkers on the Beckman Coulter immunoassay systems: a CALIPER study of healthy community children. Clin Chem Lab Med. 2016 Apr 1;54(4):643-57. doi: 10.1515/cclm-2015-0558. View abstract
  11. Kelly J, Raizman JE, Bevilacqua V, Chan MK, Chen Y, Quinn F, Shodin B, Armbruster D, Adeli K. Complex reference value distributions and partitioned reference intervals across the pediatric age range for 14 specialized biochemical markers in the CALIPER cohort of healthy community children and adolescents. Clinica Chimica Acta. 2015 Aug 24;450:196-202. doi: 10.1016/j.cca.2015.08.020. View abstract
  12. Adeli K, Raizman JE, Chen Y, Higgins V, Nieuwesteeg M, Abdelhaleem M, Wong SL, Blais D. Complex biological profile of hematologic markers across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey. Clinical Chemistry 2015 Aug;61(8):1075-86. doi: 10.1373/clinchem.2015.24053. View abstract
  13. Adeli K, Higgins V, Nieuwesteeg M, Raizman JE, Chen Y, Wong SL, Blais D. Complex reference values for endocrine and special chemistry biomarkers across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey. Clinical Chemistry 2015 Aug;61(8):1063-74. 10.1373/clinchem.2015.240523. View abstract
  14. Adeli K, Higgins V, Nieuwesteeg M, Raizman JE, Chen Y, Wong SL, Blais D. Biochemical marker reference values across pediatric, adult, and geriatric ages: establishment of robust pediatric and adult reference intervals on the basis of the Canadian Health Measures Survey. Clinical Chemistry 2015 Aug;61(8):1049-62. doi: 10.1373/clinchem.2015.240515. View abstract
  15. Teodoro-Morrison T, Kyriakopoulou L, Chen YK, Raizman JE, Bevilacqua V, Chan MK, Wan B, Yazdanpanah M, Schulze A, Adeli K. Dynamic biological changes in metabolic disease biomarkers in childhood and adolescence: a CALIPER study of healthy community children. Clinical Biochemistry 2015 Sep;48(13-14):828-36. doi: 10.1016/j.clinbiochem.2015.05.005. View abstract
  16. Raizman JE, Quinn F, Armbruster DA, Adeli K. Pediatric reference intervals for calculated free testosterone, bioavailable testosterone and free androgen index in the CALIPER cohort. Clinical Chemistry and Laboratory Medicine 2015 Sep 1;53(10):e239-43. doi: 10.1515/cclm-2015-0027. View abstract
  17. Devgun MS, Chan MK, El-Nujumi AM, Abara R, Armbruster D, Adeli K. Clinical decision limits for interpretation of direct bilirubin--a CALIPER study of healthy multiethnic children and case report reviews. Clinical Biochemistry 2015 Jan;48(1-2):93-6. doi: 10.1016/j.clinbiochem.2014.10.011. View abstract
  18. Bevilacqua V, Chan MK, Chen Y, Armbruster D, Schodin B, Adeli K. Pediatric population reference value distributions for cancer biomarkers and covariate- stratified reference intervals in the CALIPER cohort. Clinical Chemistry 2014 Dec;60(12):1532-42. doi: 10.1373/clinchem.2014.229799. View abstract
  19. Adeli K. Closing the gaps in pediatric reference intervals: the CALIPER project - an update. Clinical Biochemistry 2014;epub ahead of print. doi: 10.1016/j.clinbiochem.2014.05.037. View abstract
  20. Raizman JE, Cohen AH, Teodoro-Morrison T, Wan B, Khun-Chen M, Wilkenson C, Bevilaqua V, Adeli K. Pediatric reference value distributions for vitamins A and E in the CALIPER cohort and establishment of age-stratified reference intervals. Clinical Biochemistry 2014; epub ahead of print. doi: 10.1016/j.clinbiochem.2014.03.025. View abstract
  21. Bailey D, Bevilacqua V, Colantonio DA, Pasic MD, Perumal N, Chan MK, Adeli K. Pediatric within-day biological variation and quality specifications for 38 biochemical markers in the CALIPER cohort. Clinical Chemistry. 2014 Mar;60(3):518-29. doi: 10.1373/clinchem.2013.214312. View abstract
  22. Shaw JL, Cohen A, Konforte D, Binesh-Marvasti T, Colantonio DA, Adeli K. Validity of establishing pediatric reference intervals based on hospital patient data: a comparison of the modified Hoffmann approach to CALIPER reference intervals obtained in healthy children. Clinical Biochemistry 2014 Feb;47(3):166-72. doi: 10.1016/j.clinbiochem.2013.11.008. View abstract
  23. Konforte D, Shea JL, Kyriakopoulou L, Colantonio D, Cohen AH, Shaw J, Bailey D, Chan MK, Armbruster D, Adeli K. Complex biological pattern of fertility hormones in children and adolescents: a study of healthy children from the CALIPER cohort and establishment of pediatric reference intervals. Clinical Chemistry 2013;epub ahead of print. doi: 10.1373/clinchem.2013.204123. View abstract
  24. Bailey D, Colantonio D, Kyriakopoulou L, Cohen AH, Chan MK, Armbruster D, Adeli K. Marked biological variance in endocrine and biochemical markers in childhood: establishment of pediatric reference intervals using healthy community children from the Canadian Laboratory Initiative for Pediatric Reference Intervals Cohort. Clinical Chemistry 2013;epub ahead of print. doi: 10.1373/clinchem.2013.204222. View abstract
  25. Pasic MD, Colantonio DA, Chan MK, Venner AA, Brinc D, Adeli K. Influence of fasting and sample collection time on 38 biochemical markers in healthy children: a CALIPER substudy. Clinical Biochemistry 2012 Oct;45(15):1125-30. doi: 10.1016/j.clinbiochem.2012.07.089. View abstract
  26. Colantonio DA, Kyriakopoulou L, Chan MK, Daly CH, Brinc D, Venner AA, Pasic MD, Armbruster D, Adeli K. Closing the gaps in pediatric laboratory reference intervals: a CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clinical Biochemistry 2012 May;58(5):854-68. doi: 10.1373/clinchem.2011.177741. View abstract
  27. Henderson MP, Grey V. Establishing and evaluating pediatric thyroid reference intervals on the Roche Modular Analytics e 170 using computational statistics and data-mining techniques. Clinical Biochemistry 2011 Jul;44(10-11):767-70. doi: doi.org/10.1016/j.clinbiochem.2011.05.006. View abstract
  28. Huang Y, Eapen E, Steele S, Grey V. Establishment of reference intervals for bone markers in children and adolescents. Clinical Biochemistry 2011 Jul;44(10-11):771-8. doi: 10.1016/j.clinbiochem.2011.04.008. View abstract
  29. Blasutig IM, Jung B, Kulasingam V, Baradaran S, Chen Y, Chan MK, Colantonio D, Adeli K. Analytical evaluation of the Vitros 5600 integrated system in a pediatric setting and determination of pediatric reference intervals. Clinical Biochemistry 2010 Sept;43(13-14):1039-44. doi: doi.org/10.1016/j.clinbiochem.2010.05.011. View abstract
  30. Kulasingam V, Jung BP, Blasutig IM, Baradaran S, Chan MK, Aytekin M, Colantonio D, Adeli K. Pediatric reference intervals for 28 chemistries and immunoassays on the Roche Cobas 6000 analyzer--a caliper pilot study. Clinical Biochemistry 2010;43:1045-50. doi: doi.org/10.1016/j.clinbiochem.2010.05.008. View abstract
  31. Chan MK, Seiden-Long I, Aytekin M, Quinn F, Ravalico T, Ambruster D, Adeli K. Canadian laboratory initiative on pediatric reference interval database (CALIPER): pediatric reference intervals for an integrated clinical chemistry and immunoassay analyzer, Abbott Architect ci8200. Clinical Biochemistry 2009 Jun;42(9):885-91. doi: 10.1016/j.clinbiochem.2009.01.014. View abstract
  32. Yip PM, Chan MK, Nelken J, Lepage N, Brotea G, Adeli K. Pediatric reference intervals for lipids and apolipoproteins on the Vitros 5,1 FS chemistry system. Clinical Biochemistry 2006 Oct;39(10):978-83. doi: doi.org/10.1016/j.clinbiochem.2006.06.012. View abstract

Transference Studies and CALIPER Sub-Studies

  1. Higgins V, Truong D, Woroch A, Chan MK, Tahmasebi H, Adeli K. CLSI-based transference and verification of CALIPER pediatric reference intervals for 29 Ortho VITROS 5600 chemistry assays. Clin Biochem. 2018 Mar;53:93-103. doi: 10.1016/j.clinbiochem.2017.12.011. View abstract
  2. Higgins V, Chan MK, Nieuwesteeg M, Hoffman BR, Bromberg IL, Gornall D, Randell E, Adeli K. Transference of CALIPER pediatric reference intervals to biochemical assays on the Roche cobas 6000 and the Roche Modular P. Clinical Biochemistry 2016 Jan 1;49(1-2):139-49; epub ahead of print. doi: 10.1016/j.clinbiochem.2015.08.018. View abstract
  3. Araújo PA, Thomas D, Sadeghieh T, Bevilacqua V, Chan MK, Chen Y, Randell E, Adeli K. CLSI-based transference of the CALIPER database of pediatric reference intervals to Beckman Coulter DxC biochemical assays. Clinical Biochemistry 2015 Sep;48(13-14):870-80. doi: 10.1016/j.clinbiochem.2015.06.002. View abstract
  4. Abou El Hassan M, Stoianov A, Araújo PA, Sadeghieh T, Chan MK, Chen Y, Randell E, Nieuwesteeg M, Adeli K. CLSI-based transference of CALIPER pediatric reference intervals to Beckman Coulter AU biochemical assays. Clinical Biochemistry 2015 May 13; epub ahead of print. doi: 10.1016/j.clinbiochem.2015.05.002. View abstract
  5. Estey MP, Cohen AH, Colantonio DA, Chan MK, Marvasti TB, Randell E, Delvin E, Cousineau J, Grey V, Greenway D, Meng QH, Jung B, Bhuiyan J, Seccombe D, Adeli K. CLSI-based transference of the CALIPER database of pediatric reference intervals from Abbott to Beckman, Ortho, Roche and Siemens Clinical Chemistry Assays: direct validation using reference samples from the CALIPER cohort. Clinical Biochemistry 2013; epub ahead of print. doi: 10.1016/j.clinbiochem.2013.04.001. View abstract
  6. Kyriakopoulou L, Yazdanpanah M, Colantonio DA, Chan MK, Daly CH, Adeli K. A sensitive and rapid mass spectrometric method for the simultaneous measurement of eight steroid hormones and CALIPER pediatric reference intervals. Clinical Biochemistry 2013;46:642-51. doi: 10.1016/j.clinbiochem.2013.01.002. View abstract
  7. Brinc D, Chan MK, Venner AA, Pasic MD, Colantonio D, Kyriakopolou L, Adeli K. Long-term stability of biochemical markers in pediatric serum specimens stored at -80°C: a CALIPER substudy. Clinical Biochemistry 2012 Apr 5. doi: 10.1016/j.clinbiochem.2012.03.029. View abstract

Review Articles and Gap Analyses

  1. Konforte D, Shea JL, Kyriakopoulou L, Colantonio D, Cohen AH, Shaw J, Bailey D, Chan MK, Armbruster D, Adeli K. (2013). Complex biological pattern of fertility hormones in children and adolescents: a study of healthy children from the CALIPER cohort and establishment of pediatric reference intervals. Clin Chem. 2013 Aug;59(8):1215-27. doi: 10.1373/clinchem.2013.204123. Epub 2013 May 1. View abstract
  2. Ozarda Y, Higgins V, Adeli K. Verification of reference intervals in routine clinical laboratories: practical challenges and recommendations. Clin Chem Lab Med. 2018 May 5; epub ahead of print. pii: /j/cclm.ahead-of-print/cclm-2018-0059/cclm-2018-0059.xml. doi: 10.1515/cclm-2018-0059. View abstract
  3. Parker ML, Adeli K, Lévy É, Delvin E. Are universal upper reference limits for alanine aminotransferase (ALT) appropriate for assessing pediatric liver injury? Clin Biochem. 2018 Mar;53:55-57. doi: 10.1016/j.clinbiochem.2018.01.010. View abstract
  4. Parker ML, Adeli K; CSCC Working Group on Reference Interval Harmonization. Pediatric and adult reference interval harmonization in Canada: an update. Clin Chem Lab Med. 2018 Jan 5. pii: /j/cclm.ahead-of-print/cclm-2017-0965/cclm-2017-0965.xml. doi: 10.1515/cclm-2017-0965. View abstract
  5. Adeli K. Laboratory medicine - A hidden treasure in healthcare. Clin Biochem. 2017 Aug;50(12):645-647. doi: 10.1016/j.clinbiochem.2017.03.022. View abstract
  6. Tahmasebi H, Higgins V, Fung AWS, Truong D, White-Al Habeeb NMA, Adeli K. Pediatric reference intervals for biochemical markers: gaps and challenges, recent national initiatives and future perspectives. EJIFCC. 2017 Mar 8;28(1):43-63. eCollection 2017 Mar. View abstract
  7. Jung B, Adeli K. Clinical laboratory reference intervals in pediatrics: the CALIPER initiative. Clinical Biochemistry 2009;42:1589-95. doi: 10.1016/j.clinbiochem.2009.06.025. View abstract
  8. Schnabl K, Chan MK, Gong Y, Adeli K. Closing the gaps in pediatric reference intervals: the CALIPER initiative. Clinical Biochemist Reviews 2008;29:89-96. PMCID: PMC2605413. View abstract
  9. Delvin EE, Laxmi Grey V, Vergee Z. Gap analysis of pediatric reference intervals related to thyroid hormones and the growth hormone-insulin growth factor axis. Clinical Biochemistry 2006;39:588-94. doi: 10.1016/j.clinbiochem.2006.03.006. View abstract
  10. Lepage N, Li D, Kavsak PA, Bamforth F, Callahan J, Dooley K, Potter M. Incomplete pediatric reference intervals for the management of patients with inborn errors of metabolism. Clinical Biochemistry 2006;39:595-9. doi: 10.1016/j.clinbiochem.2006.02.011. View abstract
  11. Mansoub S, Chan MK, Adeli K. Gap analysis of pediatric reference intervals for risk biomarkers of cardiovascular disease and the metabolic syndrome. Clinical Biochemistry 2006;39:569-87. doi: 10.1016/j.clinbiochem.2006.02.013. View abstract